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  1. Article ; Online: Mechanosensitive Angiotensin II Receptor Signaling in Pressure-Induced Vasoconstriction.

    Chen, Yen-Lin / Sonkusare, Swapnil K

    Journal of the American Heart Association

    2022  Volume 11, Issue 4, Page(s) e024740

    MeSH term(s) Muscle, Smooth, Vascular ; Receptor, Angiotensin, Type 1 ; Vasoconstriction
    Chemical Substances Receptor, Angiotensin, Type 1
    Language English
    Publishing date 2022-02-12
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.024740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Calcium regulation and Mechano-transduction in vascular diseases: obligatory role of transient receptor potential and Piezo channels.

    Ayon, Ramon J / Kuppusamy, Maniselvan / Ceolotto, Giulio / Chen, Yen-Lin

    Frontiers in physiology

    2024  Volume 15, Page(s) 1375432

    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1375432
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  3. Article ; Online: Effects of aging and diabetes on the deformation mechanisms and molecular structural characteristics of collagen fibrils under daily activity.

    Hui, Wei-Han / Chen, Yen-Lin / Chang, Shu-Wei

    International journal of biological macromolecules

    2023  Volume 254, Issue Pt 1, Page(s) 127603

    Abstract: Crosslinking plays an important role in collagen-based tissues since it affects mechanical behavior and tissue metabolism. Aging and diabetes affect the type and density of crosslinking, effectively altering tissue properties. However, most studies focus ...

    Abstract Crosslinking plays an important role in collagen-based tissues since it affects mechanical behavior and tissue metabolism. Aging and diabetes affect the type and density of crosslinking, effectively altering tissue properties. However, most studies focus on these effects under large stress rather than daily activities. We focus on the deformation mechanisms and structural change at the binding sites for integrins, proteoglycans, and collagenase in collagen fibrils using a fully atomistic model. We show that high-connectivity enzymatic crosslinking (our "HC" model, representing normal tissues) and advanced-glycation end-products (our "Glucosepane" model, which increase in diabetes) result in uniform deformation under daily activity, but low-connectivity enzymatic crosslinking (our "LC" model, representing aging tissues) does not. In particular, the HC model displays more sliding, which may explain the ability of healthy tissues to absorb more strain energy. In contrast, AGEs induce instability in the structures near the binding sites, which would affect the tissue metabolism of the collagen molecule. Our results provide important insights into the molecular mechanisms of collagen and a possible explanation for the role of crosslinking in tissues undergoing daily activity.
    MeSH term(s) Humans ; Diabetes Mellitus/metabolism ; Glycation End Products, Advanced/metabolism ; Extracellular Matrix/metabolism ; Collagen/chemistry ; Collagenases/metabolism
    Chemical Substances Glycation End Products, Advanced ; Collagen (9007-34-5) ; Collagenases (EC 3.4.24.-)
    Language English
    Publishing date 2023-10-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127603
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    Zs.B 2374: Show issues Location:
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  4. Article ; Online: Sol-Gel Prepared Spinel HTLs for Assembling 20% Efficiency Perovskite Solar Cell in Air Without Using Anti-Solvent and Toxic Solvent.

    Chiang, Chien-Hung / Chen, Yen-Lin / Wu, Chun-Guey

    Small methods

    2023  Volume 7, Issue 10, Page(s) e2300399

    Abstract: Low-temperature sol-gel prepared ... ...

    Abstract Low-temperature sol-gel prepared ZnCo
    Language English
    Publishing date 2023-06-15
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202300399
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  5. Article ; Online: RE: Does Segmental Mandibulectomy Involving Critical Functional Sites Affect Quality of Life?

    Chen, Yen-Lin / Chiu, Yu-Wei / Chen, Yi-Tzu

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2023  Volume 81, Issue 8, Page(s) 939

    MeSH term(s) Humans ; Mandibular Osteotomy ; Quality of Life ; Mandible/surgery ; Mouth Neoplasms/surgery
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2023.04.018
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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.113: Show issues Location:
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  6. Article ; Online: The Use of Proton and Carbon Ion Radiation Therapy for Sarcomas.

    Ioakeim-Ioannidou, Myrsini / Rose, Melanie / Chen, Yen-Lin / MacDonald, Shannon M

    Seminars in radiation oncology

    2024  Volume 34, Issue 2, Page(s) 207–217

    Abstract: The unique physical and biological characteristics of proton and carbon ions allow for improved sparing of normal tissues, decreased integral dose to the body, and increased biological effect through high linear energy transfer. These properties are ... ...

    Abstract The unique physical and biological characteristics of proton and carbon ions allow for improved sparing of normal tissues, decreased integral dose to the body, and increased biological effect through high linear energy transfer. These properties are particularly useful for sarcomas given their histology, wide array of locations, and age of diagnosis. This review summarizes the literature and describes the clinical situations in which these heavy particles have advantages for treating sarcomas.
    MeSH term(s) Humans ; Protons ; Heavy Ion Radiotherapy ; Sarcoma/radiotherapy ; Proton Therapy
    Chemical Substances Protons
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2024.02.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3654: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Flipped classroom teaching model with video instruction improves skills in local anesthesia training.

    Chen, Yen-Lin / Chiu, Yu-Wei / Yu, Chuan-Hang / Chang, Yu-Chao / Chen, Yi-Tzu

    Journal of dental sciences

    2024  Volume 19, Issue 2, Page(s) 1070–1074

    Abstract: Background/purpose: Local anesthesia (LA) training is an essential clinical skill in dental education. However, the traditional teaching method of student-to-student injection has ethical concerns. This study investigated whether a flipped classroom (FC) ...

