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Article ; Online: Disturbed cerebral circulation and metabolism matters: A preface to the special issue "Stroke and Energy Metabolism": A preface to the special issue "Stroke and Energy Metabolism".

Chen, Yujie

2021 Volume 160, Issue 1, Page(s) 10–12

Abstract: Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood vessels. Two main aims in acute stroke therapy include the restoration of cerebral blood flow in order to preserve energy supply to neurons and other brain cells, ... ...

Abstract	Stroke is a serious neurological disorder caused by blockage or rupture of cerebral blood vessels. Two main aims in acute stroke therapy include the restoration of cerebral blood flow in order to preserve energy supply to neurons and other brain cells, and minimizing neuronal loss. Maintenance of energy homeostasis in the brain drives neural network dynamics, which preserves normal brain function under physiological conditions. As such, cerebral energy homeostasis is a key target in stroke therapy. The various articles in this special issue highlight energy metabolism changes following stroke, including disturbed cerebral blood circulation, mitochondrial dysfunction, programmed neuronal cell death and cell-cell communication in brain metabolism. Collectively, this series of articles provides insight and presents new avenues for further research to improve the clinical management of stroke patients.
MeSH term(s)	Animals ; Brain/blood supply ; Brain/metabolism ; Brain/physiopathology ; Cerebrovascular Circulation/physiology ; Humans ; Stroke/metabolism ; Stroke/physiopathology
Language	English
Publishing date	2021-12-11
Publishing country	England
Document type	Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15552
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Article: Feeding via duodenostomy can reduce intestinal obstruction after radical resection of esophageal cancer better than jejunostomy.

Chen, Yujie / Wang, Feng

Journal of gastrointestinal oncology

2023 Volume 14, Issue 5, Page(s) 1993–2005

Abstract: Background: Enteral nutrition (EN) is superior to parenteral nutrition (PN) in improving the nutritional status of esophageal cancer (EC) patients and accelerating postoperative recovery. Therefore, feeding via jejunostomy (FJ) is currently placed ... ...

Abstract	Background: Enteral nutrition (EN) is superior to parenteral nutrition (PN) in improving the nutritional status of esophageal cancer (EC) patients and accelerating postoperative recovery. Therefore, feeding via jejunostomy (FJ) is currently placed during esophagectomy to maintain the postoperative nutrition supply. However, FJ have some serve complications. The aim of this study was to explore the value of feeding via duodenostomy (FD) in reducing the complications associated with FJ. Methods: In this retrospective cohort study, the clinical data of 154 patients with EC who underwent surgical treatment in our center from January 1, 2020, to June 30, 2020 were collected. A concurrent, nonrandomized control group of 154 patients underwent thoraco-laparoscopic esophagectomy (TLE) was enrolled consisting of 82 males and 72 females. These patients were randomly divided into two groups according to the different ostomy method applied, including 80 cases in the FD group and 74 cases in the FJ group. The ostomy-related complications during the 180-day follow-up and indicators including perioperative nutritional markers, length of stay (LoS), and operative time were recorded. Results: After 1 week, the albumin level in the FD group was noninferior to that in the FJ group (36.8 Conclusions: The method of FD is safe, effective and acceptable. It is worthwhile to use in clinic practice.
Language	English
Publishing date	2023-10-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-23-667
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Article ; Online: Technical, economic, and environmental assessment of a stand-alone power system based on diesel engine with/without energy storage using an optimization algorithm: A case study in China.

Chen, Yujie / Zhang, Shuo

Environmental science and pollution research international

2023

Abstract: In stand-alone power systems, technical, economic, and environmental (TEE) assessment of hybrid energy systems under uncertainty is an important issue. This paper focuses on the TEE assessment of a stand-alone hybrid energy system composed of ... ...

Abstract	In stand-alone power systems, technical, economic, and environmental (TEE) assessment of hybrid energy systems under uncertainty is an important issue. This paper focuses on the TEE assessment of a stand-alone hybrid energy system composed of photovoltaic (PV) and diesel generator (DG) with/without battery energy storage (BS) in remote islands in China. So, determining the optimal sizes of PV and DG with/without BS for economic, reliable, and efficient operation of a hybrid power system in a microgrid is important. For this goal, a modified swarm intelligence algorithm is used to optimize, techno-economic feasibility and avoid potential CO
Language	English
Publishing date	2023-12-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31488-3
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Article ; Online: Deciphering the Molecular Mechanism of the Intermediate Secondary Growth and Internode Elongation of the Castor Bean (

Chen, Yujie / Orlov, Yuriy L / Chen, Ming

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: The length of internodes plays a crucial role in determining the height of the castor plant ( ...

