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Book ; Online: Computational Fluid Mechanics

Du, Peng / Ouahsine, Abdellatif / Hu, Haibao / Chen, Xiaopeng

2023

Keywords	Technology: general issues ; History of engineering & technology ; high sea state ; USV ; large scale ; motion in waves ; safety of the trip ; hydrodynamics ; inland convoy ; bridge pier ; confined waterway ; resistance ; high-speed supercavitation vehicle ; wet surface ; hydrodynamic force ; damping force ; periodic swing ; heaving foil ; different waveform perturbation ; hydrodynamic characteristics ; vortex structure ; pump-jet propulsor ; SST ; stator solidity ; stator angle ; rotor-stator spacing ; blade number ; vortices ; submarine-launched vehicle ; pressure-equalizing exhaust ; multiphase flow ; air film fusion ; convective heat transfer ; impinging jet ; VTOL (vertical take-off and landing) ; thermal flow ; stagnation point ; CFD (computational fluid dynamics) ; numerical simulations ; multiple discharges ; inclined dense jets ; mixing and dilution ; discharge inclination ; cable-laying vessel ; submarine cable ; dynamic interactions ; numerical simulation ; combination excitation ; liquid cargo tank ; sloshing ; manta rays ; fish schooling ; tandem gliding ; the bow of the submarine ; turbulent boundary layer ; pressure fluctuation ; stress-blended eddy simulation ; horizontal submerged jet ; Wray-Agarwal turbulence model ; flow field structure ; speed distribution ; n/a
Language	English
Size	1 electronic resource (274 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030377115
ISBN	9783036571706 ; 3036571701
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Comparison of the effects of ampulla-guided realignment and conventional gallbladder triangle anatomy in difficult laparoscopic cholecystectomy.

Wang, Yong / Chen, Xiao-Peng

Langenbeck's archives of surgery

2023 Volume 409, Issue 1, Page(s) 17

Abstract: Objective: To compare the effects of ampulla-guided realignment and conventional gallbladder triangle anatomy in difficult laparoscopic cholecystectomy (DLC).: Methods: From June 2021 to August 2022, data from 100 patients undergoing DLC at Nanjing ... ...

Abstract	Objective: To compare the effects of ampulla-guided realignment and conventional gallbladder triangle anatomy in difficult laparoscopic cholecystectomy (DLC). Methods: From June 2021 to August 2022, data from 100 patients undergoing DLC at Nanjing Hospital of Traditional Chinese Medicine were analyzed retrospectively. Patients were divided into two groups: the experimental group (LC with the ampulla-guided realignment) and the control group (conventional LC with triangular gallbladder anatomy), with 50 patients per group. The intraoperative blood loss, operation time, postoperative drainage tube indwelling time, hospitalization time, bile duct injury rate, operation conversion rate, and incidence of postoperative complications were recorded and compared between the two groups. The pain response and daily activities of the patients in the two groups were evaluated 48 h after the operation. Results: The amount of intraoperative blood loss, postoperative drainage tube indwelling time, hospital stay, operation conversion rate, pain degree at 24 and 48 h after operation, bile duct injury incidence, and total postoperative complication rate were shorter or lower in the experimental group than those in the control group (p < 0.05). The Barthel index scores of both groups were higher 48 h after the operation than before the operation, and the experimental group was higher than the control group (p < 0.05). Conclusion: The ampulla-guided alignment in DLC surgery was more beneficial in promoting postoperative recovery, reducing postoperative pain response, reducing the incidence of postoperative complications, and reducing bile duct injury.
MeSH term(s)	Humans ; Abdominal Injuries ; Blood Loss, Surgical ; Cholecystectomy, Laparoscopic/adverse effects ; Gallbladder/surgery ; Pain, Postoperative/epidemiology ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2023-12-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-023-03205-8
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Article: Preoperative plasma fibrinogen and C-reactive protein/albumin ratio as prognostic biomarkers for pancreatic carcinoma.

