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Article: Mechanical stability of polarization signatures in biological tissue characterization.

Chen, Yongtai / Chu, Jinkui / Xin, Benda / Qi, Ji

2024 Volume 15, Issue 4, Page(s) 2652–2665

Abstract: Mueller matrix imaging polarimetry (MMIP) is a promising technique for investigating structural abnormalities in pathological diagnosis. The characterization stability of polarization signatures, described by Mueller matrix parameters (MMPs), correlates ... ...

Abstract	Mueller matrix imaging polarimetry (MMIP) is a promising technique for investigating structural abnormalities in pathological diagnosis. The characterization stability of polarization signatures, described by Mueller matrix parameters (MMPs), correlates with the mechanical state of the biological medium. In this study, we developed an MMIP system capable of applying quantitative forces to samples and measuring the resulting polarization signatures. Mechanical stretching experiments were conducted on a mimicking phantom and a tissue sample at different force scales. We analyzed the textural features and data distribution of MMP images and evaluated the force effect on the characterization of MMPs using the structural similarity index. The results demonstrate that changes in the mechanical microenvironment (CMM) can cause textural fluctuations in MMP images, interfering with the stability of polarization signatures. Specifically, parameters of anisotropic orientation, retardance, and optical rotation are the most sensitive to CMM, inducing a dramatic change in the overall image texture, while other parameters (e.g., polarization, diattenuation, and depolarization) exhibit locality in their response to CMM. For some MMPs, CMM can enhance regional textural contrasts. This study elucidates the mechanical stability of polarization signatures in biological tissue characterization and provides a valuable reference for further research toward minimizing CMM influence.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.518756
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Article: Association between Lipid-Lowering Drugs and Traumatic Subdural Hemorrhage: A Mendelian Randomization Study.

Chen, Kaiqin / Li, He / Chen, Yongtai / Huang, Hesen / Wei, Liangfeng

Journal of integrative neuroscience

2024 Volume 23, Issue 4, Page(s) 76

Abstract: Background: There are current clinical observations that atorvastatin may promote subdural hematoma resorption. We aimed to assess the causal effects of lipid-lowering agents 3-hydroxy-3-methylglutaryl coenzyme A reductase (: Methods: We used genetic ...

Abstract	Background: There are current clinical observations that atorvastatin may promote subdural hematoma resorption. We aimed to assess the causal effects of lipid-lowering agents 3-hydroxy-3-methylglutaryl coenzyme A reductase ( Methods: We used genetic instruments to proxy lipid-lowering drug exposure, with genetic instruments being genetic variants within or near low-density lipoprotein (LDL cholesterol)-associated drug target genes. These were analyzed by using a two-sample Mendelian randomization (MR) study. Results: A causal relationship was found between Conclusions: This two-sample MR study suggests a potential causal relationship between
MeSH term(s)	Humans ; Mendelian Randomization Analysis ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hematoma, Subdural ; PCSK9 Inhibitors ; Membrane Transport Proteins/genetics ; Membrane Proteins/genetics ; Hypolipidemic Agents/administration & dosage ; Hypolipidemic Agents/pharmacology ; Atorvastatin/adverse effects ; Atorvastatin/administration & dosage ; Atorvastatin/pharmacology ; Proprotein Convertase 9 ; Hydroxymethylglutaryl CoA Reductases
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; NPC1L1 protein, human ; PCSK9 Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Membrane Transport Proteins ; HMGCR protein, human (EC 1.1.1.-) ; Membrane Proteins ; Hypolipidemic Agents ; Atorvastatin (A0JWA85V8F) ; Proprotein Convertase 9 (EC 3.4.21.-) ; Hydroxymethylglutaryl CoA Reductases (EC 1.1.1.-)
Language	English
Publishing date	2024-04-29
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2136427-8
ISSN	0219-6352
ISSN	0219-6352
DOI	10.31083/j.jin2304076
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Article ; Online: Erratum to "Protective Effect of Retrograde Reperfusion Against Hepatic Autophagy Impairment in Rat Liver Transplantation" by Yuan Cheng, Haibin Lan, Yongtai Chen, Yi Jiang, Yongbiao Chen, Transplantation Proceedings, 2021, Vol 53, pages 443-449.

