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Article: Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1.

Dang, Yun-Zhi / Chen, Xiao-Jiao / Yu, Jiao / Zhao, Shu-Hong / Cao, Xi-Ming / Wang, Qing

2023 Volume 70, Issue 1, Page(s) 123–135

Abstract: Since metastasis remains the primary reason for colorectal cancer (CRC) associated death, a better understanding of the molecular mechanism underlying CRC metastasis is urgently needed. Here, we elucidated the role of Cathepsin C (CTSC) in promoting CRC ... ...

Abstract	Since metastasis remains the primary reason for colorectal cancer (CRC) associated death, a better understanding of the molecular mechanism underlying CRC metastasis is urgently needed. Here, we elucidated the role of Cathepsin C (CTSC) in promoting CRC metastasis. The expression of CTSC was detected by real-time PCR and immunohistochemistry in the human CRC cohort. The metastatic capacities of CTSC-mediated metastasis were analyzed by in vivo metastasis model. Elevated CSTC expression was positively associated with tumor differentiation, tumor invasion, lymph node metastasis, and AJCC stage and indicated poor prognosis in human CRC. CTSC overexpression in CRC cells promoted myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) recruitment by the CSF1/CSF1R axis. In contrast, the knockdown of CSF1 reduced CTSC-mediated MDSCs and TAMs infiltration and CRC metastasis. Depletion of either MDSCs or TAMs decreased CTSC-mediated CRC metastasis. In human CRC tissues, CTSC expression was positively associated with intratumoral MDSCs and TAMs infiltration. Furthermore, the combination of CTSC inhibitor AZD7986 and anti-PD-L1 antibody blocked CTSC-induced CRC metastasis. CTSC overexpression promoted MDSCs and TAMs infiltration by CSF1/CSF1R axis. Interruption of this oncogenic loop may provide a promising treatment strategy for inhibiting CTSC-driven CRC metastasis.
MeSH term(s)	Humans ; Cathepsin C ; Cell Differentiation ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Lymphatic Metastasis ; Neoplasm Metastasis
Chemical Substances	Cathepsin C (EC 3.4.14.1) ; CTSC protein, human (EC 3.4.14.1) ; CSF1 protein, human
Language	English
Publishing date	2023-03-14
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	415445-9
ISSN	0028-2685
ISSN	0028-2685
DOI	10.4149/neo_2023_220726N757
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Article ; Online: Genomic characterization of a new enamovirus infecting common bean.

Lu, Ruo-Bin / Lan, Ping-Xiu / Kang, Ru-Jing / Tan, Guan-Lin / Chen, Xiao-Jiao / Li, Ruhui / Li, Fan

Archives of virology

2022 Volume 167, Issue 3, Page(s) 999–1002

Abstract: A novel enamovirus was identified in common bean plants with disease symptoms. Its genome of 5,781 nucleotides (nt) contains five open reading frames. This virus and other members of the genus Enamovirus share 50.4-68.4% nucleotide sequence identity in ... ...

Abstract	A novel enamovirus was identified in common bean plants with disease symptoms. Its genome of 5,781 nucleotides (nt) contains five open reading frames. This virus and other members of the genus Enamovirus share 50.4-68.4% nucleotide sequence identity in the complete genome and 19.9-51.9% amino acid sequence identity in the P0 protein, 24.9-52.5% in P1, 33.4-62.9% in P1-P2, 30.6-81.1% in P3, and 32.3-74.2% in P3-P5. Phylogenetic analysis showed that the virus is most closely related to alfalfa enamovirus 1 and pea enation mosaic virus 1 in the genus Enamovirus of the family Solemoviridae. These results suggest that this virus, tentatively named "bean enamovirus 1", should be classified as a member of a new species in the genus Enamovirus.
MeSH term(s)	Genome, Viral ; Genomics ; Luteoviridae/genetics ; Open Reading Frames ; Phaseolus ; Phylogeny ; Plant Diseases ; RNA, Viral/genetics
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-02-10
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05387-w
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Article ; Online: Complete genome sequence of Aconitum amalgavirus 1, a distinct member of the genus Amalgavirus.

Yang, Jie / Lan, Ping-Xiu / Li, Jin-Ming / Chen, Xiao-Jiao / Tan, Guan-Lin / Wei, Tai-Yun / Li, Ru-Hui / Li, Fan

Archives of virology

2022 Volume 167, Issue 11, Page(s) 2351–2353

Abstract: A novel virus named Aconitum amalgavirus 1 (AcoAV-1) was identified in Chinese aconite (Aconitum carmichaelii) plants. The complete genome of AcoAV-1 is 3,370 nucleotides long, containing two partially overlapping open reading frames encoding a putative ... ...

