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  1. Article ; Online: Upregulation of MED7 was associated with progression in hepatocellular carcinoma.

    Chen, Zheng-Lin / Ma, Ying-Yu / Mou, Xiao-Zhou / Zhang, Jun-Gang

    Cancer biomarkers : section A of Disease markers

    2024  Volume 38, Issue 4, Page(s) 603–611

    Abstract: Objective: MED subunits have been reported to be associated with various types of tumors, however, the potential role of MED7 in hepatocellular carcinoma (HCC) was still unclear. The aim of the study was to explore the role of MED7 in HCC.: Methods: ... ...

    Abstract Objective: MED subunits have been reported to be associated with various types of tumors, however, the potential role of MED7 in hepatocellular carcinoma (HCC) was still unclear. The aim of the study was to explore the role of MED7 in HCC.
    Methods: In this study, MED7 mRNA expression levels between HCC and adjacent normal tissues were first analyzed by several public datasets. Then we utilized a tissue microarray (TMA) to investigate the clinical role of MED7 in HCC by immunohistochemistry (IHC). Meanwhile, the potential mechanisms of MED7 based on gene-gene correlation analyses were also explored.
    Results: High mRNA level of MED7 correlated with advanced stage and worse grade of differentiation. IHC results showed that MED7 protein level was upregulated in HCC and associated with Edmondson grade and Microvascular invasion in 330 cases of HCC. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis revealed that MED7 co-expressed genes participate primarily in ribonucleoprotein complex biogenesis, protein targeting, mRNA processing and nucleoside triphosphate metabolic process et cetera. Further analysis also revealed that MED7 mRNA level has significant correlation with immune cells infiltration levels.
    Conclusion: MED7 was upregulated in HCC and correlated with progression of HCC. Meanwhile, MED7 may promote HCC through participating in multiple gene networks to influence tumorigenesis as well as immune response in HCC microenvironment.
    MeSH term(s) Humans ; Carcinogenesis ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; RNA, Messenger/genetics ; Tumor Microenvironment ; Up-Regulation ; Mediator Complex/genetics
    Chemical Substances RNA, Messenger ; MED7 protein, human ; Mediator Complex
    Language English
    Publishing date 2024-01-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2203517-5
    ISSN 1875-8592 ; 1574-0153 ; 1875-8592
    ISSN (online) 1875-8592 ; 1574-0153
    ISSN 1875-8592
    DOI 10.3233/CBM-220439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Converting formaldehyde in methanol with MoO

    Deng, Banghong / Chen, Zhenglin / Yang, Lixia / Guo, Jiawei / Cheng, Cheng / Li, Xuefei / Zhang, Shuqu / Luo, Shenglian

    Journal of hazardous materials

    2024  Volume 466, Page(s) 133606

    Abstract: Direct photocatalytic reduction of toxic formaldehyde (HCHO) in value-added chemicals and fuels is promising because that not only abates the environmental pollution, but also solves the energy shortage. Herein, self-supported ... ...

    Abstract Direct photocatalytic reduction of toxic formaldehyde (HCHO) in value-added chemicals and fuels is promising because that not only abates the environmental pollution, but also solves the energy shortage. Herein, self-supported MoO
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unleashing the potential of tungsten disulfide: Current trends in biosensing and nanomedicine applications.

    Bahri, Mohamed / Yu, Dongmei / Zhang, Can Yang / Chen, Zhenglin / Yang, Chengming / Douadji, Lyes / Qin, Peiwu

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24427

    Abstract: The discovery of graphene ignites a great deal of interest in the research and advancement of two-dimensional (2D) layered materials. Within it, semiconducting transition metal dichalcogenides (TMDCs) are highly regarded due to their exceptional ... ...

    Abstract The discovery of graphene ignites a great deal of interest in the research and advancement of two-dimensional (2D) layered materials. Within it, semiconducting transition metal dichalcogenides (TMDCs) are highly regarded due to their exceptional electrical and optoelectronic properties. Tungsten disulfide (WS
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Towards carbon neutrality: Sustainable recycling and upcycling strategies and mechanisms for polyethylene terephthalate via biotic/abiotic pathways.

    Yang, Jiaqi / Li, Zhiling / Xu, Qiongying / Liu, Wenzong / Gao, Shuhong / Qin, Peiwu / Chen, Zhenglin / Wang, Aijie

    Eco-Environment & Health

    2024  Volume 3, Issue 2, Page(s) 117–130

    Abstract: Polyethylene terephthalate (PET), one of the most ubiquitous engineering plastics, presents both environmental challenges and opportunities for carbon neutrality and a circular economy. This review comprehensively addressed the latest developments in ... ...

