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Article ; Online: Cesarean Delivery and Insulin Sensitivity in the Older Adult: The Microbiome and Insulin Longitudinal Evaluation Study.

Jensen, Elizabeth T / Bertoni, Alain G / Crago, Osa L / Rotter, Jerome I / Chen, Yii-Der I / Wood, Alexis / Rich, Stephen S / Goodarzi, Mark O

Journal of the Endocrine Society

2022 Volume 6, Issue 7, Page(s) bvac072

Abstract: The present study was designed to evaluate if mode of delivery at birth is associated with body mass index (BMI) and glucose homeostasis traits in later life, controlling for possible confounders, including maternal history of diabetes. Data were ... ...

Abstract	The present study was designed to evaluate if mode of delivery at birth is associated with body mass index (BMI) and glucose homeostasis traits in later life, controlling for possible confounders, including maternal history of diabetes. Data were obtained through a racially diverse, prospective cohort study of nondiabetic, older adults, the Microbiome and Insulin Longitudinal Evaluation Study (MILES). We used generalized linear models to estimate the association between mode of delivery and glycemic status, BMI (kg/m
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvac072
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Article ; Online: Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines.

Theusch, Elizabeth / Chen, Yii-Der I / Rotter, Jerome I / Krauss, Ronald M / Medina, Marisa W

BMC genomics

2020 Volume 21, Issue 1, Page(s) 555

Abstract: Background: Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Though statins reduce cardiovascular disease risk overall, statin efficacy varies, and some people experience adverse side effects while on statin ... ...

Abstract	Background: Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Though statins reduce cardiovascular disease risk overall, statin efficacy varies, and some people experience adverse side effects while on statin treatment. Statins also have pleiotropic effects not directly related to their cholesterol-lowering properties, but the mechanisms are not well understood. To identify potential genetic modulators of clinical statin response, we looked for genetic variants associated with statin-induced changes in gene expression (differential eQTLs or deQTLs) in lymphoblastoid cell lines (LCLs) derived from participants of the Cholesterol and Pharmacogenetics (CAP) 40 mg/day 6-week simvastatin clinical trial. We exposed CAP LCLs to 2 μM simvastatin or control buffer for 24 h and performed polyA-selected, strand-specific RNA-seq. Statin-induced changes in gene expression from 259 European ancestry or 153 African American ancestry LCLs were adjusted for potential confounders prior to association with genotyped and imputed genetic variants within 1 Mb of each gene's transcription start site. Results: From the deQTL meta-analysis of the two ancestral populations, we identified significant cis-deQTLs for 15 genes (TBC1D4, MDGA1, CHI3L2, OAS1, GATM, ASNSD1, GLUL, TDRD12, PPIP5K2, OAS3, SERPINB1, ANKDD1A, DTD1, CYFIP2, and GSDME), eight of which were significant in at least one of the ancestry subsets alone. We also conducted eQTL analyses of the endogenous (control-treated), statin-treated, and average of endogenous and statin-treated LCL gene expression levels. We identified eQTLs for approximately 6000 genes in each of the three (endogenous, statin-treated, and average) eQTL meta-analyses, with smaller numbers identified in the ancestral subsets alone. Conclusions: Several of the genes in which we identified deQTLs have functions in human health and disease, such as defense from viruses, glucose regulation, and response to chemotherapy drugs. This suggests that DNA variation may play a role in statin effects on various health outcomes. These findings could prove useful to future studies aiming to assess benefit versus risk of statin treatment using individual genetic profiles.
MeSH term(s)	Cell Line ; Chitinases ; Cholesterol ; Gene Expression ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Phosphotransferases (Phosphate Group Acceptor) ; Serpins ; Simvastatin/pharmacology
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Serpins ; SERPINB1 protein, human (147416-07-7) ; Cholesterol (97C5T2UQ7J) ; Simvastatin (AGG2FN16EV) ; Phosphotransferases (Phosphate Group Acceptor) (EC 2.7.4.-) ; PPIP5K2 protein, human (EC 2.7.4.24) ; CHI3L2 protein, human (EC 3.2.1.14) ; Chitinases (EC 3.2.1.14)
Language	English
Publishing date	2020-08-12
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-020-06966-4
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Article ; Online: Increased Plasma Branched Short-Chain Fatty Acids and Improved Glucose Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Aslamy, Arianne / Wood, Alexis C / Jensen, Elizabeth T / Bertoni, Alain G / Sheridan, Patricia A / Wong, Kari E / Ramesh, Gautam / Rotter, Jerome I / Chen, Yii-Der I / Goodarzi, Mark O

