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Article ; Online: Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review).

Qiu, Mengjun / Chen, Youxiang / Zeng, Chunyan

2024 Volume 64, Issue 5

Abstract: Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells in 1979, but it was not characterized in detail until 2012, when high‑throughput sequencing technology was more advanced and available. Consequently, the mechanism of circRNA ... ...

Abstract	Circular RNA (circRNA) was first observed in the cytoplasm of eukaryotic cells in 1979, but it was not characterized in detail until 2012, when high‑throughput sequencing technology was more advanced and available. Consequently, the mechanism of circRNA formation and its biological function have been progressively elucidated by researchers. circRNA is abundant in eukaryotic cells and exhibits a certain degree of organization, timing and disease‑specificity. Additionally, it is poorly degradable, meeting the characteristics of an ideal clinical biomarker. In the present review, the recent research progress of circRNAs in digestive tract malignant tumors was primarily discussed. This included the roles, biological functions and clinical significance of circRNA, providing references for its research value and clinical potential in gastrointestinal cancer.
MeSH term(s)	Humans ; RNA, Circular/genetics ; RNA/genetics ; Biomarkers ; Gastrointestinal Neoplasms/genetics ; MicroRNAs/genetics
Chemical Substances	RNA, Circular ; RNA (63231-63-0) ; Biomarkers ; MicroRNAs
Language	English
Publishing date	2024-03-15
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2024.5637
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Zs.A 3690: Show issues

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Article ; Online: Sintilimab-induced severe erosive hemorrhagic gastritis and pyloric obstruction: a case report and literature review.

Xiong, Wenfang / Yang, Zhenzhen / Chen, Youxiang

Immunotherapy

2024

Abstract: Immune checkpoint inhibitors could restore immune surveillance to attack tumor through targeting CTLA-4, PD-1 or PD-L1, and have achieved huge success. However, immune-related adverse events (irAEs) have been attracting attention as their application is ... ...

Abstract	Immune checkpoint inhibitors could restore immune surveillance to attack tumor through targeting CTLA-4, PD-1 or PD-L1, and have achieved huge success. However, immune-related adverse events (irAEs) have been attracting attention as their application is expanding. Gastritis is relatively rare as a subtype of irAEs, particularly severe gastritis. Guidelines on its clinical management still remain undefined due to limited data. Sintilimab is a PD-1 inhibitor approved in China. Here we offer a case of sintilimab-induced severe erosive hemorrhagic gastritis and pyloric obstruction. Conventional proton pump inhibitors and mucosal protective agents did not take effect, so glucocorticoid was chosen. This severe gastritis was successfully cured finally. Our report describing its clinical performances, endoscopic characteristics and treatments, could assist clinicians to better know this rare irAE.
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2023-0325
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Article ; Online: Treatment with antituberculosis agents after tuberculosis activation during ustekinumab treatment: Safety and effectiveness.

Wang, Zhizhi / Liao, Wangdi / Chen, Youxiang / Long, Shunhua

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2024

Abstract: We report, for the first time, the safety and effectiveness of antituberculosis drugs after tuberculosis activation during ustekinumab treatment in Crohn's disease. ...

Abstract	We report, for the first time, the safety and effectiveness of antituberculosis drugs after tuberculosis activation during ustekinumab treatment in Crohn's disease.
Language	English
Publishing date	2024-02-28
Publishing country	Egypt
Document type	Case Reports
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2024.01.010
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Article ; Online: Development and validation of a preoperative risk nomogram prediction model for gastric gastrointestinal stromal tumors.

Liu, Zide / Gao, Jiaxin / Zeng, Chunyan / Chen, Youxiang

Surgical endoscopy

2024 Volume 38, Issue 4, Page(s) 1933–1943

Abstract: Background and study aims: Gastrointestinal stromal tumors (GIST) carry a potential risk of malignancy, and the treatment of GIST varies for different risk levels. However, there is no systematic preoperative assessment protocol to predict the malignant ...

Abstract	Background and study aims: Gastrointestinal stromal tumors (GIST) carry a potential risk of malignancy, and the treatment of GIST varies for different risk levels. However, there is no systematic preoperative assessment protocol to predict the malignant potential of GIST. The aim of this study was to develop a reliable and clinically applicable preoperative nomogram prediction model to predict the malignant potential of gastric GIST. Patients and methods: Patients with a pathological diagnosis of gastric GIST from January 2015 to December 2021 were screened retrospectively. Univariate and multivariate logistic analyses were used to identify independent risk factors for gastric GIST with high malignancy potential. Based on these independent risk factors, a nomogram model predicting the malignant potential of gastric GIST was developed and the model was validated in the validation group. Results: A total of 494 gastric GIST patients were included in this study and allocated to a development group (n = 345) and a validation group (n = 149). In the development group, multivariate logistic regression analysis revealed that tumor size, tumor ulceration, CT growth pattern and monocyte-to- lymphocyte ratio (MLR) were independent risk factors for gastric GIST with high malignancy potential. The AUC of the model were 0.932 (95% CI 0.890-0.974) and 0.922 (95% CI 0.868-0.977) in the development and validation groups, respectively. The best cutoff value for the development group was 0.184, and the sensitivity and specificity at this value were 0.895 and 0.875, respectively. The calibration curves indicated good agreement between predicted and actual observed outcomes, while the DCA indicated that the nomogram model had clinical application. Conclusions: Tumor size, tumor ulceration, CT growth pattern and MLR are independent risk factors for high malignancy potential gastric GIST, and a nomogram model developed based on these factors has a high ability to predict the malignant potential of gastric GIST.
MeSH term(s)	Humans ; Nomograms ; Gastrointestinal Stromal Tumors/pathology ; Retrospective Studies ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Risk Factors
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10674-5
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Zs.A 2214: Show issues