Cheng, Yuan / Lan, Haibin / Chen, Yongtai / Jiang, Yi / Chen, Yongbiao

Transplantation proceedings

2021 Volume 55, Issue 7, Page(s) 1762

Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2021.05.001
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Article ; Online: Association of hemicolectomy with survival in stage II colorectal cancer: a retrospective cohort study.

Zeng, Hao / Chen, Yongtai / Lan, Qilong / Lu, Geng / Chen, Dongbo / Li, Fudi / Xu, Dongbo / Lin, Shuangming

Updates in surgery

2023 Volume 75, Issue 8, Page(s) 2211–2223

Abstract: To compare the oncological survival outcomes of partial colectomy (PC) and hemicolectomy (HC) in patients with stage II colon cancer. A total of 18,795 patients with stage II colon cancer who underwent hemicolectomy (n = 12,022) or partial colectomy (n = ...

Abstract	To compare the oncological survival outcomes of partial colectomy (PC) and hemicolectomy (HC) in patients with stage II colon cancer. A total of 18,795 patients with stage II colon cancer who underwent hemicolectomy (n = 12,022) or partial colectomy (n = 6773) from 2010 to 2019 were included in the the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and cancer-specific survival (CSS) were compared between the two groups, and the threshold of harvested lymph nodes was determined. The results showed that age, gender, race, tumor site, scope of regional lymph nodes, postoperative chemotherapy, postoperative radiotherapy, harvested lymph nodes, and tumor size were significantly different between the PC and HC groups (all P < 0.05). The OS rate was slightly lower in hemicolectomy patients than in partial colectomy patients (69.9% vs. 74.5%, respectively, P < 0.001), but CSS was similar between the two groups (87.9% vs. 88.1%, respectively, P = 0.32). After propensity score matching (PSM) was performed, the OS and CSS rates in the two groups were significantly different (CSS 84.3% vs. 88.0%, P < 0.001; OS 62.2% vs. 72.5%, P < 0.001). The survminer R package determined that the optimum threshold for the harvested lymph node count in stage II colon cancer patients was 16. CSS was significantly different between patients with ≥ 12 lymph nodes harvested and patients with ≥ 16 lymph nodes harvested (P = 0.043). Univariate and multivariate Cox regression and survival analyses of stage II colon cancer patients showed that the survival benefit of stage II colon cancer patients receiving partial colectomy was superior to that of patients receiving hemicolectomy. Partial colectomy has significant oncological benefits over hemicolectomy in the treatment of stage II colon cancer patients, even in the case of pT4b or tumor deposits. Removal of 16 lymph nodes during colectomy for stage II colon cancer correlated with improved survival, and this threshold was more effective than the standard threshold of 12 lymph nodes in distinguishing between patients with good and poor prognoses.
MeSH term(s)	Humans ; Neoplasm Staging ; Retrospective Studies ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Colonic Neoplasms ; Lymph Node Excision/methods ; Colectomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-11-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-023-01646-w
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Article ; Online: Protective Effect of Retrograde Reperfusion Against Hepatic Autophagy Impairment in Rat Liver Transplantation.

Cheng, Yuan / Lan, Haibin / Chen, Yongtai / Jiang, Yi / Chen, Yongbiao

Transplantation proceedings

2020 Volume 53, Issue 1, Page(s) 443–449

Abstract: The retrograde reperfusion (RTR) technique was introduced in orthotopic liver transplantation (OLT) to improve initial postoperative liver function, but the related mechanisms remain unexplained. We investigated the influences of different reperfusion ... ...

