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Article ; Online: CD4+ T cell count in HIV/TB co-infection and co-occurrence with HL

Xiao Pingping / Chen Xuyan / Chen Yongquan / Fan Wei / Dong Zhigao / Huang Jinmei / Zhang Yi

Open Life Sciences, Vol 18, Iss 1, Pp S51-

Case report and literature review

2023 Volume 7

Abstract: In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin’s lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4+ T cell count was ... ...

Abstract	In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin’s lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4+ T cell count was recognized as the common risk factor. We report a case of a patient with HIV and TB and HL co-occurrence, in which patient’s CD4+ T cell count was inconsistent with disease. A 58-year-old male presented with fever and shortness of breath that persisted for 2 months. The patient had a 4-year history of HIV infection and underwent antiretroviral therapy (ART) effectively. After blood test, computed tomography, bone biopsy, and lymphoma biopsy, the patient was diagnosed with skeletal TB and HL, underwent TB treatment and received ART, and underwent four cycles of chemotherapy. CD4+ T cell count was not decreased before diagnosed with TB/HL and increased in this case after the fourth cycle of chemotherapy. We collected and analyzed CD4+ T cell counts in our case and reviewed relevant literature. It is suggested that CD4+ T cell count may be insufficient to predict the risk of HIV-related disease, especially lymphoproliferative disorders.
Keywords	hiv ; tuberculosis ; hodgkin’s lymphoma ; cd4+ t cells ; antiretroviral therapy ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [True stories in an emergency ICU].

Chen, Xuyan

Zhonghua yi xue za zhi

2014 Volume 94, Issue 18, Page(s) 1375–1376

MeSH term(s)	Emergency Service, Hospital ; Humans ; Intensive Care Units ; Physician-Patient Relations
Language	Chinese
Publishing date	2014-05-13
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
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Article ; Online: CD4

Xiao, Pingping / Chen, Xuyan / Chen, Yongquan / Fan, Wei / Dong, Zhigao / Huang, Jinmei / Zhang, Yi

Open life sciences

2023 Volume 18, Issue 1, Page(s) 20220744

Abstract: In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin's lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased ... ...

Abstract	In the human immunodeficiency virus (HIV)-infected population, especially HIV with concomitant tuberculosis (TB) or Hodgkin's lymphoma (HL), numerous risk factors have been reported in recent years. Among them, the decreased CD4
Language	English
Publishing date	2023-09-20
Publishing country	Poland
Document type	Case Reports
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0744
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Article ; Online: Severe pneumonia with empyema caused by

Duan, Yao / Feng, Wenshi / Shen, Yuxin / Li, Yue / Li, Ni / Chen, Xuyan / Wang, Yiqun

The Journal of international medical research

2023 Volume 51, Issue 11, Page(s) 3000605231210657

Abstract: Empyema is a common complication of pneumonia, caused by the accumulation of purulent exudate due to pathogenic bacteria invading the pleural cavity. ...

Abstract	Empyema is a common complication of pneumonia, caused by the accumulation of purulent exudate due to pathogenic bacteria invading the pleural cavity.
MeSH term(s)	Humans ; Male ; Streptococcus constellatus/genetics ; Empyema, Pleural/complications ; Empyema, Pleural/diagnosis ; Empyema, Pleural/microbiology ; Coinfection ; Pneumonia/complications ; Pneumonia/diagnosis ; Pleural Effusion
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231210657
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Article ; Online: Efficacy and safety of azathioprine plus prednisone versus prednisone alone as first-line treatment for antinuclear antibody-positive immune thrombocytopenia: a retrospective cohort study.

Su, Junnan / Xu, Meihong / Dong, Zhigao / Wang, Qingqing / Ma, Lili / Xiao, Pingping / Chen, Xuyan

Hematology (Amsterdam, Netherlands)

2023 Volume 28, Issue 1, Page(s) 2196864

Abstract: Objective: Antinuclear antibody (ANA)-positive immune thrombocytopenia (ITP) patients have an unsatisfactory prognosis due to the more severe conditions of these patients and poor response to first-line glucocorticoids (GCs). The current study intended ... ...

Abstract	Objective: Antinuclear antibody (ANA)-positive immune thrombocytopenia (ITP) patients have an unsatisfactory prognosis due to the more severe conditions of these patients and poor response to first-line glucocorticoids (GCs). The current study intended to compare the efficacy and safety of AZA plus prednisone and prednisone alone as first-line treatment in ANA-positive ITP patients. Methods: Fifteen ANA-positive ITP patients receiving AZA plus prednisone (AZA + GC group) and eighteen ANA-positive ITP patients receiving prednisone alone (GC group) as first-line treatment were retrospectively enrolled. Results: The complete response (CR) rate (60.0% versus 22.2%) ( Conclusion: First-line AZA plus prednisone realizes a better hematological response and relapse-free duration with acceptable adverse events compared to prednisone alone in ANA-positive ITP patients.
MeSH term(s)	Humans ; Antibodies, Antinuclear ; Azathioprine/adverse effects ; Immunosuppressive Agents ; Prednisone/adverse effects ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Retrospective Studies ; Thrombocytopenia/drug therapy
Chemical Substances	Antibodies, Antinuclear ; Azathioprine (MRK240IY2L) ; Immunosuppressive Agents ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1341428-8
ISSN	1607-8454 ; 1024-5332 ; 1024-5340
ISSN (online)	1607-8454
ISSN	1024-5332 ; 1024-5340
DOI	10.1080/16078454.2023.2196864
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Article ; Online: The role of CXCL chemokine family in the development and progression of gastric cancer.

