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Book ; Online: Microfluidics for Biosensing and Diagnostics

Inglis, David W. / Warkiani, Majid Ebrahimi / Qasaimeh, Mohammad A. / Chen, Weiqiang

2021

Keywords	History of engineering & technology ; therapeutic drug monitoring (TDM) ; aminoglycosides ; size and mobility traps (SMT) ; microfluidics ; numerical techniques ; Microsoft Excel ; finite difference method ; Navier-Stokes ; time dependent flow ; dynamic flow ; initiation of flow ; Poiseuille flow ; point-of-care ; biosensor ; hybrid integration ; acoustofluidics ; cavitation ; micromixing ; optical absorbance ; colorimetry ; salivary potassium ; biomolecules ; microfluidic ; dielectrophoretic immobilization ; CMOS biosensor ; lab-on-chip ; microfluidic probe ; droplet ; sampling ; Taylor dispersion ; diagnostic ; GMR sensor ; whole cell ; microdroplets ; photo-isomerisation ; photokinetics ; opto-mechanics ; conformational states
Size	1 electronic resource (114 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021044662
ISBN	9783036500638 ; 3036500634
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.

Chen, Yan / Liu, Xiaobin / Chen, Weiqiang / Zhu, Lei

Plant molecular biology

2024 Volume 114, Issue 1, Page(s) 6

Abstract: tRNA-derived small RNAs (tsRNAs), a new category of regulatory small non-coding RNA existing in almost all branches of life, have recently attracted broad attention. Increasing evidence has shown that tsRNAs are not random degradation debris of tRNAs, ... ...

Abstract	tRNA-derived small RNAs (tsRNAs), a new category of regulatory small non-coding RNA existing in almost all branches of life, have recently attracted broad attention. Increasing evidence has shown that tsRNAs are not random degradation debris of tRNAs, but products cleaved by specific endoribonucleases, with versatile functions in response to various developmental and environmental cues. However, it is still unclear about the diversity, biogenesis and function of tsRNAs in plants. In this study, we comprehensively profiled 10-60 nts small RNAs in Arabidopsis thaliana leaf with or without wounding stress and identified four 16 nts tiny tRFs (tRNA-derived fragments) sharply increased after wounding, namely tRF
MeSH term(s)	Arabidopsis ; Computational Biology ; RNA ; RNA, Transfer ; Arabidopsis Proteins/genetics ; Ribonucleases/genetics
Chemical Substances	RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; RNS2 protein, Arabidopsis (EC 3.1.-) ; Arabidopsis Proteins ; Ribonucleases (EC 3.1.-)
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/s11103-023-01399-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electroacupuncture combined with Qianzhengsan decoction for the treatment of peripheral facial paralysis: A retrospective study.

Chen, Wei-Qiang / Li, Qiang

Medicine

2022 Volume 101, Issue 37, Page(s) e30740

Abstract: This study retrospectively explored the effectiveness of electroacupuncture (EA) combined with Qianzhengsan decoction (QZSD) for the treatment of peripheral facial paralysis (PFP). This retrospective study included patients with PFP admitted to a single ... ...

Abstract	This study retrospectively explored the effectiveness of electroacupuncture (EA) combined with Qianzhengsan decoction (QZSD) for the treatment of peripheral facial paralysis (PFP). This retrospective study included patients with PFP admitted to a single hospital between July 2018 and June 2020. Ninety patients were included and divided into treatment (n = 45) and control (n = 45) groups. All the patients in both groups received oral prednisone tablets and mecobalamin. In addition, patients in the treatment group received EA and QZSD. The outcomes were the overall response rate, facial nerve function, facial nerve electromyography, and adverse events. All outcome data were analyzed before and after treatment. Patients in the treatment group achieved better outcomes than those in the control group in improving overall response rate (P = .04), facial nerve function (P < .01), and facial nerve electromyography (P < .01). Patients in both groups reported adverse events. The results of this study showed that patients with PFP and QZSD received better outcomes than those who did not. Further studies are required to confirm these results.
MeSH term(s)	Electroacupuncture ; Facial Nerve ; Facial Paralysis/drug therapy ; Humans ; Prednisone ; Retrospective Studies
Chemical Substances	Prednisone (VB0R961HZT)
Language	English
Publishing date	2022-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030740
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Effect of Dexamethasone on Neuroinflammation and Cerebral Edema in Rats With Traumatic Brain Injury Combined With Seawater Drowning.

