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Article ; Online: Comment on: The Relationship Between Frailty and Emotional Health in Older Patients With Advanced Cancer.

Chen, Zi-Xiang / Yang, Tian

2022 Volume 27, Issue 10, Page(s) e819

MeSH term(s)	Aged ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Mental Health ; Neoplasms/epidemiology
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1093/oncolo/oyac151
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Preoperative prediction of microvascular invasion: Is invasive biopsy of HCC necessary?

Chen, Zi-Xiang / Liu, Si-Yu / Tong, Xiang-Min

Journal of hepatology

2022 Volume 77, Issue 3, Page(s) 892–893

MeSH term(s)	Biopsy ; Carcinoma, Hepatocellular/blood supply ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/pathology ; Liver Transplantation ; Neoplasm Invasiveness ; Retrospective Studies
Language	English
Publishing date	2022-04-26
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2022.04.016
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Zs.A 2027: Show issues

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Article ; Online: Synthesis and biological evaluation of ruthenium complexes containing phenylseleny against Gram-positive bacterial infection by damage membrane integrity and avoid drug-resistance.

Huang, Hai-Yan / Wang, Qian / Zhang, Chun-Yan / Chen, Zi-Xiang / Wang, Jin-Tao / Liao, Xiang-Wen / Yu, Ru-Jian / Xiong, Yan-Shi

Journal of inorganic biochemistry

2023 Volume 242, Page(s) 112175

Abstract: Compounds modified with selenium atom as potential antibacterial agents have been exploited to combat the nondrug-resistant bacterial infection. In this study, we designed and synthesized four ruthenium complexes retouching of selenium-ether. Fortunately, ...

Abstract	Compounds modified with selenium atom as potential antibacterial agents have been exploited to combat the nondrug-resistant bacterial infection. In this study, we designed and synthesized four ruthenium complexes retouching of selenium-ether. Fortunately, those four ruthenium complexes shown excellent antibacterial bioactive (MIC: 1.56-6.25 μg/mL) against Staphylococcus aureus (S. aureus), and the most active complex Ru(II)-4 could kill S. aureus by targeting the membrane integrity and avoid the bacteria to evolve drug resistance. Moreover, Ru(II)-4 was found to significantly inhibit the formation of biofilms and biofilm eradicate capacity. In toxicity experiments, Ru(II)-4 exhibited poor hemolysis and low mammalian toxicity. To illustrate the antibacterial mechanism: we conducted scanning electron microscope (SEM), fluorescent staining, membrane rupture and DNA leakage assays. Those results demonstrated that Ru(II)-4 could destroy the integrity of bacterial cell membrane. Furthermore, both G. mellonella wax worms infection model and mouse skin infection model were established to evaluate the antibacterial activity of Ru(II)-4 in vivo, the results indicated that Ru(II)-4 was a potential candidate for combating S. aureus infections, and almost non-toxic to mouse tissue. Thus, all the results indicated that introducing selenium-atom into ruthenium compounds were a promising strategy for developing interesting antibacterial agents.
MeSH term(s)	Animals ; Mice ; Staphylococcus aureus ; Ruthenium/pharmacology ; Coordination Complexes/pharmacology ; Selenium/pharmacology ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Gram-Positive Bacterial Infections ; Drug Resistance ; Microbial Sensitivity Tests ; Mammals
Chemical Substances	Ruthenium (7UI0TKC3U5) ; Coordination Complexes ; Selenium (H6241UJ22B) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2023.112175
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Zs.B 1730: Show issues

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Article ; Online: Platelet-rich fibrin membrane nerve guidance conduit: a potentially promising method for peripheral nerve injuries.

Huang, Min-Lu / Zhai, Zhen / Chen, Zi-Xiang / Yang, Xiao-Nan / Qi, Zuo-Liang

Chinese medical journal

2020 Volume 133, Issue 8, Page(s) 999–1001

MeSH term(s)	Animals ; Female ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nerve Regeneration/physiology ; Peripheral Nerve Injuries/surgery ; Peripheral Nerves/physiology ; Platelet-Rich Fibrin/metabolism ; Rats, Sprague-Dawley ; Sciatic Nerve/physiology
Language	English
Publishing date	2020-03-10
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000000726
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Zs.B 1207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.425: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Oncological prognosis and morbidity of hepatectomy in elderly patients with hepatocellular carcinoma: a propensity score matching and multicentre study.

