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  1. Article ; Online: Retrosynthetic Analysis of the Synthetic Pathway for Antineocyclocitrinol A.

    Chen, Sihan

    Studies in health technology and informatics

    2023  Volume 308, Page(s) 749–756

    Abstract: With the discovery and exploration of deep-sea fungal metabolites, researchers have found that these abundant metabolites have a wide range of therapeutic effects on human diseases. Mutagenesis, purification and structural analysis of diverse deep-sea ... ...

    Abstract With the discovery and exploration of deep-sea fungal metabolites, researchers have found that these abundant metabolites have a wide range of therapeutic effects on human diseases. Mutagenesis, purification and structural analysis of diverse deep-sea fungal metabolites have led to a new molecule named Antineocyclocitrinol A. This molecule is difficult to synthesize because it contains a complex structure such as the unusual bicyclo [4.4.1] A/B ring system with a bridgehead double bond. This paper explains an analytical strategy for retrosynthesis concretely and provides a theoretically feasible new synthetic pathway for synthesizing Antineocyclocitrinol A. This pathway fills a gap in the specific retrosynthetic analysis of Antineocyclocitrinol A and also serves as an application idea for a more detailed synthesis of cyclocitrinols analogs. Furthermore, this pathway promotes the development of the biopharmaceutical field by using deep-sea fungal metabolites.
    Language English
    Publishing date 2023-11-26
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Glioma Subtypes Based on the Activity Changes of Immunologic and Hallmark Gene Sets in Cancer.

    Chen, Sihan

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 879233

    Abstract: Purpose: Glioma is the most common primary cranial brain tumor that arises from the cancelation of glial cells (which can be in the brain or spinal cord). It is due to innate genetic risk factors or induced by a carcinogenic environment. If left ... ...

    Abstract Purpose: Glioma is the most common primary cranial brain tumor that arises from the cancelation of glial cells (which can be in the brain or spinal cord). It is due to innate genetic risk factors or induced by a carcinogenic environment. If left untreated, the disease has a poor prognosis.
    Methods: In this study, we downloaded glioma data from TCGA database and GEO (GSE4412). The GSEA database was used to screen tumor microenvironment-related gene sets. Cancer subtypes were classified by GSVA enrichment method.
    Results: By GSVA enrichment analysis, we obtain three Gliomas cancer subtypes. After further survival prognosis analysis and biological function analysis, we obtained 13 tumor microenvironment gene sets and 14 core genes that affect patients' survival prognosis, and these genes have the potential to become targets for targeted therapies and disease detection.
    Conclusion: We screened a total of 13 gene sets through a series of enrichment analyses, statistical and prognostic analyses, etc. Among them, 14 core genes were identified, namely: TOP2A, TPX2, BUB1, AURKB, AURKA, CDK1, BUB1B, CCNA2, CCNB2, CDCA8, CDC20, KIF11, KIF20A and KIF2C.
    MeSH term(s) Computational Biology/methods ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Humans ; Prognosis ; Protein Serine-Threonine Kinases ; Tumor Microenvironment/genetics
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.879233
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  3. Article ; Online: Advances in field-effect biosensors towards point-of-use.

    Chen, Sihan / Bashir, Rashid

    Nanotechnology

    2023  Volume 34, Issue 49

    Abstract: The future of medical diagnostics calls for portable biosensors at the point of care, aiming to improve healthcare by reducing costs, improving access, and increasing quality-what is called the 'triple aim'. Developing point-of-care sensors that provide ... ...

    Abstract The future of medical diagnostics calls for portable biosensors at the point of care, aiming to improve healthcare by reducing costs, improving access, and increasing quality-what is called the 'triple aim'. Developing point-of-care sensors that provide high sensitivity, detect multiple analytes, and provide real time measurements can expand access to medical diagnostics for all. Field-effect transistor (FET)-based biosensors have several advantages, including ultrahigh sensitivity, label-free and amplification-free detection, reduced cost and complexity, portability, and large-scale multiplexing. They can also be integrated into wearable or implantable devices and provide continuous, real-time monitoring of analytes
    MeSH term(s) Biosensing Techniques ; Point-of-Care Systems ; Transistors, Electronic
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/acf3f0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection.

