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  1. Article ; Online: The Role of Bioactive Small Molecules in COPD Pathogenesis.

    Liao, Sha / Chen, Yahong

    COPD

    2024  Volume 21, Issue 1, Page(s) 2307618

    Abstract: Chronic obstructive pulmonary disease (COPD) is recognized as a predominant contributor to mortality worldwide, which causes significant burdens to both society and individuals. Given the limited treatment options for COPD, there lies a critical ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is recognized as a predominant contributor to mortality worldwide, which causes significant burdens to both society and individuals. Given the limited treatment options for COPD, there lies a critical realization: the imperative for expeditious development of novel therapeutic modalities that can effectively alleviate disease progression and enhance the quality of life experienced by COPD patients. Within the intricate field of COPD pathogenesis, an assortment of biologically active small molecules, encompassing small protein molecules and their derivatives, assumes crucial roles through diverse mechanisms. These mechanisms relate to the regulation of redox balance, the inhibition of the release of inflammatory mediators, and the modulation of cellular functions. Therefore, the present article aims to explore and elucidate the distinct roles played by different categories of biologically active small molecules in contributing to the pathogenesis of COPD.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Quality of Life ; Disease Progression
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.1080/15412555.2024.2307618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5990: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Interpretation of the Key Issues of Expert Consensus on Immunomodulatory Therapies for Chronic Obstructive Pulmonary Disease.

    Sun, Lina / Chen, Yahong

    Journal of translational internal medicine

    2023  Volume 10, Issue 4, Page(s) 277–280

    Language English
    Publishing date 2023-01-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2861892-0
    ISSN 2224-4018 ; 2450-131X
    ISSN (online) 2224-4018
    ISSN 2450-131X
    DOI 10.2478/jtim-2022-0069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of sulfur compounds in chronic obstructive pulmonary disease.

    Jiang, Simin / Chen, Yahong

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 928287

    Abstract: Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that brings about great social and economic burden, with oxidative stress and inflammation affecting the whole disease progress. Sulfur compounds such as hydrogen sulfide ( ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that brings about great social and economic burden, with oxidative stress and inflammation affecting the whole disease progress. Sulfur compounds such as hydrogen sulfide (H
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.928287
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  4. Article ; Online: Digital health in chronic obstructive pulmonary disease.

    Long, Huanyu / Li, Shurun / Chen, Yahong

    Chronic diseases and translational medicine

    2023  Volume 9, Issue 2, Page(s) 90–103

    Abstract: Chronic obstructive pulmonary disease (COPD) can be prevented and treated through effective care, reducing exacerbations and hospitalizations. Early identification of individuals at high risk of COPD exacerbation is an opportunity for preventive measures. ...

    Abstract Chronic obstructive pulmonary disease (COPD) can be prevented and treated through effective care, reducing exacerbations and hospitalizations. Early identification of individuals at high risk of COPD exacerbation is an opportunity for preventive measures. However, many patients struggle to follow their treatment plans because of a lack of knowledge about the disease, limited access to resources, and insufficient clinical support. The growth of digital health-which encompasses advancements in health information technology, artificial intelligence, telehealth, the Internet of Things, mobile health, wearable technology, and digital therapeutics-offers opportunities for improving the early diagnosis and management of COPD. This study reviewed the field of digital health in terms of COPD. The findings showed that despite significant advances in digital health, there are still obstacles impeding its effectiveness. Finally, we highlighted some of the major challenges and possibilities for developing and integrating digital health in COPD management.
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2831148-6
    ISSN 2589-0514 ; 2589-0514
    ISSN (online) 2589-0514
    ISSN 2589-0514
    DOI 10.1002/cdt3.68
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Relationship between Hemoglobin Level Variability and Effect of Repeated Blood Transfusion Therapeutic in Patients with Renal Anemia].

    Liu, Yi-Hua / Chen, Ya-Hong / Wang, Su-Jian

    Zhongguo shi yan xue ye xue za zhi

    2023  Volume 31, Issue 6, Page(s) 1831–1837

    Abstract: Objective: To observe the variability of hemoglobin (HB) level in patients with renal anemia, and to analyze its relationship with effect of repeated blood transfusion therapeutic in patients.: Methods: A retrospective cohort study and propensity ... ...

