LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 19

Search options

  1. Article: Changes in the bacterial communities of

    Sun, Yuanxing / Hao, Yanan / Wang, Senshan / Chen, Xinling

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1276668

    Abstract: Bacteria have a profound influence on life history and reproduction of numerous insects, while the associations between hosts and bacteria are substantially influenced by environmental pressures. Cold storage is crucial for extending the shelf life of ... ...

    Abstract Bacteria have a profound influence on life history and reproduction of numerous insects, while the associations between hosts and bacteria are substantially influenced by environmental pressures. Cold storage is crucial for extending the shelf life of insects used as tools for biological control, but mostly causes detrimental effects. In this study, we observed a great decrease in egg hatch rate of cold-stored
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1276668
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Brain Systems Underlying Fundamental Motivations of Human Social Conformity.

    Chen, Xinling / Liu, Jiaxi / Luo, Yue-Jia / Feng, Chunliang

    Neuroscience bulletin

    2022  Volume 39, Issue 2, Page(s) 328–342

    Abstract: From birth to adulthood, we often align our behaviors, attitudes, and opinions with a majority, a phenomenon known as social conformity. A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives: a desire ... ...

    Abstract From birth to adulthood, we often align our behaviors, attitudes, and opinions with a majority, a phenomenon known as social conformity. A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives: a desire to gain more information to be accurate, to obtain social approval from others, and to maintain a favorable self-concept. Despite extensive interest in neuroimaging investigation of social conformity, the relationship between brain systems and these fundamental motivations has yet to be established. Here, we reviewed brain imaging findings of social conformity with a componential framework, aiming to reveal the neuropsychological substrates underlying different conformity motivations. First, information-seeking engages the evaluation of social information, information integration, and modification of task-related activity, corresponding to brain networks implicated in reward, cognitive control, and tasks at hand. Second, social acceptance involves the anticipation of social acceptance or rejection and mental state attribution, mediated by networks of reward, punishment, and mentalizing. Third, self-enhancement entails the excessive representation of positive self-related information and suppression of negative self-related information, ingroup favoritism and/or outgroup derogation, and elaborated mentalizing processes to the ingroup, supported by brain systems of reward, punishment, and mentalizing. Therefore, recent brain imaging studies have provided important insights into the fundamental motivations of social conformity in terms of component processes and brain mechanisms.
    MeSH term(s) Humans ; Social Conformity ; Motivation ; Brain ; Social Behavior ; Brain Mapping
    Language English
    Publishing date 2022-10-26
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2419741-5
    ISSN 1995-8218 ; 1673-7067
    ISSN (online) 1995-8218
    ISSN 1673-7067
    DOI 10.1007/s12264-022-00960-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Can Sexual Appeal, Beauty, or Virtue Increase the Opportunity for a Woman to Be Selected as a Spouse? The Mediating Role of Human Uniqueness.

    Lai, Ji / Ding, Daoqun / Chen, Xinling / Li, Shenglan

    Frontiers in psychology

    2021  Volume 12, Page(s) 698712

    Abstract: High mating value is believed to correspond with high mating opportunities. On that premise, this study explores three cues that are linked to women of high long-term mating value, namely a "beautiful" facial appearance, "sexually attractive" body shape, ...

    Abstract High mating value is believed to correspond with high mating opportunities. On that premise, this study explores three cues that are linked to women of high long-term mating value, namely a "beautiful" facial appearance, "sexually attractive" body shape, and "virtuous" behavior. With exclusive attention focused on the above cues, this study examines what kind of human attributes would make a contribution to women's mating opportunities. The results reveal that both "beautiful" women and "virtuous" women were assessed (in this study) as having greater mating opportunities than "sexually attractive" women. In regard to the human attributes, only the "beautiful" woman was assessed as having high levels of human uniqueness and human nature. Meanwhile, "virtuous" women were assessed as having higher levels of human uniqueness but lower levels of human nature. In contrast, "sexually attractive" women were assessed as having lower levels of human uniqueness but higher levels of human nature. In addition, the results of a mediation analysis show that the trait of human uniqueness, and not human nature, was the mediator between the three types of women and women's mating opportunities. This finding means that, when women have higher levels of human uniqueness, they can acquire more mating opportunities. These findings contribute an improved understanding to why and how "beauty" or "virtue" increases the opportunity for woman to be selected as a spouse.
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.698712
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Different drives of herding: An exploratory study of motivations underlying social conformity.

