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Article: Implantation of a toric intraocular lens after repeated radial keratotomy procedures: A case report.

Chen, Steve S W / Torii, Hidemasa / Yotsukura, Erisa / Nishi, Yasuyo / Negishi, Kazuno

2023 Volume 9, Issue 12, Page(s) e22500

Abstract: Corneal alterations due to radial keratotomy (RK) complicate intraocular lens calculations, which may explain why there have been few reports of toric intraocular lens (TIOL) implantation after excessive or multiple operations. A 71-year-old male with a ... ...

Abstract	Corneal alterations due to radial keratotomy (RK) complicate intraocular lens calculations, which may explain why there have been few reports of toric intraocular lens (TIOL) implantation after excessive or multiple operations. A 71-year-old male with a history of repeated RKs and at least 30 corneal incisions in each eye was referred for cataract surgery. Preoperatively, the best-corrected distance visual acuity was 0.7 decimal (0.15 logMAR) in the right eye and 0.9 decimal (0.05 logMAR) in the left eye. The refractive errors were -8.00 -3.00 × 80 and -6.00 -3.50 × 80, respectively. The total corneal cylindrical powers (real power; anterior and posterior) were, respectively, -0.90 D and -3.60 D at 9 a.m., compared to -1.60 D and -3.80 D at 1 p.m. Corneal astigmatism in the left eye was considered symmetric and diurnally stable; therefore, an XY1AT6 TIOL (Hoya, Tokyo, Japan; cylindrical power at the plane, +3.75 D) was implanted. A non-toric intraocular lens, the XY1 (Hoya), was implanted in the right eye. Six-month postoperative best-corrected distance visual acuities were 1.2 decimal (-0.08 logMAR) and 1.0 decimal (0.00 logMAR) in the right and left eyes, respectively. Post-operative manifest refractions were +0.00 -3.00 × 70 and -1.00 -2.00 × 85, respectively. The TIOL reduced refractive astigmatism in the left eye; therefore, we believe that even after multiple RKs, the TIOL can be a suitable candidate to correct astigmatism if the corneal astigmatism is diurnally stable and symmetric.
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e22500
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Article ; Online: Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral Replication.

Wong, Mun-Teng / Chen, Steve S

Journal of virology

2017 Volume 91, Issue 16

Abstract: In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein 5A (NS5A) and phosphatidylinositol-4-kinase IIIα (PI4KIIIα), the lipid kinase crucial for maintaining the integrity of virus-induced ... ...

Abstract	In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein 5A (NS5A) and phosphatidylinositol-4-kinase IIIα (PI4KIIIα), the lipid kinase crucial for maintaining the integrity of virus-induced membranous webs, and modulates hepatitis C virus (HCV) replication. hCKα activity positively modulated phosphatidylinositol-4-phosphate (PI4P) levels in HCV-expressing cells, and hCKα-mediated PI4P accumulation was abolished by AL-9, a PI4KIIIα-specific inhibitor. hCKα colocalized with NS5A and PI4KIIIα or PI4P; NS5A expression increased hCKα and PI4KIIIα colocalization; and hCKα formed a ternary complex with PI4KIIIα and NS5A, supporting the functional interplay of hCKα with PI4KIIIα and NS5A. PI4KIIIα inactivation by AL-9 or hCKα inactivation by CK37, a specific hCKα inhibitor, impaired the endoplasmic reticulum (ER) localization and colocalization of these three molecules. Interestingly, hCKα knockdown or inactivation inhibited PI4KIIIα-NS5A binding. In an
MeSH term(s)	1-Phosphatidylinositol 4-Kinase/metabolism ; Cell Line ; Choline Kinase/metabolism ; Endoplasmic Reticulum/metabolism ; Hepacivirus/physiology ; Hepatocytes/virology ; Host-Pathogen Interactions ; Humans ; Protein Transport ; Viral Nonstructural Proteins/metabolism ; Virus Replication
Chemical Substances	Viral Nonstructural Proteins ; CHKA protein, human (EC 2.7.1.32) ; Choline Kinase (EC 2.7.1.32) ; 1-Phosphatidylinositol 4-Kinase (EC 2.7.1.67) ; PI4KIIIalpha protein, human (EC 2.7.1.67) ; NS-5 protein, hepatitis C virus (EC 2.7.7.48)
Language	English
Publishing date	2017-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00355-17
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Article ; Online: Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation.