Abstract	The retrograde reperfusion (RTR) technique was introduced in orthotopic liver transplantation (OLT) to improve initial postoperative liver function, but the related mechanisms remain unexplained. We investigated the influences of different reperfusion sequences, including initial portal reperfusion (IPR) and RTR, on hepatic ischemia/reperfusion (I/R) injury and autophagic activity in a simplified rat orthotopic liver transplantation (ROLT) model. Methods: First, we established an ROLT model of male Sprague-Dawley rats to simulate either the IPR or RTR technique. The operative times and survival rates until postoperative day (POD) 7 were recorded. Liver enzyme levels, histologic damage, and in situ apoptosis were assessed. Second, we evaluated differences in the autophagic flux of liver grafts at 1, 2, and 6 hours after reperfusion between the IPR and RTR techniques. All experimental procedures involving animals were approved by the Institutional Animal Ethics Committee of the 900th Hospital of PLA. Results: In the first experiment, all animals survived to POD 7. In contrast to the IPR sequence, the RTR technique decreased the extent of graft I/R injury. In the second experiment, reperfusion markedly impaired the autophagic flux of ischemic liver grafts, but the RTR technique could alleviate and postpone the reduction in autophagy after I/R. Conclusions: A feasible modified ROLT model with the cuff method was described and could flexibly simulate 2 reperfusion techniques: IPR and RTR. The use of the RTR sequence exhibited a protective effect against I/R injury and impairment of autophagy in liver grafts.
MeSH term(s)	Animals ; Autophagy ; Liver/pathology ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Male ; Rats ; Rats, Sprague-Dawley ; Reperfusion/methods ; Reperfusion Injury/pathology
Language	English
Publishing date	2020-12-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2020.10.010
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Article ; Online: Study of the spatial scale stability of Mueller matrix parameters for textural characterization of biological tissues.

Chen, Yongtai / Chu, Jinkui / Tang, William C / Zhang, Ran / Zhao, Mingyu / Xin, Benda

Journal of biophotonics

2021 Volume 15, Issue 5, Page(s) e202100269

Abstract: Mueller matrix imaging polarimetry (MMIP) is a promising technique for the textural characterization of biological tissue structures. To reveal the influence of imaging magnification on the robustness of Mueller matrix parameters (MMPs), the spatial ... ...

Abstract	Mueller matrix imaging polarimetry (MMIP) is a promising technique for the textural characterization of biological tissue structures. To reveal the influence of imaging magnification on the robustness of Mueller matrix parameters (MMPs), the spatial scale stability of MMPs was studied. We established a new MMIP detector and derived the mathematical model of the spatial scale stability of MMPs. The biological tissues with well-defined structural components were imaged under different magnifications. Then, we compared and analyzed the textural features of the MMPs in the resulting images. The experimental results match the predictions of the mathematical model in these aspects: (a) magnification exhibits a strong nonlinear effect on the textural contrasts of MMPs images; (b) higher magnification does not necessarily lead to superior contrast for textural characterization; and (c) for different biological tissues, MMPs contrasts can be optimized differently, with some showing superior results. This study provides a reference for the experimental design and operation of the MMIP technique and is helpful for improving the characterization ability of MMPs.
MeSH term(s)	Diagnostic Imaging/methods ; Matrix Metalloproteinases ; Models, Theoretical ; Spectrum Analysis
Chemical Substances	Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2021-12-23
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202100269
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Article ; Online: Polarization clustering of biological structures with Mueller matrix parameters.

Chen, Yongtai / Chu, Jinkui / Lin, Fanlu / Jiang, Bing / Liu, Yadong / Huang, Bo / Zhang, Ran / Xin, Benda / Ding, Xiaohan

Journal of biophotonics

2022 Volume 16, Issue 2, Page(s) e202200255

Abstract: Mueller matrix imaging polarimetry (MMIP) is a promising technique for the characterization of biological tissues, including the classification of microstructures in pathological diagnosis. To expand the parameter space of Mueller matrix parameters, we ... ...