    Chen, Xinling / Li, Suiqing / Zhang, Yijie / Zhai, Yuzhu / Zhang, Zhixin / Feng, Chunliang

    PsyCh journal

    2022  Volume 11, Issue 2, Page(s) 247–258

    Abstract: We often align our behaviors, attitudes, and opinions in line with a majority of others, a phenomenon known as "social conformity." A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives: a desire to ... ...

    Abstract We often align our behaviors, attitudes, and opinions in line with a majority of others, a phenomenon known as "social conformity." A seminal framework has proposed that conformity behaviors are mainly driven by three fundamental motives: a desire to gain more information to be accurate, to obtain social approval from others, and to maintain a favorable self-concept. However, previous studies usually have interpreted conformity behaviors as driven by one motive or another, largely ignoring the fact that human behaviors could be concurrently induced by multiple and even conflicting motivations. Adopting a typical conformity paradigm widely used in previous studies, we explored distinct and concurrent motives underlying the same conformity behavior, combining personality and individual differences with more nuanced analyses of observed conformity behaviors. Our findings provide novel evidence to show that three motivations exist within a single conformity behavior, suggesting that multiple motivations drive the conformity concurrently. These findings provide a potential solution for the extensive debate about what drives human social conformity and help to better understand the conformity behavior in daily life.
    MeSH term(s) Humans ; Motivation ; Personality ; Self Concept ; Social Behavior ; Social Conformity
    Language English
    Publishing date 2022-01-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2717141-3
    ISSN 2046-0260 ; 2046-0252
    ISSN (online) 2046-0260
    ISSN 2046-0252
    DOI 10.1002/pchj.515
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Association between minimally invasive surgery and late seizures in patients with intracerebral hemorrhage: A propensity score matching study.

    Lin, Jiahe / Lin, Ru / Li, Xianxian / Ye, Jiahe / Wang, Yuchen / Zhang, Beining / Chen, Xinling / Wang, Xinshi / Huang, Shanshan / Zhu, Suiqiang

    Frontiers in surgery

    2022  Volume 9, Page(s) 949804

    Abstract: Purpose: The association between minimally invasive surgery (MIS) for hematoma evacuation and late seizures after intracerebral hemorrhage (ICH) remains uncertain. We aimed to investigate whether MIS increases the risk of late seizures after ICH and ... ...

    Abstract Purpose: The association between minimally invasive surgery (MIS) for hematoma evacuation and late seizures after intracerebral hemorrhage (ICH) remains uncertain. We aimed to investigate whether MIS increases the risk of late seizures after ICH and identify the risk factors for late seizures in this patient subgroup.
    Methods: We retrospectively included consecutive inpatients diagnosed with ICH at two tertiary hospitals in China. The subjects were divided into the MIS group (ICH patients who received MIS including hematoma aspiration and thrombolysis) and conservative treatment group (ICH patients who received conservative medication). Propensity score matching was performed to balance possible risk factors for late seizures between the MIS and conservative treatment groups. Before and after matching, between-group comparisons of the incidence of late seizures were performed between the MIS and conservative treatment groups. Univariate and multivariate logistic regression analyses were used to identify independent risk factors for late seizures in MIS-treated patients.
    Results: A total of 241 and 1,689 patients were eligible for the MIS and conservative treatment groups, respectively. After matching, 161 ICH patients from the MIS group were successfully matched with 161 ICH patients from the conservative treatment group (1:1). Significant differences (
    Conclusion: Our study revealed that receiving MIS did not increase the incidence of late seizures after ICH. Additionally, cortical involvement and NIHSS scores were independent risk factors for late seizures in MIS-treated patients.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.949804
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: LINC00665 affects the malignant biological behavior of ovarian cancer via the miR-148b-3p/KLF5.

