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Article: Application of Ion Exchangers with the N-Methyl-D-Glucamine Groups in the V(V) Ions Adsorption Process.

Burdzy, Katarzyna / Chen, Yi-Gong / Lv, Gui-Yuan / Chen, Su-Hong / Kołodyńska, Dorota

2022 Volume 15, Issue 3

Abstract: The adsorption capacities of ion exchangers with N-methyl-D-glucamine (NMDG) groups (Amberlite IRA 743, Lewatit MK 51, Purolite S110 and Purolite S108) relative to V(V) ions were tested in a batch system, taking into account the influence of various ... ...

Abstract	The adsorption capacities of ion exchangers with N-methyl-D-glucamine (NMDG) groups (Amberlite IRA 743, Lewatit MK 51, Purolite S110 and Purolite S108) relative to V(V) ions were tested in a batch system, taking into account the influence of various parameters, such as the adsorbent mass (0.05-0.20 g), phase contact time (1-240 min), initial concentration (10-150 mg/L), and temperature (293-333 K), as well as in a column system where the variable operating parameters were initial concentration (50, 100 mg/L), bed volume (10, 100 mL) and flow rate (0.6, 6 mL/min). Pseudo-first order, pseudo-second order, intraparticle diffusion and Boyd models were used to describe the kinetic studies. The best fit was obtained for the pseudo-second order model. The Langmuir, Freundlich and Temkin adsorption models were used to describe the equilibrium data to acquire better knowledge about the adsorption mechanism. The thermodynamic parameters were also calculated, which showed that the studied processes are endothermic, spontaneous and thermodynamically favorable. The physicochemical properties of the ion exchangers were characterized by nitrogen adsorption/desorption analyses, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photo electron spectroscopy (XPS). The point of zero charge (pH
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15031026
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Article ; Online: Development and validation of a novel CD4

Zhang, Da-Wei / Li, Fang / Wei, Yuan-Yuan / Hu, Lei / Chen, Su-Hong / Yang, Ming-Ming / Zhang, Wen-Ting / Fei, Guang-He

Clinical and translational medicine

2023 Volume 13, Issue 6, Page(s) e1294

MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/genetics ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Letter
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1294
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Article: Differential Characteristics of Patients for Hospitalized Severe COVID-19 Infected by the Omicron Variants and Wild Type of SARS-CoV-2 in China.

Wei, Yuan-Yuan / Wang, Rui-Rui / Zhang, Da-Wei / Chen, Su-Hong / Tan, Yuan-Yuan / Zhang, Wen-Ting / Han, Ming-Feng / Fei, Guang-He

Journal of inflammation research

2023 Volume 16, Page(s) 3063–3078

Abstract: Background: As multiple mutations of : Methods: A total of 554 confirmed : Results: Compared to the wild-type cases, the severe Omicron cases were older (median age 48.36 vs 73.24), and had more upper-respiratory symptoms and comorbidities. ... ...

Abstract	Background: As multiple mutations of Methods: A total of 554 confirmed Results: Compared to the wild-type cases, the severe Omicron cases were older (median age 48.36 vs 73.24), and had more upper-respiratory symptoms and comorbidities. Decreased leukocyte counts were less pronounced, although more instances of significantly decreased CD4+ and CD8+ T-cell counts, elevated infection-related biomarkers (eg procalcitonin and C-reactive protein), and abnormal coagulation factors (including increased D-dimer and fibrinogen levels) were detected in the severe Omicron cases. The mean length of hospital stay was significantly shorter in the severe Omicron cases. CD4+ and CD8+ T cell numbers were negatively correlated with neutrophil-to-lymphocyte ratios, as well as serum interleukin-6, procalcitonin, and C-reactive protein levels. Conclusion: There were significant clinical differences between patients hospitalized with severe cases of Omicron- variant
Language	English
Publishing date	2023-07-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S420721
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Article ; Online: Exploring the Action Mechanism and Validation of the Key Pathways of

Fang, Xi / Jiang, Xiao-Feng / Zhang, Yi-Piao / Zhou, Cheng-Liang / Dong, Ying-Jie / Bo-Li / Lv, Gui-Yuan / Chen, Su-Hong

Combinatorial chemistry & high throughput screening

2023 Volume 27, Issue 3, Page(s) 479–496

Abstract: Aim: This study investigated the molecular action mechanism of a compound herb, also known as the : Methods: The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug- ...

