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  1. Article ; Online: Treatment of uveitis following tattoo: A case report.

    Chen, Yi-Xuan / Jiang, Yuan-Yuan / Wang, Xiang-Li / Liu, Qin

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-05-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.05.049
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Inhibition of acid sensing ion channels by eugenol in rat trigeminal ganglion neurons.

    Mao, Xiao-Li / Chen, Yi-Xuan / Yu, Huan / Yang, Quan-Wei

    Neuroscience letters

    2023  Volume 803, Page(s) 137192

    Abstract: Eugenol is widely used as an analgesic in the dental treatment. The underlying mechanisms may involve its modulation of various ion channels. Acid-sensing ion channels (ASICs) are pH sensors and expressed in trigeminal ganglion (TG) neurons. In the ... ...

    Abstract Eugenol is widely used as an analgesic in the dental treatment. The underlying mechanisms may involve its modulation of various ion channels. Acid-sensing ion channels (ASICs) are pH sensors and expressed in trigeminal ganglion (TG) neurons. In the present study, we found that eugenol concentration-dependently inhibited ASIC currents in TG neurons with an IC
    MeSH term(s) Rats ; Animals ; Cricetinae ; Acid Sensing Ion Channels ; Eugenol/pharmacology ; CHO Cells ; Trigeminal Ganglion ; Cricetulus ; Neurons ; Analgesics/pharmacology ; Hydrogen-Ion Concentration
    Chemical Substances Acid Sensing Ion Channels ; Eugenol (3T8H1794QW) ; Analgesics
    Language English
    Publishing date 2023-03-15
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2023.137192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Ultra-low switching reverse mode liquid crystal gels.

    Chen, Yi-Xuan / Hsu, Jy-Shan

    Optics express

    2020  Volume 28, Issue 18, Page(s) 26783–26791

    Abstract: This research investigates the electro-optical properties of reverse mode liquid crystal gel (LC-gel) scattering films. The LC-gel has been fabricated through the fibrous self-assembly of the gelator 12-hydroxydodecanoic acid (G12) and mesogen monomer ( ... ...

    Abstract This research investigates the electro-optical properties of reverse mode liquid crystal gel (LC-gel) scattering films. The LC-gel has been fabricated through the fibrous self-assembly of the gelator 12-hydroxydodecanoic acid (G12) and mesogen monomer (RM257) in nematic LC HTW106700-100 (HTW). Adding RM257 monomer improves the transparency in the OFF state and enhances scattering effects in the ON state. Moreover, an extremely low switching voltage (∼ 1 V) is demonstrated.
    Language English
    Publishing date 2020-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.402338
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  4. Article: Down-regulation of histone deacetylase 7 reduces biological activities of retinal microvascular endothelial cells under high glucose condition and related mechanism.

    Ning, Jia-Yi / Yang, Han-Yi / Xie, Ting-Ke / Chen, Yi-Xuan / Han, Jing

    International journal of ophthalmology

    2023  Volume 16, Issue 8, Page(s) 1210–1217

    Abstract: Aim: To investigate the expression and effect of histone deacetylase 7 (HDAC7) in human retinal microvascular endothelial cells (HRMECs) under high glucose condition and related mechanism, and the expression of HDAC7 in the retinal tissue in diabetic ... ...

