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Book ; Online ; E-Book: Genomic approach to asthma

Wang, Xiangdong / Chen, Zhihong

(Translational bioinformatics ; 12)

2018

Author's details	Xiangdong Wang, Zhihong Chen editors
Series title	Translational bioinformatics ; 12
Collection
Keywords	Life sciences ; Human physiology ; Bioinformatics
Language	English
Size	1 Online-Ressource (xvi, 385 Seiten)
Publisher	Springer
Publishing place	Singapore
Publishing country	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019756739
ISBN	978-981-10-8764-6 ; 9789811087639 ; 981-10-8764-4 ; 9811087636
DOI	10.1007/978-981-10-8764-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: SARS-CoV-2 infection increases airway bleeding risk in patients after tracheostomies.

Tang, Shupin / Lin, Gongbiao / Wu, Xiaobo / Chen, Zhihong

Virology journal

2024 Volume 21, Issue 1, Page(s) 61

Abstract: Background: Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency of SARS-CoV-2 RNA test results ...

Abstract	Background: Airway bleeding events are a rare incident in SARS-CoV-2-infected patients after tracheostomies. We aimed to explore the correlation between airway bleeding and SARS-CoV-2 infection and evaluate the consistency of SARS-CoV-2 RNA test results in the upper and lower airway samples from patients after tracheostomies. Methods: Forty-four patients after temporary or permanent tracheostomy were divided into a positive group (29 patients) and a negative group (15 patients) based on the SARS-CoV-2 RNA test results of their oropharyngeal swabs. The oropharyngeal and tracheal swabs of the positive group were re-collected for SARS-CoV-2 RNA detection. Demographic and clinical characteristics and airway bleeding events were recorded for all enrolled patients. Results: Airway bleeding was reported in eleven patients of the positive group (11/29), with seven displaying bloody sputum or hemoptysis, and four featuring massive sputum crust formation in the trachea that resulted in dyspnea, and only one patient in the negative group (1/15), with a significant difference in the airway bleeding rate (37.9% vs. 6.7%, p < 0.05). The SARS-CoV-2 RNA test results showed a statistical difference in cycle threshold (Ct) values between oropharyngeal swabs and tracheal swabs (p < 0.05). Conclusions: After tracheostomies, patients are more susceptible to airway bleeding if they are infected with SARS-CoV-2. The findings signify that in addition to droplet transmission through tracheostoma, SARS-CoV-2 may infect the oropharynx by airborne and close contact transmission, and that given the higher viral load and longer infection time in the trachea, tracheal swabs are more reliable for SARS-CoV-2 detection in these patients.
MeSH term(s)	Humans ; COVID-19 ; Tracheostomy/adverse effects ; SARS-CoV-2/genetics ; RNA, Viral/genetics ; Respiratory System
Chemical Substances	RNA, Viral
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-024-02320-2
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Article ; Online: Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries.

Chen, Zhihong / Zhang, Jingang / Pan, Yongli / Hao, Zhongnan / Li, Shuang

Frontiers in immunology

2024 Volume 15, Page(s) 1343364

Abstract: Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular ... ...

Abstract	Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular dynamics and protein production. The polarization of macrophages/microglia involves a pivotal impact in modulating the development of inflammatory disorders, namely lung and traumatic brain injuries. Recent evidence indicates shared signaling pathways in lung and traumatic brain injuries, regulated through non-coding RNAs (ncRNAs) loaded into extracellular vesicles (EVs). This packaging protects ncRNAs from degradation. These vesicles are subcellular components released through a paracellular mechanism, constituting a group of nanoparticles that involve exosomes, microvesicles, and apoptotic bodies. EVs are characterized by a double-layered membrane and are abound with proteins, nucleic acids, and other bioactive compounds. ncRNAs are RNA molecules with functional roles, despite their absence of coding capacity. They actively participate in the regulation of mRNA expression and function through various mechanisms. Recent studies pointed out that selective packaging of ncRNAs into EVs plays a role in modulating distinct facets of macrophage/microglia polarization, under conditions of lung and traumatic brain injuries. This study will explore the latest findings regarding the role of EVs in the progression of lung and traumatic brain injuries, with a specific focus on the involvement of ncRNAs within these vesicles. The conclusion of this review will emphasize the clinical opportunities presented by EV-ncRNAs, underscoring their potential functions as both biomarkers and targets for therapeutic interventions.
MeSH term(s)	Humans ; Microglia/metabolism ; Macrophages/metabolism ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Brain Injuries, Traumatic/metabolism ; Lung/metabolism ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1343364
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Article ; Online: Alveolar rhabdomyosarcoma with multiple bone marrow infiltration.

