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  1. Article ; Online: Identification of

    Zhang, Na / Lan, Ruilong / Chen, Yingyu / Hu, Jianda

    Open life sciences

    2024  Volume 19, Issue 1, Page(s) 20220848

    Abstract: Bortezomib (BTZ), a proteasome inhibitor, is a promising therapeutic option for multiple myeloma (MM) patients. However, drug resistance often occurs, leading to disease relapse and poor prognosis. In this study, we aimed to identify novel genes ... ...

    Abstract Bortezomib (BTZ), a proteasome inhibitor, is a promising therapeutic option for multiple myeloma (MM) patients. However, drug resistance often occurs, leading to disease relapse and poor prognosis. In this study, we aimed to identify novel genes associated with drug resistance and investigate their roles in BTZ resistance. Through the screening of 26 genes frequently associated with chemosensitivity or drug resistance, we discovered that KDM4C, a histone demethylase, exhibited increased expression in BTZ-resistant MM cells compared to their sensitive counterparts. Overexpression of
    Language English
    Publishing date 2024-04-12
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2817958-4
    ISSN 2391-5412 ; 2391-5412
    ISSN (online) 2391-5412
    ISSN 2391-5412
    DOI 10.1515/biol-2022-0848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-parameter estimation resistant to the random polarization effect for coherent optical receivers.

    Qiao, Meng / Chen, Yingyu / Wang, Dawei / Li, Zhaohui

    Optics express

    2023  Volume 31, Issue 11, Page(s) 18454–18467

    Abstract: Optical parameter estimation based on the data obtained by coherent optical receivers is critical for optical performance monitoring (OPM) and the stable operation of the receiver digital signal processing (DSP). A robust multi-parameter estimation is ... ...

    Abstract Optical parameter estimation based on the data obtained by coherent optical receivers is critical for optical performance monitoring (OPM) and the stable operation of the receiver digital signal processing (DSP). A robust multi-parameter estimation is intricate due to the interference of various system effects. By resorting to the cyclostationary theory, we are able to formulate a chromatic dispersion (CD), frequency offset (FO), and optical signal-to-noise ratio (OSNR) joint estimation strategy that is resistant to the random polarization effect, including polarization mode dispersion (PMD) and polarization rotation. The method uses data directly after the DSP resampling and matched filtering. Both numerical simulation and field optical cable experiment validate our method.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.489827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Investigation of the Optimal Immunization Dose and Protective Efficacy of an Attenuated and Marker

    Zhang, Sen / Liu, Guoxing / Wu, Wenying / Yang, Li / Shirani, Ihsanullah / Guo, Aizhen / Chen, Yingyu

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 5

    Abstract: Bovine respiratory disease (BRD) is one of the most common diseases in the cattle industry; it is a globally prevalent multifactorial infection primarily caused by viral and bacterial coinfections. In China, ...

    Abstract Bovine respiratory disease (BRD) is one of the most common diseases in the cattle industry; it is a globally prevalent multifactorial infection primarily caused by viral and bacterial coinfections. In China,
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14050748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Noninvasive hemoglobin quantification across different cohorts using a wearable diffuse reflectance spectroscopy system.

    Chen, Ying-Yu / Lai, Guan-Hua / Chen, Chia-Te / Cheng, Hsiu-Chi / Tseng, Sheng-Hao

    Biomedical optics express

    2024  Volume 15, Issue 3, Page(s) 1739–1749

    Abstract: Quantifying hemoglobin is vital yet invasive through blood draws. We developed a wearable diffuse reflectance spectroscopy device comprising control and sensor boards with photodiodes and light-emitting diodes to noninvasively determine hemoglobin. ... ...