Abstract	Mueller matrix imaging polarimetry (MMIP) is a promising technique for the characterization of biological tissues, including the classification of microstructures in pathological diagnosis. To expand the parameter space of Mueller matrix parameters, we propose new vector parameters (VPs) according to the Mueller matrix polar decomposition method. We measure invasive bladder cancer (IBC) with extensive necrosis and high-grade ductal carcinoma in situ (DCIS) with MMIP, and the regions of cancer cells and fibrotic stroma are classified with the VPs. Then the proposed and existing VPs are mapped on the Poincaré sphere with 3D visualization, and an indicator of spatial feature is defined based on the minimum enclosing sphere to evaluate the classification capability of the VPs. For both IBC and DCIS, the results show that the proposed VPs exhibit evident contrast between the regions of cancer cells and fibrotic stroma. This study broadens the fundamental Mueller matrix parameters and helps to improve the characterization ability of the MMIP technique.
MeSH term(s)	Humans ; Carcinoma, Intraductal, Noninfiltrating ; Diagnostic Imaging/methods ; Spectrum Analysis
Language	English
Publishing date	2022-11-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202200255
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Article ; Online: Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells.

Lan, Weifeng / Chen, Zhijian / Chen, Yongtai / Tan, Miduo / Chen, Yuan / Chen, Jianwei / Chi, Xiaobin / Chen, Yongbiao

Toxicology letters

2020 Volume 331, Page(s) 11–21

Abstract: Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is ... ...

Abstract	Cholestasis represents pathophysiologic syndromes defined as impaired bile flow from the liver. As an outcome, bile acids accumulate and promote hepatocyte injury, followed by liver cirrhosis and liver failure. Glycochenodeoxycholic acid (GCDCA) is relatively toxic and highly concentrated in bile and serum after cholestasis. However, the mechanism underlying GCDCA-induced hepatotoxicity remains unclear. In this study, we found that GCDCA inhibits autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH, contributing to defects in autophagic clearance and subsequently leading to the death of L02 human hepatocyte cells. Notably, through tandem mass tag (TMT)-based quantitative proteomic analysis and database searches, 313 differentially expressed proteins were identified, of which 71 were increased and 242 were decreased in the GCDCA group compared with those in the control group. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that GCDCA suppressed the signaling pathway of transcription factor E3 (TFE3), which was the most closely associated with autophagic flux impairment. In contrast, GCDCA-inhibited lysosomal function and autophagic flux were efficiently attenuated by TFE3 overexpression. Specifically, the decreased expression of TFE3 was closely related to the disruption of reactive oxygen species (ROS) homeostasis, which could be prevented by inhibiting intracellular ROS with N-acetyl cysteine (NAC). In summary, our study is the first to demonstrate that manipulation of ROS/TFE3 signaling may be a therapeutic approach for antagonizing GCDCA-induced hepatotoxicity.
MeSH term(s)	Autophagy/drug effects ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism ; Bile Acids and Salts/metabolism ; Cell Line ; Gene Expression/drug effects ; Glycochenodeoxycholic Acid/toxicity ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Homeostasis/drug effects ; Humans ; Lysosomes/drug effects ; Proteomics ; Reactive Oxygen Species/metabolism
Chemical Substances	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Bile Acids and Salts ; Reactive Oxygen Species ; TFE3 protein, human ; Glycochenodeoxycholic Acid (640-79-9)
Language	English
Publishing date	2020-05-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2020.05.017
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Zs.A 1367: Show issues

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Article ; Online: Nonlinear Ion Harmonics in the Paul Trap with Added Octopole Field: Theoretical Characterization and New Insight into Nonlinear Resonance Effect.

Xiong, Caiqiao / Zhou, Xiaoyu / Zhang, Ning / Zhan, Lingpeng / Chen, Yongtai / Nie, Zongxiu

Journal of the American Society for Mass Spectrometry

2016 Volume 27, Issue 2, Page(s) 344–351

Abstract: The nonlinear harmonics within the ion motion are the fingerprint of the nonlinear fields. They are exclusively introduced by these nonlinear fields and are responsible to some specific nonlinear effects such as nonlinear resonance effect. In this ... ...

