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  1. Article: Research Progress of MicroRNAs in Spinal Cord Injury.

    Deng, Zhi-Zhong / Chen, Ya-Hui

    Journal of integrative neuroscience

    2023  Volume 22, Issue 2, Page(s) 31

    Abstract: Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. ... ...

    Abstract Spinal cord injury is a serious and devastating condition. Recently, research into microRNAs (miRNAs) has become increasingly exhaustive and it has been determined that they are closely related to the pathophysiological processes of spinal cord injury. They participate in the regulation of the inflammatory response of spinal cord injury, the death of neuronal cells, and the repair of neural functions, which are related to the recovery of spinal cord injury. This review focuses on the relationship between miRNA and spinal cord injury, lists miRNA-324-5p, miRNA-221 and miRNA-124, which are helpful for the repair of spinal cord injury, and finally summarizes the current research progress of miRNA-based therapies, so as to provide a foundational reference for clinical and scientific researchers.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/therapy ; Neurons ; Spinal Cord
    Chemical Substances MicroRNAs ; MIRN221 microRNA, human ; MIRN324 microRNA, human
    Language English
    Publishing date 2023-03-30
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2136427-8
    ISSN 0219-6352
    ISSN 0219-6352
    DOI 10.31083/j.jin2202031
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6117: Show issues Location:
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  2. Article ; Online: Can access to urban networks promote urban development? Evidence from the Yangtze River Delta region of China.

    Ding, Liang / Yang, Zhiqiong / Zhang, Junshen / Chen, Yahui / Wang, Xiaohan

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300199

    Abstract: The regional networking strategy is widely implemented in China as a normative policy aimed at fostering cohesion and enhancing competitiveness. However, the empirical basis for this strategy remains relatively weak due to limitations in measurement ... ...

    Abstract The regional networking strategy is widely implemented in China as a normative policy aimed at fostering cohesion and enhancing competitiveness. However, the empirical basis for this strategy remains relatively weak due to limitations in measurement methods and data availability. This paper establishes the urban networks by the enterprise investment data, and then accurately measures the network's external effects of each city by the method of MGWR model. The results show that: (1) Regional networking plays a significant role in urban development, although it is not the dominant factor. (2) The benefits of network connections may vary depending on the location and level of cities. (3) The major cities assume a pivotal role in the urban network. Based upon the aforementioned research conclusions, this paper presents strategic measures to enhance the network's external impacts, aiming to offer insights for other regions in formulating regional development strategies and establishing regional urban networks.
    MeSH term(s) Urbanization ; Urban Renewal ; Cities ; Rivers ; China ; Economic Development
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300199
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  3. Article ; Online: Endometrioid adenocarcinoma caused by adenomyosis: A case report.

    Chen, Ya-Hui / Zhou, Yan / Xue, Mei / Sun, Lin

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 1921–1922

    MeSH term(s) Female ; Humans ; Carcinoma, Endometrioid/surgery ; Carcinoma, Endometrioid/complications ; Adenomyosis/complications ; Adenomyosis/surgery ; Adenomyosis/pathology ; Endometrial Neoplasms/etiology ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Adenocarcinoma/pathology
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.11.091
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  4. Article ; Online: Yeast One-Hybrid Screening for Transcription Factors of IbbHLH2 in Purple-Fleshed Sweet Potato

    Fu, Danwen / Chen, Yahui / Gao, Feng

    Genes (Basel). 2023 May 05, v. 14, no. 5

    2023  

    Abstract: The transcription factor IbbHLH2 has been identified as involved in the biosynthesis of anthocyanins in purple-flesh sweet potatoes. However, little is known about the upstream transcription regulators of the promoter of IbbHLH2 in terms of their ... ...

    Abstract The transcription factor IbbHLH2 has been identified as involved in the biosynthesis of anthocyanins in purple-flesh sweet potatoes. However, little is known about the upstream transcription regulators of the promoter of IbbHLH2 in terms of their involvement in anthocyanin biosynthesis. For this study, the transcription regulators of the promoter of IbbHLH2 were screened via yeast one-hybrid assays in purple-fleshed sweet potato storage roots. Seven proteins, namely IbERF1, IbERF10, IbEBF2, IbPDC, IbPGP19, IbUR5GT, and IbDRM, were screened as upstream binding proteins of the promoter of IbbHLH2. The interactions between the promoter and these upstream binding proteins were verified using dual-luciferase reporter and yeast two-hybrid assays. Furthermore, the gene expression levels of transcription regulators, transcription factors, and structural genes involved in the anthocyanin biosynthesis of different root stages of purple and white-fleshed sweet potatoes were analyzed via real-time PCR. The obtained results indicate that IbERF1 and IbERF10 are key transcription regulators of the promoter of IbbHLH2 and are involved in anthocyanin biosynthesis in purple-fleshed sweet potatoes.
    Keywords anthocyanins ; biosynthesis ; gene expression ; quantitative polymerase chain reaction ; sweet potatoes ; transcription factors ; two hybrid system techniques ; yeasts
    Language English
    Dates of publication 2023-0505
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051042
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Effects of Myo-Inositol on NaCl Stress in Tamarix ramosissima: Insights from Transcriptomics and Metabolomics

