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Article ; Online: Potential application of Atractylodes macrocephala Koidz. as a natural drug for bone mass regulation: A review.

Yu, Yikang / Fu, Danqing / Zhou, Hengpu / Su, Jie / Chen, Suhong / Lv, Guiyuan

2023 Volume 315, Page(s) 116718

Abstract: Ethnopharmacological relevance: The root of Atractylodes macrocephala Koidz. (AM) has been used for thousands of years in China, and it's extracts contain various constituents, such as volatile oils, polysaccharides, and lactones, with a myriad of ... ...

Abstract	Ethnopharmacological relevance: The root of Atractylodes macrocephala Koidz. (AM) has been used for thousands of years in China, and it's extracts contain various constituents, such as volatile oils, polysaccharides, and lactones, with a myriad of pharmacological effects, including improves the healthy state of the gastrointestinal system and regulating immunity, hormone secretion, anti-inflammatory, antibacterial, antioxidation, anti-aging, and antitumor properties. Recently, researchers have focused on the effect of AM in regulating bone mass; therefore, its potential mechanism of action in regulating bone mass needs to be elucidated. Aim of review: This study reviewed the known and possible mechanisms of bone mass regulation by AM. Materials and methods: Cochrane, Medline via PubMed, Embase, CENTRAL, CINAHL, Web of Science, Chinese biomedical literature database, Chinese Science and Technology Periodical Database, and Wanfang Database were used to search AM root extracts-related studies. The retrieval date was from the establishment of the database to January 1, 2023. Results: By summarizing 119 natural active substances that have been isolated from AM root to date, we explored its possible targets and pathways (such as Hedgehog, Wnt/β-catenin, and BMP/Smads pathways etc.) for bone growth and presented our position on possible future research/perspectives in the regulation of bone mass using this plant. Conclusions: AM root extracts (incuding aqueous, ethanol etc.) promotes osteogenesis and inhibits osteoclastogenesis. These functions promote the absorption of nutrients, regulate gastrointestinal motility and intestinal microbial ecology, regulate endocrine function, strengthen bone immunity, and exert anti-inflammatory and antioxidant effects.
MeSH term(s)	Atractylodes ; Oils, Volatile ; China ; Plant Extracts/pharmacology ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Oils, Volatile ; Plant Extracts ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-06-01
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116718
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Article ; Online: Targeting tumor glycolysis metabolism in oral squamous cell carcinoma cells by brusatol

Zhang, Guilian / Wu, Yanlin / Chen, Suhong / Su, Ying / Yin, Panpan / Fu, Jie / Zhang, Xinyan

Pharmacological Research - Modern Chinese Medicine. 2022 Dec., v. 5 p.100172-

2022

Abstract: Brusatol is a natural quassinoid terpenoid that shows a potential therapeutic use in treating various ailments. Recently, brusatol was shown to have anti-tumor activity and ameliorating chemoresistance or enhancing chemotherapeutic drug efficacy in vitro ...

Abstract	Brusatol is a natural quassinoid terpenoid that shows a potential therapeutic use in treating various ailments. Recently, brusatol was shown to have anti-tumor activity and ameliorating chemoresistance or enhancing chemotherapeutic drug efficacy in vitro and in vivo cancer models, but its molecular mechanisms remained to be clarified. Here, we aim to investigate the roles of brusatol in oral squamous cell carcinoma (OSCC) cells and its possible mechanism, especially on tumor cell glycolytic metabolism. In this study, we found that brusatol exerted significant anti-tumor effects in OSCC cells by repressing tumor cells proliferation, cycles, migration, invasion, and colony formation and inducing cell apoptosis in vitro through MTT, cell cycle, cell migration and invasion, colony formation and cell apoptosis assays. The result of metabolic assay and Seahorse XF glycolysis stress test assay showed that brusatol directly targeted glycolysis by inhibiting the extracellular acidification rate represented by a decreased glycolysis, glycolytic capacity and reserve capacity, and repressing activity of the key glycolytic enzymes pyruvate kinase and hexokinase. We also found that the expression of glucose transporter 1 (GLUT1) and several important glycolysis related genes, including HIF-1α and c-Myc was downregulated by brusatol through real-time PCR. Furthermore, in vivo studies supported anti-tumor role for brusatol, demonstrating that brusatol inhibited tumor growth, angiogenesis, glycolysis metabolism and induction of apoptosis in OSCC cells nude mice xenografts. Our data clearly demonstrated the anti-tumor effects of brusatol in OSCC cells by targeting glycolytic metabolism, and it could become a promising tumor chemotherapeutic agent in oral cancer.
Keywords	Oriental traditional medicine ; acidification ; angiogenesis ; antineoplastic activity ; apoptosis ; cell cycle ; cell movement ; drug therapy ; drugs ; glucose transporters ; glycolysis ; hexokinase ; mouth neoplasms ; neoplasm cells ; pyruvate kinase ; quantitative polymerase chain reaction ; research ; squamous cell carcinoma ; terpenoids ; xenotransplantation ; Brusatol ; Glycolytic metabolism ; Oral squamous cell carcinoma ; ECAR ; HK2 ; PK ; OSCC ; HNSCC
Language	English
Dates of publication	2022-12
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ISSN	2667-1425
DOI	10.1016/j.prmcm.2022.100172
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Article: Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension.

