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  1. Article: Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study.

    Hwang, Juen-Haur / Yu, Ben-Hui / Chen, Yi-Chun

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Otosclerosis is an early adult-onset disease that is associated with 5-9% and 18-22% of all cases of hearing and conductive hearing loss, respectively, and it is suspected to have a viral etiology. However, the role of viral infection in otosclerosis is ... ...

    Abstract Otosclerosis is an early adult-onset disease that is associated with 5-9% and 18-22% of all cases of hearing and conductive hearing loss, respectively, and it is suspected to have a viral etiology. However, the role of viral infection in otosclerosis is still inconclusive. This study aimed to investigate whether rubella infection was associated with otosclerosis risk. We conducted a nationwide case-control study in Taiwan. Data were retrospectively analyzed from the Taiwan National health Insurance Research Database. Cases consisted of all patients who were aged ≥6 years and had a first-time diagnosis of otosclerosis for the period between 2001 and 2012. The controls were exact matched to cases in a 4:1 ratio by birth year, sex, and must survive in the index year of their matched cases. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by using conditional logistic regression. We examined 647 otosclerosis cases and 2588 controls without otosclerosis. Among the 647 patients with otosclerosis, 241 (37.2%) were male and 406 (62.8%) were female, with most aged between 40 and 59 years, with a mean age of 44.9 years. After adjusting for age and sex, conditional logistic regression revealed that exposure to rubella was not associated with a significant increase in otosclerosis risk (adjusted OR, 2.0; 95% CI, 0.18-22.06,
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12051761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Harnessing cell reprogramming for cardiac biological pacing.

    Liu, Chih-Min / Chen, Yi-Chun / Hu, Yu-Feng

    Journal of biomedical science

    2023  Volume 30, Issue 1, Page(s) 74

    Abstract: Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. The current therapy is to implant electronic ... ...

    Abstract Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. The current therapy is to implant electronic devices to generate backup electricity. However, complications inherent to electronic devices remain unbearable suffering. Therefore, cardiac biological pacing has been developed as a hardware-free alternative. The approaches to generating biological pacing have evolved recently using cell reprogramming technology to generate pacemaker cardiomyocytes in-vivo or in-vitro. Different from conventional methods by electrical re-engineering, reprogramming-based biological pacing recapitulates various phenotypes of de novo pacemaker cardiomyocytes and is more physiological, efficient, and easy for clinical implementation. This article reviews the present state of the art in reprogramming-based biological pacing. We begin with the rationale for this new approach and review its advances in creating a biological pacemaker to treat bradyarrhythmia.
    MeSH term(s) Cellular Reprogramming ; Myocytes, Cardiac ; Phenotype
    Language English
    Publishing date 2023-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193378-1
    ISSN 1423-0127 ; 1021-7770
    ISSN (online) 1423-0127
    ISSN 1021-7770
    DOI 10.1186/s12929-023-00970-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4037: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Artificial Intelligence in U.S. Health Care Delivery.

    Chen, Yi-Chun / Chiang, Hsiu-Yin / Kuo, Chin-Chi

    The New England journal of medicine

    2023  Volume 389, Issue 15, Page(s) 1442–1443

    MeSH term(s) Humans ; Artificial Intelligence ; Delivery of Health Care
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2310288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: CPST

    Chen, Yi-Chun / Jhala, Arnav

    Comprehension-Preserving Style Transfer for Multi-Modal Narratives

    2023  

    Abstract: We investigate the challenges of style transfer in multi-modal visual narratives. Among static visual narratives such as comics and manga, there are distinct visual styles in terms of presentation. They include style features across multiple dimensions, ... ...

    Abstract We investigate the challenges of style transfer in multi-modal visual narratives. Among static visual narratives such as comics and manga, there are distinct visual styles in terms of presentation. They include style features across multiple dimensions, such as panel layout, size, shape, and color. They include both visual and text media elements. The layout of both text and media elements is also significant in terms of narrative communication. The sequential transitions between panels are where readers make inferences about the narrative world. These feature differences provide an interesting challenge for style transfer in which there are distinctions between the processing of features for each modality. We introduce the notion of comprehension-preserving style transfer (CPST) in such multi-modal domains. CPST requires not only traditional metrics of style transfer but also metrics of narrative comprehension. To spur further research in this area, we present an annotated dataset of comics and manga and an initial set of algorithms that utilize separate style transfer modules for the visual, textual, and layout parameters. To test whether the style transfer preserves narrative semantics, we evaluate this algorithm through visual story cloze tests inspired by work in computational cognition of narrative systems. Understanding the connection between style and narrative semantics provides insight for applications ranging from informational brochure designs to data storytelling.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Multimedia
    Subject code 400
    Publishing date 2023-12-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Panel Transitions for Genre Analysis in Visual Narratives