Diabetes

2023 Volume 73, Issue 3, Page(s) 385–390

MeSH term(s)	Humans ; Insulin/metabolism ; Blood Glucose/metabolism ; Glucose/metabolism ; Insulin Resistance ; Prediabetic State/metabolism ; Insulin, Regular, Human ; Fatty Acids, Volatile ; Microbiota ; Homeostasis ; Diabetes Mellitus, Type 2/metabolism
Chemical Substances	Insulin ; Blood Glucose ; Glucose (IY9XDZ35W2) ; Insulin, Regular, Human ; Fatty Acids, Volatile
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db23-0401
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Article: Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Wood, Alexis C / Jensen, Elizabeth T / Bertoni, Alain G / Ramesh, Gautam / Rich, Stephen S / Rotter, Jerome I / Chen, Yii-Der I / Goodarzi, Mark O

Metabolites

2021 Volume 11, Issue 7

Abstract: Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while ... ...

Abstract	Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while simultaneously examining decreased insulin sensitivity and secretion. The goal of this study was to conduct such an investigation in a cohort of 353 non-Hispanic White and African American individuals recruited in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). Participants underwent oral glucose tolerance tests from which insulin sensitivity, insulin secretion, insulin clearance, and disposition index were calculated. Regression models examined the individual and joint contributions of these traits to early dysglycemia (prediabetes or newly diagnosed diabetes). In separate models, reduced insulin sensitivity, reduced disposition index, and reduced insulin clearance were associated with dysglycemia. In a joint model, only insulin resistance and reduced insulin secretion were associated with dysglycemia. Models with insulin sensitivity, disposition index, or three insulin traits had the highest discriminative value for dysglycemia (area under the receiver operating characteristics curve of 0.82 to 0.89). These results suggest that in the race groups studied, insulin resistance and compromised insulin secretion are the main independent underlying defects leading to early dysglycemia.
Language	English
Publishing date	2021-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11070420
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Article: Associations between adherence to the dietary approaches to stop hypertension (DASH) diet and six glucose homeostasis traits in the Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Ramesh, Gautam / Wood, Alexis C. / Allison, Matthew A. / Rich, Stephen S. / Jensen, Elizabeth T. / Chen, Yii-Der I. / Rotter, Jerome I. / Bertoni, Alain G. / Goodarzi, Mark O.

The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University Nutrition, metabolism, and cardiovascular diseases. 2022 Mar. 14,

2022

Abstract: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH ...

Abstract	The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH diet and six glucose homeostasis traits, probing whether associations could be attributed to the plant-based (DASH-P) and/or non-plant based (DASH-NP) components. We included data from 295 adults without T2D (age 59.3 ± 9.00 years; 63.46% non-Hispanic White and 36.54% African American, self-reported race ancestry) participating in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). An oral glucose tolerance test (OGTT) yielded fasting plasma glucose, insulin, C-peptide, and insulin secretion, sensitivity, and disposition index. Habitual dietary intake was assessed by food frequency questionnaire (FFQ). Associations between DASH components and glucose homeostasis traits were examined, controlling for demographics, body mass index (BMI), physical activity, and energy intake. For significant associations, the models were repeated with scores for DASH-P and DASH-NP as predictors in the same model. DASH and DASH-P scores were inversely associated with fasting plasma glucose (DASH:β = −0.036 ± 0.012,P = 0.005; DASH-P: β = −0.04 ± 0.017,P = 0.002), and positively associated with insulin sensitivity (DASH:β = 0.022 ± 0.012,P = 0.042; DASH-P: = 0.036 ± 0.015,P = 0.014). The DASH score was also associated with disposition index (β = 0.026 ± 0.013,P = 0.038), but this association did not reach significance with DASH-P (β = 0.035 ± 0.018,P = 0.051). No associations were observed with DASH-NP score (all P > 0.05). DASH diet is associated with improvement in specific glucose homeostasis traits, likely arising from increased plant-based foods. Such research may help tailor future dietary advice to specific metabolic risk, and to food groups most effective at improving these.
Keywords	Dietary Approaches to Stop Hypertension diet ; ancestry ; blood glucose ; body mass index ; c-peptide ; demographic statistics ; energy intake ; food frequency questionnaires ; food intake ; glucose ; glucose tolerance tests ; homeostasis ; hypertension ; insulin resistance ; insulin secretion ; metabolism ; microbiome ; models ; noninsulin-dependent diabetes mellitus ; physical activity ; risk
Language	English
Dates of publication	2022-0314
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2022.03.014
Database	NAL-Catalogue (AGRICOLA)