    Abstract Polyethylene terephthalate (PET), one of the most ubiquitous engineering plastics, presents both environmental challenges and opportunities for carbon neutrality and a circular economy. This review comprehensively addressed the latest developments in biotic and abiotic approaches for PET recycling/upcycling. Biotically, microbial depolymerization of PET, along with the biosynthesis of reclaimed monomers [terephthalic acid (TPA), ethylene glycol (EG)] to value-added products, presents an alternative for managing PET waste and enables CO
    Language English
    Publishing date 2024-02-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-9850
    ISSN (online) 2772-9850
    DOI 10.1016/j.eehl.2024.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An Up-To-Date Overview of Dental Tissue Regeneration Using Dental Origin Mesenchymal Stem Cells: Challenges and Road Ahead.

    Wang, Lin-Hong / Gao, Si-Zhe / Bai, Xiao-Lei / Chen, Zheng-Lin / Yang, Fan

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 855396

    Abstract: Stem cells (SCs) research has experienced exponential growth in recent years. SC-based treatments can enhance the lives of people suffering from cardiac ischemia, Alzheimer's disease, and regenerative drug conditions, like bone or loss of teeth. Numerous ...

    Abstract Stem cells (SCs) research has experienced exponential growth in recent years. SC-based treatments can enhance the lives of people suffering from cardiac ischemia, Alzheimer's disease, and regenerative drug conditions, like bone or loss of teeth. Numerous kinds of progenitor/SCs have been hypothesized to depend on their potential to regain and/or heal wounded tissue and partly recover organ function. Growing data suggest that SCs (SCs) are concentrated in functions and that particular tissues have more SCs. Dental tissues, in particular, are considered a significant cause of mesenchymal stem cells (MSCs) cells appropriate for tissue regeneration uses. Tissue regeneration and SCs biology have particular attention in dentistry because they may give a novel method for creating clinical material and/or tissue redevelopment. Dental pulp, dental papilla, periodontal ligament, and dental follicle contain mesenchymal SCs. Such SCs, which must be identified and cultivated in specific tissue culture environments, may be used in tissue engineering applications such as tooth tissue, nerve regeneration, and bone redevelopment. A new cause of SCs, induced pluripotent SCs, was successfully made from human somatic cells, enabling the generation of the patient and disease-specific SCs. The dental SC's (DSCs) multipotency, rapid proliferation rate, and accessibility make it an ideal basis of MSC for tissue redevelopment. This article discusses current advances in tooth SC investigation and its possible application in tissue redevelopment.
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.855396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effect of 2'-Fucosyllactose on Beige Adipocyte Formation in 3T3-L1 Adipocytes and C3H10T1/2 Cells.

    Chen, Siru / Fu, Yankun / Wang, Tianlin / Chen, Zhenglin / Zhao, Peijun / Huang, Xianqing / Qiao, Mingwu / Li, Tiange / Song, Lianjun

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 22

    Abstract: 2'-Fucosyllactose (2'-FL), the functional oligosaccharide naturally present in milk, has been shown to exert health benefits. This study was aimed to investigate the effect of 2'-fucosyllactose (2'-FL) on the browning of white adipose tissue in 3T3-L1 ... ...

    Abstract 2'-Fucosyllactose (2'-FL), the functional oligosaccharide naturally present in milk, has been shown to exert health benefits. This study was aimed to investigate the effect of 2'-fucosyllactose (2'-FL) on the browning of white adipose tissue in 3T3-L1 adipocytes and C3H10T1/2 cells. The results revealed that 2'-FL decreased lipid accumulations with reduced intracellular triglyceride contents in vitro. 2'-FL intervention increased the mitochondria density and the proportion of UCP1-positive cells. The mRNA expressions of the mitochondrial biogenesis-related and browning markers (
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12224137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Chinese herb medicine in augmented reality

    Zhu, Qianyun / Xie, Yifeng / Ye, Fangyang / Gao, Zhenyuan / Che, Binjie / Chen, Zhenglin / Yu, Dongmei

    2023  

    Abstract: Augmented reality becomes popular in education gradually, which provides a contextual and adaptive learning experience. Here, we develop a Chinese herb medicine AR platform based the 3dsMax and the Unity that allows users to visualize and interact with ... ...