Abstract	The nonlinear harmonics within the ion motion are the fingerprint of the nonlinear fields. They are exclusively introduced by these nonlinear fields and are responsible to some specific nonlinear effects such as nonlinear resonance effect. In this article, the ion motion in the quadrupole field with a weak superimposed octopole component, described by the nonlinear Mathieu equation (NME), was studied by using the analytical harmonic balance (HB) method. Good accuracy of the HB method, which was comparable with that of the numerical fourth-order Runge-Kutta (4th RK), was achieved in the entire first stability region, except for the points at the stability boundary (i.e., β = 1) and at the nonlinear resonance condition (i.e., β = 0.5). Using the HB method, the nonlinear 3β harmonic series introduced by the octopole component and the resultant nonlinear resonance effect were characterized. At nonlinear resonance, obvious resonant peaks were observed in the nonlinear 3β series of ion motion, but were not found in the natural harmonics. In addition, both resonant excitation and absorption peaks could be observed, simultaneously. These are two unique features of the nonlinear resonance, distinguishing it from the normal resonance. Finally, an approximation equation was given to describe the corresponding working parameter, q nr , at nonlinear resonance. This equation can help avoid the sensitivity degradation due to the operation of ion traps at the nonlinear resonance condition.
MeSH term(s)	Mass Spectrometry/methods ; Nonlinear Dynamics ; Signal Processing, Computer-Assisted
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1007/s13361-015-1291-y
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Zs.A 4618: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Theoretical Method for Characterizing Nonlinear Effects in Paul Traps with Added Octopole Field.

Xiong, Caiqiao / Zhou, Xiaoyu / Zhang, Ning / Zhan, Lingpeng / Chen, Yongtai / Chen, Suming / Nie, Zongxiu

Journal of the American Society for Mass Spectrometry

2015 Volume 26, Issue 8, Page(s) 1338–1348

Abstract: In comparison with numerical methods, theoretical characterizations of ion motion in the nonlinear Paul traps always suffer from low accuracy and little applicability. To overcome the difficulties, the theoretical harmonic balance (HB) method was ... ...

Abstract	In comparison with numerical methods, theoretical characterizations of ion motion in the nonlinear Paul traps always suffer from low accuracy and little applicability. To overcome the difficulties, the theoretical harmonic balance (HB) method was developed, and was validated by the numerical fourth-order Runge-Kutta (4th RK) method. Using the HB method, analytical ion trajectory and ion motion frequency in the superimposed octopole field, ε, were obtained by solving the nonlinear Mathieu equation (NME). The obtained accuracy of the HB method was comparable with that of the 4th RK method at the Mathieu parameter, q = 0.6, and the applicable q values could be extended to the entire first stability region with satisfactory accuracy. Two sorts of nonlinear effects of ion motion were studied, including ion frequency shift, Δβ, and ion amplitude variation, Δ(C(2n)/C0) (n ≠ 0). New phenomena regarding Δβ were observed, although extensive studies have been performed based on the pseudo-potential well (PW) model. For instance, the \|Δβ\| at ε = 0.1 and ε = -0.1 were found to be different, but they were the same in the PW model. This is the first time the nonlinear effects regarding Δ(C(2n)/C0) (n ≠ 0) are studied, and the associated study has been a challenge for both theoretical and numerical methods. The nonlinear effects of Δ(C(2n)/C0) (n ≠ 0) and Δβ were found to share some similarities at q < 0.6: both of them were proportional to ε, and the square of the initial ion displacement, z(0)(2).
MeSH term(s)	Mass Spectrometry/instrumentation ; Mass Spectrometry/methods ; Models, Theoretical ; Nonlinear Dynamics
Language	English
Publishing date	2015-04-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1073671-2
ISSN	1879-1123 ; 1044-0305
ISSN (online)	1879-1123
ISSN	1044-0305
DOI	10.1007/s13361-015-1145-7
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