Chen, Xuyan / Chen, Renpin / Jin, Ruifang / Huang, Zhiming

International journal of clinical and experimental pathology

2020 Volume 13, Issue 3, Page(s) 484–492

Abstract: The chemokine (C-X-C motif) ligand (CXCL) family plays an important role in inflammation. In order to understand the role of CXC chemokine family in carcinogenesis, this study explored a group of early gastric cancer (GC) patients, and assessed the level ...

Abstract	The chemokine (C-X-C motif) ligand (CXCL) family plays an important role in inflammation. In order to understand the role of CXC chemokine family in carcinogenesis, this study explored a group of early gastric cancer (GC) patients, and assessed the level of CXC chemokine ligand (CXCL) in blood samples of patients representing systemic circulation and tumor microenvironment, detected the expression of CXC chemokine receptor (CXCR) in tumor tissues, and measured tumor infiltrating immune cell subsets. 69 patients with GC were included in a single center prospective study and were followed up for 6 years. The level of CXCL1-14 was determined by ELISA and the concentration gradient of chemokine was calculated. Western blot was used to detect the expression of CXCR1, CXCR2, CXCR3, and CXCR4 in tumor tissue. CXCL1-14 expression was inhibited by siRNA in HGC27 cells and then the migration ability of HGC27 cells was detected by cell scratch test. The results of this study showed that the chemokine concentrations of CXCL1, CXCL2, CXCL5, CXCL8, CXCL11, and CXCL13 in peripheral blood and tumor drainage blood of patients without recurrence after treatment were significantly lower than those before treatment. The concentrations of CXCL1, CXCL2, CXCL4, CXCL5, CXCL7, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13, and CXCL14 in peripheral blood and tumor drainage blood were significantly higher than those in patients without recurrence. Patients with low expression of CXCR1 and CXCR3 had lower AFP (alpha fetoprotein), smaller tumor volume, and lower TNM tumor stage. Patients with lower expression of CXCR2 and CXCR4 had higher AFP (alpha fetoprotein) level, larger tumor volume, and higher TNM tumor stage. After down-regulation of CXCLs expression, the migration ability of most cell lines was significantly inhibited. This study suggests that CXCL chemokine family plays an important role in the pathogenesis of GC and can be used as a marker for the development of GC.
Language	English
Publishing date	2020-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article: Fabrication and Electrical Characterization of High Aspect Ratio Through-Silicon Vias with Polyimide Liner for 3D Integration.

Chen, Xuyan / Chen, Zhiming / Xiao, Lei / Hao, Yigang / Wang, Han / Ding, Yingtao / Zhang, Ziyue

Micromachines

2022 Volume 13, Issue 7

Abstract: High aspect ratio (HAR) through-silicon vias (TSVs) are in urgent need to achieve smaller keep-out zones (KOZs) and higher integration density for the miniaturization of high-performance three-dimensional (3D) integration of integrated circuits (IC), ... ...

Abstract	High aspect ratio (HAR) through-silicon vias (TSVs) are in urgent need to achieve smaller keep-out zones (KOZs) and higher integration density for the miniaturization of high-performance three-dimensional (3D) integration of integrated circuits (IC), micro-electro-mechanical systems (MEMS), and other devices. In this study, HAR TSVs with a diameter of 11 μm and an aspect ratio of 10:1 are successfully fabricated in a low-cost process flow. Conformal polyimide (PI) liners are deposited using a vacuum-assisted spin coating technique, and the effects of spin coating time and speed on the deposition results are discussed. Then, continuous Cu seed layers are fabricated by sequential sputtering and ultrasound-assisted electroless plating. Additionally, void-free and seamless Cu conductors are formed by electroplating. Moreover, a semi-additive method is used to fabricate the redistribution layers (RDLs) on the insulating layers of photosensitive PI (PSPI). Notably, a plasma bombardment process is introduced to remove residual PSPI in the contact windows between RDLs and central pillars. Results show that the resistance of a single TSV from a daisy chain of 144 TSVs with density of 2000/mm
Language	English
Publishing date	2022-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13071147
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Article ; Online: Klebsiella pneumoniae

Zhang, Chen-Guang / Wang, Yan / Duan, Min / Zhang, Xiang-Yang / Chen, Xu-Yan

The Journal of international medical research

2022 Volume 50, Issue 3, Page(s) 3000605221084881

Abstract: Klebsiella ... ...