Chen, Xiaopeng / Chen, Zhaohui / Guo, Jianyang / Xiu, Zhe / Chen, Huangxiang

Frontiers in oncology

2024 Volume 14, Page(s) 1301059

Abstract: Objective: Pancreatic carcinoma is characterised by high aggressiveness and a bleak prognosis; optimising related treatment decisions depends on the availability of reliable prognostic markers. This study was designed to compare various blood biomarkers, ...

Abstract	Objective: Pancreatic carcinoma is characterised by high aggressiveness and a bleak prognosis; optimising related treatment decisions depends on the availability of reliable prognostic markers. This study was designed to compare various blood biomarkers, such as neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), albumin (Alb), plasma fibrinogen (PF), and CRP/Alb in patients with pancreatic carcinoma. Methods: Our study retrospectively reviewed 250 patients with pancreatic carcinoma diagnosed between July 2007 and December 2018. The Cutoff Finder application was used to calculate the optimal values of CRP/Alb and PF. The Chi-square test or Fisher's exact test was used to analyse the correlation of CRP/Alb and PF with other clinicopathological factors. Conducting univariate and multivariate analyses allowed further survival analysis of these prognostic factors. Results: Multivariate analysis revealed that, in a cohort of 232 patients with pancreatic ductal adenocarcinoma (PDAC), the PF level exhibited statistical significance for overall survival (hazard ratio (HR) = 0.464; Conclusion: PF concentration is a convenient, rapid, and noninvasive biomarker, and its combination with the CRP/Alb ratio could significantly enhance the accuracy of prognosis prediction in pancreatic carcinoma patients, especially those with the most common histological subtype of PDAC.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1301059
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Article: Breaking genetic shackles: The advance of base editing in genetic disorder treatment.

Xu, Fang / Zheng, Caiyan / Xu, Weihui / Zhang, Shiyao / Liu, Shanshan / Chen, Xiaopeng / Yao, Kai

Frontiers in pharmacology

2024 Volume 15, Page(s) 1364135

Abstract: The rapid evolution of gene editing technology has markedly improved the outlook for treating genetic diseases. Base editing, recognized as an exceptionally precise genetic modification tool, is emerging as a focus in the realm of genetic disease therapy. ...

Abstract	The rapid evolution of gene editing technology has markedly improved the outlook for treating genetic diseases. Base editing, recognized as an exceptionally precise genetic modification tool, is emerging as a focus in the realm of genetic disease therapy. We provide a comprehensive overview of the fundamental principles and delivery methods of cytosine base editors (CBE), adenine base editors (ABE), and RNA base editors, with a particular focus on their applications and recent research advances in the treatment of genetic diseases. We have also explored the potential challenges faced by base editing technology in treatment, including aspects such as targeting specificity, safety, and efficacy, and have enumerated a series of possible solutions to propel the clinical translation of base editing technology. In conclusion, this article not only underscores the present state of base editing technology but also envisions its tremendous potential in the future, providing a novel perspective on the treatment of genetic diseases. It underscores the vast potential of base editing technology in the realm of genetic medicine, providing support for the progression of gene medicine and the development of innovative approaches to genetic disease therapy.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1364135
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Article: MicroRNA-378 inhibits hepatocyte apoptosis during acute liver failure by targeting caspase-9 in mice.

Feng, Zhiwen / Bao, Shenghua / Kong, Lianbao / Chen, Xiaopeng

Gastroenterologia y hepatologia

2022 Volume 46, Issue 2, Page(s) 124–134

Abstract: Background: Acute liver failure (ALF) is a severe and potentially lethal clinical syndrome. It has been demonstrated that micro ribonucleic acids (miRNAs) are crucial mediators of nearly all pathological processes, including liver disease.: Objective!# ...