    Abstract Background/purpose: Local anesthesia (LA) training is an essential clinical skill in dental education. However, the traditional teaching method of student-to-student injection has ethical concerns. This study investigated whether a flipped classroom (FC) teaching model with instructional videos improves students' skills in administering LA.
    Materials and methods: Fourth-year dental students in 2017 (traditional teaching, n = 70) and 2018 (FC model, n = 79) were assessed for their ability to perform an inferior alveolar nerve block and lingual nerve block. The FC group watched pre-recorded videos prior to a hands-on training session. Skills were evaluated using a 24-item checklist converted to letter grades. Perceptions of the FC approach were also surveyed.
    Results: The FC group showed statistically significantly higher final grades than the traditional teaching group (
    Conclusion: The FC teaching model with procedural video instruction improved skills and confidence in administering LA over traditional teaching methods. Videos can be a beneficial supplement in pre-clinical dental training.
    Language English
    Publishing date 2024-02-13
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2024.02.001
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  8. Article ; Online: Therapeutic Effects of Treating COVID-19 Vaccine-Induced Anti-TIF1-γ-Positive Dermatomyositis.

    Wu, Chih-Feng / Chen, Wan-Ting / Chen, Yen-Lin / Liu, Feng-Cheng

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 9

    Abstract: An increase in skin-related autoimmune disorders has been reported as an adverse effect of coronavirus disease 2019 (COVID-19) vaccines. We present the case of a 90-year-old Taiwanese female who was newly diagnosed with anti-transcription intermediary ... ...

    Abstract An increase in skin-related autoimmune disorders has been reported as an adverse effect of coronavirus disease 2019 (COVID-19) vaccines. We present the case of a 90-year-old Taiwanese female who was newly diagnosed with anti-transcription intermediary factor 1-gamma (anti-TIF1-γ)-positive dermatomyositis (DM) after receiving a second dose of the AstraZeneca COVID-19 vaccine. Under treatment with prednisolone and monoclonal antibody therapy of abatacept, her skin lesions improved, and her muscle power increased. The serum creatinine phosphokinase level decreased from 4858 to 220 U/L, and the anti-TIF1-γ antibody titer decreased from 202 to 99. Flow cytometry data showed an increase in T cells, while NK cells, B cells (CD19), and plasma blasts all decreased. These findings suggest that standard DM treatment might be beneficial to patients with COVID-19 vaccine-induced DM.
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59091688
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    Zs.A 6270: Show issues Location:
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  9. Article: Endothelial TRPV4 channels and vasodilator reactivity.

    Chen, Yen-Lin / Sonkusare, Swapnil K

    Current topics in membranes

    2020  Volume 85, Page(s) 89–117

    Abstract: Transient receptor potential vanilloid 4 (TRPV4) ion channels on the endothelial cell membrane are widely regarded as a crucial ... ...

    Abstract Transient receptor potential vanilloid 4 (TRPV4) ion channels on the endothelial cell membrane are widely regarded as a crucial Ca
    MeSH term(s) Animals ; Disease ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Signal Transduction ; TRPV Cation Channels/metabolism ; Vasodilation
    Chemical Substances TRPV Cation Channels
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/bs.ctm.2020.01.007
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  10. Article: Machine learning deciphers structural features of RNA duplexes measured with solution X-ray scattering.

    Chen, Yen-Lin / Pollack, Lois

    IUCrJ

    2020  Volume 7, Issue Pt 5, Page(s) 870–880

    Abstract: Macromolecular structures can be determined from solution X-ray scattering. Small-angle X-ray scattering (SAXS) provides global structural information on length scales of 10s to 100s of Ångstroms, and many algorithms are available to convert SAXS data ... ...

    Abstract Macromolecular structures can be determined from solution X-ray scattering. Small-angle X-ray scattering (SAXS) provides global structural information on length scales of 10s to 100s of Ångstroms, and many algorithms are available to convert SAXS data into low-resolution structural envelopes. Extension of measurements to wider scattering angles (WAXS or wide-angle X-ray scattering) can sharpen the resolution to below 10 Å, filling in structural details that can be critical for biological function. These WAXS profiles are especially challenging to interpret because of the significant contribution of solvent in addition to solute on these smaller length scales. Based on training with molecular dynamics generated models, the application of extreme gradient boosting (XGBoost) is discussed, which is a supervised machine learning (ML) approach to interpret features in solution scattering profiles. These ML methods are applied to predict key structural parameters of double-stranded ribonucleic acid (dsRNA) duplexes. Duplex conformations vary with salt and sequence and directly impact the foldability of functional RNA molecules. The strong structural periodicities in these duplexes yield scattering profiles with rich sets of features at intermediate-to-wide scattering angles. In the ML models, these profiles are treated as 1D images or features. These ML models identify specific scattering angles, or regions of scattering angles, which correspond with and successfully predict distinct structural parameters. Thus, this work demonstrates that ML strategies can integrate theoretical molecular models with experimental solution scattering data, providing a new framework for extracting highly relevant structural information from solution experiments on biological macromolecules.
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2754953-7
    ISSN 2052-2525
    ISSN 2052-2525
    DOI 10.1107/S2052252520008830
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