Abstract	A novel virus named Aconitum amalgavirus 1 (AcoAV-1) was identified in Chinese aconite (Aconitum carmichaelii) plants. The complete genome of AcoAV-1 is 3,370 nucleotides long, containing two partially overlapping open reading frames encoding a putative coat protein and a RNA-dependent RNA polymerase, respectively. Its fusion protein shares 34.9%-50.7% amino acid sequence identity with other amalgaviruses. Phylogenetic analysis showed that this virus formed a clade with blueberry latent virus and four other related viruses, suggesting that it belongs to the genus Amalgavirus in the family Amalgaviridae.
MeSH term(s)	Aconitum/genetics ; Genome, Viral ; Nucleotides ; Open Reading Frames ; Phylogeny ; RNA Viruses/genetics ; RNA, Viral/genetics ; RNA-Dependent RNA Polymerase
Chemical Substances	Nucleotides ; RNA, Viral ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2022-07-17
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05521-8
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Article ; Online: Complete genome sequence of Aconitum amalgavirus 1, a distinct member of the genus Amalgavirus

Yang, Jie / Lan, Ping-Xiu / Li, Jin-Ming / Chen, Xiao-Jiao / Tan, Guan-Lin / Wei, Tai-Yun / Li, Ru-Hui / Li, Fan

Arch Virol. 2022 Nov., v. 167, no. 11 p.2351-2353

2022

Abstract	A novel virus named Aconitum amalgavirus 1 (AcoAV-1) was identified in Chinese aconite (Aconitum carmichaelii) plants. The complete genome of AcoAV-1 is 3,370 nucleotides long, containing two partially overlapping open reading frames encoding a putative coat protein and a RNA-dependent RNA polymerase, respectively. Its fusion protein shares 34.9%-50.7% amino acid sequence identity with other amalgaviruses. Phylogenetic analysis showed that this virus formed a clade with blueberry latent virus and four other related viruses, suggesting that it belongs to the genus Amalgavirus in the family Amalgaviridae.
Keywords	Aconitum carmichaelii ; Blueberry latent virus ; RNA-directed RNA polymerase ; amino acid sequences ; coat proteins ; genome ; nucleotide sequences ; nucleotides ; phylogeny ; sequence analysis ; viruses
Language	English
Dates of publication	2022-11
Size	p. 2351-2353.
Publishing place	Springer Vienna
Document type	Article ; Online
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05521-8
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Article: Genomic characterization of a new enamovirus infecting common bean

Lu, Ruo-bin / Lan, Ping-xiu / Kang, Ru-jing / Tan, Guan-lin / Chen, Xiao-jiao / Li, Ruhui / Li, Fan

Archives of virology. 2022 Mar., v. 167, no. 3

2022

Abstract	A novel enamovirus was identified in common bean plants with disease symptoms. Its genome of 5,781 nucleotides (nt) contains five open reading frames. This virus and other members of the genus Enamovirus share 50.4-68.4% nucleotide sequence identity in the complete genome and 19.9-51.9% amino acid sequence identity in the P0 protein, 24.9-52.5% in P1, 33.4-62.9% in P1-P2, 30.6-81.1% in P3, and 32.3-74.2% in P3-P5. Phylogenetic analysis showed that the virus is most closely related to alfalfa enamovirus 1 and pea enation mosaic virus 1 in the genus Enamovirus of the family Solemoviridae. These results suggest that this virus, tentatively named “bean enamovirus 1”, should be classified as a member of a new species in the genus Enamovirus.
Keywords	Solemoviridae ; alfalfa ; amino acid sequences ; beans ; genome ; genomics ; new species ; nucleotides ; peas ; phylogeny ; sequence analysis ; virology ; viruses
Language	English
Dates of publication	2022-03
Size	p. 999-1002.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05387-w
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Virome Analysis of

Yang, Jie / Lan, Ping-Xiu / Wang, Yun / Li, Jin-Ming / Li, Ruhui / Wylie, Steve / Chen, Xiao-Jiao / Yang, Gen-Hua / Cai, Hong / Li, Fan

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: ... Aconitum ... ...

Abstract	Aconitum carmichaelii
MeSH term(s)	Aconitum ; Phylogeny ; Virome ; China ; Viruses ; Potyvirus ; Cucumovirus ; Secoviridae ; Cytomegalovirus Infections
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115558
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Article: Protective effect and mechanism of Polygonatum kingianum against hypoxia-induced injury.

Li, Xue / Mei, MiJia / Pu, XueMei / Chen, XiaoJiao / Li, XueFang / Meng, FanYing / He, Sen / Li, JingPing / Gu, Wen / Yang, XingXin / Zhang, Fan / Yu, Jie

Heliyon

2023 Volume 9, Issue 3, Page(s) e14353

Abstract: Background: Hypoxia is an essential cause of fatigue and aging, and is associated with the occurrence and development of many diseases. : Aim of the study: The present study aimed to evaluate the anti-hypoxia efficacy and understand the corresponding ...