    Abstract Quantifying hemoglobin is vital yet invasive through blood draws. We developed a wearable diffuse reflectance spectroscopy device comprising control and sensor boards with photodiodes and light-emitting diodes to noninvasively determine hemoglobin. Neural networks enabled recovery of optical parameters for chromophore fitting to calculate hemoglobin. Testing healthy and elderly subjects revealed strong correlation (r=0.9) between our system and invasive methods after data conversion. Bland-Altman analysis demonstrated tight 95% limits of agreement from -1.98 to 1.98 g/dL between the DRS and invasive hemoglobin concentrations. By spectroscopically isolating hemoglobin absorption, interference from melanin was overcome. Our device has the potential for future integration into wearable technology, enabling hemoglobin level tracking.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.517645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: MbovP0725, a secreted serine/threonine phosphatase, inhibits the host inflammatory response and affects metabolism in

    Zhang, Hui / Zhang, Yiqiu / Lu, Doukun / Chen, Xi / Chen, Yingyu / Hu, Changmin / Guo, Aizhen

    mSystems

    2024  Volume 9, Issue 4, Page(s) e0089123

    Abstract: Mycoplasma: Importance: Mycoplasma ... ...

    Abstract Mycoplasma
    Importance: Mycoplasma bovis
    MeSH term(s) Female ; Humans ; Mycoplasma bovis/genetics ; Lipopolysaccharides ; Bacterial Adhesion ; Mycoplasma Infections ; Immunity ; Phosphoprotein Phosphatases ; RNA, Messenger ; Serine
    Chemical Substances Lipopolysaccharides ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; RNA, Messenger ; Serine (452VLY9402)
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN (online) 2379-5077
    DOI 10.1128/msystems.00891-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SCA-Former: transformer-like network based on stream-cross attention for medical image segmentation.

    Gao, Chengrui / Cheng, Junlong / Yang, Ziyuan / Chen, Yingyu / Zhu, Min

    Physics in medicine and biology

    2023  Volume 68, Issue 24

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Rivers ; Neural Networks, Computer ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad00fe
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Cooperation and Lateral Forces: Moving Beyond Bottom-Up and Top-Down Drivers of Animal Population Dynamics.

    Chen, Ying-Yu / Rubenstein, Dustin R / Shen, Sheng-Feng

    Frontiers in psychology

    2022  Volume 13, Page(s) 768773

    Abstract: Biologists have long known that animal population dynamics are regulated by a combination of bottom-up (resource availability) and top-down forces (predation). Yet, economists have argued that human population dynamics can also be influenced by ... ...

    Abstract Biologists have long known that animal population dynamics are regulated by a combination of bottom-up (resource availability) and top-down forces (predation). Yet, economists have argued that human population dynamics can also be influenced by intraspecific cooperation. Despite awareness of the role of interspecific cooperation (mutualism) in influencing resource availability and animal population dynamics, the role of intraspecific cooperation (sociality) under different environmental conditions has rarely been considered. Here we examine the role of what we call "lateral forces" that act within populations and interact with external top-down and bottom-up forces in influencing population dynamics using an individual-based model linking environmental quality, intraspecific cooperation, and population size. We find that the proportion of cooperators is higher when the environment is poor and population sizes are greatest under intermediate resources levels due to the contrasting effects of resource availability on behavior and population size. We also show that social populations are more resilient to environmental change than non-social ones because the benefits of intraspecific cooperation can outweigh the effects of constrained resource availability. Our study elucidates the complex relationship between environmental harshness, cooperation, and population dynamics, which is important for understanding the ecological consequences of cooperation.
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.768773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia.

    Chen, Yingyu / Hu, Jianda

    Therapeutic advances in hematology

    2020  Volume 11, Page(s) 2040620719899818

    Abstract: Nucleophosmin ( ...

    Abstract Nucleophosmin (
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2585183-4
    ISSN 2040-6215 ; 2040-6207
    ISSN (online) 2040-6215
    ISSN 2040-6207
    DOI 10.1177/2040620719899818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unique Fluorescent Protein-Encoded Microbeads with Supramaximal Encoding Capacity and High Sensitivity for Multiplex Bioassays

    Zheng, Bingjie / Qin, Yuqing / Xiang, Yuqiang / Guo, Aizhen / Chen, Yingyu / Hu, Yonggang

    Analytical Chemistry. 2023 Apr. 05, v. 95, no. 16, p. 6452-6549

    2023  , Page(s) 6452–6549

    Abstract: Fluorescence-encoded microbeads (FEBs) have been widely used as a critical component in multiplexed biomolecular assays. Here, we propose a simple, sustainable, low-cost, and safe strategy for preparing FEBs by assembling fluorescent proteins (FPs) onto ... ...