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Article: Participant-derived cell line transcriptomic analyses and mouse studies reveal a role for ZNF335 in plasma cholesterol statin response.

Theusch, Elizabeth / Ting, Flora Y / Qin, Yuanyuan / Stevens, Kristen / Naidoo, Devesh / King, Sarah M / Yang, Neil / Orr, Joseph / Han, Brenda Y / Cyster, Jason G / Chen, Yii-Der I / Rotter, Jerome I / Krauss, Ronald M / Medina, Marisa W

bioRxiv : the preprint server for biology

2023

Abstract: Background: Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that remains ... ...

Abstract	Background: Statins lower circulating low-density lipoprotein cholesterol (LDLC) levels and reduce cardiovascular disease risk. Though highly efficacious in general, there is considerable inter-individual variation in statin efficacy that remains largely unexplained. Methods: To identify novel genes that may modulate statin-induced LDLC lowering, we used RNA-sequencing data from 426 control- and 2 μM simvastatin-treated lymphoblastoid cell lines (LCLs) derived from European and African American ancestry participants of the Cholesterol and Pharmacogenetics (CAP) 40 mg/day 6-week simvastatin clinical trial (ClinicalTrials.gov Identifier: NCT00451828). We correlated statin-induced changes in LCL gene expression with plasma LDLC statin response in the corresponding CAP participants. For the most correlated gene identified ( Results: The statin-induced expression changes of 147 human LCL genes were significantly correlated to the plasma LDLC statin responses of the corresponding CAP participants Conclusions: Our
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.14.544860
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Article ; Online: Associations between adherence to the dietary approaches to stop hypertension (DASH) diet and six glucose homeostasis traits in the Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Ramesh, Gautam / Wood, Alexis C / Allison, Matthew A / Rich, Stephen S / Jensen, Elizabeth T / Chen, Yii-Der I / Rotter, Jerome I / Bertoni, Alain G / Goodarzi, Mark O

Nutrition, metabolism, and cardiovascular diseases : NMCD

2022 Volume 32, Issue 6, Page(s) 1418–1426

Abstract: Background and aims: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations ... ...

Abstract	Background and aims: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH diet and six glucose homeostasis traits, probing whether associations could be attributed to the plant-based (DASH-P) and/or non-plant based (DASH-NP) components. Methods and results: We included data from 295 adults without T2D (age 59.3 ± 9.00 years; 63.46% non-Hispanic White and 36.54% African American, self-reported race ancestry) participating in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). An oral glucose tolerance test (OGTT) yielded fasting plasma glucose, insulin, C-peptide, and insulin secretion, sensitivity, and disposition index. Habitual dietary intake was assessed by food frequency questionnaire (FFQ). Associations between DASH components and glucose homeostasis traits were examined, controlling for demographics, body mass index (BMI), physical activity, and energy intake. For significant associations, the models were repeated with scores for DASH-P and DASH-NP as predictors in the same model. DASH and DASH-P scores were inversely associated with fasting plasma glucose (DASH:β = -0.036 ± 0.012,P = 0.005; DASH-P: β = -0.04 ± 0.017,P = 0.002), and positively associated with insulin sensitivity (DASH:β = 0.022 ± 0.012,P = 0.042; DASH-P: = 0.036 ± 0.015,P = 0.014). The DASH score was also associated with disposition index (β = 0.026 ± 0.013,P = 0.038), but this association did not reach significance with DASH-P (β = 0.035 ± 0.018,P = 0.051). No associations were observed with DASH-NP score (all P > 0.05). Conclusions: DASH diet is associated with improvement in specific glucose homeostasis traits, likely arising from increased plant-based foods. Such research may help tailor future dietary advice to specific metabolic risk, and to food groups most effective at improving these.
MeSH term(s)	Adult ; Aged ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/prevention & control ; Diet ; Dietary Approaches To Stop Hypertension/methods ; Homeostasis ; Humans ; Hypertension ; Insulin/metabolism ; Microbiota ; Middle Aged
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2022-03-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2022.03.014
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Article ; Online: Physical Activity Associations with Bone Mineral Density and Modification by Metabolic Traits.

