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Article ; Online: The effect of internet-based three-member coordinated rehabilitation nursing on syndrome score and intervention effect in patients with peptic ulcer.

Chen, Yuanyuan / Li, Xia

2024

Language	English
Publishing date	2024-05-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.24.10279-1
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Zs.A 25: Show issues

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Article ; Online: A Hierarchical Multi-Dimensional Cognitive Training Program for Preventive Cognitive Decline in Acute Ischemic Stroke Patients: Study Protocol for a Randomized Controlled Trial.

Chen, Yuanyuan / Lan, Meijuan

Journal of Alzheimer's disease reports

2023 Volume 7, Issue 1, Page(s) 1267–1275

Abstract: Background: One of the most popular ways to address cognitive decline is cognitive training. The fact that cognitive deterioration is permanent is one of the main issues. This issue might be resolved by preventive cognitive training when it is acute. As ...

Abstract	Background: One of the most popular ways to address cognitive decline is cognitive training. The fact that cognitive deterioration is permanent is one of the main issues. This issue might be resolved by preventive cognitive training when it is acute. As a result, this study aims to design and assess how well stroke patients respond to hierarchical, multi-dimensional preventative cognitive training. Objective: To describe the study design of this center implementation trial. Methods: Participants in the study will be recruited from a hospital in China and randomly assigned to the intervention group or the usual care group. Interventions will include four-week hierarchical multi-dimensional preventive cognitive training through a WeChat program. for Primary outcome measures will be the Montreal Cognitive Assessment, Mini-Mental State Examination, and Post-Stroke Cognitive Impairment (PSCI) Incidence. The secondary outcome measure will include the Hamilton Depression Scale, Hamilton Anxiety Scale, Modified Barthel Index, and National Institutes of Health Neurological Deficit Score. Outcomes will be measured at baseline, 12 weeks, and 24 weeks from the baseline. Results: We expect that the hierarchical multi-dimensional preventive cognitive training program will be easy to implement, and the cognitive function, cognitive psychology, ability of daily living will vary in each setting. Conclusions: The results will provide evidence highlighting differences in a new strategy of cognitive training through the WeChat program, which allows the home-based practice, puts forward an advanced idea of preventive cognitive training in the acute stage, and has the highest effectiveness of reducing cognitive impairment, and Alzheimer's disease.
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Clinical Trial
ISSN	2542-4823
ISSN (online)	2542-4823
DOI	10.3233/ADR-230097
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Article ; Online: Ochratoxin A induces mitochondrial dysfunction, oxidative stress, and apoptosis of retinal ganglion cells (RGCs), leading to retinal damage in mice.

Fu, Miao / Chen, Yuanyuan / Yang, Anhuai

International ophthalmology

2024 Volume 44, Issue 1, Page(s) 72

Abstract: Purpose: Ochratoxin A (OTA) contamination of food and feed is a serious problem worldwide. OTA is considered a carcinogen and immunotoxic, nephrotoxic, and neurotoxic mycotoxin. The present study aims to determine the toxic effects of OTA on retinal ... ...

Abstract	Purpose: Ochratoxin A (OTA) contamination of food and feed is a serious problem worldwide. OTA is considered a carcinogen and immunotoxic, nephrotoxic, and neurotoxic mycotoxin. The present study aims to determine the toxic effects of OTA on retinal ganglion cells (RGCs) and assess the resulting impairment of retinal function in mice. Methods: RGC-5 cells were exposed to OTA (100 and 200 μg/L) for 3 days, and the mice were fed OTA-contain (100 and 200 μg/kg) diets for 4 weeks. Antioxidant indices were detected by spectrophotometer. The apoptosis of RGC-5 cells was determined by flow cytometry. Mitochondrial morphology and mitochondrial membrane potential were detected by immunofluorescence. RGC survival was determined by immunofluorescence staining with Brn3a. Flash electroretinography (ERG) was conducted to assess visual function. Results: The oxidative-antioxidant balance suggested that OTA-induced severe oxidative stress, including increased reactive oxygen species (ROS) and malondialdehyde (MDA) levels in the OTA-exposed RGC-5 cells, and the reduced activity of superoxide dismutase (SOD) and glutathione-S-transferase (GST) in the OTA exposed group. Furthermore, OTA exposure led to remarkable apoptosis in RGC-5 cells. The mitochondrial detection showed that OTA caused significant mitochondrial membrane potential reduction and mitochondrial fragmentation, which may be the cause of apoptosis of RGC-5 cells. Additionally, in vivo experiments demonstrated that OTA resulted in significant death of RGCs and subsequent retinal dysfunction in mice. Conclusion: Ochratoxin A induces mitochondrial dysfunction, oxidative stress, and RGCs death in mice.
MeSH term(s)	Animals ; Mice ; Retinal Ganglion Cells ; Antioxidants ; Apoptosis ; Oxidative Stress ; Retinal Diseases ; Mitochondrial Diseases ; Ochratoxins
Chemical Substances	ochratoxin A (1779SX6LUY) ; Antioxidants ; Ochratoxins
Language	English
Publishing date	2024-02-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-024-03032-w
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Zs.A 1479: Show issues