Wong, Mun-Teng / Chen, Steve S

Journal of virology

2016 Volume 90, Issue 20, Page(s) 9075–9095

Abstract: Unlabelled: Hepatitis C virus (HCV) infection reorganizes cellular membranes to create an active viral replication site named the membranous web (MW). The role that human choline kinase-α (hCKα) plays in HCV replication remains elusive. Here, we first ... ...

Abstract	Unlabelled: Hepatitis C virus (HCV) infection reorganizes cellular membranes to create an active viral replication site named the membranous web (MW). The role that human choline kinase-α (hCKα) plays in HCV replication remains elusive. Here, we first showed that hCKα activity, not the CDP-choline pathway, promoted viral RNA replication. Confocal microscopy and subcellular fractionation of HCV-infected cells revealed that a small fraction of hCKα colocalized with the viral replication complex (RC) on the endoplasmic reticulum (ER) and that HCV infection increased hCKα localization to the ER. In the pTM-NS3-NS5B model, NS3-NS5B expression increased the localization of the wild-type, not the inactive D288A mutant, hCKα on the ER, and hCKα activity was required for effective trafficking of hCKα and NS5A to the ER. Coimmunoprecipitation showed that hCKα was recruited onto the viral RC presumably through its binding to NS5A domain 1 (D1). hCKα silencing or treatment with CK37, an hCKα activity inhibitor, abolished HCV-induced MW formation. In addition, hCKα depletion hindered NS5A localization on the ER, interfered with NS5A and NS5B colocalization, and mitigated NS5A-NS5B interactions but had no apparent effect on NS5A-NS4B and NS4B-NS5B interactions. Nevertheless, hCKα activity was not essential for the binding of NS5A to hCKα or NS5B. These findings demonstrate that hCKα forms a complex with NS5A and that hCKα activity enhances the targeting of the complex to the ER, where hCKα protein, not activity, mediates NS5A binding to NS5B, thereby promoting functional membranous viral RC assembly and viral RNA replication. Importance: HCV infection reorganizes the cellular membrane to create an active viral replication site named the membranous web (MW). Here, we report that human choline kinase-α (hCKα) acts as an essential host factor for HCV RNA replication. A fraction of hCKα colocalizes with the viral replication complex (RC) on the endoplasmic reticulum (ER) in HCV-infected cells. NS3-NS5B expression increases ER localization of wild-type, but not D288A mutant, hCKα, and hCKα activity facilitates the transport of itself and NS5A to the ER. Silencing or inactivation of hCKα abrogates MW formation. Moreover, hCKα is recruited by NS5A independent of hCKα activity, presumably through binding to NS5A D1. hCKα activity then mediates the ER targeting of the hCKα-NS5A complex. On the ER membrane, hCKα protein, per se, induces NS5A binding to NS5B, thereby promoting membranous RC formation and viral RNA replication. Our study may benefit the development of hCKα-targeted anti-HCV therapeutics.
MeSH term(s)	Cell Line ; Choline Kinase ; Endoplasmic Reticulum/virology ; Hepacivirus/physiology ; Hepatocytes/virology ; Host-Pathogen Interactions ; Humans ; Protein Binding ; RNA, Viral/biosynthesis ; Viral Nonstructural Proteins/metabolism ; Virus Replication
Chemical Substances	RNA, Viral ; Viral Nonstructural Proteins ; CHKA protein, human (EC 2.7.1.32) ; Choline Kinase (EC 2.7.1.32) ; NS-5 protein, hepatitis C virus (EC 2.7.7.48)
Language	English
Publishing date	2016-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00960-16
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Article ; Online: Development of an Electronic Medical Tool to Facilitate Allocation of Limited Resources in Times of Crisis.

Griffin, Ian / Vieira, Yvette L / Donohue-Ryan, Mary Ann / Paris, Glen A / Moriarty, Daniel / Peleg, Natalie A / Chen, Steve D

Computers, informatics, nursing : CIN

2022 Volume 40, Issue 5, Page(s) 317–324

Abstract: The COVID-19 pandemic has made decisions about resource allocation and reallocation real possibilities even in high-resource settings. In April 2020, in preparation for such an eventuality, Atlantic Health System began to develop a real-time instrument ... ...

