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Article ; Online: Decoration with electronegative 2D materials based on chemical transition layers on CFR-PEEK implants for promoting osteogenesis.

Qin, Wen / Xing, Tong / Ma, Jing / Tang, Bin / Chen, Weiyi

Journal of the mechanical behavior of biomedical materials

2024 Volume 152, Page(s) 106436

Abstract: Due to the unique lamellar structures, physicochemical and biological properties, electronegative two-dimensional (2D) materials have been explored for surface modification of carbon fibers reinforced polyetheretherketone (CFR-PEEK) composite. Deposition ...

Abstract	Due to the unique lamellar structures, physicochemical and biological properties, electronegative two-dimensional (2D) materials have been explored for surface modification of carbon fibers reinforced polyetheretherketone (CFR-PEEK) composite. Deposition of electronegative 2D materials based on a porous surface created by concentrated H
MeSH term(s)	Carbon Fiber ; Osteogenesis ; Prostheses and Implants ; Ketones ; Phosphorus ; Polyethylene Glycols ; Benzophenones ; Graphite ; Polymers
Chemical Substances	polyetheretherketone (31694-16-3) ; Carbon Fiber ; graphene oxide ; Ketones ; Phosphorus (27YLU75U4W) ; Polyethylene Glycols (3WJQ0SDW1A) ; Benzophenones ; Graphite (7782-42-5) ; Polymers
Language	English
Publishing date	2024-02-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2024.106436
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: BMSCs-driven graphite oxide-grafted-carbon fibers reinforced polyetheretherketone composites as functional implants:

Qin, Wen / Xing, Tong / Qin, Shengnan / Tang, Bin / Chen, Weiyi

Journal of biomaterials science. Polymer edition

2024 , Page(s) 1–16

Abstract: Mesenchymal stem cells (MSCs) are increasingly becoming a potential treatment approach for bone injuries due to the multi-lineage differentiation potential, ability to recognize damaged tissue sites and secrete bioactive factors that can enhance tissue ... ...

Abstract	Mesenchymal stem cells (MSCs) are increasingly becoming a potential treatment approach for bone injuries due to the multi-lineage differentiation potential, ability to recognize damaged tissue sites and secrete bioactive factors that can enhance tissue repair. The aim of this work was to improve osteogenesis of carbon fibers reinforced polyetheretherketone (CF/PEEK) implants through bone marrow mesenchymal stem cells (BMSCs)-based therapy. Moreover, bioactive graphene oxide (GO) was introduced into CF/PEEK by grafting GO onto CF to boost the osteogenic efficiency of BMSCs. Subsequently, CF/PEEK was implanted into the symmetrical skull defect models of SD rats. Then
Language	English
Publishing date	2024-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1014190-x
ISSN	1568-5624 ; 1568-5616 ; 0920-5063
ISSN (online)	1568-5624 ; 1568-5616
ISSN	0920-5063
DOI	10.1080/09205063.2024.2328877
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Article: Building vulnerability assessment in seismic areas using ensemble learning: A Nepal case study

Chen, Weiyi / Zhang, Limao

Journal of cleaner production. 2022 May 20, v. 350

2022

Abstract: The vulnerability assessment is a crucial method for earthquake-prone areas to manage seismic risk. This paper develops an Extreme gradient boosting (XGBoost)-based model to assess the seismic vulnerability of buildings in Kavrepalanchok, Nepal. The ... ...

