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Article ; Online: Association between thyroid hormone levels in the acute stage of stroke and risk of poststroke depression: A meta-analysis.

Fu, Jie / Zhao, Qin / Li, Jinglun / Chen, Xiu / Peng, Lilei

2024 Volume 14, Issue 1, Page(s) e3322

Abstract: Background: Thyroid hormones have been indicated to be associated with depression, but their relationship with poststroke depression (PSD) remains controversial. Therefore, we performed a meta-analysis to explore the correlation between thyroid hormone ... ...

Abstract	Background: Thyroid hormones have been indicated to be associated with depression, but their relationship with poststroke depression (PSD) remains controversial. Therefore, we performed a meta-analysis to explore the correlation between thyroid hormone levels in acute stroke and PSD. Methods: We searched databases for eligible studies. Standard mean differences (SMD) and 95% confidence intervals (CI) were applied to evaluate the association among levels of thyroid hormones, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4), in acute stroke patients and the risk of PSD. Results: A total of 13 studies were included in the analysis. Compared to non-PSD patients, PSD patients had remarkably lower serum TSH and FT3 levels (TSH: SMD = -0.59, 95%CI = -1.04 to -.15, p = .009; FT3: SMD = -0.40, 95%CI = -.51 to -.30, p = .000) and higher serum FT4 levels (SMD = 0.33, 95%CI = .07-.59, p = .013). Subgroup analysis showed that there may be a more statistically significant association between FT3 and the risk of PSD compared to TSH and FT4. Conclusions: Our results suggested that patients with lower serum TSH and FT3 levels as well as higher serum FT4 levels in the acute stage of stroke may be more susceptible to PSD.
MeSH term(s)	Humans ; Depression/etiology ; Thyroid Hormones ; Thyrotropin ; Stroke/complications ; Databases, Factual
Chemical Substances	Thyroid Hormones ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3322
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ping-Pong Gaze in Sporadic Creutzfeldt-Jakob Disease.

Yang, Yuan / Tan, Hua / Xiang, Shuli / Chen, Xiu / Guo, Xiaoyan

Movement disorders clinical practice

2024 Volume 11, Issue 3, Page(s) 301–302

MeSH term(s)	Humans ; Creutzfeldt-Jakob Syndrome/diagnosis ; Nystagmus, Pathologic
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ISSN	2330-1619
ISSN (online)	2330-1619
DOI	10.1002/mdc3.13914
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Article ; Online: Metagenomic Next-generation Sequencing for Pathogen Identification in Bronchoalveolar Lavage Fluid From Neonates Receiving Extracorporeal Membrane Oxygenation.

Zheng, Yi-Rong / Chen, Xiu-Hua / Chen, Qiang / Cao, Hua

The Pediatric infectious disease journal

2024 Volume 43, Issue 4, Page(s) 371–377

Abstract: Background: Neonates on extracorporeal membrane oxygenation (ECMO) are at high risk of infection. Rapid and accurate identification of pathogens is essential to improve the prognosis of children on ECMO. Metagenome next-generation sequencing (mNGS) has ... ...

Abstract	Background: Neonates on extracorporeal membrane oxygenation (ECMO) are at high risk of infection. Rapid and accurate identification of pathogens is essential to improve the prognosis of children on ECMO. Metagenome next-generation sequencing (mNGS) has been used in recent years to detect pathogenic bacteria, but evidence for its use in neonates on ECMO is lacking. Methods: This retrospective study was conducted using an electronic medical record system. We analyzed the results of mNGS and conventional microbiological tests (CMTs) in bronchoalveolar lavage fluid of neonates receiving ECMO support with pulmonary infections in our hospital from July 2021 to January 2023. Results: We screened 18 ECMO-supported neonates with pneumonia for inclusion in the study. The median age of the included children was 2 (1-4) days, the median gestational age was 38.3 (33-40 +4 ) weeks, and the median weight was 3.3 (2.2-4.8) kg. The detection rate of mNGS was 77.8% (14/18), higher than the 44.4% (8/18) of CMT ( P = 0.04). A total of 20 pathogens were detected in mNGS, with the top 3 most common pathogens being Klebsiella pneumoniae , Acinetobacter baumannii and Escherichia coli . Mixed infections were found in 14 cases (77.8%), including 13 cases (72.2%) with mixed infections detected by mNGS and 7 cases (27.8%) with mixed infections detected by CMT. A total of 9 children underwent treatment changes based on mNGS results and all of them experienced relief of symptoms. Conclusion: Compared with CMT, mNGS can detect pathogens earlier and more sensitively, and may play an important role in ECMO-supported neonatal pneumonia pathogen detection and optimization of antibiotic therapy.
MeSH term(s)	Child ; Infant, Newborn ; Humans ; Bronchoalveolar Lavage Fluid ; Coinfection ; Extracorporeal Membrane Oxygenation ; Metagenome ; Retrospective Studies ; High-Throughput Nucleotide Sequencing ; Escherichia coli ; Metagenomics ; Pneumonia ; Sensitivity and Specificity
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004250
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Zs.A 1852: Show issues

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Article ; Online: Primary mediastinal choriocarcinoma in an 18-year-old male with pulmonary and brain metastasis: A case report.