    Abstract Objective: To observe the variability of hemoglobin (HB) level in patients with renal anemia, and to analyze its relationship with effect of repeated blood transfusion therapeutic in patients.
    Methods: A retrospective cohort study and propensity score matching method were used, 60 patients with renal anemia who had effective treatment with repeated blood transfusion in Changzhou No.2 People's Hospital from May 2018 to May 2021 were retrospectively analyzed and set as the effective group; 153 patients with renal anemia who had ineffective treatment with repeated blood transfusion in the hospital in the same period were collected and set as the ineffective group, the propensity score matching method was used, the patients who were effective and ineffective in repeated blood transfusion were matched 1∶1 for analysis; the medical records and laboratory indexes of the two groups were checked; the Hb level of patients within 6 months (1/month) were recorded, the residual standard deviation (Res-SD) of Hb of patients was calculated according to the Hb level and evaluated the variability of Hb level; the relationship between HB variability level and therapeutic effect of repeated blood transfusion in patients with renal anemia was analyzed.
    Results: After propensity score matching, there was no statistical significant difference between the two groups in terms of baseline data such as age, sex, dialysis age and BMI (
    Conclusion: The therapeutic effect of repeated blood transfusion in patients with renal anemia may be related to the variability of Hb level.
    MeSH term(s) Humans ; Male ; Female ; Retrospective Studies ; Hemoglobins/therapeutic use ; Anemia/therapy ; Chronic Disease ; Blood Transfusion ; Kidney Diseases
    Chemical Substances Hemoglobins
    Language Chinese
    Publishing date 2023-10-20
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2023.06.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6603: Show issues Location:
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  6. Article ; Online: Impact of radiation therapy and alpha-fetoprotein level on survival outcomes for patients with hepatocellular carcinoma: A population-based study.

    Chen, Yahong / Yang, Xueqing / Li, Xiawei

    Clinics and research in hepatology and gastroenterology

    2023  Volume 47, Issue 8, Page(s) 102196

    Abstract: Background: The use of radiation therapy (RT) in hepatocellular carcinoma (HCC) remains a matter for debate. Recently published research indicate that advanced RT techniques may improve survival in patients with HCC. This study aimed to evaluate this ... ...

    Abstract Background: The use of radiation therapy (RT) in hepatocellular carcinoma (HCC) remains a matter for debate. Recently published research indicate that advanced RT techniques may improve survival in patients with HCC. This study aimed to evaluate this hypothesis in a large-scale retrospective cohort. The effect of alpha-fetoprotein (AFP) was taken into account because of its important role in the prognosis of HCC.
    Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried for adults patients diagnosed 2010-2019 with HCC (≥ 18 years). The study population was divided into four groups: Non-radiation & AFP-positive (reference), Non-radiation & AF-negative, Radiation & AFP-positive, Radiation & AFP-negative. Distant metastasis (DM) was used as a stratification factor. Differences in 5-year overall survival (OS) of the four groups were assessed using the Kaplan-Meier method. Univariate and multivariable Cox proportional hazards model were used to estimate unadjusted and adjusted hazard ratios (HR).
    Results: A total of 34,656 patients were eligible for this analysis, including 21,084 (60.8%), 8,449 (24.4%), 3,810 (11.0%) and 1,313 (3.8%) in the Non-radiation & AFP-positive, Non-radiation & AF-negative, Radiation & AFP-positive and Radiation & AFP-negative groups, respectively. Median OSs of the four groups were 3, 4, 5 and 11 months in the DM cohort, and 12, 28, 15, and 28 months in the Non-DM cohort. Patients in the Radiation & AFP - group had the best OS and patients in the Non-radiation & AFP + group had the worst OS (adjusted HR [95% confidence interval (CI)]: 0.497 [0.399-0.619] in the DM cohort, and 0.405 [0.372-0.441] in the Non-DM cohort). Radiation & AFP + also showed improved survival compared with the reference group (adjusted HR [95%CI]: 0.725 [0.657-0.801] in the DM cohort, and 0.630 [0.600-0.661] in the Non-DM cohort).
    Conclusions: This population-based cohort study confirmed a significant improvement in overall survival with radiation therapy in HCC. AFP-negative patients benefit the most from RT. Superior OS of radiation therapy and AFP-negative status persisted even in patients with complex metastasis patterns. Our data suggest that radiation may provide an alternative modality for unresectable HCC.
    Language English
    Publishing date 2023-08-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2023.102196
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  7. Article ; Online: A Novel Hybrid Algorithm for Multiobjective Location-Allocation Problem in Emergency Logistics.