Abstract	Background: Acute liver failure (ALF) is a severe and potentially lethal clinical syndrome. It has been demonstrated that micro ribonucleic acids (miRNAs) are crucial mediators of nearly all pathological processes, including liver disease. Objective: The present study investigates the role of miR-378 in ALF. An ALF mouse model was induced using intraperitoneal injections of d-galactosamine/lipopolysaccharide (d-GalN/LPS). A hepatocyte cell line and miR-378 analogue were used in vitro to investigate the possible roles of miR-378 in ALF. Methods: The expressions of miR-378 and predicted target genes were measured via reverse transcription-quantitative polymerase chain reaction and western blotting, and cell apoptosis was assayed using flow cytometry. Results: Compared with mice in the control group, the mice challenged with d-GalN/LPS showed higher levels of alanine aminotransferase, aspartate aminotransferase, tumour necrosis factor-alpha and interleukin-6, more severe liver damage and increased numbers of apoptotic hepatocytes. Hepatic miR-378 was distinctly downregulated, while messenger RNA and protein levels of cysteinyl aspartate specific proteinase 9 (caspase-9) were upregulated in the ALF model. Furthermore, miR-378 was downregulated in d-GalN/TNF-induced hepatocyte cells, and miR-378 was found to inhibit hepatocyte apoptosis by targeting caspase-9. Conclusion: Together, the present results indicate that miR-378 is a previously unrecognised post-ALF hepatocyte apoptosis regulator and may be a potential therapeutic target in the context of ALF.
MeSH term(s)	Mice ; Animals ; Lipopolysaccharides/adverse effects ; Lipopolysaccharides/metabolism ; Caspase 9/metabolism ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/genetics ; Liver Failure, Acute/metabolism ; Liver/pathology ; Hepatocytes/metabolism ; Apoptosis ; Tumor Necrosis Factor-alpha/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism
Chemical Substances	Lipopolysaccharides ; Caspase 9 (EC 3.4.22.-) ; Tumor Necrosis Factor-alpha ; MicroRNAs ; MIRN378 microRNA, mouse
Language	Spanish
Publishing date	2022-08-12
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2022.07.004
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Article ; Online: Influence of the deterioration type and age on the deterioration degree of 191 ancient limestone steles in the Guihai Forest of Steles, southern China

Zhang, Qiong / Zhang, Zhongjian / Chen, Xiaopeng

Environ Earth Sci. 2022 Oct., v. 81, no. 19 p.477-477

2022

Abstract: The relationship between the deterioration type (DT) of ancient limestone steles and deterioration degree (DD) and the relationship between the carved age and DD were investigated and studied. Data on the DT, DD and carved age were collected and analysed ...

Abstract	The relationship between the deterioration type (DT) of ancient limestone steles and deterioration degree (DD) and the relationship between the carved age and DD were investigated and studied. Data on the DT, DD and carved age were collected and analysed from 191 ancient limestone steles in the Guihai Forest of Steles, Guangxi Zhuang Autonomous Region, southern China. A distribution map of deterioration on each stele was drawn, and six DTs were identified, including biological colonization, missing parts, exfoliation, erosion, encrustation and graffiti. The DDs were visually assessed on a generalized 4-point scale: intact, slight, serious and extremely serious. The carved ages of steles, which ranged from 894 to 1940 A.D., were verified. The relationship between the DT and DD was analysed using partial correlation analytical methods. The correspondence between the carved age of the limestone stele and the DD was established and analysed. The results show that (1) the DD was strongly correlated with erosion, which was mainly caused by seepage water and rainwater, and the DD was weakly or not correlated with the other five DTs; (2) the DD was related to the carved age, but the relationships were weak. The results provide a scientific reference for the conservation and restoration of these caves.
Keywords	forests ; limestone ; rain ; seepage ; stele ; China
Language	English
Dates of publication	2022-10
Size	p. 477.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-022-10597-1
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of biochar nanoparticles as a soil amendment on the structure and hydraulic characteristics of a sandy loam soil

Chen, Xiaopeng / Duan, Manli / Zhou, Beibei / Cui, Lei

Soil use and management. 2022 Jan., v. 38, no. 1

2022

Abstract: Biochar as a soil amendment can influence the physical and solute transport properties of soils and, thus, provide a means to improve soil fertility. However, the use of different sized biochar particles down to the nano‐scale has revealed inconsistent ... ...

