LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 10 von insgesamt 107

Artikel ; Online: Ability of

Chen, Zheng-Hong / Sun, Jian-Chao / Yang, Ting-Xiu / Cui, Gu-Zhen

2024 Band 30, Heft 16, Seite(n) 2281–2284

Abstract: The following are our views regarding the "letter to the editor" ( ...

Abstract	The following are our views regarding the "letter to the editor" (
Mesh-Begriff(e)	Helicobacter pylori/pathogenicity ; Humans ; Helicobacter Infections/microbiology ; Candida/physiology ; Candida/growth & development ; Candida/pathogenicity ; Vacuoles/microbiology ; Vacuoles/metabolism ; Stomach/microbiology ; Gastric Mucosa/microbiology
Sprache	Englisch
Erscheinungsdatum	2024-04-29
Erscheinungsland	United States
Dokumenttyp	Letter ; Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v30.i16.2281
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 6039: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel: Investigation of Damage and Creep for Bedding's Carbonaceous Slate with Chemical Erosion Effect.

Zeng, Weihao / Chen, Zhenghong / Xie, Yunpeng / Chen, Qiunan

Materials (Basel, Switzerland)

2023 Band 16, Heft 14

Abstract: Tunnel projects in the southwestern mountainous area of China are in full swing. According to the tunnel burial depth, structural characteristics, and chemical erosion environments of the Lixiang railway tunnel, carbonaceous slate specimens obtained in ... ...

Abstract	Tunnel projects in the southwestern mountainous area of China are in full swing. According to the tunnel burial depth, structural characteristics, and chemical erosion environments of the Lixiang railway tunnel, carbonaceous slate specimens obtained in the field were taken to experimentally investigate the physical, mechanical, and creep characteristics of the bedding's slate specimens after chemical erosion. The results of scanning electron microscopy (SEM) indicate that chemical erosion leads to internal damage in the carbonaceous slate specimens, and the internal damages are increasing with the increase of erosion days. Moreover, the specimens' ultrasonic test (UT) results prove that specimens with smaller bedding angles suffer a more serious erosion and induce more internal cracks. Under conventional triaxial compression conditions with 40 MPa of confining pressures, the conventional triaxial compressive strength (σ
Sprache	Englisch
Erscheinungsdatum	2023-07-22
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16145163
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel: Study on the Degradation Effect of Carbonaceous Shale under the Coupling Effect of Chemical Erosion and High Temperature.

Xiong, Guangwei / Chen, Qiunan / He, Yongchao / Chen, Zhenghong / Huang, Xiaocheng / Xie, Yunpeng

Materials (Basel, Switzerland)

2024 Band 17, Heft 3

Abstract: The southwest region of China has abundant groundwater and high-temperature geothermal energy. Carbonaceous shale, as one of the typical surrounding rocks in this region, often suffers from deterioration effects due to the coupled action of groundwater ... ...

Abstract	The southwest region of China has abundant groundwater and high-temperature geothermal energy. Carbonaceous shale, as one of the typical surrounding rocks in this region, often suffers from deterioration effects due to the coupled action of groundwater chemical erosion and high temperature, which affects the long-term stability of tunnel engineering. In order to investigate the deterioration effects of carbonaceous shale under the coupled action of chemical erosion and high temperature, carbonaceous shale from a tunnel of Lixiang Railway in Yunnan Province was taken as the research object. The microstructure and mineral composition of the samples before and after chemical erosion were obtained with a scanning electron microscope-energy dispersive spectrometer and an X-ray diffraction test. Then, triaxial compression tests were conducted on the samples under different time points and different temperature effects of chemical erosion, and the stress-strain curves and the deterioration laws under a single factor were obtained. An improved numerical simulation method based on the parallel bond model was developed, which can account for the coupled effects of chemical erosion and high temperature on the rock. By simulating the triaxial compression test of carbonaceous shale, the deterioration law of carbonaceous shale under the coupled action was discussed. The results show that chemical erosion has a significant deterioration effect on the triaxial compressive strength of carbonaceous shale, and the degree of deterioration is related to the erosion time. In the first 30 days of erosion, the triaxial compressive strength of carbonaceous shale decreased by 11.38%, which was the largest deterioration range. With the increase in erosion time, the deterioration rate gradually decreased; temperature had a significant threshold effect on the strength of carbonaceous shale, and a clear turning point appeared at about 200 °C. By simulating the deterioration effects of carbonaceous shale under the coupled action of chemical erosion and high temperature, it was found that the longer the duration of chemical erosion, the stronger the temperature sensitivity of carbonaceous shale, and the more serious the loss of compressive strength during the heating process. When the temperature was low, the strength of carbonaceous shale changed little, and some samples even showed an increase in strength; when the temperature was high, the strength of carbonaceous shale decreased significantly, showing deterioration characteristics. The numerical simulation method was compared and verified with the indoor test results, and it was found that the numerical calculation had a good agreement with the test results.
Sprache	Englisch
Erscheinungsdatum	2024-02-01
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17030701
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: [Group Ⅱ introns and the application in biotechnology: a review].