    Abstract Aim: To investigate the expression and effect of histone deacetylase 7 (HDAC7) in human retinal microvascular endothelial cells (HRMECs) under high glucose condition and related mechanism, and the expression of HDAC7 in the retinal tissue in diabetic rats.
    Methods: The expression of HDAC7 in HRMECs under high glucose and the retinal tissue from normal or diabetic rats were detected with immunohistochemistry and Western blot. LV-shHDAC7 HRMECs were used to study the effect of HDAC7 on cell activities. Cell count kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), flow cytometry, scratch test, Transwell test and tube formation assay were used to examine the ability of cell proliferation, migration, and angiogenesis. Finally, a preliminary exploration of its mechanism was performed by Western blot.
    Results: The expression of HDAC7 was both up-regulated in retinal tissues of diabetic rats and high glucose-treated HRMECs. Down-regulation of HDAC7 expression significantly reduced the ability of proliferation, migration, and tube formation, and reversed the high glucose-induced high expression of CDK1/Cyclin B1 and vascular endothelial growth factor in high glucose-treated HRMECs.
    Conclusion: High glucose can up-regulate the expression of HDAC7 in HRMECs. Down-regulation of HDAC7 can inhibit HRMECs activities. HDAC7 is proposed to be involved in pathogenesis of diabetic retinopathy and a therapeutic target.
    Language English
    Publishing date 2023-08-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2023.08.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Visible-light-driven oxidation of organosilanes by a charge-transfer complex.

    Chen, Yi-Xuan / He, Jun-Tao / Wu, Mei-Chun / Liu, Zhi-Lin / Xia, Peng-Ju / Chen, Kai / Xiang, Hao-Yue / Yang, Hua

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 43, Page(s) 6588–6591

    Abstract: Direct oxidation of organosilanes is one of the most straightforward ways to access silanols. Herein, we describe a novel photo-induced strategy for oxidation of organosilanes to access silanols, promoted by a photoactive charge-transfer complex (CTC) ... ...

    Abstract Direct oxidation of organosilanes is one of the most straightforward ways to access silanols. Herein, we describe a novel photo-induced strategy for oxidation of organosilanes to access silanols, promoted by a photoactive charge-transfer complex (CTC) between sodium benzenesulfinate and molecular O
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01972a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterization the prognosis role and effects of snoRNAs in melanoma patients.

    Wang, Lei-Yun / Song, Jia-Nan / Chen, Yi-Xuan / Zhu, Ying / Ren, Hui-Li / Li, Qiu-Qi / Zhang, Shao-Hui

    Experimental dermatology

    2023  Volume 33, Issue 1, Page(s) e14944

    Abstract: Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable ... ...

    Abstract Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable diagnostic and prognostic markers is crucial for improving patient outcomes. In the search for biomarkers, various types of RNAs have been discovered and recognized as reliable prognostic markers. Among these, small nucleolar RNAs (snoRNAs) have emerged as a promising avenue for studying early diagnosis and prognostic markers in tumours due to their widespread presence in tissues, tumour specificity and stability. In our study, we analysed snoRNAs data from melanoma samples in the TCGA-SKCM cohort and developed a prognostic model comprising 12 snoRNAs (SNORD9, SNORA31, SNORD14E, SNORA14A, SNORA5A, SNORD83A, SNORA75, AL096855, AC007684, SNORD14A, SNORA65 and AC004839). This model exhibited unique prognostic accuracy and demonstrated a significant correlation with the immune infiltration tumour microenvironment. Additionally, analysis of the GSE213145 dataset, which explored the sensitivity and resistance of immune checkpoint inhibitors, further supported the potential of snoRNAs as prognostic markers for immunotherapy. Overall, our study contributes reliable prognostic and immune-related biomarkers for melanoma patients. These findings can offer valuable insights for the future discovery of novel melanoma treatment strategies and hold promise for improving clinical outcomes in melanoma patients.
    MeSH term(s) Humans ; Melanoma/genetics ; RNA, Small Nucleolar/genetics ; Prognosis ; Skin Neoplasms/genetics ; Biomarkers ; Tumor Microenvironment
    Chemical Substances RNA, Small Nucleolar ; Biomarkers
    Language English
    Publishing date 2023-09-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14944
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Idiopathic hypophosphatemic osteomalacia: recurrent pseudofracture of the proximal femur in a 65-year-old man.