Abstract	The vulnerability assessment is a crucial method for earthquake-prone areas to manage seismic risk. This paper develops an Extreme gradient boosting (XGBoost)-based model to assess the seismic vulnerability of buildings in Kavrepalanchok, Nepal. The vulnerability assessment model is trained based on the building survey data of the 2015 Gorkha earthquake. To rectify the impacts of class imbalance in raw data, the Synthetic Minority Oversampling Technique (SMOTE) technique is adopted in the data preprocessing stage. Then, XGBoost models for the 3 selected target variables are developed respectively. Finally, the performances of the developed models are evaluated, and the significant features that influence the vulnerability are investigated using the SHapley Additive exPlanations (SHAP) technique. Important findings are: (1) The developed SMOTE-XGBoost model for the overall building damage achieves the highest macro f1 score of 0.729 compared with other machine learning models. (2) The SMOTE technique is favorable when the label requiring more attention is the minor group (e.g., severe damage). (3) The foundation type, the roof type, and the building age are identified as the most significant features for the overall building damage grade. The developed learning model can be used as a decision tool to automate building vulnerability assessment in seismic areas using pre-earthquake data, providing decision support for disaster risk reduction at an early stage.
Keywords	case studies ; earthquakes ; geophysics ; models ; risk ; risk assessment ; risk reduction ; surveys ; Nepal
Language	English
Dates of publication	2022-0520
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.131418
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A fully digital 1-day technique for fabricating complete dentures based on an existing denture.

Zhang, Sihui / Lin, Yuxuan / Chen, Weiyi / Chen, Jiang

The Journal of prosthetic dentistry

2023

Abstract: This technical report describes a fully digital workflow for the design and fabrication of removable complete dentures in a single day. This technique integrates facial and intraoral scans, uses a computer-aided design software program to modify the ... ...

Abstract	This technical report describes a fully digital workflow for the design and fabrication of removable complete dentures in a single day. This technique integrates facial and intraoral scans, uses a computer-aided design software program to modify the orientation of the maxillary occlusal plane in the sagittal and frontal planes and evaluate the esthetics and finally produces complete dentures with a clinically acceptable design, simplifying the clinical workflow.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2022.11.023
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Article ; Online: The "Hand as Foot" teaching method in orbital anatomy.

Yang, Jun / Zhou, Wei / Chen, Weiyi / Li, Zhenzhu

Asian journal of surgery

2023 Volume 46, Issue 6, Page(s) 2631–2632

MeSH term(s)	Humans ; Hand ; Upper Extremity ; Foot/diagnostic imaging ; Lower Extremity
Language	English
Publishing date	2023-01-07
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.12.144
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Article: Research on the Comparison Properties of PDMS Specimens Demolding Processes and the Mechanical Performance of Hollow-Solid Ratios of Flexible Telescopic Rods.

Shang, Ruining / Li, Xiaona / Wu, Xiaogang / Chen, Weiyi

Micromachines

2023 Volume 14, Issue 6

Abstract: The main motivation of this work was to demonstrate a hollow telescopic rod structure that could be used for minimally invasive surgery. The telescopic rods were fabricated using 3D printing technology to make mold flips. During fabrication, differences ... ...

Abstract	The main motivation of this work was to demonstrate a hollow telescopic rod structure that could be used for minimally invasive surgery. The telescopic rods were fabricated using 3D printing technology to make mold flips. During fabrication, differences in biocompatibility, light transmission, and ultimate displacement were compared between telescopic rods fabricated via different processes, so as to select the appropriate process. To achieve these goals, flexible telescopic rod structures were designed and 3D-printed molds were fabricated using Fused Deposition Modeling (FDM) and Stereolithography (SLA) techniques. The results showed that the three molding processes had no impact on the doping of the PDMS specimens. However, the FDM molding process had lower surface flatness accuracy compared to SLA. The SLA mold flip fabrication exhibited superior surface accuracy and light transmission compared to the other methods. The sacrificial template method and the use of HTL direct demolding technique had no significant impact on cellular activity and biocompatibility, but the mechanical properties of the PDMS specimens were weakened after swelling recovery. The height and radius of the hollow rod were found to have a significant impact on the mechanical properties of the flexible hollow rod. The hyperelastic model was fitted appropriately with the mechanical test results, and the ultimate elongation increased with an increase in hollow-solid ratios under the uniform force.
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14061105
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Article: [Matrix stiffening related lncRNA SNHG8 regulates chemosensitivity of ovarian cancer].