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Article ; Online: Transpapillary gallbladder stent placement remains a challenge for endoscopists.

Hong, Junbo / Chen, Youxiang

Gastrointestinal endoscopy

2022 Volume 95, Issue 5, Page(s) 1022

MeSH term(s)	Abdomen ; Cholecystitis, Acute ; Drainage ; Gallbladder/surgery ; Humans ; Stents
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2021.11.035
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Comparable long‑term survival outcomes of endoscopic treatment versus surgical treatment for gastrointestinal stromal tumors with a diameter of 5-10 cm.

Liu, Zide / Tao, Qing / Wu, Yonghui / Zeng, Chunyan / Chen, Youxiang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8513

Abstract: Currently, endoscopic treatment for small gastrointestinal stromal tumors (GIST) has been widely accepted. However, for tumors larger than 5 cm, endoscopic treatment has not been recognized by national guidelines as the standard therapy due to concerns ... ...

Abstract	Currently, endoscopic treatment for small gastrointestinal stromal tumors (GIST) has been widely accepted. However, for tumors larger than 5 cm, endoscopic treatment has not been recognized by national guidelines as the standard therapy due to concerns about safety and adverse tumor outcomes. Therefore, this study compares the long-term survival outcomes of endoscopic treatment and surgical treatment for GIST in the range of 5-10 cm. We selected patients with GIST from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. Kaplan-Meier analysis and the log-rank test were employed to compare the long-term survival outcomes between endoscopic treatment and surgical treatment. A multivariate Cox proportional hazards model was used for analysis to identify risk factors influencing patient prognosis. To balance baseline data, we performed 1:1 propensity score matching (PSM). A total of 1223 GIST patients were included, with 144 patients (11.8%) received endoscopic treatment and 1079 patients (88.2%) received surgical treatment. Before PSM, there was no significant difference in the long-term survival rates between the two groups [5-year OS (86.5% vs. 83.5%, P = 0.42), 10-year OS (70.4% vs. 66.7%, P = 0.42)]. After adjusting for covariates, we found that the overall survival (HR = 1.26, 95% CI 0.89-1.77, P = 0.19) and cancer-specific survival (HR = 1.69, 95% CI 0.99-2.89, P = 0.053) risks were comparable between the endoscopic treatment group and the surgical treatment group. In the analysis after PSM, there was no significant difference between the endoscopic treatment group and the surgical treatment group. Our study found that for GIST patients with tumor sizes between 5 and 10 cm, the long-term OS and CSS outcomes were similar between the endoscopic treatment group and the surgical treatment group.
MeSH term(s)	Humans ; Gastrointestinal Stromal Tumors/surgery ; Endoscopy ; Databases, Factual ; Kaplan-Meier Estimate ; Propensity Score
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58802-4
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Article: Identification of glutamine metabolism-related gene signature to predict colorectal cancer prognosis.

Xie, Yang / Li, Jun / Tao, Qing / Wu, Yonghui / Liu, Zide / Zeng, Chunyan / Chen, Youxiang

Journal of Cancer

2024 Volume 15, Issue 10, Page(s) 3199–3214

Abstract: Backgrounds: ...

Abstract	Backgrounds:
Language	English
Publishing date	2024-04-15
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.91687
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Article: Identification of a Diagnosis and Therapeutic Inflammatory Response-Related Gene Signature Associated with Esophageal Adenocarcinoma.

Xie, Yang / Li, Jun / Tao, Qing / Zeng, Chunyan / Chen, Youxiang

Critical reviews in eukaryotic gene expression

2023 Volume 33, Issue 7, Page(s) 65–80

Abstract: The purpose of this study is to identify the key regulatory genes related to the inflammatory response of esophageal adenocarcinoma (EAC) and to find new diagnosis and therapeutic options. We downloaded the dataset GSE72874 from the Gene Expression ... ...