Abstract	Background: Hypoxia is an essential cause of fatigue and aging, and is associated with the occurrence and development of many diseases. Aim of the study: The present study aimed to evaluate the anti-hypoxia efficacy and understand the corresponding mechanism of PK water extract. Materials and methods: The main active ingredients and targets of PK were predicted using network pharmacology, and the anti-hypoxia activities of Gracillin and Liquiritigenin were verified by Results: Fifty active ingredients and 371 potential targets were screened by network pharmacology, then, we confirmed that Gracillin and Liquiritigenin were the main active components of PK to exert anti-hypoxia effect Conclusion: The network pharmacology results suggested that PK exerts its anti-hypoxia effect through a multi-component and multi-target manner. Simultaneously, we also observed that Gracillin (saponins) and Liquiritigenin (flavonoids) are the main active components of PK to play a role in anti-hypoxia. The anti-hypoxia effect of PK could be associated with scavenging excess free radicals, maintaining the activities of antioxidant enzymes, and inhibiting oxidative stress due to lipid peroxidation. These findings provide insight into the
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14353
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Protective effect and mechanism of Polygonatum kingianum against hypoxia-induced injury

Li, Xue / Mei, MiJia / Pu, XueMei / Chen, XiaoJiao / Li, XueFang / Meng, FanYing / He, Sen / Li, Jingping / Gu, Wen / Yang, XingXin / Zhang, Fan / Yu, Jie

Heliyon. 2023 Mar., v. 9, no. 3 p.e14353-

2023

Abstract: Hypoxia is an essential cause of fatigue and aging, and is associated with the occurrence and development of many diseases. Polygonatum kingianum (PK) is a deficiency-nourishing Chinese herbal medicine utilized as both medicine and food, and it has long ... ...

Abstract	Hypoxia is an essential cause of fatigue and aging, and is associated with the occurrence and development of many diseases. Polygonatum kingianum (PK) is a deficiency-nourishing Chinese herbal medicine utilized as both medicine and food, and it has long been used to ameliorate human conditions associated with fatigue and aging over 2000 years in China. PK is an important genuine-medicinal-materials cultivated in Yunnan, China, and is used by the Bai, Wa, and Zhuang nationalities as a traditional medicine for enhancing immunity, anti-fatigue, and anti-aging, while the preventive effect of PK on hypoxia-induced injury and the underlying mechanism are indefinite. The present study aimed to evaluate the anti-hypoxia efficacy and understand the corresponding mechanism of PK water extract. The main active ingredients and targets of PK were predicted using network pharmacology, and the anti-hypoxia activities of Gracillin and Liquiritigenin were verified by in vitro experiments. The pharmacodynamic experiments were conducted to evaluate the major signal pathways of PK for detecting anti-hypoxia activity. Fifty active ingredients and 371 potential targets were screened by network pharmacology, then, we confirmed that Gracillin and Liquiritigenin were the main active components of PK to exert anti-hypoxia effect in vitro. The pharmacodynamic experiments revealed that PK enhanced the extension rate of the survival time (ERST) and regulated the targets-related biochemical parameters of rats under hypoxia, showing significant anti-hypoxia effects on rats. The network pharmacology results suggested that PK exerts its anti-hypoxia effect through a multi-component and multi-target manner. Simultaneously, we also observed that Gracillin (saponins) and Liquiritigenin (flavonoids) are the main active components of PK to play a role in anti-hypoxia. The anti-hypoxia effect of PK could be associated with scavenging excess free radicals, maintaining the activities of antioxidant enzymes, and inhibiting oxidative stress due to lipid peroxidation. These findings provide insight into the Polygonatum kingianum as promising medicines or healthcare products for preventing and treating hypoxia.
Keywords	Polygonatum ; antioxidants ; flavonoids ; health services ; herbal medicines ; humans ; hypoxia ; immunity ; lipid peroxidation ; oxidative stress ; pharmacodynamics ; protective effect ; saponins ; traditional medicine ; China ; Anti-hypoxia ; HIF-1α ; Network pharmacology ; Polygonatum kingianum ; Survival time
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14353
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Article ; Online: Extracts of

Chen, Xiao-Jiao / Pu, Xin-Ying / Pu, Xue-Mei / Li, Xue / Liu, Zhi-Bo / Mei, Mi-Jia / Wang, Xin-Ge / Zhang, Fan / Qiu, Bin / Yu, Jie

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: ... Knoxia ... ...

Abstract	Knoxia roxburghii
MeSH term(s)	Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Apoptosis ; Apoptosis Regulatory Proteins ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Butanols ; Carcinoma, Non-Small-Cell Lung ; Caspases/metabolism ; Cell Proliferation ; Female ; Humans ; Lung Neoplasms ; MCF-7 Cells ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Reactive Oxygen Species/metabolism ; Rubiaceae/metabolism
Chemical Substances	Antineoplastic Agents, Phytogenic ; Apoptosis Regulatory Proteins ; Butanols ; Plant Extracts ; Reactive Oxygen Species ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2022-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196435
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Article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.

Yin, Wen / Zhang, Si-Qi / Pang, Wen-Lin / Chen, Xiao-Jiao / Wen, Jing / Hou, Jiong / Wang, Cui / Song, Li-Yun / Qiu, Zhen-Ming / Liang, Peng-Tao / Yuan, Jia-Li / Yang, Zhong-Shan / Bian, Yao

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2563–2581

Abstract: Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the ...

Abstract	Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated. Patients and methods: In the present study, we established an animal model of T2DM using a high‑fat diet (HFD) with intraperitoneal injection streptozotocin injection. Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the pro-inflammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
Language	English
Publishing date	2022-08-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S375572
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