Wang, Ting / He, Mao / Du, Yuzhong / Chen, Suhong / Lv, Guiyuan

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 5579129

Abstract: Background: Yeju Jiangya decoction (CIF) is an herbal formula from traditional Chinese medicine (TCM) for the treatment of hypertension.: Materials and methods: Based on the analysis of network pharmacology, combined with in animal experiments, the ... ...

Abstract	Background: Yeju Jiangya decoction (CIF) is an herbal formula from traditional Chinese medicine (TCM) for the treatment of hypertension. Materials and methods: Based on the analysis of network pharmacology, combined with in animal experiments, the network pharmacology was used to explore the potential proteins and mechanisms of CIF against hypertension. The bioactive compounds of CIF were screened by using the platform, and the targets of hypertension and CIF were collected. Then, the Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction network (PPI) core targets were carried out, and the useful proteins were found by molecular docking technology. Finally, we used N-nitro-L-arginine (L-NNA) induced hypertension model rats to confirm the effect and mechanism of CIF on hypertension. Results: 14 bioactive compounds of CIF passed the virtual screening criteria, and 178 overlapping targets were identified as core targets of CIF against hypertension. The CIF-related target network with 178 nodes and 344 edges is constructed. The topological results show that quercetin and luteolin are the key components in the network. The key targets NOS3 (nitric oxide synthase 3) and NOS2 (nitric oxide synthase 2) were screened by the protein-protein interaction network. The analysis of target protein pathway enrichment showed that the accumulation pathway is related to the vascular structure of CIF regulation of hypertension. Further verification based on molecular docking results showed that NOS3 had the good binding ability with quercetin and luteolin. On the other hand, NOS3 has an important relationship with the composition of blood vessels. Furthermore, the animal experiment indicated that after the L-NNA-induced hypertension rat model was established, CIF intervention was given by gavage for 3 weeks, and it can decrease serum concentrations of endothelin-1 (ET-1) and thromboxane B2 (TXB Conclusions: The results of this study indicate that CIF has the ability to improve target organs, protect endothelial function, and reduce blood pressure and that CIF might be a potential therapeutic drug for the prevention of hypertension. It provides new insight into hypertension and the potential biological basis and mechanism for CIF clinical research.
Language	English
Publishing date	2021-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/5579129
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Article: Application of Ion Exchangers with the N-Methyl-D-Glucamine Groups in the V(V) Ions Adsorption Process.

Burdzy, Katarzyna / Chen, Yi-Gong / Lv, Gui-Yuan / Chen, Su-Hong / Kołodyńska, Dorota

Materials (Basel, Switzerland)

2022 Volume 15, Issue 3

Abstract: The adsorption capacities of ion exchangers with N-methyl-D-glucamine (NMDG) groups (Amberlite IRA 743, Lewatit MK 51, Purolite S110 and Purolite S108) relative to V(V) ions were tested in a batch system, taking into account the influence of various ... ...

Abstract	The adsorption capacities of ion exchangers with N-methyl-D-glucamine (NMDG) groups (Amberlite IRA 743, Lewatit MK 51, Purolite S110 and Purolite S108) relative to V(V) ions were tested in a batch system, taking into account the influence of various parameters, such as the adsorbent mass (0.05-0.20 g), phase contact time (1-240 min), initial concentration (10-150 mg/L), and temperature (293-333 K), as well as in a column system where the variable operating parameters were initial concentration (50, 100 mg/L), bed volume (10, 100 mL) and flow rate (0.6, 6 mL/min). Pseudo-first order, pseudo-second order, intraparticle diffusion and Boyd models were used to describe the kinetic studies. The best fit was obtained for the pseudo-second order model. The Langmuir, Freundlich and Temkin adsorption models were used to describe the equilibrium data to acquire better knowledge about the adsorption mechanism. The thermodynamic parameters were also calculated, which showed that the studied processes are endothermic, spontaneous and thermodynamically favorable. The physicochemical properties of the ion exchangers were characterized by nitrogen adsorption/desorption analyses, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray photo electron spectroscopy (XPS). The point of zero charge (pH
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15031026
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Article ; Online: The Mechanisms of Polysaccharides from Tonic Chinese Herbal Medicine on the Enhancement Immune Function: A Review.