Zeng, Zihuan / Wei, Liangfeng / Zhang, Hao / Chen, Weiqiang / Wang, Shousen

Cureus

2024 Volume 16, Issue 3, Page(s) e55309

Abstract: Objective: To investigate the effect and mechanism of dexamethasone (DX) on axonal injury after traumatic brain injury (TBI) combined with seawater drowning (SWD) in rats.: Methods: To gain an in-depth understanding of TBI + SWD in rats, we ... ...

Abstract	Objective: To investigate the effect and mechanism of dexamethasone (DX) on axonal injury after traumatic brain injury (TBI) combined with seawater drowning (SWD) in rats. Methods: To gain an in-depth understanding of TBI + SWD in rats, we established the compound injury model of rats by the Marmarou method and intratracheal pumping of seawater to simulate the pathological conditions. Rats in the DX group received intraperitoneal injections of DX (1 mg/kg) immediately after injury, and rats in the sham group and TBI + SWD group received intraperitoneal injections of the same amount of normal saline. Results: Hematoxylin-eosin (HE) showed that DX improved matrix looseness, cell swelling, and nuclear condensation 168 hours after injury. Immunohistochemistry (IHC) staining showed that the protein expression of AQP4 was decreased in the DX group compared with the TBI + SWD group from 12 hours to 168 hours after injury. DX decreased the modified neurological severity score (mNSS) significantly at 24 hours and 168 hours after injury (P < 0.05). At 72 h and 168 h after injury, DX significantly lowered the expressions of IL-8 and TNF-α (P < 0.05). Conclusion: DX may play a neuroprotective role by reducing cerebral edema and inflammatory response after TBI + SWD injury in rats.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Spatio-temporal dynamics and human-land synergistic relationship of urban expansion in Chinese megacities.

Cai, Enxiang / Zhang, Shengnan / Chen, Weiqiang / Li, Ling

Heliyon

2023 Volume 9, Issue 9, Page(s) e19872

Abstract: Megacities play important roles in countries' politics, economy, culture, etc. Exploring the law of urban expansion of megacities has important reference for sustainable urbanization. Here, the spatiotemporal dynamics of urban expansion were quantified ... ...

Abstract	Megacities play important roles in countries' politics, economy, culture, etc. Exploring the law of urban expansion of megacities has important reference for sustainable urbanization. Here, the spatiotemporal dynamics of urban expansion were quantified analyzed in 21 Chinese megacities from 2000 to 2020 with quantitative measurement indicators and explored the human-land synergistic relationship used the decoupling model. Results are as follows: (1) China's megacities experienced significant expansion, and urban expansion characterized as rapid initially but slowed down thereafter. (2) Urban expansion in megacities was characterized as having significant spatial differences, and rapidly expanding megacity centers moved from eastern to midwestern China. (3) Urban spatial expansion of megacities was mainly an enclave type in 2000-2010 and marginal type in 2010-2020. (4) The main type of human-land synergistic relationship in megacities were weak decoupling, there is a significant increase in expansive coupling and expansive negative decoupling in 2010-2020; (5) Lastly, human-land synergy relationship in most megacities was uncoordinated based on the per capita urban land area and decoupling type. The findings of this study can deepen the understanding of the characteristics and quality of urbanization evolution, and provides reference for high-quality development planning and decision-making in megacities.
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e19872
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association between serum creatinine and 30 days all-cause mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: analysis of the MIMIC-IV database.