    Chen, Sihan / Tang, Die / Deng, Lian / Xu, Shuhua

    iScience

    2024  Volume 27, Issue 5, Page(s) 109560

    Abstract: The European-centered genome-wide association studies of schizophrenia (SCZ) may not be well applied to non-European populations. We analyzed 1,592 reported SCZ-associated genes using the public genome data and found an overall higher Asian-European ... ...

    Abstract The European-centered genome-wide association studies of schizophrenia (SCZ) may not be well applied to non-European populations. We analyzed 1,592 reported SCZ-associated genes using the public genome data and found an overall higher Asian-European differentiation on the SCZ-associated variants than at the genome-wide level. Notable examples included 15 missense variants, a regulatory variant
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109560
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  5. Article ; Online: The emerging role of lactate in tumor microenvironment and its clinical relevance.

    Chen, Sihan / Xu, Yining / Zhuo, Wei / Zhang, Lu

    Cancer letters

    2024  Volume 590, Page(s) 216837

    Abstract: In recent years, the significant impact of lactate in the tumor microenvironment has been greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is also an imperative signaling molecule. It plays key roles in metabolic ... ...

    Abstract In recent years, the significant impact of lactate in the tumor microenvironment has been greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is also an imperative signaling molecule. It plays key roles in metabolic remodeling, protein lactylation, immunosuppression, drug resistance, epigenetics and tumor metastasis, which has a tight relation with cancer patients' poor prognosis. This review illustrates the roles lactate plays in different aspects of tumor progression and drug resistance. From the comprehensive effects that lactate has on tumor metabolism and tumor immunity, the therapeutic targets related to it are expected to bring new hope for cancer therapy.
    MeSH term(s) Humans ; Tumor Microenvironment ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/genetics ; Neoplasms/drug therapy ; Lactic Acid/metabolism ; Drug Resistance, Neoplasm ; Animals ; Signal Transduction ; Clinical Relevance
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-03-26
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2024.216837
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Precipitation- rather than temperature-driven pattern in belowground biomass and root:shoot ratio across the Qinghai-Tibet Plateau.

    Chen, Sihan / Huang, Kailing / Hu, Lingyan / Wang, Peng / Hu, Shuijin

    The Science of the total environment

    2024  Volume 915, Page(s) 170158

    Abstract: The Qinghai-Tibet Plateau faces dramatic global change, which can greatly affect its plant growth, biomass accumulation, and carbon cycling. However, it is still unclear how belowground plant biomass, which is the major part of vegetation biomass on the ... ...

    Abstract The Qinghai-Tibet Plateau faces dramatic global change, which can greatly affect its plant growth, biomass accumulation, and carbon cycling. However, it is still unclear how belowground plant biomass, which is the major part of vegetation biomass on the plateau, changes with different environmental factors, impeding accurate prediction of ecosystem carbon cycling under future global change scenarios. To reveal the patterns of belowground biomass and root:shoot ratio with environmental factors in different vegetation types on the Qinghai-Tibet Plateau, we synthesized data for 158 sites from 167 publications, including 585 and 379 observations for above- and below-ground biomass, respectively. Data on temperature, precipitation, soil nitrogen content, evapotranspiration and solar radiation were collected from open databases. The results showed that precipitation, rather than temperature, was closely associated with other environmental factors including soil N and solar radiation. Also, both above- and below-ground biomass significantly increased with annual precipitation and its related environmental factors, while elevation-related coldness only slightly decreased aboveground biomass. In addition, the positive effect of precipitation on belowground biomass is more obvious in higher elevations (colder areas). As a result, root:shoot ratio significantly increased with precipitation in colder areas but not in warmer areas. Finally, the positive relationship between biomass and precipitation was stronger for dryer steppes than for wetter meadows and shrublands. Our findings indicate that precipitation, as well as the associated nitrogen availability and solar radiation, together are more important drivers than temperature for ecosystem productivity and biomass allocation on the Qinghai-Tibet Plateau. Given the heterogeneous trend of precipitation change on the plateau, productivity response to global change can be highly variable across different regions and vegetation types, which can consequently impact soil carbon dynamics and regional carbon cycling.
    MeSH term(s) Biomass ; Ecosystem ; Tibet ; Temperature ; Soil ; Carbon ; Nitrogen/analysis ; Grassland
    Chemical Substances Soil ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170158
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Programmable photochemical deoxygenation for 2.5D grayscale printing.