    Chen, Yi-Chun / Jhala, Arnav

    2023  

    Abstract: Understanding how humans communicate and perceive narratives is important for media technology research and development. This is particularly important in current times when there are tools and algorithms that are easily available for amateur users to ... ...

    Abstract Understanding how humans communicate and perceive narratives is important for media technology research and development. This is particularly important in current times when there are tools and algorithms that are easily available for amateur users to create high-quality content. Narrative media develops over time a set of recognizable patterns of features across similar artifacts. Genre is one such grouping of artifacts for narrative media with similar patterns, tropes, and story structures. While much work has been done on genre-based classifications in text and video, we present a novel approach to do a multi-modal analysis of genre based on comics and manga-style visual narratives. We present a systematic feature analysis of an annotated dataset that includes a variety of western and eastern visual books with annotations for high-level narrative patterns. We then present a detailed analysis of the contributions of high-level features to genre classification for this medium. We highlight some of the limitations and challenges of our existing computational approaches in modeling subjective labels. Our contributions to the community are: a dataset of annotated manga books, a multi-modal analysis of visual panels and text in a constrained and popular medium through high-level features, and a systematic process for incorporating subjective narrative patterns in computational models.
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Multimedia
    Subject code 004
    Publishing date 2023-12-14
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Online: A Customizable Generator for Comic-Style Visual Narrative

    Chen, Yi-Chun / Jhala, Arnav

    2023  

    Abstract: We present a theory-inspired visual narrative generator that incorporates comic-authoring idioms, which transfers the conceptual principles of comics into system layers that integrate the theories to create comic content. The generator creates comics ... ...

    Abstract We present a theory-inspired visual narrative generator that incorporates comic-authoring idioms, which transfers the conceptual principles of comics into system layers that integrate the theories to create comic content. The generator creates comics through sequential decision-making across layers from panel composition, object positions, panel transitions, and narrative elements. Each layer's decisions are based on narrative goals and follow the respective layer idioms of the medium. Cohn's narrative grammar provides the overall story arc. Photographic compositions inspired by the rule of thirds is used to provide panel compositions. McCloud's proposed panel transitions based on focus shifts between scene, character, and temporal changes are encoded in the transition layer. Finally, common overlay symbols (such as the exclamation) are added based on analyzing action verbs using an action-verb ontology. We demonstrate the variety of generated comics through various settings with example outputs. The generator and associated modules could be a useful system for visual narrative authoring and for further research into computational models of visual narrative understanding.
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Human-Computer Interaction
    Publishing date 2023-12-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Preparation and optimization of WPU dispersion from polyether/polyester polyols for film and coating applications

    Liao, Yi-Han / Chen, Yi-Chun

    Journal of the Taiwan Institute of Chemical Engineers. 2023 Apr., v. 145, p. 104832

    2023  , Page(s) 104832

    Abstract: Castor oil and polytetramethylene ether glycol (PTMG) are used as polyester and polyether polyols. The waterborne polyurethane (WPU) resin is synthesized from polyether/polyester polyols following a ketone and catalyst-free pre-polymerization process. ... ...