Zhong, Yuan / Sun, Hao / Jing, Wenjuan / Liao, Lixian / Huang, Jiayi / Ma, Junqiang / Chen, Weiqiang

Frontiers in neurology

2024 Volume 15, Page(s) 1359749

Abstract: Background: Serum creatinine is a prognostic marker for various conditions, but its significance of spontaneous subarachnoid hemorrhage is still poorly understood. This study aims to elucidate the correlation between admission serum creatinine (sCr) ... ...

Abstract	Background: Serum creatinine is a prognostic marker for various conditions, but its significance of spontaneous subarachnoid hemorrhage is still poorly understood. This study aims to elucidate the correlation between admission serum creatinine (sCr) levels and all-cause mortality within 30 days among individuals affected by non-traumatic subarachnoid hemorrhage (SAH). Methods: This cohort study included 672 non-traumatic SAH adults. It utilized data from the MIMIC-IV database from 2008 to 2019. The patients' first-time serum creatinine was recorded. Subsequently, an examination of the 30-day all-cause mortality was conducted. Employing a multiple logistic regression model, a nomogram was constructed, while the association between sCr and 30-day all-cause mortality was evaluated using Kaplan-Meier survival curves. The calibration curve was employed to assess the model's performance, while subgroup analysis was employed to examine the impact of additional complications and medication therapy on outcomes. Results: A total of 672 patients diagnosed with non-traumatic subarachnoid hemorrhage were included in the study. The mortality rate within this timeframe was found to be 24.7%. Multiple logistic regression analysis revealed that sCr served as an independent prognostic indicator for all-cause mortality within 30 days of admission for SAH patients [OR: 2(1.18-3.41); Conclusion: Creatinine emerges as a significant biomarker, closely associated with heightened in-hospital mortality in individuals suffering from SAH.
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1359749
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: HSA-net with a novel CAD pipeline boosts both clinical brain tumor MR image classification and segmentation.

Yu, Zekuan / Li, Xiang / Li, Jiaxin / Chen, Weiqiang / Tang, Zhiri / Geng, Daoying

Computers in biology and medicine

2024 Volume 170, Page(s) 108039

Abstract: Brain tumors are among the most prevalent neoplasms in current medical studies. Accurately distinguishing and classifying brain tumor types accurately is crucial for patient treatment and survival in clinical practice. However, existing computer-aided ... ...

Abstract	Brain tumors are among the most prevalent neoplasms in current medical studies. Accurately distinguishing and classifying brain tumor types accurately is crucial for patient treatment and survival in clinical practice. However, existing computer-aided diagnostic pipelines are inadequate for practical medical use due to tumor complexity. In this study, we curated a multi-centre brain tumor dataset that includes various clinical brain tumor data types, including segmentation and classification annotations, surpassing previous efforts. To enhance brain tumor segmentation accuracy, we propose a new segmentation method: HSA-Net. This method utilizes the Shared Weight Dilated Convolution module (SWDC) and Hybrid Dense Dilated Convolution module (HDense) to capture multi-scale information while minimizing parameter count. The Effective Multi-Dimensional Attention (EMA) and Important Feature Attention (IFA) modules effectively aggregate task-related information. We introduce a novel clinical brain tumor computer-aided diagnosis pipeline (CAD) that combines HSA-Net with pipeline modification. This approach not only improves segmentation accuracy but also utilizes the segmentation mask as an additional channel feature to enhance brain tumor classification results. Our experimental evaluation of 3327 real clinical data demonstrates the effectiveness of the proposed method, achieving an average Dice coefficient of 86.85 % for segmentation and a classification accuracy of 95.35 %. We also validated the effectiveness of our proposed method using the publicly available BraTS dataset.
MeSH term(s)	Humans ; Brain Neoplasms/diagnostic imaging ; Diagnosis, Computer-Assisted ; Brain/diagnostic imaging ; Image Processing, Computer-Assisted
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.108039
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The feasibility of the posterior tibial nerve-flexor hallucis brevis pathway applied in neuromuscular monitoring: a multicentric, controlled, and prospective clinical trial.