Abstract	Aim: This study investigated the molecular action mechanism of a compound herb, also known as the Methods: The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and protein-protein interaction networks were constructed, and the core targets were obtained through network topology. The Metascape database was screened, and the core targets were enriched with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Results: In total, 1403 and 241 potential targets for drugs and diseases, respectively, and 81 intersecting targets were yielded. The core targets included TNF, IL-6, and IL-1β, and the core pathways included PI3K-Akt. The QYF treatment group exhibited effectively improved general signs, enhanced anti-inflammatory ability Conclusion: QYF could inhibit LPS production, which regulated the expression of the TLR4/PI3K/Akt/NF-κB signaling pathway to suppress the expression of the related inflammatory factors (i.e., TNF-α, IL-6, and IL-1β), thereby alleviating the CP process.
MeSH term(s)	Dendrobium/chemistry ; Pharyngitis/drug therapy ; Animals ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Mice ; Chronic Disease/drug therapy ; Male ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-10-24
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073261351231005111817
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Zs.A 5577: Show issues

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Article ; Online: Bioinformatics and LC-QTOF-MS based discovery of pharmacodynamic and Q-markers of Pitongshu against functional dyspepsia.

Chen, Su-Hong / Wu, Han-Song / Jiang, Xiao-Feng / Zhou, Cong / Bian, Xue-Ren / He, Xinglishang / Li, Bo / Dong, Ying-Jie / Wang, Kun-Gen / Shen, Shu-Hua / Lv, Gui-Yuan / Zhi, Yi-Hui

Journal of ethnopharmacology

2024 Volume 329, Page(s) 118096

Abstract: Ethnopharmacological relevance: Pitongshu (PTS) is a clinically effective empirical formula for the treatment of FD. The efficacy and safety of PTS have been demonstrated in randomized, controlled, double-blind trials, but there is a lack of ... ...

Abstract	Ethnopharmacological relevance: Pitongshu (PTS) is a clinically effective empirical formula for the treatment of FD. The efficacy and safety of PTS have been demonstrated in randomized, controlled, double-blind trials, but there is a lack of understanding of the systematic evaluation of the efficacy of PTS and its material basis. Objective: To investigate the efficacy of PTS in Functional dyspepsia (FD) mice and possible Q-markers. Method: In this study, we used "irregular feeding + chronic unpredictable chronic stimulation" to establish a mice model of FD with hepatogastric disharmony. The efficacy of PTS was assessed from hair condition, behavioral, pain, gastrointestinal function, and serum 5-HT, GAS, MTL levels in mice by instillation of different doses of PTS. In addition, the composition of drugs in blood was analyzed by LC-QTOF-MS and potential Q-markers were selected by combining network pharmacology, molecular docking and actual content. Result: Our study showed that different doses of PTS increased pain threshold and writhing latency, decreased the number of writhings, increased gastric emptying rate and small intestinal propulsion rate, decreased total acidity of gastric contents and gastric acid secretion, and increased serum levels of 5-HT, GAS, and MTL in mice to different degrees. Enrichment analysis showed that PTS may be anti-FD through multiple pathways such as Serotonergic synapse, thyroid hormone signaling pathway, cholinergic synapse, and dopaminergic synapse. In addition, potential active ingredient substances were explored by LC-QTOF-MS combined with bioinformatics. Combined with the actual contentselected six constituents, hesperidin, neohesperidin, naringin, paeoniflorin, magnolol and honokiol, possible as Q-markers. Conclusion: PTS may exert its anti-FD effects through multi-component, multi-target and multi-pathway". Constituents, hesperidin, neohesperidin, naringin, paeoniflorin, magnolol and honokiol may be the Q-markers of its anti-FD effects.
Language	English
Publishing date	2024-03-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118096
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Article: The anti-hyperlipidemia effect of

Li, Bo / Chen, Xian-Fang / Wu, Han-Song / Su, Jie / Ding, Yan-Yan / Zhang, Ze-Hua / Rong, Mei / Dong, Ying-Jie / He, Xinglishang / Li, Lin-Zi / Lv, Gui-Yuan / Chen, Su-Hong

Heliyon

2024 Volume 10, Issue 7, Page(s) e28019

Abstract: Aim: Atractylodes macrocephala: Methods: SD rats were fed a high-sucrose high-fat diet in conjunction with alcohol (HSHFDAC) along with different AM extracts (AMW, AMO, AME, and AMP) for 4 weeks. AM's active components were analyzed using multiple ... ...