Abstract	The COVID-19 pandemic has made decisions about resource allocation and reallocation real possibilities even in high-resource settings. In April 2020, in preparation for such an eventuality, Atlantic Health System began to develop a real-time instrument built into the EMR to assist with such decisions. The instrument calculated the modified Sequential Organ Failure Assessment for all patients admitted, in real time, to assist triage teams make decisions if crisis standards of care were declared. A pilot assessment of the instrument was performed using retrospective data by nine members of the triage teams, who were asked to identify the six patients at highest risk of reallocation. Agreement about which patients were at highest risk of resource reallocation was good, but not perfect. All raters agreed on five of the six patients, but only seven of nine agreed on the final patient. Among the six consensus selections for reallocation, five died prior to hospital discharge. All patients at highest risk of reallocation had a predicted life expectancy of less than 1 year. In conclusion, the instrument was easy to use, and the concordance among raters was good but not perfect. Predicted life expectance was a major determinant of the triage score.
MeSH term(s)	COVID-19 ; Electronics ; Humans ; Pandemics ; Retrospective Studies ; Triage
Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078463-6
ISSN	1538-9774 ; 1538-2931
ISSN (online)	1538-9774
ISSN	1538-2931
DOI	10.1097/CIN.0000000000000880
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Article ; Online: Diagnosis of Asymptomatic COVID-19 Infection in a Patient Referred for CT Lung Biopsy.

Morris, Michael F / Goettel, Christopher / Mendenhall, Cole / Chen, Steve / Hirsch, Kevin

Journal of vascular and interventional radiology : JVIR

2020 Volume 31, Issue 7, Page(s) 1194–1195

MeSH term(s)	Betacoronavirus ; Biopsy ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Radiography, Interventional/methods ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
Keywords	covid19
Language	English
Publishing date	2020-04-11
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2020.04.002
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Article: Diagnosis of Alzheimer's disease via resting-state EEG: integration of spectrum, complexity, and synchronization signal features.

Zheng, Xiaowei / Wang, Bozhi / Liu, Hao / Wu, Wencan / Sun, Jiamin / Fang, Wei / Jiang, Rundong / Hu, Yajie / Jin, Cheng / Wei, Xin / Chen, Steve Shyh-Ching

Frontiers in aging neuroscience

2023 Volume 15, Page(s) 1288295

Abstract: Background: Alzheimer's disease (AD) is the most common neurogenerative disorder, making up 70% of total dementia cases with a prevalence of more than 55 million people. Electroencephalogram (EEG) has become a suitable, accurate, and highly sensitive ... ...

Abstract	Background: Alzheimer's disease (AD) is the most common neurogenerative disorder, making up 70% of total dementia cases with a prevalence of more than 55 million people. Electroencephalogram (EEG) has become a suitable, accurate, and highly sensitive biomarker for the identification and diagnosis of AD. Methods: In this study, a public database of EEG resting state-closed eye recordings containing 36 AD subjects and 29 normal subjects was used. And then, three types of signal features of resting-state EEG, i.e., spectrum, complexity, and synchronization, were performed by applying various signal processing and statistical methods, to obtain a total of 18 features for each signal epoch. Next, the supervised machine learning classification algorithms of decision trees, random forests, and support vector machine (SVM) were compared in categorizing processed EEG signal features of AD and normal cases with leave-one-person-out cross-validation. Results: The results showed that compared to normal cases, the major change in EEG characteristics in AD cases was an EEG slowing, a reduced complexity, and a decrease in synchrony. The proposed methodology achieved a relatively high classification accuracy of 95.65, 95.86, and 88.54% between AD and normal cases for decision trees, random forests, and SVM, respectively, showing that the integration of spectrum, complexity, and synchronization features for EEG signals can enhance the performance of identifying AD and normal subjects. Conclusion: This study recommended the integration of EEG features of spectrum, complexity, and synchronization for aiding the diagnosis of AD.
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2023.1288295
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Article ; Online: Angiotensin converting enzyme defects in shock: implications for future therapy.