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Article ; Online: Childhood maltreatment and resting-state network connectivity: The risk-buffering role of positive parenting.

Cao, Xinyu / Wang, Zhengxinyue / Chen, Yuanyuan / Zhu, Jianjun

Development and psychopathology

2024 , Page(s) 1–12

Abstract: Unraveling the neurobiological foundations of childhood maltreatment is important due to the persistent associations with adverse mental health outcomes. However, the mechanisms through which abuse and neglect disturb resting-state network connectivity ... ...

Abstract	Unraveling the neurobiological foundations of childhood maltreatment is important due to the persistent associations with adverse mental health outcomes. However, the mechanisms through which abuse and neglect disturb resting-state network connectivity remain elusive. Moreover, it remains unclear if positive parenting can mitigate the negative impact of childhood maltreatment on network connectivity. We analyzed a cohort of 194 adolescents and young adults (aged 14-25, 47.42% female) from the Neuroscience in Psychiatry Network (NSPN) to investigate the impact of childhood abuse and neglect on resting-state network connectivity. Specifically, we examined the SAN, DMN, FPN, DAN, and VAN over time. We also explored the moderating role of positive parenting. The results showed that childhood abuse was linked to stronger connectivity within the SAN and VAN, as well as between the DMN-DAN, DMN-VAN, DMN-SAN, SAN-DAN, FPN-DAN, SAN-VAN, and VAN-DAN networks about 18 months later. Positive parenting during childhood buffered the negative impact of childhood abuse on network connectivity. To our knowledge, this is the first study to demonstrate the protective effect of positive parenting on network connectivity following childhood abuse. These findings not only highlight the importance of positive parenting but also lead to a better understanding of the neurobiology and resilience mechanisms of childhood maltreatment.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036173-x
ISSN	1469-2198 ; 0954-5794
ISSN (online)	1469-2198
ISSN	0954-5794
DOI	10.1017/S0954579424000725
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Zs.A 2601: Show issues

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Article: Low interleukin-10 level indicates a good prognosis in

Chen, Yuan-Yuan / Xu, Xiang-Zhi / Xu, Xiao-Jun

World journal of clinical cases

2024 Volume 12, Issue 9, Page(s) 1660–1668

Abstract: Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) triggered by : Case summary: A 9-year-old boy with intermittent fever for 3 d presented to our hospital with positive results for : Conclusion: S. ...

Abstract	Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) triggered by Case summary: A 9-year-old boy with intermittent fever for 3 d presented to our hospital with positive results for Conclusion: S.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v12.i9.1660
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Article ; Online: High-throughput screening of the transport behavior of tetragonal perovskites.

Chen, Yuanyuan / Xiao, Lu / Shi, Libin / Qian, Ping

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 12, Page(s) 9378–9387

Abstract: Halide perovskites have attracted attention due to their low cost and excellent optoelectronic properties. Although their optical properties gained widespread consensus, there was still divergence in understanding carrier transport behavior. In this ... ...

Abstract	Halide perovskites have attracted attention due to their low cost and excellent optoelectronic properties. Although their optical properties gained widespread consensus, there was still divergence in understanding carrier transport behavior. In this study, the mobility of tetragonal perovskites was investigated by empirical models, including longitudinal acoustic phonon (LAP) and polar optical phonon (POP) models. The results revealed that the mobility predicted from the LAP model was much higher than that from the POP model. A longitudinal optical phonon (LOP) was considered as the decisive scattering source for charge carriers in perovskites. Furthermore, the mobility was extremely sensitive to
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d4cp00109e
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Article ; Online: Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory.