Abstract	Klebsiella pneumoniae
MeSH term(s)	Brain Abscess/complications ; Brain Abscess/diagnostic imaging ; Endophthalmitis/complications ; Endophthalmitis/diagnosis ; Humans ; Klebsiella pneumoniae ; Liver Abscess/complications ; Lung Abscess/complications ; Male
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605221084881
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Article ; Online: BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.

Xiao, Pingping / Chen, Xuyan / Dong, Zhigao / Fan, Wei / Chen, Yongquan / Su, Junnan / Wang, Qingqing / Ma, Lili

Hematology (Amsterdam, Netherlands)

2023 Volume 28, Issue 1, Page(s) 2231739

Abstract: Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of : Methods: A BNIP3-overexpressing plasmid was transfected into the MM.1S and RPMI8226 myeloma ... ...

Abstract	Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of Methods: A BNIP3-overexpressing plasmid was transfected into the MM.1S and RPMI8226 myeloma cell lines. Transfected cell apoptosis rate and mitochondrial function were determined via flow cytometry and western blotting. We verified the signaling pathway underlying myeloma cell sensitivity to bortezomib (BTZ). Results: Cell lines carrying the BNIP3-overexpressing plasmid exhibited higher rates of apoptosis and expression of Bax and Cleaved caspase 3 protein than the vector group, and less Bcl-2 protein expression than the control cells. Relative to the vector group, BNIP3-overexpressing strains contained more reactive oxygen species (ROS) and exhibited mitochondrial membrane potential (MMP) and dynamin-related protein 1 (Drp1) upregulation and mitofusin-1 (Mfn1) downregulation. BTZ supplementation increased BNIP3 expression. Relative to the BNIP3-OE group, the BNIP3-OE BTZ-treated group exhibited upregulated Bax and Cleaved caspase 3 protein expression, downregulated Bcl-2 protein expression, higher apoptosis rates, ROS levels, MMP, and Drp1 expression, and lower Mfn1 expression. BTZ treatment induced p38 MAPK (mitogen-activated protein kinase) signaling pathway activation in BNIP3-OE cells. Upon adding N-acetylcysteine (NAC) and the p38 MAPK inhibitor SB203580, the affected index levels returned to the baseline. Conclusions: BNIP3 overexpression induced apoptosis in myeloma cells and increased myeloma cell sensitivity to BTZ. These effects may be mediated by the ROS/p38 MAPK signaling pathway.
MeSH term(s)	Humans ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/pharmacology ; Bortezomib/pharmacology ; Caspase 3/metabolism ; Caspase 3/pharmacology ; Reactive Oxygen Species/metabolism ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/pharmacology ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Apoptosis ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-2/pharmacology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Proto-Oncogene Proteins/metabolism
Chemical Substances	p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Bortezomib (69G8BD63PP) ; Caspase 3 (EC 3.4.22.-) ; Reactive Oxygen Species ; bcl-2-Associated X Protein ; Proto-Oncogene Proteins c-bcl-2 ; BNIP3 protein, human ; Membrane Proteins ; Proto-Oncogene Proteins
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1341428-8
ISSN	1607-8454 ; 1024-5332 ; 1024-5340
ISSN (online)	1607-8454
ISSN	1024-5332 ; 1024-5340
DOI	10.1080/16078454.2023.2231739
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Article: Effects of Annealing on ultra-high pressure induced gelatinization of corn starch

Pu, Huayin / Liu, Gemei / Huang, Meng / Zhang, Chong / Niu, Wei / Chen, Xuyan / Huang, Junrong

Innovative food science & emerging technologies. 2021 Dec., v. 74

2021

Abstract: Ultra-high pressure (UHP) can induce starch gelatinization at the room temperature, while the change of starch architecture could affect the gelatinization process. This work evaluated the effects of annealing on UHP induced starch gelatinization. Native ...

Abstract	Ultra-high pressure (UHP) can induce starch gelatinization at the room temperature, while the change of starch architecture could affect the gelatinization process. This work evaluated the effects of annealing on UHP induced starch gelatinization. Native and annealed corn starches were subjected to UHP treatment (300–600 MPa) for 15 min at room temperature. The scanning electron microscopy, confocal laser scanning microscopy, differential scanning calorimetry and X-ray diffraction analysis showed that UHP treatment partially disrupted the ordered structures of native and annealed starches, which made starch gelatinized gradually and a transformation in crystal type from type A to type B. However, compared with native starch, annealing (C3 and C24) delayed the internal and external structure destruction of starch granules, as well as induced a slower decrease in ΔH and relative crystallinity as increasing pressure. Therefore, the suitable UHP treatment can increase the pressure resistance of starch, or delay the UHP gelatinization process.
Keywords	X-ray diffraction ; ambient temperature ; corn ; corn starch ; crystal structure ; food science ; gelatinization
Language	English
Dates of publication	2021-12
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2025029-0
ISSN	1466-8564
ISSN	1466-8564
DOI	10.1016/j.ifset.2021.102849
Database	NAL-Catalogue (AGRICOLA)

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