Buttan, Anshu / Cui, Jinrui / Guo, Xiuqing / Chen, Yii-Der I / Hsueh, Willa A / Rotter, Jerome I / Goodarzi, Mark O

Journal of the Endocrine Society

2020 Volume 4, Issue 8, Page(s) bvaa092

Abstract: Objective: To assess the relationship of physical activity with bone mineral density (BMD) at various sites and examine potential modifying metabolic factors.: Methods: Responses from physical activity questionnaires were used to determine total ... ...

Abstract	Objective: To assess the relationship of physical activity with bone mineral density (BMD) at various sites and examine potential modifying metabolic factors. Methods: Responses from physical activity questionnaires were used to determine total physical activity (PA), moderate physical activity (mod-PA), and sedentary time. Regression analyses were performed to evaluate association of activity traits with insulin sensitivity by euglycemic clamp, adiponectin, C-reactive protein (CRP), and plasminogen activator inhibitor-1 (PAI-1) in 741 healthy subjects. Results: The cohort was relatively sedentary. Activity level was associated with arm, pelvis, and leg BMD in univariate analyses. In multivariate association analyses of arm BMD, only female sex (β = -0.73, Conclusions: These results suggest that BMD increases with physical activity in the arms, legs, and pelvis and is inversely related to sedentary time in the pelvis and legs; these associations may be modified by age, sex, BMI, and adiponectin, depending on the site, with physical activity being more important to pelvis and leg BMD than arm BMD and sedentary time being important for pelvis BMD. Moreover, we demonstrated that CRP, PAI-1, and insulin sensitivity play a minor role in BMD.
Language	English
Publishing date	2020-07-07
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvaa092
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Article ; Online: Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES).

Cui, Jinrui / Ramesh, Gautam / Wu, Martin / Jensen, Elizabeth T / Crago, Osa / Bertoni, Alain G / Gao, Chunxu / Hoffman, Kristi L / Sheridan, Patricia A / Wong, Kari E / Wood, Alexis C / Chen, Yii-Der I / Rotter, Jerome I / Petrosino, Joseph F / Rich, Stephen S / Goodarzi, Mark O

Diabetes

2022 Volume 71, Issue 11, Page(s) 2438–2446

Abstract: Gut microbiome studies have documented depletion of butyrate-producing taxa in type 2 diabetes. We analyzed associations between butyrate-producing taxa and detailed measures of insulin homeostasis, whose dysfunction underlies diabetes in 224 non- ... ...

