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  1. Article ; Online: Lane Mark Detection with Pre-Aligned Spatial-Temporal Attention.

    Chen, Yiman / Xiang, Zhiyu

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 3

    Abstract: Lane mark detection plays an important role in autonomous driving under structural environments. Many deep learning-based lane mark detection methods have been put forward in recent years. However, most of current methods limit their solutions within one ...

    Abstract Lane mark detection plays an important role in autonomous driving under structural environments. Many deep learning-based lane mark detection methods have been put forward in recent years. However, most of current methods limit their solutions within one single image and do not make use of the de facto successive image input during the driving scene, which may lead to inferior performance in some challenging scenarios such as occlusion, shadows, and lane mark degradation. To address the issue, we propose a novel lane mark detection network which takes pre-aligned multiple successive frames as inputs to produce more stable predictions. A Spatial-Temporal Attention Module (STAM) is designed in the network to adaptively aggregate the feature information of history frames to the current frame. Various structure of the STAM is also studied to ensure the best performance. Experiments on Tusimple and ApolloScape datasets show that our method can effectively improve lane mark detection and achieve state-of-the-art performance.
    MeSH term(s) Automobile Driving ; Research Design
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22030794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Enhancing osteoporosis treatment with engineered mesenchymal stem cell-derived extracellular vesicles: mechanisms and advances.

    Chen, Yiman / Huang, Yuling / Li, Jia / Jiao, Taiwei / Yang, Lina

    Cell death & disease

    2024  Volume 15, Issue 2, Page(s) 119

    Abstract: As societal aging intensifies, the incidence of osteoporosis (OP) continually rises. OP is a skeletal disorder characterized by reduced bone mass, deteriorated bone tissue microstructure, and consequently increased bone fragility and fracture ... ...

    Abstract As societal aging intensifies, the incidence of osteoporosis (OP) continually rises. OP is a skeletal disorder characterized by reduced bone mass, deteriorated bone tissue microstructure, and consequently increased bone fragility and fracture susceptibility, typically evaluated using bone mineral density (BMD) and T-score. Not only does OP diminish patients' quality of life, but it also imposes a substantial economic burden on society. Conventional pharmacological treatments yield limited efficacy and severe adverse reactions. In contemporary academic discourse, mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) have surfaced as auspicious novel therapeutic modalities for OP. EVs can convey information through the cargo they carry and have been demonstrated to be a crucial medium for intercellular communication, playing a significant role in maintaining the homeostasis of the bone microenvironment. Furthermore, various research findings provide evidence that engineered strategies can enhance the therapeutic effects of EVs in OP treatment. While numerous reviews have explored the progress and potential of EVs in treating degenerative bone diseases, research on using EVs to address OP remains in the early stages of basic experimentation. This paper reviews advancements in utilizing MSCs and their derived EVs for OP treatment. It systematically examines the most extensively researched MSC-derived EVs for treating OP, delving not only into the molecular mechanisms of EV-based OP therapy but also conducting a comparative analysis of the strengths and limitations of EVs sourced from various cell origins. Additionally, the paper emphasizes the technical and engineering strategies necessary for leveraging EVs in OP treatment, offering insights and recommendations for future research endeavors.
    MeSH term(s) Humans ; Quality of Life ; Extracellular Vesicles ; Bone and Bones ; Osteoporosis/therapy ; Mesenchymal Stem Cells
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-024-06508-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic potential: The role of mesenchymal stem cells from diverse sources and their derived exosomes in diabetic nephropathy.

    Liu, Lixin / Chen, Yiman / Li, Xuan / Wang, Juan / Yang, Lina

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 175, Page(s) 116672

    Abstract: Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients, with its incidence continuously increasing in recent years. DN causes renal tissue damage and functional decline, expedites the aging process of the ... ...

