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  1. Article ; Online: A fake tumour based on MRI.

    Pan, Shaorong / Shao, Wanjin / Chen, Zeyang

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.02.089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A large asymptomatic rectal tonsil.

    Pan, Shaorong / Li, Yalun / Chen, Zeyang

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Giant pancreatic acinar cell carcinoma with gastrointestinal hemorrhage.

    Pan, Shaorong / Chen, Zeyang / Wang, Pengyuan

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2024.03.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of the quality and reliability of anal cancer and its precancerous lesions-related content on YouTube: a cross-sectional study.

    Chen, Zeyang / Pan, Shaorong / Zhou, Meng / Wang, Xin

    BMJ open

    2023  Volume 13, Issue 10, Page(s) e074787

    Abstract: Objectives: This research aims at evaluating the quality of anal cancer and its precancerous lesions-related videos on YouTube.: Design: Cross-sectional survey design.: Setting: USA.: Participants: The top 150 videos on YouTube were selected ... ...

    Abstract Objectives: This research aims at evaluating the quality of anal cancer and its precancerous lesions-related videos on YouTube.
    Design: Cross-sectional survey design.
    Setting: USA.
    Participants: The top 150 videos on YouTube were selected for analysis based on three search terms. The duplicate, irrelevant, commercial, operation-related and audio-free videos were excluded. Finally, 105 relevant videos were included.
    Methods: We assessed the completeness of video content from six dimensions and marked the men having sex with men (MSM)-related videos. To measure the video quality, DISCERN,
    Results: The video content was mainly about the management of the disease (mean score 1.086). Overall, the quality of videos uploaded by the non-profit organisation was relatively high. A correlation existed between each other of the
    Conclusions: Although the overall quality of information about anal cancer and its precancerous lesions videos on YouTube is acceptable, it might not fully meet the health information needs of patients. Therefore, they should exercise caution when using YouTube as a source of anal cancer-related information, especially the MSM population.
    MeSH term(s) United States ; Male ; Humans ; Cross-Sectional Studies ; Homosexuality, Male ; Reproducibility of Results ; Sexual and Gender Minorities ; Social Media ; Anus Neoplasms ; Precancerous Conditions ; Video Recording ; Information Dissemination
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-074787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A new type of supralevator fistula with an external opening located at the lumbosacral region: A case report.

    Chen, Zeyang / Sun, Guidong / Shao, Wanjin

    Asian journal of surgery

    2023  Volume 46, Issue 8, Page(s) 3230–3231

    MeSH term(s) Humans ; Lumbosacral Region ; Rectal Fistula/surgery
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Surgical intervention and management of Behcet disease with perianal abscess: A case report.

    Pan, Shaorong / Shao, Wanjin / Chen, Zeyang

    Asian journal of surgery

    2023  Volume 47, Issue 2, Page(s) 1040–1041

    MeSH term(s) Humans ; Behcet Syndrome ; Abscess/surgery ; Anus Diseases/surgery ; Rectal Fistula/surgery
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.10.096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Characteristics and functions of memory regulatory T cells in normal pregnancy cycle and pregnancy complications.

    Chen, Zeyang / Zhou, Xiaojiao / Qu, Hongmei / Zhang, Xiaolu / Kwak-Kim, Joanne / Wang, Wenjuan

    Journal of reproductive immunology

    2024  Volume 163, Page(s) 104235

    Abstract: Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than ... ...

    Abstract Regulatory T cells (Tregs) are activated and expanded after exposure to fetal-specific (paternal) antigens. A proportion of Tregs differentiate into memory Tregs (mTregs), exhibiting immune memory function and exerting more potent immunosuppression than naive Tregs (nTregs). However, it is unclear how mTregs are regulated during normal and pathological pregnancies (e.g., gestational diabetes mellitus (GDM) and preeclampsia (PE)). In this study, PD-1, HLA-G, and HLA-DR expressions on memory CD4
    Language English
    Publishing date 2024-03-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2024.104235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Does temporary transfer to preoperative hemodialysis influence postoperative outcomes in patients on peritoneal dialysis? A retrospective cohort study.

    Zhang, Yuyang / Zhou, Qingqing / Chen, Zeyang / Dong, Jie / Wang, Pengyuan

    Frontiers in surgery

    2023  Volume 9, Page(s) 1056908

    Abstract: Background: The associations between preoperative transfer to hemodialysis (HD) and postoperative outcomes in patients on chronic peritoneal dialysis (PD) remain unknown. We conducted this retrospective cohort study to investigate whether preoperative ... ...