Abstract	Gut microbiome studies have documented depletion of butyrate-producing taxa in type 2 diabetes. We analyzed associations between butyrate-producing taxa and detailed measures of insulin homeostasis, whose dysfunction underlies diabetes in 224 non-Hispanic Whites and 129 African Americans, all of whom completed an oral glucose tolerance test. Stool microbiome was assessed by whole-metagenome shotgun sequencing with taxonomic profiling. We examined associations among 36 butyrate-producing taxa (n = 7 genera and 29 species) and insulin sensitivity, insulin secretion, disposition index, insulin clearance, and prevalence of dysglycemia (prediabetes plus diabetes, 46% of cohort), adjusting for age, sex, BMI, and race. The genus Coprococcus was associated with higher insulin sensitivity (β = 0.14; P = 0.002) and disposition index (β = 0.12; P = 0.012) and a lower rate of dysglycemia (odds ratio [OR] 0.91; 95% CI 0.85-0.97; P = 0.0025). In contrast, Flavonifractor was associated with lower insulin sensitivity (β = -0.13; P = 0.004) and disposition index (β = -0.11; P = 0.04) and higher prevalence of dysglycemia (OR 1.22; 95% CI 1.08-1.38; P = 0.0013). Species-level analyses found 10 bacteria associated with beneficial directions of effects and two bacteria with adverse associations on insulin homeostasis and dysglycemia. Although most butyrate producers analyzed appear to be metabolically beneficial, this is not the case for all such bacteria, suggesting that microbiome-directed therapeutic measures to prevent or treat diabetes should be targeted to specific butyrate-producing taxa rather than all butyrate producers.
MeSH term(s)	Humans ; Insulin ; Insulin Resistance ; Diabetes Mellitus, Type 2 ; Blood Glucose/analysis ; Insulin, Regular, Human ; Homeostasis ; Microbiota ; Butyrates
Chemical Substances	Insulin ; Blood Glucose ; Insulin, Regular, Human ; Butyrates
Language	English
Publishing date	2022-07-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db22-0168
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Article ; Online: Multi-omics analysis identifies CpGs near G6PC2 mediating the effects of genetic variants on fasting glucose.

Chung, Ren-Hua / Chiu, Yen-Feng / Wang, Wen-Chang / Hwu, Chii-Min / Hung, Yi-Jen / Lee, I-Te / Chuang, Lee-Ming / Quertermous, Thomas / Rotter, Jerome I / Chen, Yii-Der I / Chang, I-Shou / Hsiung, Chao A

Diabetologia

2021 Volume 64, Issue 7, Page(s) 1613–1625

Abstract: Aims/hypothesis: An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in ... ...

Abstract	Aims/hypothesis: An elevated fasting glucose level in non-diabetic individuals is a key predictor of type 2 diabetes. Genome-wide association studies (GWAS) have identified hundreds of SNPs for fasting glucose but most of their functional roles in influencing the trait are unclear. This study aimed to identify the mediation effects of DNA methylation between SNPs identified as significant from GWAS and fasting glucose using Mendelian randomisation (MR) analyses. Methods: We first performed GWAS analyses for three cohorts (Taiwan Biobank with 18,122 individuals, the Healthy Aging Longitudinal Study in Taiwan with 1989 individuals and the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance with 416 individuals) with individuals of Han Chinese ancestry in Taiwan, followed by a meta-analysis for combining the three GWAS analysis results to identify significant and independent SNPs for fasting glucose. We determined whether these SNPs were methylation quantitative trait loci (meQTLs) by testing their associations with DNA methylation levels at nearby CpG sites using a subsample of 1775 individuals from the Taiwan Biobank. The MR analysis was performed to identify DNA methylation with causal effects on fasting glucose using meQTLs as instrumental variables based on the 1775 individuals. We also used a two-sample MR strategy to perform replication analysis for CpG sites with significant MR effects based on literature data. Results: Our meta-analysis identified 18 significant (p < 5 × 10 Conclusions/interpretation: Our analysis results suggest that rs2232326 and rs2232328 in G6PC2 may affect DNA methylation at CpGs near the gene and that the methylation may have downstream effects on fasting glucose. Therefore, SNPs in G6PC2 and CpGs near G6PC2 may reside along the pathway that influences fasting glucose levels. This is the first study to report CpGs near G6PC2, an important gene for regulating insulin secretion, mediating the effects of GWAS-significant SNPs on fasting glucose.
MeSH term(s)	Blood Glucose/genetics ; Cohort Studies ; CpG Islands/genetics ; DNA Methylation ; Fasting/blood ; Genome-Wide Association Study ; Genomics/methods ; Glucose-6-Phosphatase/genetics ; Humans ; Longitudinal Studies ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci/genetics ; Taiwan/epidemiology
Chemical Substances	Blood Glucose ; Glucose-6-Phosphatase (EC 3.1.3.9) ; G6PC2 protein, human (EC 3.1.3.9.)
Language	English
Publishing date	2021-04-12
Publishing country	Germany
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-021-05449-9
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