Abstract	Aim: Atractylodes macrocephala Methods: SD rats were fed a high-sucrose high-fat diet in conjunction with alcohol (HSHFDAC) along with different AM extracts (AMW, AMO, AME, and AMP) for 4 weeks. AM's active components were analyzed using multiple databases, and their mechanisms were explored through network pharmacology. The relationship between AM's effect of enhancing serum HDL-c and regulating the expression of reverse cholesterol transport (RCT)-related proteins (Apo-A1, LCAT, and SR-BI) was further validated in the HSHFDAC-induced hyperlipidemic rats. The kidney and liver functions of the rats were measured to evaluate the safety of AM. Results: AMO, mainly comprised of volatile and liposoluble components, contributed the most significant anti-hyperlipidemia effect among the four extracts obtained from AM, significantly improving the blood lipid profile. Network pharmacology analysis also suggested that volatile and liposoluble components, comprise AM's main active components and they might act on signaling pathways associated with elevated HDL-c. Validation experiments found that AMO substantially and dose-dependently increased HDL-c levels, upregulated the expression of Apo-A1, SR-BI, and LCAT, improved the pathological changes in the kidney and liver, and significantly reduced the serum creatinine levels in rats with hyperlipidemia. Conclusion: The main anti-hyperlipidemia active components of AM are its volatile and liposoluble components, which may enhance serum HDL-c by increasing the expression of the RCT-related proteins Apo-A1, LCAT, and SR-BI.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28019
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Article ; Online: Dendrobium officinale flowers' topical extracts improve skin oxidative stress and aging.

He, Xing-Li-Shang / Wang, Ning / Teng, Xi / Wang, Nan-Nan / Xie, Zhi-Yi / Dong, Ying-Jie / Lin, Min-Qiu / Zhang, Ze-Hua / Rong, Mei / Chen, Yi-Gong / Li, Bo / Lv, Gui-Yuan / Chen, Su-Hong

Journal of cosmetic dermatology

2024 Volume 23, Issue 5, Page(s) 1891–1904

Abstract: Background: Dendrobium officinale flowers (DOF) have the effects of antiaging and nourishing yin, but it lacks pharmacological research on skin aging.: Objective: Confirming the role of DOF in delaying skin aging based on the "in vitro animal-human" ... ...

Abstract	Background: Dendrobium officinale flowers (DOF) have the effects of antiaging and nourishing yin, but it lacks pharmacological research on skin aging. Objective: Confirming the role of DOF in delaying skin aging based on the "in vitro animal-human" model. Methods: In this experiment, three kinds of free radical scavenging experiments in vitro, D-galactose-induced aging mouse model, and human antiaging efficacy test were used to test whether DOF can improve skin aging through anti-oxidation. Results: In vitro experiment shows that DOF has certain scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, hydroxyl free radical, and superoxide free radical, and its IC Conclusion: DOF can significantly improve skin aging caused by oxidative stress, and its mechanism may be related to scavenging free radicals in the body and improving skin quality.
MeSH term(s)	Skin Aging/drug effects ; Animals ; Dendrobium/chemistry ; Flowers/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/administration & dosage ; Oxidative Stress/drug effects ; Mice ; Humans ; Skin/drug effects ; Skin/metabolism ; Antioxidants/pharmacology ; Antioxidants/administration & dosage ; Male ; Female
Chemical Substances	Plant Extracts ; Antioxidants
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.16210
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Article: Application of Modern Research Methods for the Physicochemical Characterization of Ion Exchangers.

Chen, Yi-Gong / Sofińska-Chmiel, Weronika / Lv, Gui-Yuan / Kołodyńska, Dorota / Chen, Su-Hong

Materials (Basel, Switzerland)

2021 Volume 14, Issue 22

Abstract: Ion exchange technique as the reversible exchange of ions between the substrate and the surrounding medium can be an effective way of removing traces of ion impurities from the waters and wastewaters and obtaining a product of ultrapure quality. ... ...