Abstract	Biochar as a soil amendment can influence the physical and solute transport properties of soils and, thus, provide a means to improve soil fertility. However, the use of different sized biochar particles down to the nano‐scale has revealed inconsistent results, with the mechanisms poorly understood owing to a lack of experimental data. This study investigated the effects and mechanisms of nano‐sized biochar particles (NBC) applied to a sandy loam soil with regard to impacts on the hydraulic characteristics and soil structure. Column experiments were carried out with NBC application rates of 0.0%, 0.3%, 0.5%, 0.7% and 1.0% (by weight). It was found that the NBC changed the distribution of the soil pore structure and affected the degrees of anisotropy, fractal dimension, soil porosity and stability of soil aggregates. NBC applications also increased the water repellency of the soil and reduced the surface energy of soil particles. Regarding soil hydraulic properties, NBC applications increased the saturated hydraulic conductivity of the soil and decreased soil water retention. Increasing the amount of NBC applied to the mixing‐layer decreased cumulative infiltration values (reduced by 3.75%–13.75%). The above results reveal how NBC affects the soil pore structure and soil hydraulic characteristics, which provides a theoretical basis for the systematic evaluation of soil improvement and environmental effects of nano‐sized biochar.
Keywords	administrative management ; anisotropy ; biochar ; energy ; fractal dimensions ; porosity ; sandy loam soils ; saturated hydraulic conductivity ; soil amendments ; soil fertility ; soil pore system ; soil water retention ; solutes
Language	English
Dates of publication	2022-01
Size	p. 836-849.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	742151-5
ISSN	1475-2743 ; 0266-0032
ISSN (online)	1475-2743
ISSN	0266-0032
DOI	10.1111/sum.12740
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MIR4435-2HG, miR-125b-5p, and Sema4D axis affects the aggressiveness of colorectal cancer cells.

Yu, Ming / Yi, Zhengguo / Chen, Shenghui / Chen, Xiaopeng / Xie, Xiaofeng

Folia histochemica et cytobiologica

2022 Volume 60, Issue 2, Page(s) 191–202

Abstract: Introduction: The purpose of this study is to elucidate the impact of long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration.: Material and methods: Sema4D ... ...

Abstract	Introduction: The purpose of this study is to elucidate the impact of long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration. Material and methods: Sema4D expression in 73 pairs of CRC tissues and matched adjacent normal tissues was measured by qRT-PCR and western blot and its association with pathological characteristics of CRC patients was analyzed by chi-square test. Also, the expression of MIR4435-2HG, miR-125b-5p and Sema4D in CRC cell lines was detected by qRT-PCR and Western blot. Knockdown or overexpression of MIR4435-2HG, miR-125b- 5p and Sema4D were separately performed in Caco-2 and LoVo cells, and the cell propagation, migration and invasiveness were detected by cell-counting kit 8, scratch, and transwell assays. Results: LncRNA MIR4435-2HG and Sema4D were highly expressed, while miR-125b-5p expression was decreased in CRC tissues and cells. Knockdown of MIR4435-2HG/Sema4D or overexpression of miR-125b-5p inhibited CRC cell proliferation and aggressiveness; overexpression of MIR4435-2HG/Sema4D or knockdown of miR-125b-5p prompted the malignant behaviors of cancer cells. MIR4435-2HG and Sema4D competitively bound to miR-125b-5p. Conclusions: LncRNA MIR4435-2HG targets miR-125b-5p to upregulate Sema4D expression, and thus regulates CRC cell propagation, migration and invasiveness.
MeSH term(s)	Antigens, CD ; Caco-2 Cells ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Semaphorins/genetics ; Semaphorins/metabolism
Chemical Substances	Antigens, CD ; CD100 antigen ; MicroRNAs ; RNA, Long Noncoding ; Semaphorins
Language	English
Publishing date	2022-06-22
Publishing country	Poland
Document type	Journal Article
ZDB-ID	605761-5
ISSN	1897-5631 ; 0015-5586 ; 0239-8508
ISSN (online)	1897-5631
ISSN	0015-5586 ; 0239-8508
DOI	10.5603/FHC.a2022.0018
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Article: Facile Synthesis of Two-Dimensional Natural Vermiculite Films for High-Performance Solid-State Electrolytes.