    Abstract Castor oil and polytetramethylene ether glycol (PTMG) are used as polyester and polyether polyols. The waterborne polyurethane (WPU) resin is synthesized from polyether/polyester polyols following a ketone and catalyst-free pre-polymerization process. WPU resins are prepared from PTMG/castor oil with various hydroxyl molar ratios, such as 1/0, 3/1, 1/1, 1/3, and 0/1. The results indicate that the WPU dispersions has a long shelf-life, high colloidal stability, and narrow distribution of molecular size. The addition of castor oil can increase the proportion of the cross-linking density, hard segments and hydrogen bonds of the WPU molecular chain. The addition of PTMG/castor oil increases from the molar ratio 1/0 to 1/1, the tensile strength of WPU film increases from 17.1 MPa to 25.6 MPa; the T₅% increases from 250°C to 262°C; the water swelling ratio at 24 h decreases from 33.2 g/g to 19.4 g/g. The results indicate the using PTMG/castor oil can improve the mechanical strength, water resistance, and thermal stability of WPU film. The WPU could be applied to wood coatings with high properties. This study provides a cleaner process for optimizing the performance of WPU resin, which can replace conventional ketone- and organotin-based films and coatings.
    Keywords castor oil ; crosslinking ; hydrogen ; molecular weight ; polyesters ; polyols ; polyurethanes ; shelf life ; tensile strength ; thermal stability ; Taiwan ; Cleaner process ; Colloidal stability, Pre-polymerization, Waterborne polyurethane
    Language English
    Dates of publication 2023-04
    Size p. 104832
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ISSN 1876-1070
    DOI 10.1016/j.jtice.2023.104832
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Renal and survival benefits of seventeen prescribed Chinese herbal medicines against oxidative-inflammatory stress in systemic lupus erythematosus patients with chronic kidney disease: a real-world longitudinal study.

    Chen, Hsiao-Tien / Tung, Chien-Hsueh / Yu, Ben-Hui / Chang, Ching-Mao / Chen, Yi-Chun

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1309582

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1309582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death.

    Chen, Yi-Chun / Lutkewitte, Andrew J / Basavarajappa, Halesha D / Fueger, Patrick T

    Metabolites

    2023  Volume 13, Issue 5

    Abstract: A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely ... ...

    Abstract A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely failed to achieve robust clinical success. The molecular mechanisms preventing the activation of mitogenic signaling pathways from maintaining functional beta cell mass during the development of T2D remain unknown. We speculated that endogenous negative effectors of mitogenic signaling cascades impede beta cell survival/expansion. Thus, we tested the hypothesis that a stress-inducible epidermal growth factor receptor (EGFR) inhibitor, mitogen-inducible gene 6 (Mig6), regulates beta cell fate in a T2D milieu. To this end, we determined that: (1) glucolipotoxicity (GLT) induces Mig6, thereby blunting EGFR signaling cascades, and (2) Mig6 mediates molecular events regulating beta cell survival/death. We discovered that GLT impairs EGFR activation, and Mig6 is elevated in human islets from T2D donors as well as GLT-treated rodent islets and 832/13 INS-1 beta cells. Mig6 is essential for GLT-induced EGFR desensitization, as Mig6 suppression rescued the GLT-impaired EGFR and ERK1/2 activation. Further, Mig6 mediated EGFR but not insulin-like growth factor-1 receptor nor hepatocyte growth factor receptor activity in beta cells. Finally, we identified that elevated Mig6 augmented beta cell apoptosis, as Mig6 suppression reduced apoptosis during GLT. In conclusion, we established that T2D and GLT induce Mig6 in beta cells; the elevated Mig6 desensitizes EGFR signaling and induces beta cell death, suggesting Mig6 could be a novel therapeutic target for T2D.
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13050627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of COVID-19 Outbreak on Influenza and Pneumococcal Vaccination Uptake: A Multi-Center Retrospective Study.

    Lan, Chieh / Chen, Yi-Chun / Chang, Ye-In / Chuang, Po-Chun

    Vaccines

    2023  Volume 11, Issue 5

    Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, global vaccination efforts declined due to the burden on health systems and community resistance to epidemic control measures. Influenza and pneumococcal vaccines have been recommended for ... ...

    Abstract During the coronavirus disease 2019 (COVID-19) pandemic, global vaccination efforts declined due to the burden on health systems and community resistance to epidemic control measures. Influenza and pneumococcal vaccines have been recommended for vulnerable populations to prevent severe pneumonia. We investigated community response towards influenza and pneumococcal vaccines (pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine) after the COVID-19 outbreak in Taiwan. We retrospectively included adults who visited Chang Gung Memorial Hospital (CGMH) institutions for influenza or pneumococcal vaccination from January 2018 to December 2021. The first case of COVID-19 in Taiwan was detected in January 2020; therefore, in this study, hospitalized cases from January 2018 to December 2019 were defined as "before COVID-19 outbreak," and hospitalized cases from January 2020 to December 2021 were defined as "after COVID-19 outbreak". A total of 105,386 adults were enrolled in the study. An increase in influenza vaccination (
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11050986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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