Abstract	The length of internodes plays a crucial role in determining the height of the castor plant (
MeSH term(s)	Ricinus communis/genetics ; Transcriptome ; Plant Breeding ; Ricinus ; Metabolome ; Castor Oil
Chemical Substances	Castor Oil (8001-79-4)
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021053
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Article ; Online: Kinetic and elemental characterization of HAP-based high-rate partial nitritation/anammox system orienting stability and inorganic elemental requirements.

Chen, Yujie / Guo, Guangze / Li, Yu-You

Water research

2024 Volume 251, Page(s) 121169

Abstract: Anammox-based processes are attractive for biological nitrogen removal, and the combination of anammox and hydroxyapatite (HAP) is promising for the simultaneous removal of nitrogen and phosphorus from wastewater. However, the kinetics of one-stage ... ...

Abstract	Anammox-based processes are attractive for biological nitrogen removal, and the combination of anammox and hydroxyapatite (HAP) is promising for the simultaneous removal of nitrogen and phosphorus from wastewater. However, the kinetics of one-stage partial nitritation/anammox (PNA) in which ammonia-oxidizing bacteria (AOB) and anammox bacteria (AnAOB) exist in a reactor are poorly understood. Moreover, inorganic elements are required to promote microbial cell synthesis and growth; therefore, monitoring of elements to prevent the limitation and inhibition of the process is critical. The minimum amounts of inorganic elements required for a one-stage PNA process and the elemental flow remain unknown. Therefore, in this study, kinetics, stoichiometry, and element flow in the long-term, high-rate, continuous, one-stage HAP-PNA process with microaerobic granular sludge at 25 °C were determined using process modeling, parameter estimation, and mass balance. The biomass elemental composition was determined to be CH
MeSH term(s)	Anaerobic Ammonia Oxidation ; Oxidation-Reduction ; Bioreactors/microbiology ; Wastewater ; Sewage/microbiology ; Nitrogen ; Bacteria ; Ammonium Compounds ; Denitrification
Chemical Substances	Wastewater ; Sewage ; Nitrogen (N762921K75) ; Ammonium Compounds
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121169
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Article ; Online: Safety and efficiency of crossing Y-stent-assisted coiling with LEO stents in treatment of wide-necked intracranial bifurcation aneurysms

WANG Kaishan / CHEN Yujie / ANG Jun

陆军军医大学学报, Vol 45, Iss 21, Pp 2252-

2023 Volume 2259

Abstract: Objective To explore the safety and efficiency of crossing Y-stent-assisted coiling with LEO stents in treatment of wide-necked intracranial bifurcation aneurysms. Methods The clinical data and follow-up images of 336 patients with wide-necked ... ...