Wang, Kun / Chen, Zhihong / Li, Yanchun / Mao, Zhiqun

The Lancet. Oncology

2023 Volume 24, Issue 5, Page(s) e228

MeSH term(s)	Humans ; Bone Marrow ; Rhabdomyosarcoma, Alveolar/therapy ; Diagnosis, Differential ; Rhabdomyosarcoma
Language	English
Publishing date	2023-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(23)00015-3
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Investigation on the association between serum lipid levels and periodontitis: a bidirectional Mendelian randomization analysis.

Chen, Zhihong / Song, Jukun / Tang, Liszen

BMC oral health

2023 Volume 23, Issue 1, Page(s) 827

Abstract: Objective: Several research has considered the potential correlation between periodontitis and serum lipids. However, serum lipid profiles correlation with periodontitis remains largely unknown. The investigation objective was to examine periodontitis ... ...

Abstract	Objective: Several research has considered the potential correlation between periodontitis and serum lipids. However, serum lipid profiles correlation with periodontitis remains largely unknown. The investigation objective was to examine periodontitis correlation with serum lipid levels using a bidirectional Mendelian randomization (MR) analysis. Methods: The study employed a bidirectional MR analysis with two samples, utilizing a freely accessible genome-wide association study (GWAS). Furthermore, the primary analysis employed the inverse variance weighted (IVW) method. To determine whether the lipid profiles were associated with periodontitis, a variety of sensitivity analyses (including MR-Egger regression, MR-PRESSO, and weighted median), as well as multivariable MR, were employed. Results: MR analysis performed by IVW did not reveal any relationship between periodontitis and low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), or total cholesterol (TC). It was also found that LDL, HDL, TG, and TC were not associated to periodontitis. Furthermore, the MR estimations exhibited consistency with other MR sensitivity and multivariate MR (MVMR) analyses. These results show that the correlation between serum lipid levels and periodontitis could not be established. Conclusion: The finding indicates a negligible link between periodontitis and serum lipid levels were identified, despite previous observational studies reporting a link between periodontitis and serum lipid levels.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Periodontitis/genetics ; Triglycerides ; Polymorphism, Single Nucleotide
Chemical Substances	Triglycerides
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03575-x
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Article ; Online: Step-back anterior repositioning splint retraction for temporomandibular joint disc displacement with reduction in adult patients.

Li, Hui / Shen, Da / Chen, Zhihong / Li, Jian

Journal of oral rehabilitation

2023 Volume 50, Issue 10, Page(s) 965–971

Abstract: Background: Anterior repositioning splint (ARS) is used to treat temporomandibular joint (TMJ) disc displacement with reduction (DDwR). However, high recurrence rate remains a problem especially in patients with unstable occlusions.: Objective: This ... ...

Abstract	Background: Anterior repositioning splint (ARS) is used to treat temporomandibular joint (TMJ) disc displacement with reduction (DDwR). However, high recurrence rate remains a problem especially in patients with unstable occlusions. Objective: This study optimised standard ARS therapy and proposed a step-back ARS retraction (SAR) method in adult patients with DDwR. Methods: Dental examinations and magnetic resonance imaging of TMJ were obtained before treatment (T0), 1 to 3 months (T1), 3 to 6 months (T2) and 6 to 12 months (T3) during treatment in 48 adults (average age 27.1 ± 5.7 years). After 3 months of basic ARS wearing, personalised treatment for patients with normal disc-condyle relationship was prescribed depending on bilaminar zone adaptations and severity of molar openbite. SAR which required sequential ARS wearing was designed for patients with deep overbite/overjet until retrodiscal tissue adaptations and stable occlusions were achieved. Results: The maximum interincisal opening was increased from 44.3 ± 6.9 to 45.3 ± 6.3 mm (p < .01), and joint pain was alleviated after ARS treatment. The overall success rate of ARS wearing was 92.1% (58/63) featured by a recaptured disc. Fifteen patients who underwent SAR therapy all showed bilaminar zone adaptations in the end, and one patient had positive condylar bone remodelling. Conclusions: ARS treatment could improve mouth opening and joint symptoms in adult DDwR patients. SAR method was suitable for treating DDwR patients with deep overbite and overjet and improved retrodiscal tissue adaptations and condylar bone remodelling.
MeSH term(s)	Humans ; Adult ; Young Adult ; Splints ; Temporomandibular Joint Disc/diagnostic imaging ; Overbite ; Joint Dislocations/diagnostic imaging ; Joint Dislocations/therapy ; Temporomandibular Joint Disorders/diagnostic imaging ; Temporomandibular Joint Disorders/therapy
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13485
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Zs.A 991: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: EMX2OS targeting IGF2BP1 represses Wilms' tumour stemness,epithelial-mesenchymal transition and metastasis.