    Chen, Yi-Xuan / Gao, You-Shui

    Endocrine

    2017  Volume 55, Issue 2, Page(s) 651–652

    MeSH term(s) Aged ; Calcitriol/therapeutic use ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/drug therapy ; Femoral Fractures/etiology ; Humans ; Hypophosphatemia/complications ; Hypophosphatemia/diagnostic imaging ; Hypophosphatemia/drug therapy ; Male ; Osteomalacia/complications ; Osteomalacia/diagnostic imaging ; Osteomalacia/drug therapy ; Phosphates/therapeutic use ; Treatment Outcome
    Chemical Substances Phosphates ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-016-1205-1
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    Zs.A 3884: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF

    Chen, Yi-Xuan / Wang, Zhu-Jun / Xiao, Jun-An / Chen, Kai / Xiang, Hao-Yue / Yang, Hua

    Organic letters

    2021  Volume 23, Issue 16, Page(s) 6558–6562

    Abstract: Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex ... ...

    Abstract Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D
    Language English
    Publishing date 2021-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.1c02365
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  9. Article: Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF₃-Substituted Tertiary Alcohol

    Chen, Yi-Xuan / Wang, Zhu-Jun / Xiao, Jun-An / Chen, Kai / Xiang, Hao-Yue / Yang, Hua

    Organic letters. 2021 Aug. 03, v. 23, no. 16

    2021  

    Abstract: Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex ... ...

    Abstract Reported herein is a visible-light-induced sulfonation of α-trifluoromethylstyrenes with sodium sulfinates, which provides a series of α-trifluoromethyl-β-sulfonyl tertiary alcohols. This new synthetic protocol is enabled by a charge-transfer complex between oxygen and sulfinates, featuring broad substrate scope and scalability. Excellent functional group compatibility and chemoselectivity render this method suitable for sulfonation of pharmaceutically relevant molecules. In the presence of D₂O, deuteriotrifluorinated products were also obtained, further demonstrating the flexibility and synthetic potentials of this strategy.
    Keywords alcohols ; chemoselectivity ; oxygen ; sodium
    Language English
    Dates of publication 2021-0803
    Size p. 6558-6562.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.1c02365
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis.

    Zhu, Daoyu / Fang, Haoyu / Yu, Hongping / Liu, Pei / Yang, Qianhao / Luo, Pengbo / Zhang, Changqing / Gao, Youshui / Chen, Yi-Xuan

    Bone & joint research

    2022  Volume 11, Issue 6, Page(s) 386–397

    Abstract: Aims: Alcoholism is a well-known detrimental factor in fracture healing. However, the underlying mechanism of alcohol-inhibited fracture healing remains poorly understood.: Methods: MicroRNA (miR) sequencing was performed on bone mesenchymal stem ... ...

    Abstract Aims: Alcoholism is a well-known detrimental factor in fracture healing. However, the underlying mechanism of alcohol-inhibited fracture healing remains poorly understood.
    Methods: MicroRNA (miR) sequencing was performed on bone mesenchymal stem cells (BMSCs). The effects of alcohol and miR-19a-3p on vascularization and osteogenic differentiation were analyzed in vitro using BMSCs and human umbilical vein endothelial cells (HUVECs). An in vivo alcohol-fed mouse model of femur fracture healing was also established, and radiological and histomorphometric analyses were used to evaluate the role of miR-19a-3p. The binding of miR-19a-3p to forkhead box F2 (FOXF2) was analyzed using a luciferase reporter assay.
    Results: miR-19a-3p was identified as one of the key regulators in the osteogenic differentiation of BMSCs, and was found to be downregulated in the alcohol-fed mouse model of fracture healing. In vitro, miR-19a-3p expression was downregulated after ethanol administration in both BMSCs and HUVECs. Vascularization and osteogenic differentiation were independently suppressed by ethanol and reversed by miR-19a-3p. In addition, the luciferase reporter assay showed that FOXF2 is the direct binding target of miR-19a-3p. In vivo, miR-19a-3p agomir stimulated callus transformation and improved the alcohol-impaired fracture healing.
    Conclusion: This study is the first to demonstrate that the miR-19a-3p/FOXF2 axis has a pivotal role in alcohol-impaired fracture healing, and may be a potential therapeutic target. Cite this article:
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.116.BJR-2021-0596.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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