Abstract	Objective To explore the safety and efficiency of crossing Y-stent-assisted coiling with LEO stents in treatment of wide-necked intracranial bifurcation aneurysms. Methods The clinical data and follow-up images of 336 patients with wide-necked intracranial bifurcation aneurysms admitted to the neurosurgery department of the First Affiliated Hospital of Army Medical University from 2018 to 2022 were collected and analyzed retrospectively.Among them, 55 patients received crossing Y-stent-assisted coiling with LEO stents.The success rate of aneurysm treatment, operation-related complications, incidences of perioperative ischemic and hemorrhagic complications were observed.Raymond classification were conducted on cerebral angiographs immediately after operation and at the end of follow-up to evaluate the efficiency of embolization.Modified Rankin Scale (mRS) was used to evaluate the neurological function of the patients at discharge and during clinical follow-up.Computed tomography angiography (CTA) and magnetic resonance angiography (MRA) were performed to evaluate the recurrence rate during postoperative follow-up. Results Successful embolization was performed in the 55 patients with LEO stent-based crossing Y-shaped stenting, and no adverse events such as poor stent opening or stent folding were observed.Intraoperative stent thrombosis occurred in 1 case (1.82%), delayed ischemia in 2 cases (3.64%), and no perioperative bleeding events was observed.Immediate postoperative angiography showed dense embolism (Raymond class Ⅰ) in 50 cases (90.91%), residual tumor neck (Raymond class Ⅱ) in 3 cases (5.45%), and Raymond class Ⅲ in 2 cases (3.64%).The imaging results of 40 patients during a follow-up from 6 months to 2 years postoperatively revealed that 38 cases (95%) were at Raymond Class Ⅰ and 2 cases (5%) at Raymond Class Ⅱ.For the 9 patients undergoing CTA or MRA re-examination, no recurrence was observed.The imaging results during postoperative follow-up indicated that efficiency improvement was achieved in all ...
Keywords	endovascular treatment ; wide-necked aneurysm ; crossing y-stent-assisted coiling with leo stents ; leo stent ; Medicine (General) ; R5-920
Subject code	616
Language	Chinese
Publishing date	2023-11-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Do Personality Traits Matter? Exploring Anti-drug Behavioral Patterns in a Computer-Assisted Situated Learning Environment.

Huang, Tien-Chi / Chen, Yu-Jie

Frontiers in psychology

2022 Volume 13, Page(s) 812793

Abstract: Drug abuse has been and continues to be, a common social issue worldwide, yet the efficiency of widely adopted sweeping speech for anti-drug campaigns has proven inefficient. To provide students with a safe and efficient learning situation related to ... ...

Abstract	Drug abuse has been and continues to be, a common social issue worldwide, yet the efficiency of widely adopted sweeping speech for anti-drug campaigns has proven inefficient. To provide students with a safe and efficient learning situation related to drug refusal skills, we used a novel approach rooted in a serious learning game and concept map during a brief extracurricular period to help students understand drugs and their negative effects. The proposed game-based situational learning system allowed all students to participate simultaneously and individually in multiple scenarios of drug temptation posed by peers and classmates to practice responding and refusing drugs in school and community settings. Moreover, to explore whether different personality traits (such as the Big Five personality traits) result in different anti-drug responses, we used a serious game to conduct an anti-drug experiment on 53 junior middle school students aged 13-15. Each participant's decision-making process was recorded in the serious game as behavioral patterns for lag sequential analysis (LSA). The outcomes revealed seven behavioral patterns including differentiation (D), acceptance (A), effective (ER) and ineffective responses (IR), effective (ES) and ineffective solution-seeking (IS), and failure to refuse (F). The GSEQ (Generalized Sequential Querier) which is a computer program for analyzing sequential observational data was used. The results indicated the following: (1) Neuroticism was performed at a relatively low level under the guidance of a concept map. (2) "Neuroticism" was associated with the lowest risk of accepting drugs. (3) Students with "openness to experiences" were at high risk of accepting drugs. (4) Almost all personality behavioral transition diagrams showed that failure to refuse (F) drugs was followed by inefficient seeking of help (SI) and inefficient refusal (RI). These findings provide reference points for designing adaptive anti-drug education programs.
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.812793
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Article ; Online: Competitive bio-augmentation overcoming unusual direct inhibitor inefficacy in mainstream nitrite-oxidizing bacteria suppression: Unveiling the underpinnings in microbial and nitrogen metabolism aspects.

Wei, Yanxiao / Ye, Min / Chen, Yujie / Li, Yu-You

The Science of the total environment

2024 Volume 926, Page(s) 171900

Abstract: The long-stabilized mainstream partial nitritation/Anammox (PN/A) process continues to encounter significant challenges from nitrite-oxidizing bacteria (NOB). Therefore, this study aimed to determine an efficient, rapid, and easily implementable strategy ...