Xie, Zhiyi / Jiang, Ninghua / Lin, Minqiu / He, Xinglishang / Li, Bo / Dong, Yingjie / Chen, Suhong / Lv, Guiyuan

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 21

Abstract: Tonic Chinese herbal medicine is a type of traditional Chinese medicine, and its primary function is to restore the body's lost nutrients, improve activity levels, increase disease resistance, and alleviate physical exhaustion. The body's immunity can be ...

Abstract	Tonic Chinese herbal medicine is a type of traditional Chinese medicine, and its primary function is to restore the body's lost nutrients, improve activity levels, increase disease resistance, and alleviate physical exhaustion. The body's immunity can be strengthened by its polysaccharide components, which also have a potent immune-system-protecting effect. Several studies have demonstrated that tonic Chinese herbal medicine polysaccharides can improve the body's immune response to tumor cells, viruses, bacteria, and other harmful substances. However, the regulatory mechanisms by which various polysaccharides used in tonic Chinese herbal medicine enhance immune function vary. This study examines the regulatory effects of different tonic Chinese herbal medicine polysaccharides on immune organs, immune cells, and immune-related cytokines. It explores the immune response mechanism to understand the similarities and differences in the effects of tonic Chinese herbal medicine polysaccharides on immune function and to lay the foundation for the future development of tonic Chinese herbal medicine polysaccharide products.
MeSH term(s)	Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional ; Cytokines ; Caffeine ; Polysaccharides/pharmacology ; Immunity
Chemical Substances	Drugs, Chinese Herbal ; Cytokines ; Caffeine (3G6A5W338E) ; Polysaccharides
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28217355
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Article ; Online: Chemical Constitution, Pharmacological Effects and the Underlying Mechanism of Atractylenolides: A Review.

Xie, Zhiyi / Lin, Minqiu / He, Xinglishang / Dong, Yingjie / Chen, Yigong / Li, Bo / Chen, Suhong / Lv, Guiyuan

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 10

Abstract: Atractylenolides, comprising atractylenolide I, II, and III, represent the principal bioactive constituents ... ...

Abstract	Atractylenolides, comprising atractylenolide I, II, and III, represent the principal bioactive constituents of
MeSH term(s)	Phosphatidylinositol 3-Kinases ; Medicine, Chinese Traditional ; Signal Transduction ; Atractylodes/chemistry ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	atractylenolide I ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28103987
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Article: Differential Characteristics of Patients for Hospitalized Severe COVID-19 Infected by the Omicron Variants and Wild Type of SARS-CoV-2 in China.

Wei, Yuan-Yuan / Wang, Rui-Rui / Zhang, Da-Wei / Chen, Su-Hong / Tan, Yuan-Yuan / Zhang, Wen-Ting / Han, Ming-Feng / Fei, Guang-He

Journal of inflammation research

2023 Volume 16, Page(s) 3063–3078

Abstract: Background: As multiple mutations of : Methods: A total of 554 confirmed : Results: Compared to the wild-type cases, the severe Omicron cases were older (median age 48.36 vs 73.24), and had more upper-respiratory symptoms and comorbidities. ... ...

Abstract	Background: As multiple mutations of Methods: A total of 554 confirmed Results: Compared to the wild-type cases, the severe Omicron cases were older (median age 48.36 vs 73.24), and had more upper-respiratory symptoms and comorbidities. Decreased leukocyte counts were less pronounced, although more instances of significantly decreased CD4+ and CD8+ T-cell counts, elevated infection-related biomarkers (eg procalcitonin and C-reactive protein), and abnormal coagulation factors (including increased D-dimer and fibrinogen levels) were detected in the severe Omicron cases. The mean length of hospital stay was significantly shorter in the severe Omicron cases. CD4+ and CD8+ T cell numbers were negatively correlated with neutrophil-to-lymphocyte ratios, as well as serum interleukin-6, procalcitonin, and C-reactive protein levels. Conclusion: There were significant clinical differences between patients hospitalized with severe cases of Omicron- variant
Language	English
Publishing date	2023-07-21
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S420721
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Article ; Online: Development and validation of a novel CD4