    Abstract Background: The associations between preoperative transfer to hemodialysis (HD) and postoperative outcomes in patients on chronic peritoneal dialysis (PD) remain unknown. We conducted this retrospective cohort study to investigate whether preoperative HD could influence surgical outcomes in PD patients undergoing major surgeries.
    Methods: All chronic PD patients who underwent major surgeries from January 1, 2007, to December 31, 2020, at Peking University First Hospital were screened. Major surgery was defined as surgical procedures under general, lumbar or epidural anesthesia, with more than an overnight hospital stay. Patients under the age of 18, with a dialysis duration of less than 3 months, and those who underwent renal implantation surgeries and procedures exclusively aimed at placing or removing PD catheters were excluded. Patients involved were divided into either HD or PD group based on their preoperative dialysis status for further analysis.
    Results: Of 105 PD patients enrolled, 65 continued PD, and 40 switched to HD preoperatively. Patients with preoperative HD were significantly more likely to develop postoperative hyperkalemia. The total complication rates were numerically higher in patients undergoing preoperative HD. After adjustment, the incidence of postoperative hyperkalemia or any other postoperative complication rates were similar between groups. There were no differences in long-term survival between the two groups.
    Conclusions: It does not seem indispensable for PD patients to switch to temporary HD before major surgeries.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.1056908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Memory regulatory T cells in pregnancy.

    Chen, Zeyang / Zhang, Yanan / Kwak-Kim, Joanne / Wang, Wenjuan

    Frontiers in immunology

    2023  Volume 14, Page(s) 1209706

    Abstract: Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta, ... ...

    Abstract Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta, such that the likelihood of adverse pregnancy outcomes can be increased. Regulatory T cells (Tregs) are capable of suppressing excessive immune responses and regulating immune homeostasis. When stimulating Tregs, specific antigens will differentiate into memory Tregs with long-term survival and rapid and powerful immune regulatory ability. Immunomodulatory effects mediated by memory Tregs at the maternal-fetal interface take on critical significance in a successful pregnancy. The impaired function of memory Tregs shows a correlation with various pregnancy complications (e.g., preeclampsia, gestational diabetes mellitus, and recurrent pregnancy losses). However, the differentiation process and characteristics of memory Tregs, especially their role in pregnancy, remain unclear. In this study, a review is presented in terms of memory Tregs differentiation and activation, the characteristics of memory Tregs and their role in pregnancy, and the correlation between memory Tregs and pregnancy complications. Furthermore, several potential therapeutic methods are investigated to restore the function of memory Tregs in accordance with immunopathologies arising from memory Tregs abnormalities and provide novel targets for diagnosing and treating pregnancy-associated diseases.
    MeSH term(s) Pregnancy ; Humans ; Female ; T-Lymphocytes, Regulatory ; Placenta ; Immune Tolerance ; Immunomodulation ; Pre-Eclampsia
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1209706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immune checkpoint inhibitors and reproductive failures.

    Chen, Zeyang / Huang, Jinxia / Kwak-Kim, Joanne / Wang, Wenjuan

    Journal of reproductive immunology

    2023  Volume 156, Page(s) 103799

    Abstract: The human conceptus is a semi-allograft, which is antigenically foreign to the mother. Hence, the implantation process needs mechanisms to prevent allograft rejection during successful pregnancy. Immune checkpoints are a group of inhibitory pathways ... ...

    Abstract The human conceptus is a semi-allograft, which is antigenically foreign to the mother. Hence, the implantation process needs mechanisms to prevent allograft rejection during successful pregnancy. Immune checkpoints are a group of inhibitory pathways expressed on the surface of various immune cells in the form of ligand receptors. Immune cells possess these pathways to regulate the magnitude of immune responses and induce maternal-fetal tolerance. Briefly, 1) CTLA-4 can weaken T cell receptor (TCR) signals and inhibit T cell response; 2) The PD-1/PD-L1 pathway can reduce T cell proliferation, enhance T cell anergy and fatigue, reduce cytokine production, and increase T regulatory cell activity to complete the immunosuppression; 3) TIM3 interacts with T cells by binding Gal-9, weakening Th1 cell-mediated immunity and T cell apoptosis; 4) The LAG-3 binding to MHC II can inhibit T cell activation by interfering with the binding of CD4 to MHC II, and; 5) TIGIT can release inhibitory signals to NK and T cells through the ITIM structure of its cytoplasmic tail. Therefore, dysregulated immune checkpoints or the application of immune checkpoint inhibitors may impair human reproduction. This review intends to deliver a comprehensive overview of immune checkpoints in pregnancy, including CTLA-4, PD-1/PD-L1, TIM-3, LAG-3, TIGIT, and their inhibitors, reviewing their roles in normal and pathological human pregnancies.
    MeSH term(s) Humans ; Neoplasms ; CTLA-4 Antigen/metabolism ; Immune Checkpoint Inhibitors/therapeutic use ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor/metabolism ; Receptors, Immunologic/metabolism ; Receptors, Immunologic/therapeutic use
    Chemical Substances CTLA-4 Antigen ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Receptors, Immunologic
    Language English
    Publishing date 2023-01-13
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 424421-7
    ISSN 1872-7603 ; 0165-0378
    ISSN (online) 1872-7603
    ISSN 0165-0378
    DOI 10.1016/j.jri.2023.103799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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