    Abstract Fluorescence-encoded microbeads (FEBs) have been widely used as a critical component in multiplexed biomolecular assays. Here, we propose a simple, sustainable, low-cost, and safe strategy for preparing FEBs by assembling fluorescent proteins (FPs) onto magnetic microbeads (MBs) via chemical coupling. Combining the type of FP, the concentration of FP, and the size of the magnetic microbeads as encoding elements, an ultralarge encoding capacity with 506 barcodes was obtained. We demonstrate that the FP-based FEBs have good stability during long-term storage and tolerate the use of an organic solution. Multiplex detection of femtomolar ssDNA molecules was achieved via flow cytometry, and the detection procedure is simple and fast because it does not require amplification and washing strategies. The advantages of this advanced method for multiplex detections including high sensitivity, specificity, accuracy, repeatability, rapidity, and cost-effectiveness show a broad application prospect in basic and applied research fields such as disease diagnosis, food safety, environmental protection, proteomics, genomics, and drug screening.
    Keywords analytical chemistry ; applied research ; barcoding ; cost effectiveness ; disease diagnosis ; drugs ; environmental protection ; flow cytometry ; fluorescence ; food safety ; genomics ; magnetism ; microbeads ; proteomics ; storage time
    Language English
    Dates of publication 2023-0405
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c05231
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
    Z 2.9: Show issues

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  10. Article ; Online: Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1

    Shāhīn, Farzānā / Raza, Sohail / Chen, Xi / Hu, Changmin / Chen, Yingyu / Chen, Huanchun / Guo, Aizhen

    Animals. 2023 Aug. 12, v. 13, no. 16

    2023  

    Abstract: Bovine herpes virus -1 (BoHV-1) infection leads to upper respiratory tract infection, conjunctivitis and genital disorders in cattle. To control BoHV-1, it is important to understand the role of viral proteins in viral infection. BoHV-1 has several gene ... ...

    Abstract Bovine herpes virus -1 (BoHV-1) infection leads to upper respiratory tract infection, conjunctivitis and genital disorders in cattle. To control BoHV-1, it is important to understand the role of viral proteins in viral infection. BoHV-1 has several gene products to help in viral replication in infected cell. One such gene is deoxyuridine triphosphate nucleotidohydrolase (dUTPase) also known as UL50. In this study, we analyzed the amino acid sequence of UL50 (dUTPase) using bioinformatics tools and found that it was highly conserved among herpesvirus family. Then, it was cloned and expressed in Escherichia coli Rosetta (DE3), induced by isopropy1-b-D-thiogalactopyranoside (IPTG) and the recombinant UL50 protein was purified to immunize rabbits for the preparation of polyclonal antiserum. The results indicated that the UL50 gene of BoHV-1 was composed of 978 nucleotides, which encoded 323 amino acids. Western blot analysis revealed that polyclonal sera against UL50 reacted with a band of 34 kDa. Furthermore, immunofluorescence assay showed that UL50 localized in the cytoplasmic area. Taken together, UL50 was successfully cloned, expressed and detected in BoHV-1-infected cells and was localized in the cytoplasm to help in the replication of BoHV-1 in infected cells.
    Keywords Bovine alphaherpesvirus 1 ; Escherichia coli ; Western blotting ; amino acid sequences ; bioinformatics ; cattle ; conjunctivitis ; cytoplasm ; fluorescent antibody technique ; genes ; nucleotides ; polyclonal antibodies ; respiratory tract diseases ; virus replication ; viruses
    Language English
    Dates of publication 2023-0812
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13162607
    Database NAL-Catalogue (AGRICOLA)

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