Cheng, Zina / Ma, Xiaolu / Zhang, Quanyou / Chen, Weiyi

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2023 Volume 40, Issue 1, Page(s) 87–94

Abstract: Extracellular matrix (ECM) has been implicated in tumor progress and chemosensitivity. Ovarian cancer brings a great threat to the health of women with a significant feature of high mortality and poor prognosis. However, the potential significance of ... ...

Abstract	Extracellular matrix (ECM) has been implicated in tumor progress and chemosensitivity. Ovarian cancer brings a great threat to the health of women with a significant feature of high mortality and poor prognosis. However, the potential significance of matrix stiffness in the pattern of long non-coding RNAs (lncRNAs) expression and ovarian cancer drug sensitivity is still largely unkown. Here, based on RNA-seq data of ovarian cancer cell cultured on substrates with different stiffness, we found that a great amount of lncRNAs were upregulated in stiff group, whereas SNHG8 was significantly downregulated, which was further verified in ovarian cancer cells cultured on polydimethylsiloxane (PDMS) hydrogel. Knockdown of SNHG8 led to an impaired efficiency of homologous repair, and decreased cellular sensitivity to both etoposide and cisplatin. Meanwhile, the results of the GEPIA analysis indicated that the expression of SNHG8 was significantly decreased in ovarian cancer tissues, which was negatively correlated with the overall survival of patients with ovarian cancer. In conclusion, matrix stiffening related lncRNA SNHG8 is closely related to chemosensitivity and prognosis of ovarian cancer, which might be a novel molecular marker for chemotherapy drug instruction and prognosis prediction.
MeSH term(s)	Female ; Humans ; Cisplatin/pharmacology ; Elasticity/physiology ; Etoposide ; Extracellular Matrix/genetics ; Extracellular Matrix/physiology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Etoposide (6PLQ3CP4P3) ; long noncoding RNA SNHG8, human ; RNA, Long Noncoding
Language	Chinese
Publishing date	2023-03-02
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202205038
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Article ; Online: A digital technique for transferring the maxillomandibular relationship for complete arch implant rehabilitation in edentulous jaws.

Zhang, Sihui / Chen, Weiyi / Lin, Yuxuan / Chen, Jiang

The Journal of prosthetic dentistry

2023

Abstract: A digital technique for transferring the maxillomandibular relationship using photogrammetry, an intraoral scanner, and a computer-aided design software program is described in a treatment involving immediate loading in a patient with mandibular ... ...

Abstract	A digital technique for transferring the maxillomandibular relationship using photogrammetry, an intraoral scanner, and a computer-aided design software program is described in a treatment involving immediate loading in a patient with mandibular edentulism. The edentulous mandible was located preoperatively in a centric occlusal relationship with a denture, and preoperative and postoperative cone beam computed tomography (CBCT) data were aligned and merged based on bone markers. This technique, which allows the transfer of the presurgical maxillomandibular relationship during the immediate loading procedure, is more objective, more straightforward, and faster than the conventional method.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2022.06.026
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Article ; Online: Mechanical properties and osteogenesis of CFR-PEEK composite with interface strengthening by graphene oxide for implant application.

Qin, Wen / Xing, Tong / Tang, Bin / Chen, Weiyi

Journal of the mechanical behavior of biomedical materials

2023 Volume 148, Page(s) 106222

Abstract: In this work, 1 wt% of graphite oxide (GO) was used to strengthen the interface of carbon fibers (CF) reinforced polyetheretherketone (CFR-PEEK) composites, so as to obtain sufficiently high mechanical properties and bioactive surfaces which are two ... ...

