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Article: Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer.

Liang, Zhipan / Chen, Qiuyun / Pan, Liuying / She, Xiaowei / Chen, Tengfei

2024 Volume 16, Issue 2, Page(s) 1412–1423

Abstract: Background: The incidence and mortality of non-small cell lung cancer (NSCLC) are extremely high. Previous research has confirmed that the signal transducer and activator of the transcription 3 (STAT3) protein critically participate in the tumorigenesis ...

Abstract	Background: The incidence and mortality of non-small cell lung cancer (NSCLC) are extremely high. Previous research has confirmed that the signal transducer and activator of the transcription 3 (STAT3) protein critically participate in the tumorigenesis of NSCLC. Mebendazole (MBZ) has exerts a larger number of pharmacological activities and has anticancer effects in lung cancer, but its mechanism of action remains unclear. This study thus aimed to clarify the impacts of MBZ on NSCLC cell. Methods: Cell proliferation, migration, and apoptosis were investigated via cell counting kit 8 (CCK-8) assay, Transwell assay, colony formation assay, wound-healing assay, and flow cytometry. Reactive oxygen species (ROS) were detected with a multifunctional microplate reader. Markers of cell migration and apoptosis were detected with Western blotting. The transcriptional activity of STAT3 was detected via luciferase assay. ROS scavenger N-acetylcysteine (NAC) was used to determine the effect of MBZ on NSCLC via ROS-regulated STAT3 inactivation and apoptosis. A xenograft model was constructed Results: The findings demonstrated that MBZ inhibited NSCLC cell proliferation and migration while promoting apoptosis through triggering ROS generation. In addition, the Janus kinase 2 (JAK2)-STAT3 signaling pathway was abrogated with the treatment of MBZ. NAC could distinctly weaken MBZ-induced apoptosis and STAT3 inactivation. Moreover, MBZ inhibited the tumor growth of NSCLC Conclusions: In summary, MBZ inhibited NSCLC cell viability and migration by inducing cell apoptosis via the ROS-JAK2-STAT3 signaling pathway. These data provide a theoretical basis for the use of MBZ in treating NSCLC.
Language	English
Publishing date	2024-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1978
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High spatial resolution elevation change dataset derived from ICESat-2 crossover points on the Tibetan Plateau.

Chen, Tengfei / Wang, Jian / Che, Tao / Hao, Xiaohua / Li, Hongyi

Scientific data

2024 Volume 11, Issue 1, Page(s) 394

Abstract: Understanding elevation changes on the Tibetan Plateau is crucial to comprehend the changes in topography, landscape, climate, environmental conditions, and water resources. However, some of the current products that track elevation changes only cover ... ...

Abstract	Understanding elevation changes on the Tibetan Plateau is crucial to comprehend the changes in topography, landscape, climate, environmental conditions, and water resources. However, some of the current products that track elevation changes only cover specific surface types or limited areas, and others have low spatial resolution. We propose an algorithm to extract ICESat-2 crossover points dataset for the Tibetan Plateau, and form a dataset. The crossover points dataset has a density of 2.015 groups/km², and each group of crossover points indicates the amount of change in elevation before and after a period of time over an area of approximately 17 meters in diameter. Comparing ICESat-2 crossover points data with existing studies on glaciers and lakes, we demonstrated the reliability of the derived elevation changes. The ICESat-2 crossover points provide a refined data source for understanding high-spatial-resolution elevation changes on the Tibetan Plateau. This dataset can provide validation data for various studies that require high-precision or high-resolution elevation change data on the Tibetan Plateau.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03214-2
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Article ; Online: Cooperative Dynamic Motion Planning for Dual Manipulator Arms Based on RRT*Smart-AD Algorithm.

Long, Houyun / Li, Guang / Zhou, Fenglin / Chen, Tengfei

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 18

Abstract: Intelligent manufacturing requires robots to adapt to increasingly complex tasks, and dual-arm cooperative operation can provide a more flexible and effective solution. Motion planning serves as a crucial foundation for dual-arm cooperative operation. ... ...