    Abstract Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetic patients, with its incidence continuously increasing in recent years. DN causes renal tissue damage and functional decline, expedites the aging process of the kidneys, and may ultimately progress leading to end-stage renal disease, severely impacting the patient's quality of life and prognosis. Mesenchymal stem cells (MSCs) are highly valued for their multipotent differentiation, paracrine functions, immunomodulatory effects, and capacity for tissue repair. Particularly, exosomes (Exo) derived from MSCs (MSCs-Exo) are rich in bioactive molecules and facilitate intercellular communication, participating in various physiological and pathological processes. MSCs and MSCs-Exo, in particular, have been demonstrated to have therapeutic effects in DN treatment research by encouraging tissue repair, fibrosis inhibition, and inflammation reduction. Research has shown that MSCs and MSCs-Exo have therapeutic effects in DN treatment by promoting tissue repair, inhibiting fibrosis, and reducing inflammation. Recent studies underscore the potential of MSCs and MSCs-Exo, highlighting their broad applicability in DN treatment. This review aims to provide a comprehensive summary of the scientific developments in treating DN using MSCs and MSCs-Exo from diverse sources, while also exploring their future therapeutic possibilities in detail.
    Language English
    Publishing date 2024-04-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Desferrioxamine Enhances 5-Aminolaevulinic Acid- Induced Protoporphyrin IX Accumulation and Therapeutic Efficacy for Hypertrophic Scar.

    Chen, Yiman / Deng, Huihui / Yang, Liya / Guo, Ling / Feng, Min

    Journal of pharmaceutical sciences

    2023  Volume 112, Issue 6, Page(s) 1635–1643

    Abstract: Hypertrophic scar is a common problem after skin burns or trauma which brings physical, psychological, and cosmetic problems to patients. Photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a promising therapy for hypertrophic scar. However, ... ...

    Abstract Hypertrophic scar is a common problem after skin burns or trauma which brings physical, psychological, and cosmetic problems to patients. Photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a promising therapy for hypertrophic scar. However, clinical applications of 5-ALA are limited because of the low permeability of 5-ALA in the skin stratum corneum and the rapid binding of protoporphyrin IX (PpIX) with iron ions, which lead to insufficient PpIX production in target tissues. Herein, a mixture of 5-ALA and DFO (deferoxamine, a special iron chelator) was applied for the treatment of hypertrophic scar. 5-ALA/DFO could efficiently block the biotransformation of PpIX to heme, thus realizing a significant accumulation of photosensitizer. In addition, injection locally into the lesion was applied, which combined with enhanced photodynamic therapy to destroy hypertrophic scar fibroblasts. In vitro experiments showed that 5-ALA/DFO could increase more ROS generation by increasing the accumulation of PpIX, resulting in the apoptosis of hypertrophic scar fibroblasts. Furthermore, 5-ALA/DFO inhibited the proliferation and migration of hypertrophic scar fibroblasts. In vivo study showed that 5-ALA/DFO could effectively inhibit the formation of proliferative scar. Therefore, 5-ALA/DFO has the potential to enhance the photodynamic therapy of 5-ALA and provides a new treatment strategy for hypertrophic scar.
    MeSH term(s) Humans ; Aminolevulinic Acid/pharmacology ; Aminolevulinic Acid/therapeutic use ; Deferoxamine/pharmacology ; Deferoxamine/therapeutic use ; Iron Chelating Agents/pharmacology ; Iron Chelating Agents/therapeutic use ; Cicatrix, Hypertrophic/drug therapy ; Photosensitizing Agents ; Protoporphyrins/metabolism ; Protoporphyrins/therapeutic use ; Photochemotherapy/methods
    Chemical Substances Aminolevulinic Acid (88755TAZ87) ; Deferoxamine (J06Y7MXW4D) ; protoporphyrin IX (C2K325S808) ; Iron Chelating Agents ; Photosensitizing Agents ; Protoporphyrins
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2023.01.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endoscopic ultrasonography in the evaluation of condition and prognosis of ulcerative colitis.

    Jin, Rui-Fang / Chen, Yi-Man / Chen, Ren-Pin / Ye, Hua-Jun

    World journal of clinical cases

    2022  Volume 10, Issue 15, Page(s) 4818–4826

    Abstract: Background: Ulcerative colitis (UC) is usually diagnosed through histopathology, enteroscopy, clinical symptoms, and physical findings; however, it is difficult to accurately evaluate disease severity.: Aim: To investigate the value of endoscopic ... ...