Zhang, Da-Wei / Li, Fang / Wei, Yuan-Yuan / Hu, Lei / Chen, Su-Hong / Yang, Ming-Ming / Zhang, Wen-Ting / Fei, Guang-He

Clinical and translational medicine

2023 Volume 13, Issue 6, Page(s) e1294

MeSH term(s)	Humans ; COVID-19/diagnosis ; COVID-19/genetics ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Letter
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1294
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Article ; Online: Exploring the Action Mechanism and Validation of the Key Pathways of

Fang, Xi / Jiang, Xiao-Feng / Zhang, Yi-Piao / Zhou, Cheng-Liang / Dong, Ying-Jie / Bo-Li / Lv, Gui-Yuan / Chen, Su-Hong

Combinatorial chemistry & high throughput screening

2023 Volume 27, Issue 3, Page(s) 479–496

Abstract: Aim: This study investigated the molecular action mechanism of a compound herb, also known as the : Methods: The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug- ...

Abstract	Aim: This study investigated the molecular action mechanism of a compound herb, also known as the Methods: The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and protein-protein interaction networks were constructed, and the core targets were obtained through network topology. The Metascape database was screened, and the core targets were enriched with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Results: In total, 1403 and 241 potential targets for drugs and diseases, respectively, and 81 intersecting targets were yielded. The core targets included TNF, IL-6, and IL-1β, and the core pathways included PI3K-Akt. The QYF treatment group exhibited effectively improved general signs, enhanced anti-inflammatory ability Conclusion: QYF could inhibit LPS production, which regulated the expression of the TLR4/PI3K/Akt/NF-κB signaling pathway to suppress the expression of the related inflammatory factors (i.e., TNF-α, IL-6, and IL-1β), thereby alleviating the CP process.
MeSH term(s)	Dendrobium/chemistry ; Pharyngitis/drug therapy ; Animals ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Mice ; Chronic Disease/drug therapy ; Male ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Signal Transduction/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-10-23
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073261351231005111817
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Zs.A 5577: Show issues

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Article: The anti-hyperlipidemia effect of

Li, Bo / Chen, Xian-Fang / Wu, Han-Song / Su, Jie / Ding, Yan-Yan / Zhang, Ze-Hua / Rong, Mei / Dong, Ying-Jie / He, Xinglishang / Li, Lin-Zi / Lv, Gui-Yuan / Chen, Su-Hong

Heliyon

2024 Volume 10, Issue 7, Page(s) e28019

Abstract: Aim: Atractylodes macrocephala: Methods: SD rats were fed a high-sucrose high-fat diet in conjunction with alcohol (HSHFDAC) along with different AM extracts (AMW, AMO, AME, and AMP) for 4 weeks. AM's active components were analyzed using multiple ... ...

Abstract	Aim: Atractylodes macrocephala Methods: SD rats were fed a high-sucrose high-fat diet in conjunction with alcohol (HSHFDAC) along with different AM extracts (AMW, AMO, AME, and AMP) for 4 weeks. AM's active components were analyzed using multiple databases, and their mechanisms were explored through network pharmacology. The relationship between AM's effect of enhancing serum HDL-c and regulating the expression of reverse cholesterol transport (RCT)-related proteins (Apo-A1, LCAT, and SR-BI) was further validated in the HSHFDAC-induced hyperlipidemic rats. The kidney and liver functions of the rats were measured to evaluate the safety of AM. Results: AMO, mainly comprised of volatile and liposoluble components, contributed the most significant anti-hyperlipidemia effect among the four extracts obtained from AM, significantly improving the blood lipid profile. Network pharmacology analysis also suggested that volatile and liposoluble components, comprise AM's main active components and they might act on signaling pathways associated with elevated HDL-c. Validation experiments found that AMO substantially and dose-dependently increased HDL-c levels, upregulated the expression of Apo-A1, SR-BI, and LCAT, improved the pathological changes in the kidney and liver, and significantly reduced the serum creatinine levels in rats with hyperlipidemia. Conclusion: The main anti-hyperlipidemia active components of AM are its volatile and liposoluble components, which may enhance serum HDL-c by increasing the expression of the RCT-related proteins Apo-A1, LCAT, and SR-BI.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28019
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