    Wang, Shenglan / Liu, Chuanchuan / Li, Yongchuan / Qiao, Jinwan / Chen, Xinling / Bao, Jin / Li, Ran / Xing, Yanxia

    Systems biology in reproductive medicine

    2022  Volume 68, Issue 5-6, Page(s) 370–383

    Abstract: This study investigated the expression and clinical significance of long intergenic noncoding RNA 00665 (LINC00665) in ovarian cancer (OC), as well as its effect on the malignant biological behavior of OC cells. The expression of LINC00665, miR-148b-3p, ... ...

    Abstract This study investigated the expression and clinical significance of long intergenic noncoding RNA 00665 (LINC00665) in ovarian cancer (OC), as well as its effect on the malignant biological behavior of OC cells. The expression of LINC00665, miR-148b-3p, and Krüppel-like factor 5 (KLF5) in OC tissues and cells were determined by RT-qPCR. Western blot was used to detect the protein expression of KLF5. The expression patterns of LINC00665 in nuclear and cytoplasm fractions were undertaken using RT-qPCR. In addition, CCK-8 assay, clone formation assay, transwell, scratch test, and flow cytometry were respectively used to detect the cell activity, proliferation, invasiveness, healing of cells, and apoptosis rate of OC cells. Furthermore, the interactions between LINC00665 and miR-148b-3p and between miR-148b-3p and KLF5 were verified by the luciferase reporter assay, and the correlations among these three genes were analyzed. LINC00665 expression was upregulated both in OC cell lines and tissues. Si-LINC00665 inhibited cell proliferation, invasion, and migration and induced apoptosis to a certain extent. The subcellular fraction assay revealed LINC00665 to be located mainly in the cytoplasm. miR-148b-3p was a target of LINC00665, and KLF5 was directly targeted by miR-148b-3p. Si-LINC00665 inhibited KLF5 expression, miR-148b-3p inhibitor promoted KLF5 expression, and si-KLF5 inhibited LINC00665 expression. Interestingly, the expression of LINC00665 was reversely associated with miR-148b-3p expression but positively correlated with KLF5. Furthermore, miR-148b-3p expression was negatively correlated with KLF5. In addition, si-KLF5 inhibited the malignant biological behavior of OC cells, whereas miR-148b-3p inhibitor had the opposite effect. Most importantly, the si-LINC00665 could reverse the promotion effect of the miR-148b-3p inhibitor on the malignant biological behavior of OC cells. LINC00665 can be used as an effective prognostic indicator of OC, which has the potential to be a new therapeutic target.
    MeSH term(s) Female ; Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; MicroRNAs/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; RNA, Long Noncoding/genetics
    Chemical Substances KLF5 protein, human ; Kruppel-Like Transcription Factors ; MicroRNAs ; RNA, Long Noncoding
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2417234-0
    ISSN 1939-6376 ; 1939-6368
    ISSN (online) 1939-6376
    ISSN 1939-6368
    DOI 10.1080/19396368.2022.2101961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling

    Xiang, Dejuan / Zou, Jie / Zhu, Xiaoyun / Chen, Xinling / Luo, Jianguang / Kong, Lingyi / Zhang, Hao

    Phytomedicine. 2020 Nov., v. 78

    2020  

    Abstract: Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is the dominant event in hepatic fibrogenesis. ...