Zhang, Linlin / Chen, Yuanyuan / Fan, Yongzhao / Shi, Lin

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7116

Abstract: This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recognition memory performance in a novel object ... ...

Abstract	This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recognition memory performance in a novel object recognition task. In this study, 24 Sprague-Dawley rats were obtained and randomly assigned into 4 groups as follows: control group (Con group, n = 6), vascular dementia (VD group, n = 6), exercise and vascular dementia group (Exe + VD group, n = 6), and exercise group (Exe group, n = 6). Initially, 4 weeks of treadmill exercise intervention was administered to the rats in the Exe + VD and Exe groups. Then, to establish the vascular dementia model, the rats both in the VD and Exe + VD groups were subjected to bilateral common carotids arteries surgery. One week later, open-field task and novel recognition memory task were adopted to evaluate anxiety-like behavior and recognition memory in each group. Then, immunofluorescence and Golgi staining were used to evaluate neuronal number and spine density in the rat medial prefrontal cortex. Transmission electron microscopy was used to observe the synaptic ultrastructure. Finally, microdialysis coupled with high-performance liquid chromatography was used to assess the levels of 5-HT and dopamine in the medial prefrontal cortex. The behavior results showed that 4 weeks of treadmill exercise pretreatment significantly alleviated recognition memory impairment and anxiety-like behavior in VD rats (P < 0.01), while the rats in VD group exhibited impaired recognition memory and anxiety-like behavior when compared with the Con group (P < 0.001). Additionally, NeuN immunostaining results revealed a significant decrease of NeuN-marked neuron in the VD group compared to Con group (P < 0.01), but a significantly increase in this molecular marker was found in the Exe + VD group compared to the Con group (P < 0.01). Golgi staining results showed that the medial prefrontal cortex neurons in the VD group displayed fewer dendritic spines than those in the Con group (P < 0.01), and there were more spines on the dendrites of medial prefrontal cortex cells in Exe + VD rats than in VD rats (P < 0.01). Transmission electron microscopy further revealed that there was a significant reduction of synapses intensity in the medial prefrontal cortex of rats in the VD group when compared with the Con group(P < 0.01), but physical exercise was found to significantly increased synapses intensity in the VD model (P < 0.01). Lastly, the levels of dopamine and 5-HT in the medial prefrontal cortex of rats in the VD group was significantly lower compared to the Con group (P < 0.01), and treadmill exercise was shown to significantly increased the levels of dopamine and 5-HT in the VD rats (P < 0.05). Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in VD rat and improved recognition memory.
MeSH term(s)	Rats ; Animals ; Rats, Sprague-Dawley ; Dopamine ; Serotonin ; Dementia, Vascular ; Neuronal Plasticity/physiology ; Memory Disorders ; Prefrontal Cortex ; Hippocampus
Chemical Substances	Dopamine (VTD58H1Z2X) ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57080-4
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Article ; Online: Effect of acute inflammatory reaction induced by biopsy on tumor microenvironment.

Chen, Yuanyuan / Liu, Hualian / Sun, Yadong

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 4, Page(s) 177

Abstract: When it comes to the diagnosis of solid tumors, biopsy is always the gold standard. However, traumatic and inflammatory stimuli are so closely related to tumor initiation and development that the acute inflammatory response induced by biopsy can give ... ...