Wang, Hanlin / Chen, Xiu / Zhang, Renquan

The clinical respiratory journal

2023 Volume 17, Issue 10, Page(s) 1082–1087

Abstract: Primary mediastinal choriocarcinoma, also known as non-pregnant choriocarcinoma, is a rare malignancy unrelated to pregnancy, with a higher incidence in males. And primary mediastinal choriocarcinoma is mostly associated with organ and lymph node ... ...

Abstract	Primary mediastinal choriocarcinoma, also known as non-pregnant choriocarcinoma, is a rare malignancy unrelated to pregnancy, with a higher incidence in males. And primary mediastinal choriocarcinoma is mostly associated with organ and lymph node metastasis, with rapid progression and poor prognosis. Here, we report an extremely rare case of the primary anterior mediastinal choriocarcinoma that occurred in an 18-year-old man with multiple metastases of the lung and brain.
MeSH term(s)	Male ; Pregnancy ; Female ; Humans ; Adolescent ; Choriocarcinoma/pathology ; Choriocarcinoma/secondary ; Testicular Neoplasms/complications ; Mediastinal Neoplasms/pathology ; Lung/pathology ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/complications
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13691
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Article: Comparison of treprostinil and oral sildenafil for the treatment of persistent pulmonary hypertension of the newborn: a retrospective cohort study.

Wei, Enhuan / Chen, Xiu-Hua / Zhou, Si-Jia

Frontiers in pediatrics

2023 Volume 11, Page(s) 1270712

Abstract: Background: This study aims to evaluate the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN).: Methods: We conducted a retrospective cohort study of 42 neonates with PPHN treated with ... ...

Abstract	Background: This study aims to evaluate the effectiveness of treprostinil and oral sildenafil in managing persistent pulmonary hypertension of newborns (PPHN). Methods: We conducted a retrospective cohort study of 42 neonates with PPHN treated with continuous intravenous treprostinil or oral sildenafil from January 2020 to October 2022 in China. Outcomes assessed included echocardiographic pulmonary artery systolic pressure (PASP), shunt direction, and arterial blood gas measures. Results: Treprostinil lowered PASP and improved oxygenation significantly better than sildenafil on days 1, 2, and 3 of treatment ( Conclusions: Treprostinil effectively lowers pulmonary artery pressure and improves oxygenation in neonates with PPHN, without being associated with severe complications. It may serve as a beneficial adjunct therapy for neonates with PPHN.
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1270712
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Article: Synovial Metastasis From Urothelial Carcinoma of the Renal Pelvis Causing Recurrent Hemarthrosis: A Rare Presentation.

Wang, Rachel Tian Shian / Zhuang, Qingyuan / Chen, Xiu Fen

Cureus

2023 Volume 15, Issue 3, Page(s) e36983

Abstract: Synovial metastases are rare for any malignancy. This case report discusses a case of synovial metastasis from urothelial carcinoma of the renal pelvis presenting with recurrent hemarthrosis. The diagnosis of malignant synovitis can be obtained by ... ...

Abstract	Synovial metastases are rare for any malignancy. This case report discusses a case of synovial metastasis from urothelial carcinoma of the renal pelvis presenting with recurrent hemarthrosis. The diagnosis of malignant synovitis can be obtained by synovial fluid aspiration, which is a quick and minimally invasive method, especially when imaging is unyielding or unspecific. Unfortunately, the diagnosis is associated with a poor prognosis of about five months, and treatment is often palliative. While no clinical guidelines exist, a multimodal and multidisciplinary management approach can help address the physical and psychosocial losses suffered.
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36983
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Article ; Online: Application of high-flow nasal cannula in fibreoptic bronchoscopy after congenital heart surgery: a retrospective cohort study.

Zheng, Yi-Rong / Chen, Xiu-Hua / Zhou, Si-Jia

BMJ paediatrics open

2023 Volume 7, Issue 1

Abstract: Background: The purpose of this study was to compare the effectiveness and safety of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in fibreoptic bronchoscopy (FB) after congenital heart surgery (CHS) in children.: Methods: We ... ...

Abstract	Background: The purpose of this study was to compare the effectiveness and safety of high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in fibreoptic bronchoscopy (FB) after congenital heart surgery (CHS) in children. Methods: We did a retrospective cohort study using patients from the electronic medical record system of Fujian Children's Hospital in China. The study population was children who underwent FB in the cardiac intensive care unit after CHS for 1 year (May 2021-May 2022). Children were classified into HFNC and COT groups according to their oxygen therapy during FB. The primary outcome was oxygenation indices during FB, including pulse oximeter oxygen saturation (SpO Results: We identified 107 children from the electronic medical record system, and 102 children after CHS were finally included in the study (53 in the HFNC group and 49 in the COT group). During the FB examination, TcPO Conclusions: Among children undergoing FB after CHS, the application of HFNC was associated with better oxygenation and fewer procedural interruptions compared with COT, without an increased risk of postoperative complications.
MeSH term(s)	Child ; Humans ; Respiratory Insufficiency ; Bronchoscopy ; Cannula ; Retrospective Studies ; Oxygen ; Oxygen Inhalation Therapy/adverse effects ; Heart Defects, Congenital/surgery ; Heart Defects, Congenital/etiology
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ISSN	2399-9772
ISSN (online)	2399-9772
DOI	10.1136/bmjpo-2023-001870
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Article ; Online: Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Older Patients with Acute Ischemic Stroke.