    Chen, Sihan / Zhou, Hongqi / Zhou, Ning / He, Jiang / Lu, Wei

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 5, Page(s) 546–549

    Abstract: Homomolecular photon upconversion-induced radical polymerization in an aerated DMSO solution occurs where molecular oxygen is depleted by sensitized photochemical deoxygenation and this photoreaction could be programmed into 2.5D grayscale printings by ... ...

    Abstract Homomolecular photon upconversion-induced radical polymerization in an aerated DMSO solution occurs where molecular oxygen is depleted by sensitized photochemical deoxygenation and this photoreaction could be programmed into 2.5D grayscale printings by digital light processing.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04147f
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  8. Article ; Online: Effective medium theory for mechanical phase transitions of fiber networks.

    Chen, Sihan / Markovich, Tomer / MacKintosh, Fred C

    Soft matter

    2023  Volume 19, Issue 42, Page(s) 8124–8135

    Abstract: Networks of stiff fibers govern the elasticity of biological structures such as the extracellular matrix of collagen. These networks are known to stiffen nonlinearly under shear or extensional strain. Recently, it has been shown that such stiffening is ... ...

    Abstract Networks of stiff fibers govern the elasticity of biological structures such as the extracellular matrix of collagen. These networks are known to stiffen nonlinearly under shear or extensional strain. Recently, it has been shown that such stiffening is governed by a strain-controlled athermal but critical phase transition, from a floppy phase below the critical strain to a rigid phase above the critical strain. While this phase transition has been extensively studied numerically and experimentally, a complete analytical theory for this transition remains elusive. Here, we present an effective medium theory (EMT) for this mechanical phase transition of fiber networks. We extend a previous EMT appropriate for linear elasticity to incorporate nonlinear effects
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191476-X
    ISSN 1744-6848 ; 1744-683X
    ISSN (online) 1744-6848
    ISSN 1744-683X
    DOI 10.1039/d3sm00810j
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  9. Article ; Online: Nonaffine Deformation of Semiflexible Polymer and Fiber Networks.

    Chen, Sihan / Markovich, Tomer / MacKintosh, Fred C

    Physical review letters

    2023  Volume 130, Issue 8, Page(s) 88101

    Abstract: Networks of semiflexible or stiff polymers such as most biopolymers are known to deform inhomogeneously when sheared. The effects of such nonaffine deformation have been shown to be much stronger than for flexible polymers. To date, our understanding of ... ...

    Abstract Networks of semiflexible or stiff polymers such as most biopolymers are known to deform inhomogeneously when sheared. The effects of such nonaffine deformation have been shown to be much stronger than for flexible polymers. To date, our understanding of nonaffinity in such systems is limited to simulations or specific 2D models of athermal fibers. Here, we present an effective medium theory for nonaffine deformation of semiflexible polymer and fiber networks, which is general to both 2D and 3D and in both thermal and athermal limits. The predictions of this model are in good agreement with both prior computational and experimental results for linear elasticity. Moreover, the framework we introduce can be extended to address nonlinear elasticity and network dynamics.
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.088101
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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  10. Article ; Online: Simultaneous measurements of Ka-band microwave angle of arrival and Doppler frequency shift based on a silicon DPMZM.

    Zhang, Qiang / Chen, Sihan / Li, Yan / Yu, Hui

    Optics express

    2023  Volume 31, Issue 9, Page(s) 14509–14520

    Abstract: We propose a system for the simultaneous measurements of Ka-band microwave angle of arrival (AOA) and Doppler frequency shift (DFS) based on a high-speed silicon dual-parallel Mach-Zehnder modulator (Si-DPMZM).. An echo signal drives a sub-MZM while the ... ...

    Abstract We propose a system for the simultaneous measurements of Ka-band microwave angle of arrival (AOA) and Doppler frequency shift (DFS) based on a high-speed silicon dual-parallel Mach-Zehnder modulator (Si-DPMZM).. An echo signal drives a sub-MZM while the combination of a phase-delay echo signal and a transmitted signal drives the other sub-MZM. Two optical bandpass filters (OBPFs) are used to select the upper and lower sidebands of the Si-DPMZM output signal, detected by low-speed photodiodes, then generating two intermediate frequency (IF) signals. Thus, both AOA and DFS (with direction) can be obtained by comparing the powers, phases and frequencies of these IF signals. The estimation error of measured AOA is less than ±3° from 0 to ±90°. Meanwhile, the DFS at 30/40 GHz were measured with an estimated error of less than 9.8 × 10
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.484218
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