Abstract	Intelligent manufacturing requires robots to adapt to increasingly complex tasks, and dual-arm cooperative operation can provide a more flexible and effective solution. Motion planning serves as a crucial foundation for dual-arm cooperative operation. The rapidly exploring random tree (RRT) algorithm based on random sampling has been widely used in high-dimensional manipulator path planning due to its probability completeness, handling of high-dimensional problems, scalability, and faster exploration speed compared with other planning methods. As a variant of RRT, the RRTSmart algorithm introduces asymptotic optimality, improved sampling techniques, and better path optimization. However, existing research does not adequately address the cooperative motion planning requirements for dual manipulator arms in terms of sampling methods, path optimization, and dynamic adaptability. It also cannot handle dual-manipulator collaborative motion planning in dynamic scenarios. Therefore, in this paper, a novel motion planner named RRTSmart-AD is proposed to ensure that the dual-arm robot satisfies obstacle avoidance constraints and dynamic characteristics in dynamic environments. This planner is capable of generating smooth motion trajectories that comply with differential constraints and physical collision constraints for a dual-arm robot. The proposed method includes several key components. First, a dynamic A* cost function sampling method, combined with an intelligent beacon sampling method, is introduced for sampling. A path-pruning strategy is employed to improve the computational efficiency. Strategies for dynamic region path repair and regrowth are also proposed to enhance adaptability in dynamic scenarios. Additionally, practical constraints such as maximum velocity, maximum acceleration, and collision constraints in robotic arm applications are analyzed. Particle swarm optimization (PSO) is utilized to optimize the motion trajectories by optimizing the parameters of quintic non-uniform rational B-splines (NURBSs). Static and dynamic simulation experiments verified that the RRTSmart-AD algorithm for cooperative dynamic path planning of dual robotic arms outperformed biased RRT and RRT*Smart. This method not only holds significant practical engineering significance for obstacle avoidance in dual-arm manipulators in intelligent factories but also provides a theoretical reference value for the path planning of other types of robots.
Language	English
Publishing date	2023-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23187759
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Article: Promotion of non-small cell lung cancer tumor growth by

Chen, Tengfei / Chen, Jun / Chen, Qiuyun / Liang, Zhipan / Pan, Liuying / Zhao, Jun / She, Xiaowei

Journal of thoracic disease

2024 Volume 16, Issue 2, Page(s) 1424–1437

Abstract: Background: Antiangiogenetic therapy is one of the effective strategies for non-small cell lung cancer (NSCLC) treatment. Four-and-a-half LIM-domain protein 2 (: Methods: FHL2: Results: We demonstrated that : Conclusions: Our study revealed the ...

Abstract	Background: Antiangiogenetic therapy is one of the effective strategies for non-small cell lung cancer (NSCLC) treatment. Four-and-a-half LIM-domain protein 2 ( Methods: FHL2 Results: We demonstrated that Conclusions: Our study revealed the role of
Language	English
Publishing date	2024-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1975
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Yinhuang buccal tablet alters airway microbiota composition and metabolite profile in healthy humans.

Li, Zhenxuan / Liu, Tengwen / Wang, Shuo / Chen, Tengfei / Wang, Xuerui / Xu, Xiaolong / Liu, Qingquan

Journal of ethnopharmacology

2024 Volume 328, Page(s) 118043

Abstract: Ethnopharmacological relevance: Perturbations in airway microbiota composition and disruption of microbe-metabolite interactions have been observed in respiratory infectious diseases (RIDs). The Yinhuang (YH) buccal tablet, as an ancient Chinese ... ...

Abstract	Ethnopharmacological relevance: Perturbations in airway microbiota composition and disruption of microbe-metabolite interactions have been observed in respiratory infectious diseases (RIDs). The Yinhuang (YH) buccal tablet, as an ancient Chinese medicinal formula, has been traditionally employed for the management of upper RIDs. However, there is a lack of evidence for the effects of YH buccal tablets on upper respiratory tract microbiota and circulating metabolites. Aim of the study: The aim of this study was to analyze the changes in respiratory microbiota composition and circulating metabolite profile after YH buccal tablets administration. Materials and methods: Throat swab samples and serum samples were collected from 60 healthy subjects for high-throughput 16S ribosomal RNA gene (16S rRNA) sequencing and non-targeted Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis. Results: Airway microbial composition changed significantly after YH administration. The abundance of Actinomyces and Prevotella_7 increased, while the abundance of potentially pathogenic Pseudomonas and Corynebacterium decreased. A total of 168 significant HMDB taxonomic metabolites were identified in serum samples, of which lipid metabolites accounted for the largest proportion. Correlation analysis showed that circulatory metabolites were significantly correlated with changes in airway microbiota composition. Conclusions: YH buccal tablets can inhibit opportunistic pathogens, increase beneficial microorganisms in the upper respiratory tract, and regulate the body's metabolic pathways. These findings provide insights into the mechanism of action of YH buccal tablets in the treatment and prevention of respiratory diseases.
MeSH term(s)	Humans ; Chromatography, Liquid ; RNA, Ribosomal, 16S/genetics ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/metabolism ; Tandem Mass Spectrometry/methods ; Respiratory System ; Microbiota ; Tablets
Chemical Substances	RNA, Ribosomal, 16S ; Drugs, Chinese Herbal ; Tablets
Language	English
Publishing date	2024-03-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118043
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Article ; Online: Effect of finerenone on cardiovascular events in kidney disease and/or diabetes: a meta analysis of randomized control trials.