Qiu, Shuang / Liao, Jie / Luo, Xin / Chen, Xiu

Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

2023 Volume 90, Issue 1, Page(s) 58–63

Abstract: Background: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR), an inflammatory indicator, for 90-day outcomes has not been determined for patients with acute ischemic stroke aged ≥ 80 years. Therefore, this study examined the predictive ... ...

Abstract	Background: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR), an inflammatory indicator, for 90-day outcomes has not been determined for patients with acute ischemic stroke aged ≥ 80 years. Therefore, this study examined the predictive significance of the NLR for estimating the 90-day outcomes of older patients with acute ischemic stroke. Methods: Data from patients aged ≥ 80 years were recorded within 7 days of ischemic stroke onset during the period from January 2019 to June 2021. A Kaplan-Meier curve was drawn based on the incidence of adverse outcomes to compare the survival probability of each group at different time periods. Cox multivariate regression was used to explore adverse events affecting patient prognosis. Results: A total of 560 patients were initially recruited; of these, 476 were eligible for inclusion. The log-rank test showed that the survival rates of the groups differed. The 90-day survival rate was significantly lower in the group with the highest NLR than in the group with the lowest NLR. Multivariate Cox regression analysis showed that after adjusting for risk factors, a high NLR and a high National Institutes of Health Stroke Scale score were independent risk factors for 90-day mortality. According to the receiver operating characteristic analysis, the area under the curve for predicting mortality at 90 days was 0.74. Conclusion: This study confirmed that a high NLR is an independent risk factor for acute ischemic stroke and has predictive value for 90-day prognosis in patients aged ≥ 80 years.
MeSH term(s)	Humans ; Aged ; Neutrophils ; Prognosis ; Ischemic Stroke ; Lymphocytes ; Risk Factors ; Retrospective Studies ; ROC Curve
Language	English
Publishing date	2023-03-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2091563-9
ISSN	1347-3409 ; 1345-4676
ISSN (online)	1347-3409
ISSN	1345-4676
DOI	10.1272/jnms.JNMS.2023_90-110
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Zs.B 620: Show issues

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Article ; Online: Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive.

Liu, Hong / Chen, Xiu

Archives of women's mental health

2021 Volume 24, Issue 6, Page(s) 1045–1050

Abstract: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune synaptic encephalitis likely mediated by neuronal surface antibody. Clinically, it is characterized by a variety of neurological and psychiatric symptoms, predominantly affecting ... ...

Abstract	Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune synaptic encephalitis likely mediated by neuronal surface antibody. Clinically, it is characterized by a variety of neurological and psychiatric symptoms, predominantly affecting young women. Recurrent anti-NMDAR cases combined with double-antibody positive during pregnancy have not been reported. We report a 19-year-old pregnant woman with recurrent anti-NMDAR encephalitis and double-antibody positive. Through our case report and a review of the literature, we hope to heighten an awareness of anti-NMDAR encephalitis, particularly in a pregnant setting.
MeSH term(s)	Adult ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnosis ; Autoantibodies ; Female ; Hashimoto Disease ; Humans ; Pregnancy ; Young Adult
Chemical Substances	Autoantibodies
Language	English
Publishing date	2021-04-09
Publishing country	Austria
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1463529-X
ISSN	1435-1102 ; 1434-1816
ISSN (online)	1435-1102
ISSN	1434-1816
DOI	10.1007/s00737-021-01124-5
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Zs.A 5115: Show issues

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Article ; Online: Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma.

Chen, Xiu / Kou, Liqiu / Xie, Xiaolu / Su, Song / Li, Jun / Li, Yaling

Immunology

2024 Volume 172, Issue 1, Page(s) 21–45

Abstract: The treatment of hepatocellular carcinoma (HCC), particularly advanced HCC, has been a serious challenge. Immune checkpoint inhibitors (ICIs) are landmark drugs in the field of cancer therapy in recent years, which have changed the landscape of cancer ... ...

Abstract	The treatment of hepatocellular carcinoma (HCC), particularly advanced HCC, has been a serious challenge. Immune checkpoint inhibitors (ICIs) are landmark drugs in the field of cancer therapy in recent years, which have changed the landscape of cancer treatment. In the field of HCC treatment, this class of drugs has shown good therapeutic prospects. For example, atezolizumab in combination with bevacizumab has been approved as first-line treatment for advanced HCC due to significant efficacy. However, sensitivity to ICI therapy varies widely among HCC patients. Therefore, there is an urgent need to search for determinants of resistance/sensitivity to ICIs and to screen biomarkers that can predict the efficacy of ICIs. This manuscript reviews the research progress of prognostic biomarkers associated with ICIs in HCC in order to provide a scientific basis for the development of clinically individualised precision medication regimens.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; Prognosis
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13751
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