    Abstract Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is the dominant event in hepatic fibrogenesis. The transforming growth factor-β1 (TGF-β1) and Yes-associated protein (YAP) pathways play a pivotal role in HSC activation, hepatic fibrosis and cirrhosis progression. Therefore, targeting the TGF-β/Smad and YAP signaling pathways is a promising strategy for antifibrotic therapy.The present study investigated the protective effects of Physalin D (PD), a withanolide isolated from Physalis species (Solanaceae), against liver fibrosis and further elucidated the mechanisms involved in vitro and in vivo.We conducted a series of experiments using carbon tetrachloride (CCl₄)- and bile duct ligation (BDL)-induced fibrotic mice and cultured LX-2 cells. Serum markers of liver injury, and the morphology, histology and fibrosis of liver tissue were investigated. Western blot assays and quantitative real-time PCR were used to investigate the mechanisms underlying the antifibrotic effects of PD.PD decreased TGF-β1-induced COL1A1 promoter activity. PD inhibited TGF-β1-induced expression of Collagen I and α-smooth muscle actin (α-SMA) in human hepatic stellate LX-2 cells. PD significantly ameliorated hepatic injury, including transaminase activities, histology, collagen deposition and α-SMA, in CCl₄- or BDL-induced mice. Moreover, PD markedly decreased the expression of phosphorylated Smad2/3 in vitro and in vivo. Furthermore, PD significantly decreased YAP protein levels, and YAP knockdown did not further enhance the effects of PD, namely α-SMA inhibition, Collagen I expression and YAP target gene expression in LX-2 cells.These results clearly show that PD ameliorated experimental liver fibrosis by inhibiting the TGF-β/Smad and YAP signaling pathways, indicating that PD has the potential to effectively treat liver fibrosis.
    Keywords Physalis ; Western blotting ; actin ; bile ducts ; blood serum ; carbon tetrachloride ; collagen ; fibrosis ; gene expression ; hepatoma ; histology ; humans ; liver ; liver cirrhosis ; muscles ; quantitative polymerase chain reaction
    Language English
    Dates of publication 2020-11
    Publishing place Elsevier GmbH
    Document type Article
    Note NAL-light
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2020.153294
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article: A Meta-Analysis of the Efficacy and Toxicity of Twice-Daily vs. Once-Daily Concurrent Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer Based on Randomized Controlled Trials.

    Wu, Qian / Xiong, Yiting / Zhang, Shujuan / Chen, Xinling / Yi, Fengming / Wei, Yiping / Zhang, Wenxiong

    Frontiers in oncology

    2020  Volume 9, Page(s) 1460

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-01-08
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01460
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Erlotinib plus tivantinib versus erlotinib alone in patients with previously treated stage IIIb/IV non-small-cell lung cancer: A meta-analysis based on randomized controlled trials.

    Deng, Huan / Wang, Li / Chen, Xinling / Zhang, Shujuan / Yi, Fengming / Wei, Yiping / Zhang, Wenxiong

    Medicine

    2020  Volume 99, Issue 25, Page(s) e20596

    Abstract: Background: Whether erlotinib plus tivantinib (ET) can achieve better clinical benefits than erlotinib plus placebo (EP) among participants with previously treated advanced non-small-cell lung cancer (NSCLC) is still disputed. We conducted a meta- ... ...