Cui, Guzhen / Hua, Dengxiong / Gu, Junying / Chen, Zhenghong

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2022 Band 38, Heft 3, Seite(n) 915–924

Abstract: Group Ⅱ introns are self-splicing ribozymes, which insert directly into target sites in DNA with high frequency through "retrohoming". They specifically and efficiently recognize and splice DNA target sites, endowing themselves with great potential in ... ...

Abstract	Group Ⅱ introns are self-splicing ribozymes, which insert directly into target sites in DNA with high frequency through "retrohoming". They specifically and efficiently recognize and splice DNA target sites, endowing themselves with great potential in genetic engineering. This paper reviewed the gene targeting principle of group Ⅱ introns and the application in microbial genetic modification, and then analyzed the limitations of them in multi-functional gene editing and eukaryotes based on the "retrohoming" characteristics and the dependence on high Mg
Mesh-Begriff(e)	DNA ; Eukaryota ; Gene Targeting ; Introns/genetics ; RNA, Catalytic/genetics
Chemische Substanzen	RNA, Catalytic ; DNA (9007-49-2)
Sprache	Chinesisch
Erscheinungsdatum	2022-03-30
Erscheinungsland	China
Dokumenttyp	Journal Article ; Review
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.210256
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 3505: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Transcranial Pulsed Ultrasound with Alteplase Intravenous Thrombolysis for Vascular Recanalisation in Acute Ischemic Stroke.

Chen, Zhenghong / Zhang, Jingyu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2020 Band 30, Heft 7, Seite(n) 765–767

Abstract: The objective of study was to investigate the effect of transcranial pulsed ultrasound combined with alteplase on treatment of vascular recanalisation in acute ischemic stroke patients. Eighty-two patients were randomly divided equally into two groups. ... ...

Abstract	The objective of study was to investigate the effect of transcranial pulsed ultrasound combined with alteplase on treatment of vascular recanalisation in acute ischemic stroke patients. Eighty-two patients were randomly divided equally into two groups. Group A was treated with transcranial pulsed ultrasound combined with alteplase intravenous thrombolysis. Group B received alteplase intravenous thrombolytic treatment. At 2 and 24 hours after treatment, National Institutes of Health Stroke Scale (NIHSS) score of group A was lower than that of group B (both p<0.001), and vascular recanalisation rate of patients in group A was higher than that of group B (p=0.004, and 0.002 respectively). At 90 days after treatment, rate of favourable prognosis [(modified rankin scale (mRS) ≤2 points)] of group A was higher than that of group B (p=0.001). Transcranial pulsed ultrasound combined with alteplase intravenous thrombolytic treatment can improve vascular recanalization rate and prognosis. Key Words: Transcranial pulsed ultrasound, Acute ischemic stroke, Alteplase, Thrombolysis, Vascular recanalisation.
Mesh-Begriff(e)	Brain Ischemia/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke/drug therapy ; Stroke/drug therapy ; Thrombolytic Therapy ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome ; Ultrasonic Waves
Chemische Substanzen	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
Sprache	Englisch
Erscheinungsdatum	2020-08-19
Erscheinungsland	Pakistan
Dokumenttyp	Journal Article ; Randomized Controlled Trial
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2020.07.765
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 6532: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾
- Im ZB MED-Bestand
- Kostenpflichtig bestellen

Artikel ; Online: Unraveling the Dynamic Molecular Motions of a Twin-Cavity Cage with Slow Configurational but Rapid Conformational Interconversions.

Zuo, Yong / Chen, Zhenghong / Li, Ziying / Fu, Enguang / Xin, Yonghang / Chen, Chenhao / Li, Chenfei / Zhang, Shaodong

Angewandte Chemie (International ed. in English)

2024 , Seite(n) e202405858

Abstract: Featuring diverse structural motions/changes, dynamic molecular systems hold promise for executing complex tasks. However, their structural complexity presents formidable challenge in elucidating their kinetics, especially when multiple structural ... ...