Abstract	When it comes to the diagnosis of solid tumors, biopsy is always the gold standard. However, traumatic and inflammatory stimuli are so closely related to tumor initiation and development that the acute inflammatory response induced by biopsy can give rise to changes in the tumor microenvironment, including recruitment of immunosuppressive cells (M2 macrophages, Treg cells, Tumor-associated neutrophils) and secretion of inflammation-associated cytokines, to create immunosuppressive conditions that enable the increase of circulating tumor cells in the peripheral circulation and promote the metastatic spread of tumors after surgery. In this review, we discuss dynamic changes and inhibitory characteristics of biopsy on tumor microenvironment. By investigating its mechanism of action and summarizing the current therapeutic strategies for biopsy-induced tumor immunosuppressive microenvironment, the future of using biopsy-induced inflammation to improve the therapeutic effects and prognosis of patients is prospected.
MeSH term(s)	Humans ; Tumor Microenvironment ; Cytokines ; Neoplastic Cells, Circulating ; Inflammation ; Biopsy ; Immunotherapy
Chemical Substances	Cytokines
Language	English
Publishing date	2024-04-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05704-7
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Article ; Online: Disentangle Then Calibrate With Gradient Guidance: A Unified Framework for Common and Rare Disease Diagnosis.

Chen, Yuanyuan / Guo, Xiaoqing / Xia, Yong / Yuan, Yixuan

IEEE transactions on medical imaging

2024 Volume 43, Issue 5, Page(s) 1816–1827

Abstract: The computer-aided diagnosis (CAD) for rare diseases using medical imaging poses a significant challenge due to the requirement of large volumes of labeled training data, which is particularly difficult to collect for rare diseases. Although Few-shot ... ...

Abstract	The computer-aided diagnosis (CAD) for rare diseases using medical imaging poses a significant challenge due to the requirement of large volumes of labeled training data, which is particularly difficult to collect for rare diseases. Although Few-shot learning (FSL) methods have been developed for this task, these methods focus solely on rare disease diagnosis, failing to preserve the performance in common disease diagnosis. To address this issue, we propose the Disentangle then Calibrate with Gradient Guidance (DCGG) framework under the setting of generalized few-shot learning, i.e., using one model to diagnose both common and rare diseases. The DCGG framework consists of a network backbone, a gradient-guided network disentanglement (GND) module, and a gradient-induced feature calibration (GFC) module. The GND module disentangles the network into a disease-shared component and a disease-specific component based on gradient guidance, and devises independent optimization strategies for both components, respectively, when learning from rare diseases. The GFC module transfers only the disease-shared channels of common-disease features to rare diseases, and incorporates the optimal transport theory to identify the best transport scheme based on the semantic relationship among different diseases. Based on the best transport scheme, the GFC module calibrates the distribution of rare-disease features at the disease-shared channels, deriving more informative rare-disease features for better diagnosis. The proposed DCGG framework has been evaluated on three public medical image classification datasets. Our results suggest that the DCGG framework achieves state-of-the-art performance in diagnosing both common and rare diseases.
MeSH term(s)	Humans ; Rare Diseases/diagnostic imaging ; Algorithms ; Image Interpretation, Computer-Assisted/methods ; Databases, Factual ; Magnetic Resonance Imaging/methods ; Machine Learning
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	622531-7
ISSN	1558-254X ; 0278-0062
ISSN (online)	1558-254X
ISSN	0278-0062
DOI	10.1109/TMI.2023.3349284
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Zs.A 2546: Show issues

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Article ; Online: Optic disc and cup segmentation for glaucoma detection using Attention U-Net incorporating residual mechanism.

Chen, Yuanyuan / Bai, Yongpeng / Zhang, Yifan

PeerJ. Computer science

2024 Volume 10, Page(s) e1941

Abstract: Glaucoma is a common eye disease that can cause blindness. Accurate detection of the optic disc and cup disc is crucial for glaucoma diagnosis. Algorithm models based on artificial intelligence can assist doctors in improving detection performance. In ... ...

Abstract	Glaucoma is a common eye disease that can cause blindness. Accurate detection of the optic disc and cup disc is crucial for glaucoma diagnosis. Algorithm models based on artificial intelligence can assist doctors in improving detection performance. In this article, U-Net is used as the backbone network, and the attention and residual modules are integrated to construct an end-to-end convolutional neural network model for optic disc and cup disc segmentation. The U-Net backbone is used to infer the basic position information of optic disc and cup disc, the attention module enhances the model's ability to represent and extract features of optic disc and cup disc, and the residual module alleviates gradient disappearance or explosion that may occur during feature representation of the neural network. The proposed model is trained and tested on the DRISHTI-GS1 dataset. Results show that compared with the original U-Net method, our model can more effectively separate optic disc and cup disc in terms of overlap error, sensitivity, and specificity.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.1941
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