Zhu, Yuhan / Song, Maifen / Chen, Tengfei / Yang, Zhihai / Liu, Yanyan

International urology and nephrology

2022 Volume 55, Issue 5, Page(s) 1373–1381

Abstract: Objective: To evaluate the effect of finerenone on cardiovascular events in Kidney Disease and/or Diabetes.: Methods: The ClinicalTrials.gov, Medline, EMBASE, Web of Science, Cochrane Library databases were systematically searched from the inception ... ...

Abstract	Objective: To evaluate the effect of finerenone on cardiovascular events in Kidney Disease and/or Diabetes. Methods: The ClinicalTrials.gov, Medline, EMBASE, Web of Science, Cochrane Library databases were systematically searched from the inception dates to December 20, 2021 in order to identify randomized controlled trials that evaluated the effect of finerenone on cardiovascular events in Kidney Disease and/or Diabetes, without language restriction. This meta-analysis collected data from 7 randomized clinical trials that evaluated the effect of finrrenone in 15,618 patients with kidney disease and/or diabetes. Risk of bias was assessed by Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed by I Results: A total of 7 randomized controlled trials involving 15,618 fulfilled the inclusion criteria. The outcomes of this meta-analysis presented that finerenone significantly reduced the death from any cause (95% CI 0.82-0.99; P = 0.031), risk of heart failure (95% CI 0.67-0.92; P = 0.002) among patients with kidney disease and/or diabetes when compared to control group. Besides, finerenone could not reduce the incidence of death from cardiovascular, myocardial infarction and hospitalization for any cause among patients with kidney disease and/or diabetes (p > 0.05). In terms of safety, finerenone shared the same risk of total advent events with placebo among patients with kidney disease and/or diabetes (p > 0.05). However, finerenone had higher risk of study-drug-related advent events than placebo among patients with kidney disease and/or diabetes (95% CI 1.27-1.48; P < 0.001). Conclusions: In patients with kidney disease and/or diabetes, treatment with finerenone resulted in lower risk of death from any cause and heart failure than placebo. However, the study-drug-related advent events also increased significantly at the same time.
MeSH term(s)	Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2 ; Diabetic Nephropathies/drug therapy ; Heart Failure ; Myocardial Infarction/epidemiology ; Myocardial Infarction/etiology ; Myocardial Infarction/prevention & control ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-12-26
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-022-03432-w
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Zs.A 733: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: Modified surgical incision suturing technique in uniportal video-assisted thoracoscopic pulmonary resection.

Pan, Liuying / Chen, Tengfei / Liang, Zhipan / Solli, Piergiorgio / Bedetti, Benedetta / Kim, Kyung Soo / She, Xiaowei

Journal of thoracic disease

2024 Volume 16, Issue 2, Page(s) 1388–1396

Abstract: Background: In recent years, single-hole thoracoscopic surgery technology is widely used in major medical centers and chest-specialized hospitals for the treatment of lung diseases. However, the single-hole minimally invasive surgery method focuses on ... ...

Abstract	Background: In recent years, single-hole thoracoscopic surgery technology is widely used in major medical centers and chest-specialized hospitals for the treatment of lung diseases. However, the single-hole minimally invasive surgery method focuses on one incision, and all surgical instruments need to pass through the same hole, resulting in repeated extrusion and tissue damage of the surgical incision. Therefore, we have improved the suture method of conventional surgical incision in order to reduce the probability of wound infection and dehiscence, promote early healing, and reduce the severity of postoperative wound scar, thereby enhancing the postoperative rapid recovery of patients. The purpose of this study is to explore the clinical efficacy of a modified surgical incision suture technique applied to uniportal thoracoscopic pulmonary resection. Methods: This study retrospectively analyzed 151 patients who were admitted to the Department of Thoracic Surgery and underwent pulmonary resection from January 2019 to October 2021 in the North District of Suzhou Municipal Hospital. The patients were divided into two groups according to the different surgical incision suture methods: a modified group and a conventional group. The postoperative general clinical indexes, incision infection rate, secondary suture rate, postoperative incision pain score, and the severity of postoperative incision scar were compared and analyzed between the two groups. Results: There were no statistically significant differences between the two groups in terms of chest tube duration or postoperative drainage and postoperative incision pain scores; the incision infection rate (1.3% Conclusions: Our modified suture method reduces the chance of infection and splitting and the severity of postoperative incision scar formation, promoting early healing. It can be safely and effectively applied to the incision suture of uniportal thoracoscopic pulmonary resection, enhancing the rapid postoperative recovery of patients.
Language	English
Publishing date	2024-02-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1968
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Type II Abernethy malformation with cystic fibrosis in a 12-year-old girl: A case report.