    Abstract Background: Ulcerative colitis (UC) is usually diagnosed through histopathology, enteroscopy, clinical symptoms, and physical findings; however, it is difficult to accurately evaluate disease severity.
    Aim: To investigate the value of endoscopic ultrasonography (EUS) in the evaluation of the severity and prognosis of UC.
    Methods: Patients with UC who were seen in our hospital from March 2019 to December 2020 were eligible, and disease severity was evaluated according to the modified Truelove and Witts and Mayo scores. We performed EUS, calculated the UC endoscopic index of severity (UCEIS) and EUS-UC scores, and administered appropriate treatment. The UCEIS and EUS-UC scores of patients were assessed in relation to disease severity, and the correlations between UCEIS and EUS-UC scores and disease severity was also analyzed. The UCEIS and EUS-UC scores before and after treatment were also compared.
    Results: A total of 79 patients were included in this study. According to the Mayo Index, 23, 32, and 24 patients had mild, moderate and severe UC, respectively. The UCEIS and EUS-UC scores were higher in moderate cases (4.98 ± 1.04 and 5.01 ± 0.99, respectively) than in mild cases (1.56 ± 0.82 and 1.64 ± 0.91, respectively,
    Conclusion: EUS can clarify the status of UC and accurately evaluate the treatment response, providing an objective basis for formulation and adjustment of the treatment plan.
    Language English
    Publishing date 2022-06-11
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i15.4818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Multiple Tissues Transcriptome of Zig-Zag Eel (

    Yang, Jinlin / Lu, Baoyue / Yu, Zhide / Zhang, Linan / Chen, Yiman / Chen, Zihui / Han, Chong / Shu, Hu

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 2

    Abstract: In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was first performed on the brain, liver, and muscle tissues of 3-month- ... ...

    Abstract In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was first performed on the brain, liver, and muscle tissues of 3-month-old
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14020248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 5-Aminolevulinic Acid-Hyaluronic Acid Complexes Enhance Skin Retention of 5-Aminolevulinic Acid and Therapeutic Efficacy in the Treatment of Hypertrophic Scar.

    Yang, Liya / Deng, Huihui / Chen, Yiman / Chen, Yuling / Guo, Ling / Feng, Min

    AAPS PharmSciTech

    2022  Volume 23, Issue 6, Page(s) 216

    Abstract: Hypertrophic scar is a serious skin disorder, which reduces the patient's quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy has been used to treat patients with hypertrophic scar. However, the poor skin retention of 5-ALA ... ...

    Abstract Hypertrophic scar is a serious skin disorder, which reduces the patient's quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy has been used to treat patients with hypertrophic scar. However, the poor skin retention of 5-ALA limited the therapeutic effect. In this study, we constructed the 5-ALA-hyaluronic acid (HA) complex to potentially prolong the skin retention of 5-ALA for improving the therapeutic efficacy. HA is a polysaccharide with viscoelasticity and the carboxyl groups could conjugate with amino groups of 5-ALA via electrostatic interaction. The protoporphyrin IX (PpIX) assay revealed that 5-ALA-HA complexes markedly enhanced the skin retention, resulting in increased generation and accumulation of endogenous photosensitizer PpIX. Furthermore, 5-ALA-HA complexes allowed PpIX to be maintained at a high level for 12 h, much longer than the 3 h of 5-ALA alone. And then, the accumulative PpIX induced by 5-ALA-HA in human hypertrophic scar fibroblasts (HSF) was triggered by laser irradiation to produce sufficient reactive oxygen species, leading to efficient necrosis and apoptosis of HSF. In vivo therapeutic efficacy study indicated that 5-ALA-HA effectively reduced the appearance and scar thickness, and the scar elevation index with 5-ALA-HA treatment was significantly lower than other groups, suggesting that the 5-ALA-HA-treated scar became flattened and was closely matched to the unwounded tissues. Moreover, 5-ALA-HA treatment markedly downregulated the gene expression levels of α-SMA and TGF-β1, demonstrating attenuated the scar formation and growth. Therefore, the 5-ALA-HA complex enhancing skin retention and PpIX accumulation at the lesion site provide a promising therapeutic strategy for hypertrophic scar.
    MeSH term(s) Aminolevulinic Acid/pharmacology ; Aminolevulinic Acid/therapeutic use ; Cicatrix, Hypertrophic/drug therapy ; Humans ; Hyaluronic Acid ; Photosensitizing Agents/pharmacology ; Quality of Life
    Chemical Substances Photosensitizing Agents ; Aminolevulinic Acid (88755TAZ87) ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-022-02370-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Multi-target antibacterial mechanism of ruthenium polypyridine complexes with anthraquinone groups against

    Jiang, Li / Ma, Yuanyuan / Chen, Yiman / Cai, Mengcheng / Wu, Zhixing / Xiong, Yanshi / Duan, Xuemin / Liao, Xiangwen / Wang, Jintao

    RSC medicinal chemistry

    2023  Volume 14, Issue 4, Page(s) 700–709

    Abstract: Three new Ru(ii) complexes, [Ru(dtb) ...