Zhang, Hong-Mei / Cui, Ming-Yu / Chen, Zhi-Hong

Journal of genetics

2023 Volume 102

Abstract: Wilms' tumour (WT) is the most typical type of renal tumour in children, which has a poor prognosis and high recurrence rate. This study explored whether lncRNA EMX2 opposite strand / antisense RNA (EMX2OS) modulated the stemness, epithelial-mesenchymal ... ...

Abstract	Wilms' tumour (WT) is the most typical type of renal tumour in children, which has a poor prognosis and high recurrence rate. This study explored whether lncRNA EMX2 opposite strand / antisense RNA (EMX2OS) modulated the stemness, epithelial-mesenchymal transition (EMT) and metastasis of WTcells through the interaction with insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). The expression levels of EMX2OS, IGF2BP1 and stem cell markers OCT4, Nanog, Sox2 and CD133 were detected by real time quantitative polymerase chain reaction (RT-qPCR). The stemness, migration and invasion of WTcells were determined by sphere formation assay, scratch and transwell assay, respectively. The levels of EMT-related proteins were detected by Western blotting. RNA pull down and RIP assays were utilized to validate the interaction between EMX2OS and IGF2BP1. The tumourigenicity of WTcells
MeSH term(s)	Child ; Humans ; Epithelial-Mesenchymal Transition/genetics ; Kidney Neoplasms/genetics ; Real-Time Polymerase Chain Reaction ; RNA, Long Noncoding ; Wilms Tumor/genetics ; Transcription Factors/genetics ; RNA-Binding Proteins/genetics
Chemical Substances	RNA, Long Noncoding ; empty spiracles homeobox proteins ; IGF2BP1 protein, human ; Transcription Factors ; RNA-Binding Proteins
Language	English
Publishing date	2023-02-01
Publishing country	India
Document type	Journal Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
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Ub I Zs.72: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MA 8: Show issues

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Article: Sericin suppresses high glucose-induced EMT in mouse podocytes via miR-30a-5p and its target Snai1.

Liu, Donghui / Chen, Cheng / Ge, Ting / Chen, Zhihong

Pakistan journal of pharmaceutical sciences

2023 Volume 36, Issue 5, Page(s) 1457–1466

Abstract: The effect of sericin in high glucose (HG)-induced podocyte injury and the mechanisms involving Snai1 and miR-30a-5p were investigated. Bioinformatics and dual-luciferase reporter assay evaluated the relationship of Snai1 with miR-31a-5p. Podocyte injury ...