Zhang, Li-Jie / Liu, Xing-Yu / Chen, Teng-Fei / Xu, Zhong-Ya / Yin, Han-Jun

World journal of clinical cases

2023 Volume 11, Issue 32, Page(s) 7865–7871

Abstract: Background: Abernethy malformation, also known as congenital extrahepatic portosystemic shunt, is an uncommon malformation resulting from aberrant development of the portal venous system. Cystic fibrosis (CF) is an autosomal recessive genetic disease ... ...

Abstract	Background: Abernethy malformation, also known as congenital extrahepatic portosystemic shunt, is an uncommon malformation resulting from aberrant development of the portal venous system. Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the Case summary: A 12-year-old girl presented with a medical history of recurring respiratory infections and hemoptysis, and chest computed tomography (CT) showed bronchiectasis. Whole exome sequencing was performed for the patient, yielding findings that revealed a compound heterozygous variant of the Conclusion: Coexisting Abernethy malformation and CF are rare. Detailed medical history information, abdominal enhanced CT, venography and genetic testing contribute to diagnosis as well as differential diagnosis.
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i32.7865
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Article ; Online: Time series-based PM2.5 concentration prediction in Jing-Jin-Ji area using machine learning algorithm models

Ma, Xin / Chen, Tengfei / Ge, Rubing / Cui, Caocao / Xu, Fan / Lv, Qi

Heliyon. 2022 Sept., v. 8, no. 9 p.e10691-

2022

Abstract: Globally all countries encounter air pollution problems along their development path. As a significant indicator of air quality, PM₂.₅ concentration has long been proven to be affecting the population's death rate. Machine learning algorithms proven to ... ...

Abstract	Globally all countries encounter air pollution problems along their development path. As a significant indicator of air quality, PM₂.₅ concentration has long been proven to be affecting the population's death rate. Machine learning algorithms proven to outperform traditional statistical approaches are widely used in air pollution prediction. However research on the model selection discussion and environmental interpretation of model prediction results is still scarce and urgently needed to lead the policy making on air pollution control. Our research compared four types of machine learning algorisms LinearSVR, K-Nearest Neighbor, Lasso regression, Gradient boosting by looking into their performance in predicting PM₂.₅ concentrations among different cities and seasons. The results show that the machine learning model is able to forecast the next day PM₂.₅ concentration based on the previous five days' data with better accuracy. The comparative experiments show that based on city level the Gradient Boosting prediction model has better prediction performance with mean absolute error (MAE) of 9 ug/m³ and root mean square error (RMSE) of 10.25-16.76 ug/m³, lower compared with the other three models, and based on season level four models have the best prediction performances in winter time and the worst in summer time. And more importantly the demonstration of models' different performances in each city and each season is of great significance in environmental policy implications.
Keywords	air pollution ; air pollution control ; air quality ; algorithms ; environmental policy ; models ; mortality ; prediction ; summer ; winter ; Jing-Jin-Ji city group ; PM2.5 prediction ; Lasso regression ; Gradient boosting ; Linear SVR ; K-Nearest Neighbor
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10691
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Two new phenylpropenoid glycosides from the roots of Illicium dunnianum

Wang, Yi-lin / Li, Han / Song, Ling / Gao, Yun-hang / Chen, Teng-fei

Natural Product Research. 2022 Nov. 1, v. 36, no. 21 p.5539-5544

2022

Abstract: Two undescribed phenylpropenoid glycosides (1 − 2) and one known analogues (3) have been isolated and identified from the roots of Illicium dunnianum. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1 D-, 2 D- ... ...

Abstract	Two undescribed phenylpropenoid glycosides (1 − 2) and one known analogues (3) have been isolated and identified from the roots of Illicium dunnianum. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1 D-, 2 D-NMR, HRESIMS, IR, UV) and chemical methods. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE₂ production in LPS stimulated RAW 264.7 macrophages.
Keywords	Illicium dunnianum ; glycosides ; macrophages ; research ; spectroscopy ; Illicium dunnianum; phenylpropenoid glycosides ; anti-inflammatory ; PGE2
Language	English
Dates of publication	2022-1101
Size	p. 5539-5544.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2021.2019736
Database	NAL-Catalogue (AGRICOLA)

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