Xing, Yan / Chen, Xiaopeng / Huang, Yujia / Zhen, Xiali / Wei, Lujun / Zhong, Xiqiang / Pan, Wei

Materials (Basel, Switzerland)

2023 Volume 16, Issue 2

Abstract: Ceramic electrolytes hold application prospects in all-solid-state lithium batteries (ASSLB). However, the ionic conductivity of ceramic electrolytes is limited by their large thickness and intrinsic resistance. To cope with this challenge, a two- ... ...

Abstract	Ceramic electrolytes hold application prospects in all-solid-state lithium batteries (ASSLB). However, the ionic conductivity of ceramic electrolytes is limited by their large thickness and intrinsic resistance. To cope with this challenge, a two-dimensional (2D) vermiculite film has been successfully prepared by self-assembling expanded vermiculite nanosheets. The raw vermiculite mineral is first exfoliated to thin sheets of several atomic layers with about 1.2 nm interlayer channels by a thermal expansion and ionic exchanging treatment. Then, through vacuum filtration, the ion-exchanged expanded vermiculite (IEVMT) sheets can be assembled into thin films with a controllable thickness. Benefiting from the thin thickness and naturally lamellar framework, the as-prepared IEVMT thin film exhibits excellent ionic conductivity of 0.310 S·cm
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16020729
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Article ; Online: Abnormal Expression of Centromere Protein U Is Associated with Hepatocellular Cancer Progression.

Yu, Yuanlin / Chen, Xiaopeng / Zhang, Weidong / Liu, Jun

BioMed research international

2021 Volume 2021, Page(s) 4051192

Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies globally, but its molecular mechanism is unclear. Abnormal expression of centromere protein U (CENPU) is closely related to diverse human cancers. The purpose of this ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies globally, but its molecular mechanism is unclear. Abnormal expression of centromere protein U (CENPU) is closely related to diverse human cancers. The purpose of this article was to evaluate the function and potential mechanisms of CENPU in HCC development. Methods: We performed bioinformatics analysis of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Gene Expression Profiling Interactive Analysis (GEPIA), and Kaplan-Meier plotter databases to investigate the clinical significance and prognostic value of CENPU in HCC. Western blotting and immunohistochemical staining were used to measure protein expression, while reverse transcription-quantitative polymerase chain reaction (qRT-PCR) was used to determine mRNA expression. Cell Counting Kit8 (CCK-8) and colony formation assays were conducted to examine cell proliferation. Transwell and wound healing assays were used to assess cell migration and invasion. Gene set enrichment analysis (GSEA) was used to explore the potential signaling pathways of CENPU involved in HCC. Results: High expression of CENPU in HCC was predicted by public database analysis and indicated a poor prognosis. CENPU expression was significantly higher in HCC tissues and cells than in normal tissues and cell. In vitro, CENPU promoted the proliferation, migration, and invasion of HCC cells. GSEA results indicated that CENPU was linked to the Notch signaling pathway, and our research supported this prediction. Conclusion: CENPU promotes the malignant biological process of HCC and may be a promising target for HCC treatment.
MeSH term(s)	Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Hep G2 Cells ; Histones/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Prognosis ; RNA, Messenger/genetics ; Signal Transduction/genetics
Chemical Substances	CENPU protein, human ; Cell Cycle Proteins ; Histones ; RNA, Messenger
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/4051192
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