Abstract	The effect of sericin in high glucose (HG)-induced podocyte injury and the mechanisms involving Snai1 and miR-30a-5p were investigated. Bioinformatics and dual-luciferase reporter assay evaluated the relationship of Snai1 with miR-31a-5p. Podocyte injury mouse induced by HG were randomly divided into control (5.5mmol/L D-glucose), HG (30mmol/L D-glucose), HG + Sericin (30mmol/L D-glucose+600μg/ml sericin), miR-30a-5p inhibitor NC (sericin+30mmol/L D-glucose+miR-30a-5p inhibitor negative control) and miR-30a-5p inhibitor groups (sericin+30mmol/L D-glucose+miR-30a-5p inhibitor). The migration ability of podocytes was detected by Transwell assay. The expressions of Snai1, podocin, E-cadherin, FSP-1, ZO-1, α-SMA, Desmin, and miR-30a-5p were assessed with RT-qPCR and Western blot. Snai1 was one direct target of miR-30a-5p. HG group had significantly larger number of migrated podocytes and higher levels of Snai1, FSP-1, α-SMA and Desmin, but significantly lower levels of podocin, ZO-1 and E-cadherin than control and HG + Sericin group. These effects of sericin were reversed by miR-30a-5p inhibitor, as evidenced by increased podocyte migration and increased expressions of Snai1, α-SMA, FSP-1 and Desmin, whereas decreased expressions of podocin, ZO-1 and E-cadherin. Sericin may protect podocytes from damage caused by HG via up-regulating epithelial phenotype markers, down-regulating mesenchymal phenotype markers, and reducing migration of podocytes. The mechanism may be through targeting miR-30a-5p and its target Snai1.
MeSH term(s)	Animals ; Mice ; Cadherins/metabolism ; Desmin ; Glucose/toxicity ; MicroRNAs/metabolism ; Podocytes/metabolism ; Sericins/pharmacology ; Epithelial-Mesenchymal Transition
Chemical Substances	Cadherins ; Desmin ; Glucose (IY9XDZ35W2) ; MicroRNAs ; Sericins ; MIRN30a microRNA, mouse ; Snai1 protein, mouse
Language	English
Publishing date	2023-10-23
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article ; Online: Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma.

Chen, Zhihong / Hambardzumyan, Dolores

Cancer cell

2021 Volume 39, Issue 6, Page(s) 743–745

Abstract: Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cellular state ... ...

Abstract	Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cellular state associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.
MeSH term(s)	Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Glioblastoma/genetics ; Humans ; Macrophages ; Neoplastic Stem Cells ; Tumor Microenvironment
Language	English
Publishing date	2021-06-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2021.05.003
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Zs.A 5650: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 104: Show issues

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Article ; Online: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma with significant granuloma: case report and literature review.

Nie, Chenchen / Xie, Xun / Li, Hangyan / Li, Yangcan / Chen, Zhihong / Li, Yanchun / Li, Zhenfeng

Diagnostic pathology

2024 Volume 19, Issue 1, Page(s) 34

Abstract: Background: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is a rare disease characterized by mild clinical symptoms and non-specific imaging findings. The diagnosis of the disease depends on pathological ... ...

Abstract	Background: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+IFDCS) is a rare disease characterized by mild clinical symptoms and non-specific imaging findings. The diagnosis of the disease depends on pathological diagnosis. However, EBV+IFDCS has a very broad spectrum of histological morphology and immune phenotypes, and its histopathological features have not been fully described by pathologists. Case presentation: A 59-year-old female, with no significant discomfort, was found to have a splenic mass during a routine physical examination. Microscopic examination at low magnification revealed numerous epithelioid granulomas, amidst which a substantial inflammatory response was observed. Interspersed among the dense inflammatory cells were spindle or oval-shaped cells, distributed sporadically with indistinct boundaries. Under high magnification, these spindle cells had subtle features: smooth and clear nuclear membranes, inconspicuous small nucleoli, and infrequent mitotic figures. Immunophenotypically, the spindle cells expressed CD21 and CD23, and Epstein-Barr encoding region (EBER) in situ hybridization yielded positive results. The inflammatory milieu predominantly consisted of T cells, with a minority of plasma cells expressing IgG4. The confluence of morphological and immunohistochemical findings led to the final pathological diagnosis of EBV+IFDCS in this case. Conclusions: The presentation of EBV+IFDCS with pronounced granulomatous changes is rare. This morphological variant poses a high risk of misdiagnosis, frequently leading to confusion with other granulomatous diseases. Accurate diagnosis necessitates a comprehensive analysis, integrating immunohistochemistry and in situ hybridization. The case presented here is instrumental in raising awareness and understanding of EBV+IFDCS, with the goal of reducing misdiagnoses and unrecognized cases.
MeSH term(s)	Female ; Humans ; Middle Aged ; Dendritic Cell Sarcoma, Follicular/diagnosis ; Dendritic Cell Sarcoma, Follicular/pathology ; Herpesvirus 4, Human/genetics ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/pathology ; Granuloma, Plasma Cell/diagnosis ; Granuloma/diagnosis ; Soft Tissue Neoplasms
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2210518-9
ISSN	1746-1596 ; 1746-1596
ISSN (online)	1746-1596
ISSN	1746-1596
DOI	10.1186/s13000-024-01457-6
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