    Abstract Augmented reality becomes popular in education gradually, which provides a contextual and adaptive learning experience. Here, we develop a Chinese herb medicine AR platform based the 3dsMax and the Unity that allows users to visualize and interact with the herb model and learn the related information. The users use their mobile camera to scan the 2D herb picture to trigger the presentation of 3D AR model and corresponding text information on the screen in real-time. The system shows good performance and has high accuracy for the identification of herbal medicine after interference test and occlusion test. Users can interact with the herb AR model by rotating, scaling, and viewing transformation, which effectively enhances learners' interest in Chinese herb medicine.
    Keywords Computer Science - Human-Computer Interaction
    Publishing date 2023-09-25
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Hybrid Full-Wave Analysis of Surface Acoustic Wave Devices for Accuracy and Fast Performance Prediction.

    Chen, Zhenglin / Zhang, Qiaozhen / Fu, Sulei / Wang, Xiaoyu / Qiu, Xiaojun / Wu, Haodong

    Micromachines

    2020  Volume 12, Issue 1

    Abstract: In this paper, a hybrid full-wave analysis of surface acoustic wave (SAW) devices is proposed to achieve accurate and fast simulation. The partial differential equation (PDE) models of the physical system in question and graphics processing unit (GPU)- ... ...

    Abstract In this paper, a hybrid full-wave analysis of surface acoustic wave (SAW) devices is proposed to achieve accurate and fast simulation. The partial differential equation (PDE) models of the physical system in question and graphics processing unit (GPU)-assisted hierarchical cascading technology (HCT) are used to calculate acoustic-electric characteristics of a SAW filter. The practical solid model of the radio frequency (RF) filter package is constructed in High Frequency Structure Simulator (HFSS) software and the parasitic electromagnetics of the entire package is considered in the design process. The PDE-based models of the two-dimensional finite element method (2D-FEM) are derived in detail and solved by the PDE module embedded in COMSOL Multiphysics. Due to the advantages of PDE-based 2D-FEM, it is universal, efficient and not restricted to handling arbitrary materials and crystal cuts, electrode shapes, and multi-layered substrate. Combining COMSOL Multiphysics with a user-friendly interface, a flexible way of modeling and mesh generation, it can greatly reduce the complicated process of modeling and physical properties definition. Based on a hybrid full-wave analysis, we present an example application of this approach on a TC-SAW ladder filter with 5° YX-cut LiNbO
    Language English
    Publishing date 2020-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi12010005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Geometric Nonlinear Model for Prediction of Frequency-Temperature Behavior of SAW Devices for Nanosensor Applications.

    Chen, Zhenglin / Zhang, Qiaozhen / Li, Congcong / Fu, Sulei / Qiu, Xiaojun / Wang, Xiaoyu / Wu, Haodong

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 15

    Abstract: Surface acoustic wave (SAW)-based sensors have become highly valued for their use as nanosensors in industrial applications. Accurate prediction of the thermal stability is a key problem for sensor design. In this work, a numerical tool based on the ... ...

    Abstract Surface acoustic wave (SAW)-based sensors have become highly valued for their use as nanosensors in industrial applications. Accurate prediction of the thermal stability is a key problem for sensor design. In this work, a numerical tool based on the finite element method combined with piezoelectric Lagrangian equations has been developed to accurately predict the thermal sensitivity characteristics of surface acoustic wave devices. Theoretical analysis for the geometric nonlinearity contributing to the frequency-temperature characteristic and material constants' dependency on temperature were taken into consideration. The thermomechanical equilibrium equation built on the three-dimensional finite element method (3D-FEM) mesh node took mesh movement into account because thermal expansion was employed. The frequency-temperature characteristics of different SAW modes, including Rayleigh waves and leaky waves excited on a piezoelectric substrate of quartz or lithium tantalate, respectively, were calculated. The theoretical accuracy of the proposed numerical tool was verified by experiments.
    Language English
    Publishing date 2020-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20154237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Optimization of Surface Acoustic Wave Resonators on 42°Y-X LiTaO

    Pan, Hongzhi / Yang, Yang / Li, Lingqi / Zhang, Qiaozhen / Zheng, Zeyu / Du, Xuesong / Chen, Pingjing / Dong, Jiahe / Lu, Chuan / Xie, Xiao / Li, Hualin / Xiao, Qiang / Ma, Jinyi / Chen, Zhenglin

    Micromachines

    2023  Volume 15, Issue 1

    Abstract: SAW devices with a multi-layered piezoelectric substrate have excellent performance due to advantages such as a high quality factor, ...

    Abstract SAW devices with a multi-layered piezoelectric substrate have excellent performance due to advantages such as a high quality factor,
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi15010012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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