Article ; Online: Association between rapid renal function deterioration and cancer mortality in the elderly: A retrospective cohort study.
2023 Volume 12, Issue 8, Page(s) 10008–10019
Abstract: Background: Kidney function is associated with clinical outcomes in patients with cancer.: Objectives: This study aimed to assess the association between kidney function decline and cancer-related mortality among community-dwelling elderly ... ...
Abstract | Background: Kidney function is associated with clinical outcomes in patients with cancer. Objectives: This study aimed to assess the association between kidney function decline and cancer-related mortality among community-dwelling elderly individuals. Design: This was a retrospective longitudinal cohort study. Participants: The 61,988 participants were from an elderly health examination database in Taipei City from 2005 to 2012. Measurements: Multivariable logistic regression was used to assess the association between baseline covariates and rapidly deteriorating estimated glomerular filtration rate (eGFR). In addition, Cox proportional hazards model and the Fine-Gray model were used to quantify the effects of covariates on total cancer mortality and six specific cancer mortalities. Results: During the follow-up period, 1482 participants died of cancer. Their baseline average eGFR was 73.8 ± 19.9 mL/min/1.73 m Conclusions: Elderly individuals with rapid kidney function decline had higher cancer mortality risks. Serial assessments of dynamic changes in eGFR might provide information relevant for cancer prognosis. |
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MeSH term(s) | Male ; Humans ; Aged ; Retrospective Studies ; Longitudinal Studies ; Glomerular Filtration Rate ; Hypertension ; Kidney/physiology ; Risk Factors ; Disease Progression ; Neoplasms |
Language | English |
Publishing date | 2023-03-07 |
Publishing country | United States |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2659751-2 |
ISSN | 2045-7634 ; 2045-7634 |
ISSN (online) | 2045-7634 |
ISSN | 2045-7634 |
DOI | 10.1002/cam4.5735 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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