    Abstract Three new Ru(ii) complexes, [Ru(dtb)
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d2md00430e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Simultaneous Semantic Segmentation and Depth Completion with Constraint of Boundary.

    Zou, Nan / Xiang, Zhiyu / Chen, Yiman / Chen, Shuya / Qiao, Chengyu

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 3

    Abstract: As the core task of scene understanding, semantic segmentation and depth completion play a vital role in lots of applications such as robot navigation, AR/VR and autonomous driving. They are responsible for parsing scenes from the angle of semantics and ... ...

    Abstract As the core task of scene understanding, semantic segmentation and depth completion play a vital role in lots of applications such as robot navigation, AR/VR and autonomous driving. They are responsible for parsing scenes from the angle of semantics and geometry, respectively. While great progress has been made in both tasks through deep learning technologies, few works have been done on building a joint model by deeply exploring the inner relationship of the above tasks. In this paper, semantic segmentation and depth completion are jointly considered under a multi-task learning framework. By sharing a common encoder part and introducing boundary features as inner constraints in the decoder part, the two tasks can properly share the required information from each other. An extra boundary detection sub-task is responsible for providing the boundary features and constructing cross-task joint loss functions for network training. The entire network is implemented end-to-end and evaluated with both RGB and sparse depth input. Experiments conducted on synthesized and real scene datasets show that our proposed multi-task CNN model can effectively improve the performance of every single task.
    Language English
    Publishing date 2020-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20030635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Integrated transcriptomic and proteomic profiling reveals the key molecular signatures of brain endothelial reperfusion injury.

    Ji, Yabin / Chen, Yiman / Tan, Xixi / Huang, Xiaowen / Gao, Qiang / Ma, Yinzhong / Yang, Shilun / Yin, Meifang / Yu, Min / Fang, Cheng / Wang, Yu / Shi, Zhu / Chang, Junlei

    CNS neuroscience & therapeutics

    2023  Volume 30, Issue 4, Page(s) e14483

    Abstract: Background: Reperfusion therapy after ischemic stroke often causes brain microvascular injury. However, the underlying mechanisms are unclear.: Methods: Transcriptomic and proteomic analyses were performed on human cerebral microvascular endothelial ... ...

    Abstract Background: Reperfusion therapy after ischemic stroke often causes brain microvascular injury. However, the underlying mechanisms are unclear.
    Methods: Transcriptomic and proteomic analyses were performed on human cerebral microvascular endothelial cells following oxygen-glucose deprivation (OGD) or OGD plus recovery (OGD/R) to identify molecules and signaling pathways dysregulated by reperfusion. Major findings were further validated in a mouse model of cerebral ischemia and reperfusion.
    Results: Transcriptomic analysis identified 390 differentially expressed genes (DEGs) between the OGD/R and OGD group. Pathway analysis indicated that these genes were mostly associated with inflammation, including the TNF signaling pathway, TGF-β signaling pathway, cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, and NF-κB signaling pathway. Proteomic analysis identified 201 differentially expressed proteins (DEPs), which were primarily associated with extracellular matrix destruction and remodeling, impairment of endothelial transport function, and inflammatory responses. Six genes (DUSP1, JUNB, NFKBIA, NR4A1, SERPINE1, and THBS1) were upregulated by OGD/R at both the mRNA and protein levels. In mice with cerebral ischemia and reperfusion, brain TNF signaling pathway was activated by reperfusion, and inhibiting TNF-α with adalimumab significantly attenuated reperfusion-induced brain endothelial inflammation. In addition, the protein level of THBS1 was substantially upregulated upon reperfusion in brain endothelial cells and the peri-endothelial area in mice receiving cerebral ischemia.
    Conclusion: Our study reveals the key molecular signatures of brain endothelial reperfusion injury and provides potential therapeutic targets for the treatment of brain microvascular injury after reperfusion therapy in ischemic stroke.
    MeSH term(s) Mice ; Humans ; Animals ; Endothelial Cells/metabolism ; Proteomics ; Brain/metabolism ; Brain Ischemia/metabolism ; Reperfusion Injury/metabolism ; Oxygen ; Brain Injuries/metabolism ; Inflammation/metabolism ; Reperfusion ; Gene Expression Profiling ; Ischemic Stroke/metabolism ; Glucose/metabolism
    Chemical Substances Oxygen (S88TT14065) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2423461-8
    ISSN 1755-5949 ; 1755-5930
    ISSN (online) 1755-5949
    ISSN 1755-5930
    DOI 10.1111/cns.14483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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