Abstract	In this work, 1 wt% of graphite oxide (GO) was used to strengthen the interface of carbon fibers (CF) reinforced polyetheretherketone (CFR-PEEK) composites, so as to obtain sufficiently high mechanical properties and bioactive surfaces which are two fundamental requirements for orthopedic/dental implants. Concretely, aminated GO was grafted onto oxidized CF in aqueous solution in a mild and non-toxic manner, subsequently, the CF grafted by GO was used for injection molding to prepare CFR-PEEK implant. The dispersibility of CF in the composites were remarkably boosted. Mechanical tests indicated that the flexural strength, compressive strength and hardness of CFR-PEEK were increased by 51%, 46%, and 30%, respectively. Furthermore, the flexural modulus increased to 11.67 ± 0.20 GPa and the compression modulus increased to 6.12 ± 0.11 GPa, which both meet the elastic modulus of human bone (6-30 GPa). The wear resistance was slightly improved. In the in vitro cell evaluation, CFR-PEEK with interface strengthening by GO showed no cytotoxicity and exhibited significantly enhanced adhesion and proliferation of Bone marrow mesenchymal stem cells (BMSCs) on the surface. More importantly, osteogenesis-related protein expression in vitro and osteogenetic evaluation in vivo all disclosed greatly accelerated osteo-differentiation of BMSCs on the composites due to the additive effect of GO at the interface. Based on this scheme, the CFR-PEEK composites with the dual functions of mechanical enhancement and osteointegration promotion holds great potential as implants in orthopedic/dental applications.
MeSH term(s)	Humans ; Graphite ; Osteogenesis ; Polymers ; Polyethylene Glycols/pharmacology ; Ketones ; Carbon Fiber
Chemical Substances	polyetheretherketone (31694-16-3) ; graphene oxide ; Graphite (7782-42-5) ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Ketones ; Carbon Fiber
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2023.106222
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Article ; Online: Biomechanical response of lower limb joints to lateral wedge insoles.

Du, Weijin / Guo, Yuan / Wang, Chenyan / Cui, Weiling / Chen, Weiyi / Li, Xiaona

Scientific reports

2024 Volume 14, Issue 1, Page(s) 107

Abstract: Lateral wedge insole (LWI) is a frequently recommended treatment option for early and midterm stages of medial knee osteoarthritis. However, studies of its effects on the lower limb joints are incomplete and imperfect. The main purpose of this study was ... ...

Abstract	Lateral wedge insole (LWI) is a frequently recommended treatment option for early and midterm stages of medial knee osteoarthritis. However, studies of its effects on the lower limb joints are incomplete and imperfect. The main purpose of this study was to quantitatively analyze the response of intervention of LWI on lower-limb joint kinematics, ground reaction forces (GRFs), and centre of pressure (COP). Gait analysis of 16 healthy subjects was conducted. Three-dimensional motion data and force plate measurements were collected in the control (barefoot) and experimental conditions (wearing a pair of assigned shoes with 0, 7, and 10 mm LWIs). Results showed that the peak knee flexion angle was increased by 3.43°, 3.09°, and 3.27° with 0, 7, and 10 mm LWIs, respectively (p < 0.01). The ankle peak dorsiflexion angle was significantly decreased by 3.79°, 2.19°, and 1.66° with 0, 7, and 10 mm LWIs, respectively (p = 0.02). The internal rotation angle was increased by 2.78°, 3.76°, and 4.58° with 0, 7, and 10 mm LWIs, respectively (p < 0.01). The forefoot with LWIs showed highly significantly smaller inversion, eversion, and adduction angles (all p < 0.01). The 1st peak of the vertical GRF (p = 0.016) also increased significantly by a maximum of 0.06 body weight (BW) with LWIs. These results indicated that biomechanical changes and limitations of lateral wedges insole should be analyzed in more detail, possibly leading to new guidelines for the design and application.
MeSH term(s)	Humans ; Knee Joint/physiology ; Gait/physiology ; Shoes ; Lower Extremity ; Osteoarthritis, Knee ; Biomechanical Phenomena
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50693-1
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