Abstract	Featuring diverse structural motions/changes, dynamic molecular systems hold promise for executing complex tasks. However, their structural complexity presents formidable challenge in elucidating their kinetics, especially when multiple structural motions are intercorrelated. We herein introduce a twin-cavity cage that features interconvertible C3- and C1-configurations, each configuration exhibiting interchangeable P- and M-conformations. This molecule is therefore composed of four interconnected chiral species (P)-C3, (M)-C3, (P)-C1, (M)-C1. We showcase an effective methodology to decouple these sophisticated structural changes into two kinetically distinct pathways. Utilizing time-dependent 1H NMR spectroscopy at various temperatures, which disregards the transition between mirror-image conformations, we first determine the rate constant (kc) for C3- to C1-configuration interconversion; while time-dependent circular dichroism spectroscopy at different temperatures quantifies the observed rate constant (kobs) of ensemble of all structural changes. As kobs >> kc, it allows us to decouple the overall molecular motions into a slow configurational transformation and rapid conformational interconversions, the latter further dissected into two independent conformational interchanges, namely (P)-C3 ⇄ (M)-C3 and (P)-C1 ⇄ (M)-C1. This work therefore sheds light on comprehensive kinetic study of complex molecular dynamics, offering valuable insights for the rational design of smart dynamic materials for applications of sensing, separation, catalysis, molecular machinery, etc.
Sprache	Englisch
Erscheinungsdatum	2024-04-11
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202405858
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Über subito bestellen

Details ▾
- Volltext online
- Kostenpflichtig bestellen

Artikel ; Online: 125

Chen, Zheng-Hong / Zhang, Yi-Li / Yuan, Bin / Chen, Wen-Juan / Lei, Guang-Yan / Han, Le

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2023 Band 25, Heft 7, Seite(n) 2127–2137

Abstract: Background and purpose: Arsenic trioxide (ATO) exerts anticancer effects on lung cancer. However, the clinical use of ATO is limited due to its systemic toxicity and resistance of lung cancer cells. The present study aimed to investigate the effects of ... ...

Abstract	Background and purpose: Arsenic trioxide (ATO) exerts anticancer effects on lung cancer. However, the clinical use of ATO is limited due to its systemic toxicity and resistance of lung cancer cells. The present study aimed to investigate the effects of ATO, alone and in combination with Methods: The transmission electron microscope observed the tumor ultrastructure of lung cancer xenograft mice. The proliferation index of Ki-67 and the number and morphology of tumor microvessels were detected with immunohistochemical staining. The protein and mRNA expression were examined by western blot and real-time PCR assay. Results: The in vivo results demonstrated that ATO combined with Conclusions: ATO combined with
Mesh-Begriff(e)	Humans ; Animals ; Mice ; Arsenic Trioxide/therapeutic use ; Heterografts ; Ki-67 Antigen ; Xenograft Model Antitumor Assays ; Apoptosis ; Lung Neoplasms/pathology ; RNA, Messenger ; Cell Line, Tumor ; Cell Proliferation ; Antineoplastic Agents/therapeutic use
Chemische Substanzen	Arsenic Trioxide (S7V92P67HO) ; Iodine-125 (GVO776611R) ; Ki-67 Antigen ; RNA, Messenger ; Antineoplastic Agents
Sprache	Englisch
Erscheinungsdatum	2023-02-01
Erscheinungsland	Italy
Dokumenttyp	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-023-03092-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 6644: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Details ▾

Buch ; Online: Spheroid Model for Molecular Packing in Crystalline Phase

Wang, Weihao / Chen, Zhenghong / Gao, Yang / Jiao, Yang / Zhang, Shaodong

2023

Abstract: Dense packing of particles has provided important models to study the structure of matter in various systems such as liquid, glassy and crystalline phase, etc. The simplest sphere packing models are able to represent and capture salient properties of the ...