    Abstract Background: Whether erlotinib plus tivantinib (ET) can achieve better clinical benefits than erlotinib plus placebo (EP) among participants with previously treated advanced non-small-cell lung cancer (NSCLC) is still disputed. We conducted a meta-analysis to evaluate the anticancer efficacy and safety of both regimens.
    Materials and methods: We searched for pertinent trials at PubMed, ScienceDirect, The Cochrane Library, Scopus, Ovid MEDLINE, Embase, Web of Science, and Google Scholar. Endpoints mainly included progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs).
    Results: We included 1522 patients who previously received ≥1 systemic anti-cancer regimen that included platinum-based chemotherapy. Although ET failed to improve OS (hazard ratio [HR] = 0.91, 95% confidence interval [CI]: 0.75-1.10, P = .35), the ET group had better PFS (HR = 0.73, 95% CI: 0.67-0.80, P < .00001), higher ORR (HR = 1.50, 95% CI: 1.06-2.12, P = .02), and better DCR (HR = 1.38, 95% CI: 1.20-1.59, P < .00001). Our subanalysis suggested that the ET group may have had better OS among patients with high Mesenchymal to epithelial transition factor (MET) expression (HR = 0.76, 95% CI: 0.58-0.99, P = .04) and good VeriStrat (HR = 0.88, 95% CI: 0.83-0.93, P < .0001). AEs were roughly similar except for specific hematological toxicities: more neutropenia and febrile neutropenia were observed in the ET group, both of which should not be overlooked.
    Conclusions: ET appears to be superior to EP due to better PFS and higher response rates, especially for patients with high MET expression and good VeriStrat. The greater hematological toxicity in the ET regimen is non-negligible.
    MeSH term(s) Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Erlotinib Hydrochloride/administration & dosage ; Erlotinib Hydrochloride/adverse effects ; Humans ; Lung Neoplasms/drug therapy ; Progression-Free Survival ; Pyrrolidinones/administration & dosage ; Pyrrolidinones/adverse effects ; Quinolines/administration & dosage ; Quinolines/adverse effects ; Randomized Controlled Trials as Topic
    Chemical Substances ARQ 197 ; Antineoplastic Agents ; Pyrrolidinones ; Quinolines ; Erlotinib Hydrochloride (DA87705X9K)
    Language English
    Publishing date 2020-07-12
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000020596
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling.

    Xiang, Dejuan / Zou, Jie / Zhu, Xiaoyun / Chen, Xinling / Luo, Jianguang / Kong, Lingyi / Zhang, Hao

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2020  Volume 78, Page(s) 153294

    Abstract: Background: Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is the dominant event in hepatic ... ...

    Abstract Background: Hepatic fibrosis is considered integral to the progression of chronic liver diseases, as it leads to the development of cirrhosis and hepatocellular carcinoma. The activation of hepatic stellate cells (HSCs) is the dominant event in hepatic fibrogenesis. The transforming growth factor-β1 (TGF-β1) and Yes-associated protein (YAP) pathways play a pivotal role in HSC activation, hepatic fibrosis and cirrhosis progression. Therefore, targeting the TGF-β/Smad and YAP signaling pathways is a promising strategy for antifibrotic therapy.
    Purpose: The present study investigated the protective effects of Physalin D (PD), a withanolide isolated from Physalis species (Solanaceae), against liver fibrosis and further elucidated the mechanisms involved in vitro and in vivo.
    Study design/methods: We conducted a series of experiments using carbon tetrachloride (CCl
    Result: PD decreased TGF-β1-induced COL1A1 promoter activity. PD inhibited TGF-β1-induced expression of Collagen I and α-smooth muscle actin (α-SMA) in human hepatic stellate LX-2 cells. PD significantly ameliorated hepatic injury, including transaminase activities, histology, collagen deposition and α-SMA, in CCl
    Conclusion: These results clearly show that PD ameliorated experimental liver fibrosis by inhibiting the TGF-β/Smad and YAP signaling pathways, indicating that PD has the potential to effectively treat liver fibrosis.
    MeSH term(s) Actins/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Carbon Tetrachloride/toxicity ; Cells, Cultured ; Collagen Type I/genetics ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/pathology ; Humans ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Mice, Inbred C57BL ; Secosteroids/pharmacology ; Signal Transduction/drug effects ; Smad Proteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta/pharmacology ; Transforming Growth Factor beta1
    Chemical Substances ACTA2 protein, human ; Actins ; Adaptor Proteins, Signal Transducing ; Collagen Type I ; Secosteroids ; Smad Proteins ; TGFB1 protein, human ; Transcription Factors ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; YAP1 protein, human ; collagen type I, alpha 1 chain ; physalin D ; Carbon Tetrachloride (CL2T97X0V0)
    Language English
    Publishing date 2020-07-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2020.153294
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top