    Li, Haijia / Fan, Yunlong / Zhang, Huanchao / Chen, Yahui

    Forests. 2023 Aug. 21, v. 14, no. 8

    2023  

    Abstract: NaCl stress adversely affects plant growth. Tamarix ramosissima Ledeb (T. ramosissima), a halophyte, thrives in saline-alkali areas. Myo-inositol, a lipid-soluble compound, is crucial for stress response, but its role in mitigating NaCl damage remains ... ...

    Abstract NaCl stress adversely affects plant growth. Tamarix ramosissima Ledeb (T. ramosissima), a halophyte, thrives in saline-alkali areas. Myo-inositol, a lipid-soluble compound, is crucial for stress response, but its role in mitigating NaCl damage remains underexplored. We analyzed transcriptome sequencing and metabolites in T. ramosissima roots under NaCl stress at various intervals (0 h, 48 h, and 168 h). We identified ten Myo-inositol oxygenase-related genes. Nine of these genes, linked to metabolic pathways involving Myo-inositol, showed differential expression. Myo-inositol accumulation increased over time, suggesting its role as an osmotic regulator and reactive oxygen species (ROS) scavenger. This accumulation likely shields T. ramosissima from NaCl-induced osmotic and oxidative damage. Notably, Unigene0002140 and Unigene0095980, associated with Myo-inositol oxygenase, appear to regulate Myo-inositol accumulation and correlate significantly with its levels. We hypothesize they are key genes in controlling Myo-inositol levels, warranting further study. This research illuminates the role of Myo-inositol oxygenase-related genes in T. ramosissima roots combating NaCl stress, offering insights for selecting salt-tolerant tree species.
    Keywords Tamarix ramosissima ; gene expression regulation ; halophytes ; metabolites ; metabolomics ; myo-inositol ; plant growth ; reactive oxygen species ; salt stress ; salt tolerance ; stress response ; transcriptome ; transcriptomics ; trees
    Language English
    Dates of publication 2023-0821
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f14081686
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Institutional capability, cooperation level and irrigation water order: Empirical analysis based on survey data from the Yellow River area

    Wang, Bo / Wan, Jingjing / Zhu, Yuchun / Chen, Yahui

    Irrigation and Drainage. 2023 July, v. 72, no. 3 p.716-728

    2023  

    Abstract: Village rules and customs, reciprocal trust and favour and mobilization ability are the main factors affecting governance ability in rural public affairs. Based on microsurvey data from 979 irrigating farmers from the Yellow River area in China, the ... ...

    Abstract Village rules and customs, reciprocal trust and favour and mobilization ability are the main factors affecting governance ability in rural public affairs. Based on microsurvey data from 979 irrigating farmers from the Yellow River area in China, the effects of three types of village institutional capacity factors (knowledge resources, relational resources and mobilization capacity) on the irrigation behaviour and the irrigation water order of village farmland were analysed. The results indicate that these factors would reduce villagers' water‐stealing behaviour and water‐use disputes during the irrigation process, strengthen water‐use satisfaction of the villagers and ultimately improve the order of farmland‐irrigation water in the whole village. The level of cooperation within irrigation organizations has a moderating effect on this process, and higher levels of cooperation lead to a greater positive impact of these institutional capacity factors on villagers' water‐use behaviour.
    Keywords agricultural land ; empirical research ; governance ; irrigation ; irrigation water ; surveys ; villages ; China ; Yellow River
    Language English
    Dates of publication 2023-07
    Size p. 716-728.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2047418-0
    ISSN 1531-0361 ; 1531-0353
    ISSN (online) 1531-0361
    ISSN 1531-0353
    DOI 10.1002/ird.2799
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  7. Article ; Online: Yeast One-Hybrid Screening for Transcription Factors of IbbHLH2 in Purple-Fleshed Sweet Potato.

    Fu, Danwen / Chen, Yahui / Gao, Feng

    Genes

    2023  Volume 14, Issue 5

    Abstract: The transcription factor IbbHLH2 has been identified as involved in the biosynthesis of anthocyanins in purple-flesh sweet potatoes. However, little is known about the upstream transcription regulators of the promoter ... ...

