Article ; Online: Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis.
Cold Spring Harbor perspectives in biology
2023 Volume 15, Issue 6
Abstract: APOB-containing lipoproteins are large, complex lipid carriers that ferry bulk lipids into the circulation via the secretory pathway, originating from the endoplasmic reticulum of specialized cells in the liver or the gut. Elevation of APOB-containing ... ...
| Abstract | APOB-containing lipoproteins are large, complex lipid carriers that ferry bulk lipids into the circulation via the secretory pathway, originating from the endoplasmic reticulum of specialized cells in the liver or the gut. Elevation of APOB-containing lipoproteins in the plasma represents a major risk factor for cardiovascular diseases. The production of these lipoproteins requires enzyme-catalyzed, cross-membrane transfer of neutral lipids and phospholipids to lipoproteins, in particular onto the structural component APOB. Transport of these lipid-bearing cargos relies on the COPII machinery and employs the transmembrane cargo receptor SURF4 and the small GTPase SAR1B, together constituting a selective transport program. Intriguingly, a number of factors implicated in lipoprotein production are also packaged into COPII vesicles and may be cotransported with APOB. These observations therefore point to a specialized produce-and-export itinerary during the secretion of these lipid-bearing cargos, warranting future investigations into this unique yet pivotal process at the crossroad of cell biology and physiology. |
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| MeSH term(s) | Carrier Proteins/metabolism ; Lipoproteins/analysis ; Lipoproteins/metabolism ; Endoplasmic Reticulum/metabolism ; Apolipoproteins B/analysis ; Apolipoproteins B/metabolism ; Homeostasis ; Protein Transport ; COP-Coated Vesicles/chemistry ; COP-Coated Vesicles/metabolism |
| Chemical Substances | Carrier Proteins ; Lipoproteins ; Apolipoproteins B |
| Language | English |
| Publishing date | 2023-06-01 |
| Publishing country | United States |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ISSN | 1943-0264 |
| ISSN (online) | 1943-0264 |
| DOI | 10.1101/cshperspect.a041260 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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