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Article: Effect of a video-based exercise intervention on depression and sleep conditions of peritoneal dialysis patients.

Luo, Yixin / Yang, Zhen / Chen, Xiuyu / Huang, Yanlin

2023 Volume 99, Issue 2, Page(s) 58–68

Abstract: Objective: To evaluate the effectiveness of a video-based exercise intervention on depression and sleep conditions of peritoneal dialysis (PD) patients.: Materials and methods: Participants satisfying the inclusion and exclusion criteria were ... ...

Abstract	Objective: To evaluate the effectiveness of a video-based exercise intervention on depression and sleep conditions of peritoneal dialysis (PD) patients. Materials and methods: Participants satisfying the inclusion and exclusion criteria were recruited from the Peritoneal Dialysis Center, Department of Nephrology of the First Affiliated Hospital of Guangxi Medical University, and they were divided into an intervention group and a control group. The intervention group received video-based exercise intervention while the control group received routine care. Then their BDI-II and PSQI scores were collected and analyzed before and after the intervention. Results: There were no significant differences in BDI-II score and the seven components of PSQI score between the two groups at the baseline measures (p > 0.05). However, after 12 weeks of intervention, the intervention group had a significantly lower score in BDI-II (p < 0.05) and in six components of PSQI (p < 0.05), with the exception of the "use of sleep medications" subscale (p > 0.05). Their depression level also improved significantly after intervention (p < 0.05), while that of the control group did not change significantly(p > 0.05). Conclusion: The video-based exercise intervention is safe and can remarkably improve the depression and sleep conditions of PD patients and is thus worthwhile to be applied widely.
MeSH term(s)	Humans ; Depression/etiology ; Depression/therapy ; China ; Peritoneal Dialysis ; Sleep ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy ; Exercise Therapy ; Quality of Life
Language	English
Publishing date	2023-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN110877
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Article ; Online: Construction of a Recyclable DNAzyme Motor for MUC1-Specific Glycoform <i>In Situ</i> Quantification.

Liu, Liang / Chen, Xiuyu / Sun, Bo

Analytical chemistry

2022 Volume 94, Issue 40, Page(s) 13745–13752

Abstract: Changes in the glycosylation content, especially in specific proteins, are of great importance for interpreting the mechanisms and development of certain diseases. However, current detection techniques are limited by the weak ionization efficiency of ... ...

Abstract	Changes in the glycosylation content, especially in specific proteins, are of great importance for interpreting the mechanisms and development of certain diseases. However, current detection techniques are limited by the weak ionization efficiency of glycosyls and poor anti-interference of fluorescence signals. Herein, we present a general in situ quantification strategy for protein-specific glycoforms by constructing a recyclable DNAzyme motor for mass spectrometric detection using MUC1-specific sialic acid (Sia) as a model. This approach relies on a DNAzyme-based recycling strategy and two well-designed probes: a protein and a glycan probe. The protein probe consists of an aptamer and a DNAzyme. The glycan probe contains three functional domains: a DNAzyme complementary sequence, a substrate peptide segment, and a dibenzocyclooctyne tag. First, these two probes bind to their corresponding targets and trigger hybridization between adjacent probes on the same protein. With the help of the metal cofactor, the DNAzyme of the protein probe hydrolyzes the double-stranded glycan probe. The protein probe then reverts to a single-stranded state and remains intact for the next round of hybridization and cleavage. In this way, the recyclable DNAzyme motor can hydrolyze all glycan probes bound to the target protein. Finally, the reporter peptide released from the hydrolyzed glycan probes can be quantified by mass spectrometry, thereby converting the signal of the protein-specific glycoform to that of mass spectrometry. This strategy has been successfully used for in situ quantification of MUC1-specific Sia in different breast cancer cell lines. It provides a promising platform for protein-specific glycoform quantification.
MeSH term(s)	Biosensing Techniques/methods ; DNA, Catalytic/chemistry ; Glycosylation ; N-Acetylneuraminic Acid ; Nucleic Acid Hybridization ; Polysaccharides/chemistry ; Proteins
Chemical Substances	DNA, Catalytic ; Polysaccharides ; Proteins ; N-Acetylneuraminic Acid (GZP2782OP0)
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c01961
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Article ; Online: How Medical Staff Alleviates Job Burnout through Sports Involvement: The Mediating Roles of Health Anxiety and Self-Efficacy.

Chen, Xiuyu / Jing, Longjun / Wang, Huilin / Yang, Jingyu

International journal of environmental research and public health

2022 Volume 19, Issue 18

Abstract: In the current healthcare environment, job burnout among medical staff is increasingly evident. Burnout not only affects the mental and physical health and career development of individuals but also affects the quality of care and the doctor-patient ... ...

Abstract	In the current healthcare environment, job burnout among medical staff is increasingly evident. Burnout not only affects the mental and physical health and career development of individuals but also affects the quality of care and the doctor-patient relationship. This paper investigates the influence of sports involvement on burnout in medical staff based on the job demands-resources theory, focusing on the mediating role of health anxiety and self-efficacy in the relationship between sports involvement and job burnout. A questionnaire survey was used to collect data from 444 medical staff in public hospitals in Wuhan, China. Structural equation modeling (SEM) with a bootstrapping approach was conducted to test the hypothesis and mediating effects. It was found that health anxiety and self-efficacy played a significant mediating role between sports involvement and job burnout. The results indicate the important role that sports involvement plays in addressing burnout, revealing that decreasing health anxiety and increasing self-efficacy attenuated job burnout. This finding suggests that hospital administrators should not only pay attention to medical staff's health conditions and improve their enthusiasm for work but also encourage them to become more engaged in sports.
MeSH term(s)	Anxiety/epidemiology ; Burnout, Professional ; Humans ; Job Satisfaction ; Medical Staff ; Physician-Patient Relations ; Self Efficacy ; Surveys and Questionnaires
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191811181
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effectiveness of a video-based exercise program on nutritional status and quality of life of peritoneal dialysis patients: A pilot randomized controlled trial.

Luo, Yixin / Yang, Zhen / Li, Haoyu / Chen, Xiuyu / Huang, Yanlin

Clinical nephrology

2022 Volume 99, Issue 3, Page(s) 105–117

Abstract: Objective: To evaluate the effectiveness of a video-based exercise program on nutritional status and quality of life (QOL) of peritoneal dialysis (PD) patients.: Materials and methods: Participants satisfying the inclusion and exclusion criteria were ...

Abstract	Objective: To evaluate the effectiveness of a video-based exercise program on nutritional status and quality of life (QOL) of peritoneal dialysis (PD) patients. Materials and methods: Participants satisfying the inclusion and exclusion criteria were recruited and divided into the intervention group and the control group. The intervention group received video-based exercise based on a manual advocated by the National Kidney Foundation, while the control group received routine exercise guidance. Their nutritional indicators and the Quality of Life Scale for Peritoneal Dialysis patients (QLSPD) scores were collected and analyzed. Results: No adverse events occurred during the study. Baseline data between the two groups were comparable, and there were no significant differences in body mass index (BMI) (t = 0.214, p = 0.831), triceps skin fold thickness (TSF) (t = 0.407, p = 0.685), arm muscle circumference (AMC) (t = 0.310, p = 0.757), grip strength (Gs) (t = 0.557, p = 0.579), calf circumference (Cc) (t = 0.441, p = 0.660), serum albumin (Alb) (t = 0.261, p = 0.795), prealbumin (PA) (t = 0.218, p = 0.828), hemoglobin (Hb) (t = 0.114, p = 0.909), triglyceride (TG) (t = 0.192, p = 0.848), total cholesterol (TC) (t = 0.092, p = 0.927), low-density lipoprotein (LDL) (t = 0.124, p = 0.902), high-density lipoprotein (HDL) (t = 0.265, p = 0.792), blood urea nitrogen (BUN) (t = 0.540, p = 0.590), serum creatinine (SCr) (t = 0.255, p = 0.799), total urea clearance index (Kt/V) (t = 0.958, p = 0.340), total creatinine clearance rate (Ccr) (t = 0.166, p = 0.868), protein equivalent of nitrogen appearance (nPNA) (t = 0.240, p = 0.811), and QLSPD scores (p > 0.05) between the two groups at the baseline measures. However, after 12 weeks of intervention, the AMC (t = 2.993, p = 0.003) and Cc (t = 2.811, p = 0.006) of the intervention group improved significantly compared with the control group. The BMI (t = 2.068, p = 0.041) and TSF (t = 2.578, p = 0.011) showed a trend of improvement compared with baseline. And the intervention group scored less in body physiology function (t = 7.084, p < 0.001), disease factors (t = 13.336, p < 0.001), mental state (t = 9.555, p < 0.001), and social role (t = 5.156, p < 0.001) components, while their satisfaction hardly changed (t = 0.240, p = 0.811). Conclusion: The video-based exercise intervention is safe and can remarkably improve the nutritional status and QOL of PD patients.
MeSH term(s)	Humans ; Nutritional Status ; Quality of Life ; Pilot Projects ; Peritoneal Dialysis ; Serum Albumin ; Exercise Therapy
Chemical Substances	Serum Albumin ; contrast agent P792 (ML3LD67ALG)
Language	English
Publishing date	2022-12-05
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN110868
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Article ; Online: Isolated cardiac sarcoidosis with rapid progressive 'malignant' arrhythmia.

Tang, Yun / Wang, Jia-Xin / Chen, Xiu-Yu / Wang, Hong-Yue / Zhao, Shi-Hua

European heart journal. Case reports

2023 Volume 7, Issue 2, Page(s) ytad056

Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad056
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Article ; Online: A Micro-Topography Measurement and Compensation Method for the Key Component Surface Based on White-Light Interferometry.

Chen, Junying / Wang, Boxuan / Chen, Xiuyu / Jiang, Qingshan / Feng, Wei / Xu, Zhilong / Zhao, Zhenye

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 19

Abstract: The grinding grooves of material removal machining and the residues of a machining tool on the key component surface cause surface stress concentration. Thus, it is critical to carry out precise measurements on the key component surface to evaluate the ... ...

Abstract	The grinding grooves of material removal machining and the residues of a machining tool on the key component surface cause surface stress concentration. Thus, it is critical to carry out precise measurements on the key component surface to evaluate the stress concentration. Based on white-light interferometry (WLI), we studied the measurement distortion caused by the reflected light from the steep side of the grinding groove being unable to return to the optical system for imaging. A threshold value was set to eliminate the distorted measurement points, and the cubic spline algorithm was used to interpolate the eliminated points for compensation. The compensation result agrees well with the atomic force microscope (AFM) measurement result. However, for residues on the surface, a practical method was established to obtain a microscopic 3D micro-topography point cloud and a super-depth-of-field fusion image simultaneously. Afterward, the semantic segmentation network U-net was adopted to identify the residues in the super-depth-of-field fusion image and achieved a recognition accuracy of 91.06% for residual identification. Residual feature information, including height, position, and size, was obtained by integrating the information from point clouds and super-depth-of-field fusion images. This work can provide foundational data to study surface stress concentration.
Language	English
Publishing date	2023-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23198307
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition.

Chen, Xiu-Yu / Zheng, Hui / Han, Ying / Sun, Jing / Yan, Chao-Guo

Beilstein journal of organic chemistry

2023 Volume 19, Page(s) 982–990

Abstract: The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2- ...

Abstract	The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-
Language	English
Publishing date	2023-06-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2192461-2
ISSN	1860-5397
ISSN	1860-5397
DOI	10.3762/bjoc.19.73
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Article ; Online: Preoperative Left Atrial Strain Predicts Outcome in Patients With Hypertrophic Obstructive Cardiomyopathy after Myectomy.

Yang, Shujuan / Zhu, Changsheng / Wang, Jiaxin / Liu, Lele / Li, Changcheng / Chen, Xiuyu / Zhao, Kankan / Lu, Minjie / Wang, Shuiyun / Zhao, Shihua

JACC. Cardiovascular imaging

2024

Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Letter
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2024.02.019
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Article: A mass-tagged MOF nanoprobe approach for ultra-sensitive protein quantification in tumor-educated platelets

Chen, Xiuyu / Zhu, Jianhua / Sun, Bo / Zhang, Xian / Hu, Yechen / Chen, Yun

Chemical communications. 2022 June 23, v. 58, no. 51

2022

Abstract: A mass-tagged metal–organic framework (MOF) nanoprobe approach was developed for ultra-sensitive quantification of platelet protein CD44 by integrating activable aptamer recognition and MOF nanoprobe signal amplification with mass spectrometric detection. ...

Abstract	A mass-tagged metal–organic framework (MOF) nanoprobe approach was developed for ultra-sensitive quantification of platelet protein CD44 by integrating activable aptamer recognition and MOF nanoprobe signal amplification with mass spectrometric detection. This approach offered high sensitivity and quantitative capability for low abundant protein analysis in tumor-educated platelets (TEPs), exhibiting great potential in cancer diagnosis and management.
Keywords	coordination polymers ; mass spectrometry ; oligonucleotides
Language	English
Dates of publication	2022-0623
Size	p. 7160-7163.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc01815b
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Epidermoid cyst in the atrial septum: a rare entity with unique imaging features.

Wang, Jia-Xin / Chen, Yi-Xin / Chen, Xiu-Yu / Wang, Hong-Yue / Zhao, Shi-Hua

European heart journal. Case reports

2022 Volume 6, Issue 7, Page(s) ytac267

Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytac267
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