    Abstract The transcription factor IbbHLH2 has been identified as involved in the biosynthesis of anthocyanins in purple-flesh sweet potatoes. However, little is known about the upstream transcription regulators of the promoter of
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Saccharomyces cerevisiae/metabolism ; Ipomoea batatas/genetics ; Ipomoea batatas/metabolism ; Anthocyanins ; Yeast, Dried
    Chemical Substances Transcription Factors ; Anthocyanins
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14051042
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  8. Article ; Online: Malignant endometriosis of the rectovaginal septum: A case report.

    Dong, Yan / Wang, Lin / Chen, Yahui / Sun, Lin

    Asian journal of surgery

    2023  Volume 46, Issue 6, Page(s) 2626–2627

    MeSH term(s) Female ; Humans ; Endometriosis/diagnosis ; Endometriosis/surgery ; Endometriosis/pathology ; Vagina/surgery ; Rectum/surgery ; Rectum/pathology ; Fascia
    Language English
    Publishing date 2023-01-10
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.12.141
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  9. Article ; Online: Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro.

    Lin, Ching-Yeh / Chen, Ya-Hui / Huang, Ying-Chih

    Current issues in molecular biology

    2023  Volume 45, Issue 2, Page(s) 1587–1600

    Abstract: Background: Hesperetin has been reported to have anticancer properties. However, the molecular mechanisms underlying its action on leukemia cells remain unclear. This in vitro study evaluated the possible mechanisms of hesperetin in leukemia cells (HL- ... ...

    Abstract Background: Hesperetin has been reported to have anticancer properties. However, the molecular mechanisms underlying its action on leukemia cells remain unclear. This in vitro study evaluated the possible mechanisms of hesperetin in leukemia cells (HL-60 and U937).
    Methods: Cell viability was evaluated using a cell counting kit-8 (CCK-8) assay. Apoptosis and autophagy assays were conducted through annexin V/PI staining and acidic vesicular organelle (AVO) staining. Cell cycle analysis was conducted through propidium iodide (PI) and flow cytometry. The expression of proteins related to apoptosis and autophagy, including cleaved-PARP-1, Bcl-2, Bax, LC3-I/II, Beclin-1, Atg5, p62, phospho-AMPK, AMPK, phospho-mTOR, mTOR, phospho-Akt, and Akt, in human leukemia cells were evaluated using Western blotting.
    Results: Hesperetin dose-dependently inhibited leukemia cell viability. However, we found a low degree of apoptosis and cell cycle arrest induced by hesperetin in U937 cells. These findings imply the presence of additional mechanisms modulating hesperetin-induced cell death. Next, we evaluated autophagy, the possible mechanism modulating cell death or survival, to clarify the underlying mechanism of hesperetin-induced cell death. Hesperetin also dose-dependently increased the ratio of LC3II/I, Atg5, and Beclin 1 and decreased p62. Moreover, 3-methyladenine (3-MA) and bafilomycin A1 (Baf-A1) inhibited hesperetin-induced autophagy. We suggest that hesperetin can protect cancer cells during the transient period and may extend survival. Furthermore, a decrease in p-mTOR and p-Akt expression and an increase in p-AMPK expression were observed. Collectively, these findings suggest that hesperetin induces autophagy by modulating the AMPK/Akt/mTOR pathway.
    Conclusion: Hesperetin promoted cell death in the human leukemic cell line U937 by inducing a low degree of slight apoptosis, cell cycle arrest, and autophagy. It is therefore a potential adjuvant to antileukemia therapy and may be combined with other chemotherapeutic drugs to reduce chemoresistance and side effects.
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45020102
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
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  10. Article: Generate Greater Gratitude When Being Help? A Study of the Psychological Mechanism of Gratitude for Chinese Poor College Students.

    Zeng, Xiaoqing / Chen, Yahui / Li, Yeqing

    Applied research in quality of life

    2023  , Page(s) 1–19

    Abstract: The Chinese government has invested much money to help poor college students complete their studies, but the gratitude of the recipients remains to be further studied. This study proposed a parallel mediation model and used questionnaires to investigate ... ...

    Abstract The Chinese government has invested much money to help poor college students complete their studies, but the gratitude of the recipients remains to be further studied. This study proposed a parallel mediation model and used questionnaires to investigate 260 thousand college students of China to examine the impact of the level of social support on poor college students' gratitude and the mediating role played by social responsibility and relative deprivation. The results showed that social support positively predicted the gratitude level of poor college students; social responsibility and relative deprivation mediated the relationship between social support and gratitude; gender, school type and difficulty level had a significant influence on gratitude level. In short, education to improve the sense of gratitude of poor college students can be summarized as "two increases and one decrease": increase social support, enhance social responsibility, and reduce relative deprivation.
    Language English
    Publishing date 2023-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2251932-4
    ISSN 1871-2576 ; 1871-2584
    ISSN (online) 1871-2576
    ISSN 1871-2584
    DOI 10.1007/s11482-023-10166-z
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