    Chu, Hongrui / Chen, Yahong

    publication RETRACTED

    Computational intelligence and neuroscience

    2021  Volume 2021, Page(s) 1951161

    Abstract: Increased frequency of disasters keeps reminding us of the importance of effective resource distribution in postdisaster. To reduce the suffering of victims, this paper focuses on how to establish an effective emergency logistics system. We first propose ...

    Abstract Increased frequency of disasters keeps reminding us of the importance of effective resource distribution in postdisaster. To reduce the suffering of victims, this paper focuses on how to establish an effective emergency logistics system. We first propose a multiobjective optimization model in which the location and allocation decisions are made for a three-level logistics network. Three objectives, deprivation costs, unsatisfied demand costs, and logistics cost, are adopted in the proposed optimization model. Several cardinality and flow balance constraints are considered simultaneously. Then, we design a novel effective IFA-GA algorithm by combining the firefly algorithm and genetic algorithm to solve this complex model effectively. Furthermore, three schemes are proposed to improve the effectiveness of the IFA-GA algorithm. Finally, the numerical results provide several insights on the theory and practice of relief distribution, which also illustrate the validity of the proposed solution algorithm.
    MeSH term(s) Algorithms ; Disasters
    Language English
    Publishing date 2021-11-28
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2021/1951161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fast measurement of coherence-orbital angular momentum matrices of random light beams using off-axis holography and coordinate transformation.

    Li, WeiHao / Liu, Yonglei / Chen, Yahong / Cai, Yangjian / Korotkova, Olga / Wang, Fei

    Optics letters

    2024  Volume 49, Issue 5, Page(s) 1173–1176

    Abstract: We propose an effective protocol to measure the coherence-orbital angular momentum (COAM) matrix of an arbitrary partially coherent beam. The method is based on an off-axis holography scheme and the Cartesian-polar coordinate transformation, which ... ...

    Abstract We propose an effective protocol to measure the coherence-orbital angular momentum (COAM) matrix of an arbitrary partially coherent beam. The method is based on an off-axis holography scheme and the Cartesian-polar coordinate transformation, which enables to simultaneously deal with all the COAM matrix elements of interest. The working principle is presented and discussed in detail. A proof-of-principle experiment is carried out to reconstruct the COAM matrices of partially coherent beams with spatially uniform and non-uniform coherence states. We find an excellent agreement between the experimental results and the theoretical predictions. In addition, we show that the OAM spectrum of a partially coherent beam can also be directly acquired from the measured COAM matrix.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.514954
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  9. Article ; Online: Corrigendum to "Potential pre-COPD indicators in association with COPD development and COPD prediction models in Chinese: a prospective cohort study" [The Lancet Regional Health - Western Pacific 44 (2024) 100984].

    Fan, Jing / Fang, Liwen / Cong, Shu / Zhang, Yang / Jiang, Xiao / Wang, Ning / Chen, Yahong

    The Lancet regional health. Western Pacific

    2024  Volume 44, Page(s) 101033

    Abstract: This corrects the article DOI: 10.1016/j.lanwpc.2023.100984.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.lanwpc.2023.100984.].
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Published Erratum
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2024.101033
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  10. Article: Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG.

    Chen, Yahong / Liu, Junhong / Yao, Yishan / Yan, Haitao / Su, Ruibin

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1021729

    Abstract: Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of ... ...

    Abstract Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1021729
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