Chen, Weiqiang / Chen, Zhijian / Cheng, Fang / Wang, Zhuodan / Li, Juan / Li, Shangrong / Xie, Hanbin

PeerJ

2024 Volume 12, Page(s) e17154

Abstract: This study aimed to investigate the clinical viability of utilizing the flexor hallucis brevis as an alternative site for neuromuscular monitoring compared to the conventional adductor pollicis. Patients were recruited from three medical centers. Cis- ... ...

Abstract	This study aimed to investigate the clinical viability of utilizing the flexor hallucis brevis as an alternative site for neuromuscular monitoring compared to the conventional adductor pollicis. Patients were recruited from three medical centers. Cis-atracurium was administered, and two monitors were employed independently to assess neuromuscular blockade of the adductor pollicis and the ipsilateral flexor hallucis brevis, following a train of four (TOF) pattern until TOF ratios exceeded 0.9 or until the conclusion of surgery. Statistical analysis revealed significant differences in onset time, duration of no-twitch response, spontaneous recovery time, and total monitoring time between the two sites, with mean differences of -53.54 s, -2.49, 3.22, and 5.89 min, respectively (
MeSH term(s)	Humans ; Anesthesia, General ; Feasibility Studies ; Neuromuscular Monitoring ; Prospective Studies ; Tibial Nerve
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Controlled Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.17154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Electrochemical coalescence of oil-in-water droplets in microchannels of TiO

Gu, Yuwei / Chen, Weiqiang / Chen, Li / Liu, Meng / Zhao, Kun / Wang, Zhichen / Yu, Hongtao

Water research

2024 Volume 255, Page(s) 121550

Abstract: Electrochemistry is a sustainable technology for oil-water separation. In the common flat electrode scheme, due to a few centimeters away from the anode, oil droplets have to undergo electromigration to and electrical neutralization at the anodic surface ...

Abstract	Electrochemistry is a sustainable technology for oil-water separation. In the common flat electrode scheme, due to a few centimeters away from the anode, oil droplets have to undergo electromigration to and electrical neutralization at the anodic surface before they coalesce into large oil droplets and rise to water surface, resulting in slow demulsification and easy anode fouling. Herein, a novel strategy is proposed on basis of a TiO
Language	English
Publishing date	2024-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121550
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Article ; Online: Liquiritin Carbomer Gel Cold Paste Promotes Healing of Solar Dermatitis in Mice.

Huang, Yanfang / Li, Sijia / Pan, Jinghua / Song, Congjing / Chen, Weiqiang / Zhang, Yun

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Ultraviolet radiation (UVR) has various effects on human cells and tissues, which can lead to a variety of skin diseases and cause inconvenience to people's lives. Among them, solar dermatitis is one of the important risk factors for malignant melanoma, ... ...

Abstract	Ultraviolet radiation (UVR) has various effects on human cells and tissues, which can lead to a variety of skin diseases and cause inconvenience to people's lives. Among them, solar dermatitis is one of the important risk factors for malignant melanoma, so prevention and treatment of solar dermatitis is very necessary. Additionally, liquiritin (LQ) has anti-inflammatory effects. In this study, we aimed to evaluate the anti-inflammatory and pro-wound healing effects of liquiritin carbomer gel cold paste (LQ-CG-CP) in vitro and in vivo. The results of MTT experiments showed no cytotoxicity of LQ at concentrations of 40 μg/mL and below and cell damage at UVB irradiation doses above 60 mJ/cm
MeSH term(s)	Animals ; Mice ; Humans ; Ultraviolet Rays ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Sunburn ; Wound Healing ; Interleukin-1beta ; Anti-Inflammatory Agents ; Dermatitis ; Acrylic Resins ; Glucosides ; Flavanones
Chemical Substances	carbomer ; liquiritin (T0O79T74CD) ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-1beta ; Anti-Inflammatory Agents ; Acrylic Resins ; Glucosides ; Flavanones
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073767
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