Abstract	The purpose of this study is to identify the key regulatory genes related to the inflammatory response of esophageal adenocarcinoma (EAC) and to find new diagnosis and therapeutic options. We downloaded the dataset GSE72874 from the Gene Expression Omnibus database for this study. Weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEGs) analysis were used to find common inflammatory response-related genes (IRRGs) in EAC. The relationship between normal and tumor immune infiltration was analyzed using an online database of CIBERSORTx. Finally, 920 DEGs were identified, of which 5 genes were key IRRGs associated with EAC, including three down-regulated genes GNA15, MXD1, and NOD2, and two down-regulated genes PLAUR and TIMP1. Further research found that GNA15, MXD1, and NOD2 were down-regulated, PLAUR and TIMP1 were up-regulated in Barrett's esophagus (BE). In addition, we found that the expression of GNA15 and MXD1 in normal esophageal squamous epithelial cells decreased after ethanol treatment, while the expression of PLAUR and TIMP1 increased after ethanol treatment. Compared with normal esophageal tissue, immune cells infiltrated such as plasma cells, macrophages M0, macrophages M1, macrophages M2, dendritic cells activated, and mast cells activated were significantly increased in EAC, while immune cells infiltrated such as T cells CD4 memory resting, T cells follicular helper, NK cells resting, and dendritic cells resting were significantly reduced. The receiver operating characteristic curve indicated that GNA15, MXD1, NOD2, PLAUR and TIMP1 expression had a performed well in diagnosing EAC from healthy control. GNA15, MXD1, NOD2, PLAUR and TIMP1 were identified and validated as novel potential biomarkers for early diagnosis and may be new molecular targets for treatment of EAC.
MeSH term(s)	Humans ; Genes, Regulator ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/genetics ; Ethanol ; Repressor Proteins ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Chemical Substances	Ethanol (3K9958V90M) ; MXD1 protein, human ; Repressor Proteins ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071345-1
ISSN	1045-4403
ISSN	1045-4403
DOI	10.1615/CritRevEukaryotGeneExpr.2023048608
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Article ; Online: NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease.

Zhang, Jiayu / Zeng, Shuyan / Wang, Peng / Chen, Youxiang / Zeng, Chunyan

Current drug targets

2023 Volume 24, Issue 14, Page(s) 1106–1116

Abstract: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact ... ...

Abstract	Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact on the lives of patients. Therefore, it is particularly important to find new therapeutic targets and innovative drugs for the development of IBD. Recent studies have revealed that NLRP3 inflammatory vesicles can play an important role in maintaining intestinal homeostasis and sustaining the intestinal immune response in IBD. On the one hand, aberrant activation of NLRP3 inflammatory vesicles may cause excessive immune response by converting caspase-1, proIL-18, and proIL-1β to their active forms and releasing pro-inflammatory cytokines to stimulate the development and progression of IBD, and we can improve IBD by targeting blockade of NLRP3 activation. On the other hand, NLRP3 may also play an enter protective role by maintaining the homeostasis of the intestinal immune system. In this paper, we reviewed the activation mechanism of NLRP3 inflammasome, and the effects of NLRP3 inflammasome activation on IBD are discussed from two different perspectives: pathology and protection. At the same time, we listed the effects of direct inhibitors, indirect inhibitors, and natural inhibitors of NLRP3 inflammasome on IBD in combination with cutting-edge advances and clinical practice results, providing new targets and new ideas for the clinical treatment of IBD.
MeSH term(s)	Humans ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Inflammatory Bowel Diseases/drug therapy ; Crohn Disease ; Intestines/pathology
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes
Language	English
Publishing date	2023-11-10
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/0113894501255960231101105113
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Zs.A 5578: Show issues

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Article ; Online: Moderately severe acute pancreatitis after snake bite: a case report from Southern China.

Cao, Ronglai / He, Jinli / Yu, Zhengping / Chen, Youxiang / Zhu, Liang

Zeitschrift fur Gastroenterologie

2023 Volume 62, Issue 4, Page(s) 508–511

Abstract: Venomous snakebites are not rare worldwide, and this is also the situation in the mountainous regions of southern China, where they pose a serious health risk to the local population. Snake venom usually causes a variety of clinical symptoms, such as ... ...

Title translation	Mäßig schwere akute Pankreatitis nach Schlangenbiss: Ein Fallbericht aus Südchina.
Abstract	Venomous snakebites are not rare worldwide, and this is also the situation in the mountainous regions of southern China, where they pose a serious health risk to the local population. Snake venom usually causes a variety of clinical symptoms, such as local pain and swelling, systemic coagulation system abnormalities, and shock, but rarely leads to acute pancreatitis. In this report, we presented a rare case of moderately severe acute pancreatitis caused by snake venom even after prompt antivenom treatment. The patient was relieved, obviously, with effective treatment of acute pancreatitis and was discharged without severe complications. Although acute pancreatitis after snake bite is a rarity, its serious complications and lethality still deserve our utmost attention, and timely and standardized treatment of acute pancreatitis is needed in addition to antivenom treatment.
MeSH term(s)	Humans ; Snake Bites/complications ; Snake Bites/diagnosis ; Snake Bites/therapy ; Antivenins/therapeutic use ; Elapid Venoms/therapeutic use ; Acute Disease ; Pancreatitis/diagnosis ; Pancreatitis/etiology ; China
Chemical Substances	Antivenins ; Elapid Venoms
Language	English
Publishing date	2023-09-20
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-2150-2291
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