Abstract	Ion exchange technique as the reversible exchange of ions between the substrate and the surrounding medium can be an effective way of removing traces of ion impurities from the waters and wastewaters and obtaining a product of ultrapure quality. Therefore, it can be used in analytical chemistry, hydrometallurgy, purification and separation of metal ions, radioisotopes and organic compounds, and it also finds great application in water treatment and pollution control. In the presented paper, the new trends for ion exchanger characteristics determination and application are presented. Special attention is paid to the ion exchangers with multifunctionality for heavy metal ions removal. They show superior actions such as sorption capacity values with excellent resistance to fouling and the possibility of application in the co-current or modern packed bed counter-current systems, as well as for the condensate polishing or the conventional mixed bed systems in combination with other resins. The results of the paper are expected to help researchers to establish a powerful strategy to find a suitable ion exchanger for heavy metal ions removal from waters and wastewaters. It is important because the best ion exchangers are selected for a specific application during laboratory tests taking into account the composition of the feed solution, pH, type of ion exchangers and then the column breakthrough tests. Therefore, the optical profilometry and the X-ray photoelectron spectroscopy can prove beneficial for this purpose in the case of three different ion exchangers such as Dowex M 4195, Amberlite IRA 743 and Purolite Arsen X
Language	English
Publishing date	2021-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14227067
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Article: [Effects of different extracts of Dendrobium officinale on rats with chronic pharyngitis induced by pepper water combined with ammonia].

Ji, Wen-Na / Yan, Mei-Qiu / Su, Jie / Yu, Jing-Jing / Chen, Su-Hong / Lyu, Gui-Yuan / Chen, Jian-Zhen

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 9, Page(s) 2525–2532

Abstract: Dendrobium officinale can serve as Chinese medicinal material effective in nourishing yin, clearing heat, and producing fluid, and is used to treat throat diseases, but its active substances and mechanism are not clear. To clarify the active fraction and ...

Abstract	Dendrobium officinale can serve as Chinese medicinal material effective in nourishing yin, clearing heat, and producing fluid, and is used to treat throat diseases, but its active substances and mechanism are not clear. To clarify the active fraction and underlying mechanism of D. officinale against chronic pharyngitis(CP), the present study induced a CP model in rats by pepper water combined with low-concentration ammonia, and crude polysaccharides of D. officinale(DOP), non-polysaccharides of D. officinale(DON), and total extract of D. officinale(DOT)(0.33 g·kg~(-1), calculated according to the crude drug) were administered by gavage for six weeks. The changes in oral secretions and pharyngeal conditions of rats with CP were observed and rated. The hematological indicators were determined by an automatic hematology analyzer. The serum levels of pro-inflammatory factors, such as tumor necrosis factor-alpha(TNF-α), interleukin 1β(IL-1β), and interleukin 6(IL-6), and T-lymphocyte cytokines, including interferon γ(IFN-γ), interleukin 4(IL-4), interleukin 17(IL-17), and transforming growth factor β1(TGF-β1) were detected by the enzyme-linked immunosorbent assay(ELISA). The proportions of CD3~+, CD4~+, and CD8~+cells in peripheral blood T lymphocyte subsets were determined by the flow cytometry. The histomorphological changes of the pharynx were observed by hematoxylin-eosin(HE) staining. The protein expression of nuclear factor-κB P65(NF-κB P65), cyclooxygenase-2(COX-2), F4/80, and monocyte chemoattractant protein-1(MCP-1) in the pharynx were detected by immunohistochemistry and Western blot. The results showed that DOP and DON could significantly relieve pharyngeal lesions, reduce white blood cells(WBC) and lymphocytes(LYMP), decrease the levels of pro-inflammatory factors TNF-α, IL-6, and IL-1β, and inhibit the protein expression of NF-κB P65, COX-2, F4/80, and MCP-1 in the pharynx. DOP was superior in reducing oral secretions and serum IL-17 level and inferior in increasing CD4~+/CD8~+ratio to DON. It is suggested that both polysaccharides and non-polysaccharides of D. officinale have anti-PC effects and the anti-inflammatory mechanism may be related to the regulation of T lymphocyte distribution and inhibition of the inflammatory signaling pathways mediated by NF-κB P65. The anti-inflammatory effect of DOP may be related to the regulation of Th17/Treg balance, while that of DON may be related to the regulation of the Th/Tc ratio.
MeSH term(s)	Ammonia/therapeutic use ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Cyclooxygenase 2 ; Dendrobium/chemistry ; Interleukin-17/therapeutic use ; Interleukin-6 ; NF-kappa B/metabolism ; Pharyngitis/drug therapy ; Plant Extracts/chemistry ; Polysaccharides/pharmacology ; Rats ; Tumor Necrosis Factor-alpha ; Water
Chemical Substances	Anti-Inflammatory Agents ; Interleukin-17 ; Interleukin-6 ; NF-kappa B ; Plant Extracts ; Polysaccharides ; Tumor Necrosis Factor-alpha ; Water (059QF0KO0R) ; Ammonia (7664-41-7) ; Cyclooxygenase 2 (EC 1.14.99.1)
Language	Chinese
Publishing date	2022-03-05
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20211223.703
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Zs.A 3056: Show issues