Abstract	Dense packing of particles has provided important models to study the structure of matter in various systems such as liquid, glassy and crystalline phase, etc. The simplest sphere packing models are able to represent and capture salient properties of the building blocks for covalent, metallic and ionic crystals; it however becomes insufficient to reflect the broken symmetry of the commonly anisotropic molecules in complex molecular crystals. Here we develop spheroid models with the minimal degree of anisotropy, which serve as a simple geometrical representation for a rich spectrum of molecules--including both isotropic and anisotropic, convex and concave ones--in crystalline phases. Our models are determined via an inverse packing approach: given a molecular crystal, an optimal spheroid model is constructed using a contact diagram, which depicts packing relationship between neighboring molecules within the crystal. The spheroid models are capable of accurately capturing the broken symmetry and characterizing the equivalent volume of molecules in the crystalline phases. Our model also allows to retrieve such molecular information from poor-quality crystal X-ray diffraction data that otherwise would be simply discarded.
Schlagwörter	Condensed Matter - Soft Condensed Matter
Thema/Rubrik (Code)	612
Erscheinungsdatum	2023-03-02
Erscheinungsland	us
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel: IGF2BP2 Regulates MALAT1 by Serving as an N6-Methyladenosine Reader to Promote NSCLC Proliferation.

Han, Le / Lei, Guangyan / Chen, Zhenghong / Zhang, Yili / Huang, Chen / Chen, Wenjuan

Frontiers in molecular biosciences

2022 Band 8, Seite(n) 780089

Abstract: Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is an important posttranscriptional regulatory for stability and m6A modification. Here, we investigated the role of IGF2BP2 in non-small-cell lung cancer (NSCLC) proliferation. TCGA ... ...

Abstract	Insulin-like growth factor 2 (IGF2) mRNA-binding protein 2 (IGF2BP2) is an important posttranscriptional regulatory for stability and m6A modification. Here, we investigated the role of IGF2BP2 in non-small-cell lung cancer (NSCLC) proliferation. TCGA database was used to predict the expression and clinical significance of IGF2BP2 in normal and NSCLC samples. The expression of IGF2BP2 was further validated in NSCLC samples from surgery. Then we performed the functional study in NSCLC cell lines through overexpressing and knocking down IGF2BP2 in NSCLC cell lines
Sprache	Englisch
Erscheinungsdatum	2022-01-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.780089
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Neuroimaging studies of acupuncture on Alzheimer's disease: a systematic review.

Yin, Zihan / Wang, Ziqi / Li, Yaqin / Zhou, Jun / Chen, Zhenghong / Xia, Manze / Zhang, Xinyue / Wu, Jiajing / Zhao, Ling / Liang, Fanrong

BMC complementary medicine and therapies

2023 Band 23, Heft 1, Seite(n) 63

Abstract: Background: Acupuncture effectively improves cognitive function in Alzheimer's disease (AD). Many neuroimaging studies have found significant brain alterations after acupuncture treatment of AD, but the underlying central modulation mechanism is unclear. ...

Abstract	Background: Acupuncture effectively improves cognitive function in Alzheimer's disease (AD). Many neuroimaging studies have found significant brain alterations after acupuncture treatment of AD, but the underlying central modulation mechanism is unclear. Objective: This review aims to provide neuroimaging evidence to understand the central mechanisms of acupuncture in patients with AD. Methods: Relevant neuroimaging studies about acupuncture for AD were retrieved from eight English and Chinese medicine databases (PubMed, Embase, Cochrane Library, Web of Science, SinoMed, CNKI, WF, VIP) and other resources from inception of databases until June 1, 2022, and their methodological quality was assessed using RoB 2.0 and ROBINS - I. Brain neuroimaging information was extracted to investigate the potential neural mechanism of acupuncture for AD. Descriptive statistics were used for data analysis. Results: Thirteen neuroimaging studies involving 275 participants were included in this review, and the overall methodological quality of included studies was moderate. The approaches applied included task-state functional magnetic resonance imaging (ts-fMRI; n = 9 studies) and rest-state functional magnetic resonance imaging (rs-fMRI; n = 4 studies). All studies focused on the instant effect of acupuncture on the brains of AD participants, including the cingulate gyrus, middle frontal gyrus, and cerebellum, indicating that acupuncture may regulate the default mode, central executive, and frontoparietal networks. Conclusion: This study provides evidence of the neural mechanisms underlying the effect of acupuncture on AD involving cognitive- and motor-associated networks. However, this evidence is still in the preliminary investigation stage. Large-scale, well-designed, multimodal neuroimaging trials are still required to provide comprehensive insight into the central mechanism underlying the effect of acupuncture on AD. (Systematic review registration at PROSPERO, No. CRD42022331527).
Mesh-Begriff(e)	Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/therapy ; Neuroimaging ; Brain/diagnostic imaging ; Acupuncture Therapy/methods ; Magnetic Resonance Imaging
Sprache	Englisch
Erscheinungsdatum	2023-02-23
Erscheinungsland	England
Dokumenttyp	Systematic Review ; Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-03888-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Zum Seitenanfang

Ihre letzten Suchen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED