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  1. Book ; Online: An innovative device for enlarging the allowable misalignment for screwing tasks

    Ku, Hao-Tien / Chen, Yu-Hsun

    eISSN: 2191-916X

    2022  

    Abstract: To ensure the repeatability in a screwing task, the robot manipulators have to be calibrated regularly. If the allowable position error of the manipulator is increased, then the frequency of stopping a production line and calibrating the manipulators can ...

    Abstract To ensure the repeatability in a screwing task, the robot manipulators have to be calibrated regularly. If the allowable position error of the manipulator is increased, then the frequency of stopping a production line and calibrating the manipulators can be lower; therefore, the cost can be also decreased. This paper presents an innovative device for enlarging the allowable misalignment (DEAM) with five mechanisms, namely detecting, trigger, positioning, pin-and-stopper, and screwing mechanisms. By scanning around the target threaded hole, the screw can be precisely positioned at the location where the hole is detected by the probe. The motion and force analysis are carried out and verified through computer-aided simulation, and the sensitivity of the linkage tolerance is analyzed to ensure that the output position error of the mechanism does not affect the function of the device. Finally, the performance of the innovative device is verified by prototype testing, and the allowable misalignment is enlarged by about 6 times for an M6 screw.
    Subject code 629
    Language English
    Publishing date 2022-08-08
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Anal condyloma mimicking lateral spreading tumour removed by loop-clip traction endoscopic submucosal dissection - A video vignette.

    Chen, Yu-Hsun / Hsu, Chao-Wen / Tseng, Chin-Lun

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  Volume 25, Issue 3, Page(s) 516–517

    MeSH term(s) Humans ; Endoscopic Mucosal Resection ; Traction ; Neoplasms ; Surgical Instruments ; Treatment Outcome
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Video-Audio Media ; Letter
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparative Effectiveness of Adjuvant Therapy on Survival in Patients With Metastatic Colorectal Cancer.

    Wu, Chih-Chien / Su, Chien-Chou / Chen, Yu-Hsun / Hsu, Chao-Wen / Chang, Yu-Ching / Su, Yi-Chia

    Anticancer research

    2024  Volume 44, Issue 4, Page(s) 1619–1628

    Abstract: Background/aim: Postoperative survival outcomes are crucial in treatment decision making. This study aimed to compare the efficacy of adjuvant chemotherapy (AC)-alone with that of chemotherapy + targeted agents (CTA) in patients with metastatic ... ...

    Abstract Background/aim: Postoperative survival outcomes are crucial in treatment decision making. This study aimed to compare the efficacy of adjuvant chemotherapy (AC)-alone with that of chemotherapy + targeted agents (CTA) in patients with metastatic colorectal cancer (mCRC) and to investigate the association between neoadjuvant therapy and survival.
    Patients and methods: Patients who underwent primary tumor excision and metastasectomy were identified in the Taiwan Cancer Registry from 2010 to 2019. The analysis assessed the influence of adjuvant therapy on survival and examined the interactions between adjuvant therapy types (AC-alone and CTA) and patient characteristics with respect to overall survival.
    Results: Overall, 1,728 and 757 patients received AC alone and CTA, respectively. Compared to AC alone, adjuvant CTA yielded similar mortality after surgery [hazard ratio (HR)=1.03; 95% confidence interval (CI)=0.91-1.17] but resulted in marginally reduced mortality among patients treated with neoadjuvant therapy with targeted agents (HR=0.6; 95%CI=0.34-1.05) after propensity score matching. In patients with mCRC, those who received targeted agents preoperatively and postoperatively in combination with AC had the highest mortality rate (HR=1.75; 95%CI=1.33-2.32).
    Conclusion: Overall survival is comparable between adjuvant CTA and AC alone, but adjuvant CTA may be more beneficial in patients with mCRC who undergo neoadjuvant therapy with targeted agents.
    MeSH term(s) Humans ; Combined Modality Therapy ; Rectal Neoplasms ; Colonic Neoplasms ; Chemotherapy, Adjuvant/methods ; Neoadjuvant Therapy ; Retrospective Studies
    Language English
    Publishing date 2024-03-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Assessing the effectiveness of targeted agents in adjuvant therapy for patients with metastatic colorectal cancer undergoing surgical resection: a retrospective cohort study.

    Su, Yi-Chia / Wu, Chih-Chien / Chen, Yu-Hsun / Su, Chien-Chou / Chang, Yu-Ching / Hsieh, Meng-Che / Kao Yang, Yea-Huei

    Therapeutic advances in medical oncology

    2024  Volume 16, Page(s) 17588359241246427

    Abstract: Background: Primary tumor resection and metastasectomy may be beneficial for many patients with metastatic colorectal cancer (mCRC).: Objective: To assess the differences in postoperative survival outcomes between adjuvant therapy with chemotherapy ... ...

    Abstract Background: Primary tumor resection and metastasectomy may be beneficial for many patients with metastatic colorectal cancer (mCRC).
    Objective: To assess the differences in postoperative survival outcomes between adjuvant therapy with chemotherapy alone and chemotherapy plus targeted agents (TAs).
    Design: Retrospective cohort study.
    Methods: Patients with mCRC who underwent surgical resection for primary colorectal tumor and distant metastases and received adjuvant therapy from 1 January 2010 to 31 December 2017 were enrolled in the Taiwan Cancer Registry. We analyzed the overall survival of patients with resectable or initially unresectable mCRC who received adjuvant chemotherapy alone and chemotherapy plus TAs.
    Results: We enrolled 1124 and 542 patients with resectable and initially unresectable mCRC, respectively. Adjuvant chemotherapy plus TAs and chemotherapy alone resulted in similar mortality rates among patients with resectable mCRC [adjusted hazard ratio (aHR) = 1.13; 95% confidence interval (CI), 0.93-1.36]; however, it marginally reduced the mortality rate among patients with initially unresectable mCRC who underwent conversion surgery after neoadjuvant therapy (aHR = 0.81; 95% CI, 0.62-1.06). The subgroup analysis of patients who received more than nine cycles of TAs preoperatively and anti-epidermal growth factor receptor agents revealed aHRs of 0.48 (95% CI, 0.27-0.87) and 0.33 (95% CI, 0.18-0.60), respectively.
    Conclusion: Adjuvant chemotherapy plus TAs may improve survival in patients with initially unresectable tumors who underwent conversion surgery following neoadjuvant therapy with TAs, especially in those who respond well to the targeted therapy. Our study underscores the importance of stratifying patients with mCRC based on tumor resectability when selecting the adjuvant therapy regimen.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359241246427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Comparative Effectiveness of Cetuximab

    Wu, Chih-Chien / Su, Chien-Chou / Chen, Yu-Hsun / Hsu, Chao-Wen / Hsieh, Meng-Che / Chang, Yu-Ching / Wang, Yung-Chang / Su, Yi-Chia

    Anticancer research

    2023  Volume 43, Issue 11, Page(s) 5127–5138

    Abstract: Background/aim: The study aimed to determine the effectiveness of cetuximab and panitumumab on the survival of patients with metastatic colorectal cancer or those who had undergone conversion surgery and to identify their prognostic factors.: Patients ...

    Abstract Background/aim: The study aimed to determine the effectiveness of cetuximab and panitumumab on the survival of patients with metastatic colorectal cancer or those who had undergone conversion surgery and to identify their prognostic factors.
    Patients and methods: This retrospective cohort study used data from patients with metastatic colorectal cancer who received cetuximab or panitumumab as first-line targeted agent-based therapy. Overall survival and conversion surgery rates were evaluated, and the prognostic factors were determined.
    Results: A total of 1,749 and 318 patients received cetuximab or panitumumab with chemotherapy, respectively. Overall survival and conversion surgery rates were similar between the cetuximab [hazard ratio (HR)=0.96] and panitumumab groups (HR=1.00). The prognostic factors associated with metastasectomy significantly lowered mortality among patients with metastatic colorectal cancer (HR=0.61). Older age (≥70 years), tumor stage 4B and 4C, right-sided tumors, mucinous adenocarcinoma, primary tumor resection, and the number of positive lymph nodes were associated with higher mortality and lower conversion surgery rates.
    Conclusion: Though panitumumab- and cetuximab-based therapies showed no differences, several factors, such as age over 70 years old, tumor stage 4B and 4C, undifferentiated carcinoma, mucinous carcinoma, right-sided tumor, number of positive lymph nodes, obstruction, and primary tumor resection increased the mortality risk of patients. This study underscores the importance of metastasectomy in current treatment guidelines and future clinical trials.
    MeSH term(s) Humans ; Aged ; Cetuximab/therapeutic use ; Panitumumab/therapeutic use ; Retrospective Studies ; Colonic Neoplasms ; Rectal Neoplasms
    Chemical Substances Cetuximab (PQX0D8J21J) ; Panitumumab (6A901E312A)
    Language English
    Publishing date 2023-11-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Utilization of the left hand to facilitate precise endoscopic control during colorectal endoscopic submucosal dissection - a video vignette.

    Hsu, Chao-Wen / Chien, Hsi-Yuan / Lin, Kung-Hung / Chen, Yu-Hsun / Chou, Chu-Kuang

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2021  Volume 24, Issue 2, Page(s) 247

    MeSH term(s) Colonoscopy ; Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection ; Humans
    Language English
    Publishing date 2021-10-23
    Publishing country England
    Document type Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.15954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Real-Time Gauging of the Gelling Maturity of Duck Eggs Pickled in Strong Alkaline Solutions

    Cheng, Ching-Wei / Lai, Kun-Ming / Liu, Wan-Yu / Li, Cheng-Han / Chen, Yu-Hsun / Jeng, Chien-Chung

    Foods. 2021 Aug. 31, v. 10, no. 9

    2021  

    Abstract: Although many ultraviolet-visible-near-infrared transmission spectroscopy techniques have been applied to chicken egg studies, such techniques are not suitable for duck eggs because duck eggshells are much thicker than chicken eggshells. In this study, a ...

    Abstract Although many ultraviolet-visible-near-infrared transmission spectroscopy techniques have been applied to chicken egg studies, such techniques are not suitable for duck eggs because duck eggshells are much thicker than chicken eggshells. In this study, a high-transmission spectrometer using an equilateral prism as a dispersive element and a flash lamp as a light source was constructed to nondestructively detect the transmission spectrum of duck eggs and monitor the pickling of eggs. The evolution of egg transmittance was highly correlated with the albumen during pickling. The transmittance exponentially decays with time during this period, and the decay rate is related to the pickling rate. The colors of the albumen and yolk remain almost unchanged in the first stage. A multiple linear regression analysis model that realizes a one-to-one association between the days of pickling and the transmission spectra was constructed to determine the pickling duration in the second stage. The coefficient of determination reached 0.88 for a single variable, wavelength, at 590 nm. This method can monitor the maturity of pickled eggs in real time and does not require the evolution of light transmittance.
    Keywords chickens ; ducks ; eggs ; evolution ; gelation ; models ; regression analysis ; spectrometers ; spectroscopy ; transmittance ; wavelengths
    Language English
    Dates of publication 2021-0831
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10092057
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Diving, lifting, and horizontal dissection followed by loop-clip traction (DLH+T) can facilitate mucosal flap creation during colorectal ESD.

    Chang, Min-Chi / Chen, Wen-Chi / Yu, Hsien-Chung / Tsay, Feng-Woei / Chen, Yu-Hsun / Wu, Chih-Chien / Lin, Kung-Hung / Hsu, Chao-Wen

    Surgical endoscopy

    2022  Volume 36, Issue 10, Page(s) 7811–7817

    Abstract: Background: Colorectal ESD is difficult because of the poor maneuverability and difficulty of mucosal flap creation. Diving, Lifting and Horizontal (DLH) dissection technique and loop-clip traction are two different methods to facilitate mucosal ... ...

    Abstract Background: Colorectal ESD is difficult because of the poor maneuverability and difficulty of mucosal flap creation. Diving, Lifting and Horizontal (DLH) dissection technique and loop-clip traction are two different methods to facilitate mucosal trimming and adequate mucosal flap creation. We combined the advantages of these two techniques (DLH+T) in our daily practice colorectal ESD since July 2020.
    Objective: The purpose of this study was to examine the outcomes of DLH+T dissection compared with the conventional dissection.
    Methods: We retrospectively reviewed the clinical using DLH+T dissection compared with the conventional dissection since January 2018 at a single tertiary care institution. Postoperative short-term outcomes were investigated after the procedure including mucosal flap creation time, dissection time, dissection speed, en bloc resection rate, and perioperative complications.
    Results: 28 lesions were in DLH+T dissection group and 39 lesions in the conventional dissection group. The outcomes including en bloc resection rate, dissection speed, and complication between the two groups were similar. The mean mucosal flap creation time (p = 0.035) and the mean dissection speed (p = 0.041) of the DLH+T dissection group was significantly shorter and faster.
    Conclusion: DLH dissection followed by loop-clip traction (DLH+T) technique is a useful technique for safe, efficient, and adequate mucosal flap creation, which can increase the dissection speed and may prevent complication, especially in biopsy-related submucosal fibrosis.
    MeSH term(s) Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection/methods ; Humans ; Lifting ; Retrospective Studies ; Surgical Instruments ; Traction/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09324-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Full-thickness resection of colonic metastasis using endo-laparoscopic approach-A video vignette.

    Tseng, Hsin-Ping / Chen, Wen-Chi / Yu, Hsien-Chung / Tsay, Feng-Woei / Chen, Yu-Hsun / Wu, Chih-Chien / Hsu, Chao-Wen

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2022  

    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Letter
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Real-Time Gauging of the Gelling Maturity of Duck Eggs Pickled in Strong Alkaline Solutions.

    Cheng, Ching-Wei / Lai, Kun-Ming / Liu, Wan-Yu / Li, Cheng-Han / Chen, Yu-Hsun / Jeng, Chien-Chung

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 9

    Abstract: Although many ultraviolet-visible-near-infrared transmission spectroscopy techniques have been applied to chicken egg studies, such techniques are not suitable for duck eggs because duck eggshells are much thicker than chicken eggshells. In this study, a ...

    Abstract Although many ultraviolet-visible-near-infrared transmission spectroscopy techniques have been applied to chicken egg studies, such techniques are not suitable for duck eggs because duck eggshells are much thicker than chicken eggshells. In this study, a high-transmission spectrometer using an equilateral prism as a dispersive element and a flash lamp as a light source was constructed to nondestructively detect the transmission spectrum of duck eggs and monitor the pickling of eggs. The evolution of egg transmittance was highly correlated with the albumen during pickling. The transmittance exponentially decays with time during this period, and the decay rate is related to the pickling rate. The colors of the albumen and yolk remain almost unchanged in the first stage. A multiple linear regression analysis model that realizes a one-to-one association between the days of pickling and the transmission spectra was constructed to determine the pickling duration in the second stage. The coefficient of determination reached 0.88 for a single variable, wavelength, at 590 nm. This method can monitor the maturity of pickled eggs in real time and does not require the evolution of light transmittance.
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10092057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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