Chawla, Lakhmir S / Chen, Steve / Bellomo, Rinaldo / Tidmarsh, George F

Critical care (London, England)

2018 Volume 22, Issue 1, Page(s) 274

MeSH term(s)	Endothelial Cells/chemistry ; Endothelial Cells/physiology ; Humans ; Peptidyl-Dipeptidase A/blood ; Peptidyl-Dipeptidase A/metabolism ; Shock/complications ; Shock/physiopathology
Chemical Substances	Peptidyl-Dipeptidase A (EC 3.4.15.1) ; angiotensin converting enzyme 2 (EC 3.4.17.-)
Language	English
Publishing date	2018-10-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2051256-9
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-018-2202-y
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Article ; Online: Utility of Transjugular Intrahepatic Portosystemic Shunt Placement for Maintaining Portal Vein Patency in Candidates on Wait Lists Who Develop Thrombus.

Alani, Mustafa / Rowley, Michael / Kang, Paul / Chen, Steve / Hirsch, Kevin / Seetharam, Anil

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2019 Volume 18, Issue 7, Page(s) 808–813

Abstract: Objectives: Although no longer a contraindication to liver transplant, portal vein thrombosis may lead to longer operative time and complexities in venous reconstruction. Strategies to maintain preoperative patency include systemic anticoagulation and/ ... ...

Abstract	Objectives: Although no longer a contraindication to liver transplant, portal vein thrombosis may lead to longer operative time and complexities in venous reconstruction. Strategies to maintain preoperative patency include systemic anticoagulation and/or transjugular intrahepatic portosystemic shunt placement. The former may not be ideal in cirrhotic patients prone to luminal gastrointestinal tract bleeding, and factors that predict improvements in portal vein thrombosis with the latter have not been well defined. Our goal was to evaluate the effectiveness of transjugular intrahepatic portosystemic shunt placement as monotherapy to improve and/or resolve portal vein thrombosis in otherwise eligible liver transplant candidates with partial or complete portal vein thrombosis and to identify factors predicting success. Materials and methods: We identified 30 patients from 2010 to 2015 who had transjugular intrahepatic portosystemic shunt placementfor primary indication to maintain portal vein patency. Results: The main portal vein was completely thrombosed in 5 of 30 (16.6%), nearly completely thrombosed in 9 of 30 (30%), and partially thrombosed in 16 patients (53.3%). Twenty-four patients (80%) had improvement and/or resolution of portal vein thrombosis after transjugular intrahepatic portosystemic shunt placement, with 18 of these (75%) having complete resolution. All 5 patients (20.8%) with complete thrombosis had improvement/resolution of portal vein thrombosis. Nine patients (30%) required hospitalization within 3 months for hepatic encephalopathy. There were 3 deaths (10%) not related to transjugular intrahepatic portosystemic shunt placement (10%). Nine patients underwent liver transplant after shunt placement (median 2.9 mo; range, 0.3-32 mo); all 9 received endto-end anastomosis without need for intraoperative thrombectomy. Conclusions: Transjugular intrahepatic portosystemic shunt placement may be effective as monotherapy for maintaining or restoring portal vein patency in selected livertransplant candidates, even in those with complete portal vein thrombosis. Further studies are needed to define potential responders to this approach.
MeSH term(s)	End Stage Liver Disease/complications ; End Stage Liver Disease/mortality ; End Stage Liver Disease/surgery ; Female ; Humans ; Liver Transplantation/adverse effects ; Liver Transplantation/mortality ; Male ; Middle Aged ; Portal Vein/physiopathology ; Portal Vein/surgery ; Portasystemic Shunt, Transjugular Intrahepatic/adverse effects ; Portasystemic Shunt, Transjugular Intrahepatic/mortality ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Vascular Patency ; Venous Thrombosis/etiology ; Venous Thrombosis/mortality ; Venous Thrombosis/physiopathology ; Venous Thrombosis/surgery ; Waiting Lists
Language	English
Publishing date	2019-11-13
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2019.0153
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Article: Diagnosis of Asymptomatic COVID-19 Infection in a Patient Referred for CT Lung Biopsy

Morris, Michael F / Goettel, Christopher / Mendenhall, Cole / Chen, Steve / Hirsch, Kevin

J Vasc Interv Radiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46524
Database	COVID19

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Article ; Online: Diagnosis of Asymptomatic COVID-19 Infection in a Patient Referred for CT Lung Biopsy

Morris, Michael F. / Goettel, Christopher / Mendenhall, Cole / Chen, Steve / Hirsch, Kevin

Journal of Vascular and Interventional Radiology

2020 Volume 31, Issue 7, Page(s) 1194–1195

Keywords	Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2020.04.002
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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