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Article ; Online: Exploring the efficacy and mechanism of Bailing capsule to improve polycystic ovary syndrome in mice based on intestinal-derived LPS-TLR4 pathway.

Guan, Hao-Ru / Li, Bo / Zhang, Ze-Hua / Wu, Han-Song / Wang, Ning / Chen, Xian-Fang / Zhou, Cheng-Liang / Bian, Xue-Ren / Li, Lu / Xu, Wan-Feng / He, Xing-Lishang / Dong, Ying-Jie / Jiang, Ning-Hua / Su, Jie / Lv, Gui-Yuan / Chen, Su-Hong

Journal of ethnopharmacology

2024 Volume 331, Page(s) 118274

Abstract: Ethnopharmacological relevance: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive dysfunction and metabolic abnormalities, particularly characterized by insulin resistance and chronic low-grade inflammation. ... ...

Abstract	Ethnopharmacological relevance: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with reproductive dysfunction and metabolic abnormalities, particularly characterized by insulin resistance and chronic low-grade inflammation. Multiple clinical studies have clearly demonstrated the significant efficacy and safety of the combination of Bailing capsules (BL) in the treatment of PCOS, but its pharmacological effects and mechanisms still require further study. Aim of the study: To evaluate the effect of BL on improving PCOS in mice and explore the mechanism. Methods: In this study, Dehydroepiandrosterone (DHEA) injection was administered alone and in combination with a high-fat and high-sugar diet to induce PCOS-like mouse. They were randomly divided into five groups: normal group (N), PCOS group (P), Bailing capsule low-dose group (BL-L), Bailing capsule high-dose group (BL-H) and Metformin + Daine-35 group (M + D). Firstly, the effects of BL on ovarian lesions, serum hormone levels, HOMA-IR, intestinal barrier function, inflammation levels, along with the expression of IRS1, PI3K, AKT, TLR4, Myd88, NF-κB p65, TNF-α, IL-6, and Occludin of the ovary, liver and colon were investigated. Finally, the composition of the gut microbiome of fecal was tested. Results: The administration of BL significantly reduced body weight, improved hormone levels, improved IR, and attenuated pathological damage to ovarian tissues, up-regulated the expression of IRS1, PI3K, and AKT in liver. It also decreased serum LPS, TNF-α, and IL-6 levels, while downregulating the expression of Myd88, TLR4, and NF-κB p65. Additionally, BL improved intestinal barrier damage and upregulated the expression of Occludin. Interestingly, the abundance of norank_f__Muribaculacea and Lactobacillus was down-regulated, while the abundance of Akkermansia was significantly up-regulated. Conclusion: The results of the study showed that BL exerts a treatment PCOS effect, which may be related to the modulation of the gut microbiota, the improvement of insulin resistance and the intestinal-derived LPS-TLR4 inflammatory pathway. Our research will provide a theoretical basis for the clinical treatment of PCOS.
Language	English
Publishing date	2024-04-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118274
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