Abstract	The long-stabilized mainstream partial nitritation/Anammox (PN/A) process continues to encounter significant challenges from nitrite-oxidizing bacteria (NOB). Therefore, this study aimed to determine an efficient, rapid, and easily implementable strategy for inhibiting NOB. A laboratory-scale reactor was operated continuously for 325 days, experiencing NOB outbreak in mainstream and recovery with simulated sidestream support. The results show that direct inhibitory strategies including intermittent aeration and approximately 35 mg/L free ammonia had unusual weak inhibitory effects on NOB activity. Subsequently, the exogenous Anammox from sidestream employed as a competitive bio-augmentation approach rapidly inhibited NOB dynamics. Evidence suggests that the damaged hydroxyapatite granules under low pH conditions might have contributed to NOB dominance by diminishing Anammox bacteria activity, thereby creating a substrate-rich environment favoring NOB survival. In contrast, the introduction of exogenous Candidatus Kuenenia facilitated the nitrogen removal efficiency from 32.5 % to over 80 %. This coincided with a decrease in the relative abundance of Nitrospira from 16.5 % to 2.7 % and NOB activity from 0.34 to 0.07 g N/(g mixed liquor volatile suspended solid)/d. Metagenomic analysis reveals a decrease in the functional potential of most nitrite transport proteins, coupled with a significant increase in eukaryotic-like serine/threonine-protein kinase involved in cellular regulation, during the Anammox activity recovery. This study's findings reveal the feasibility of the bio-augmentation based on substrate competition, wherein sidestream processes support the mainstream PN/A integration, offering significant potential for practical applications.
MeSH term(s)	Nitrites/metabolism ; Oxidation-Reduction ; Bioreactors/microbiology ; Bacteria/metabolism ; Nitrogen/metabolism ; Sewage/microbiology ; Ammonium Compounds/metabolism
Chemical Substances	Nitrites ; Nitrogen (N762921K75) ; Sewage ; Ammonium Compounds
Language	English
Publishing date	2024-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171900
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Article ; Online: Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke.

Duan, Mingxu / Xu, Ya / Li, Yuanshu / Feng, Hua / Chen, Yujie

Journal of neuroinflammation

2024 Volume 21, Issue 1, Page(s) 102

Abstract: The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous system and the peripheral immune system, ... ...

Abstract	The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence of strong links and interactions between the central nervous system and the peripheral immune system, both in the healthy state and after ischemic and hemorrhagic stroke. Although primary injury after stroke is certainly important, the limited therapeutic efficacy, poor neurological prognosis and high mortality have led researchers to realize that secondary injury and damage may also play important roles in influencing long-term neurological prognosis and mortality and that the neuroinflammatory process in secondary injury is one of the most important influences on disease progression. Here, we summarize the interactions of the central nervous system with the peripheral immune system after ischemic and hemorrhagic stroke, in particular, how the central nervous system activates and recruits peripheral immune components, and we review recent advances in corresponding therapeutic approaches and clinical studies, emphasizing the importance of the role of the peripheral immune system in ischemic and hemorrhagic stroke.
MeSH term(s)	Humans ; Hemorrhagic Stroke/complications ; Brain Ischemia/complications ; Brain ; Stroke/complications ; Brain Injuries/complications ; Brain Neoplasms/complications
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-024-03101-y
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Article ; Online: Simultaneous Profiling of Chromosome Conformation and Gene Expression in Single Cells.

Chen, Yujie / Xu, Heming / Liu, Zhiyuan / Xing, Dong

Bio-protocol

2023 Volume 13, Issue 22, Page(s) e4886

Abstract: Rapid development in single-cell chromosome conformation capture technologies has provided valuable insights into the importance of spatial genome architecture for gene regulation. However, a long-standing technical gap remains in the simultaneous ... ...

Abstract	Rapid development in single-cell chromosome conformation capture technologies has provided valuable insights into the importance of spatial genome architecture for gene regulation. However, a long-standing technical gap remains in the simultaneous characterization of three-dimensional genomes and transcriptomes in the same cell. We have described an assay named Hi-C and RNA-seq employed simultaneously (HiRES), which integrates in situ reverse transcription and chromosome conformation capture (3C) for the parallel analysis of chromatin organization and gene expression. Here, we provide a detailed implementation of the assay, using mouse embryos and cerebral cortices as examples. The versatility of this method extends beyond these two samples, with the potential to be used in various other cell types. Key features • A multi-omics sequencing approach to profile 3D genome structure and gene expression simultaneously in single cells. • Compatible with animal tissues. • One-tube amplification of both DNA and RNA components. • Requires three days to complete.
Language	English
Publishing date	2023-11-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4886
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