Wang, Chuan-Ming / Chen, Zi-Xiang / Ma, Ping-Chuan / Chen, Jiang-Ming / Jiang, Dong / Hu, Xin-Yuan / Ma, Fu-Xiao / Hou, Hui / Ma, Jin-Liang / Geng, Xiao-Ping / Liu, Fu-Bao

BMC surgery

2023 Volume 23, Issue 1, Page(s) 323

Abstract: Purpose: With increasing life expectancy, the number of elderly patients (≥ 65 years) with hepatocellular carcinoma (HCC) has steadily increased. Hepatectomy remains the first-line treatment for HCC patients. However, the prognosis of hepatectomy for ... ...

Abstract	Purpose: With increasing life expectancy, the number of elderly patients (≥ 65 years) with hepatocellular carcinoma (HCC) has steadily increased. Hepatectomy remains the first-line treatment for HCC patients. However, the prognosis of hepatectomy for elderly patients with HCC remains unclear. Methods: Clinical and follow-up data from 1331 HCC patients who underwent surgery between 2008 and 2020 were retrospectively retrieved from a multicentre database. Patients were divided into elderly (≥ 65 years) and non-elderly (< 65 years) groups, and PSM was used to balance differences in the baseline characteristics. The postoperative major morbidity and cancer-specific survival (CSS) of the two groups were compared and the independent factors that were associated with the two study endpoints were identified by multivariable regression analysis. Results: Of the 1331 HCC patients enrolled in this study, 363 (27.27%) were elderly, while 968 (72.73%) were not. After PSM, 334 matched samples were obtained. In the propensity score matching (PSM) cohort, a higher rate of major morbidity was found in elderly patients (P = 0.040) but the CSS was similar in the two groups (P = 0.087). Multivariate analysis revealed that elderly age was not an independent risk factor associated with high rates of major morbidity (P = 0.117) or poor CSS (P = 0.873). The 1-, 3- and 5-year CSS rates in the elderly and non-elderly groups were 91.0% versus 86.2%, 71.3% versus 68.8% and 55.9% versus 58.0%, respectively. Preoperative alpha fetoprotein (AFP) level, Child‒Pugh grade, intraoperative blood transfusion, extended hemi hepatectomy, and tumour diameter could affect the postoperative major morbidity and preoperative AFP level, cirrhosis, Child‒Pugh grade, macrovascular invasion, microvascular invasion (MVI), satellite nodules, and tumor diameter were independently and significantly associated with CSS. Conclusion: Age itself had no significant effect on the prognosis of elderly patients with HCC after hepatectomy. Hepatectomy can be safely performed in elderly patients after cautious perioperative management.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; alpha-Fetoproteins/analysis ; Hepatectomy ; Propensity Score ; Retrospective Studies ; Neoplasm Recurrence, Local/surgery ; Prognosis
Chemical Substances	alpha-Fetoproteins
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-023-02230-0
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Article ; Online: Outcomes of surgery for giant hepatic hemangioma.

Xie, Qing-Song / Chen, Zi-Xiang / Zhao, Yi-Jun / Gu, Heng / Geng, Xiao-Ping / Liu, Fu-Bao

BMC surgery

2021 Volume 21, Issue 1, Page(s) 186

Abstract: Background: The surgical indications for liver hemangioma remain unclear.: Methods: Data from 152 patients with hepatic hemangioma who underwent hepatectomy between 2004 and 2019 were retrospectively reviewed. We analyzed characteristics including ... ...

Abstract	Background: The surgical indications for liver hemangioma remain unclear. Methods: Data from 152 patients with hepatic hemangioma who underwent hepatectomy between 2004 and 2019 were retrospectively reviewed. We analyzed characteristics including tumor size, surgical parameters, and variables associated with Kasabach-Merritt syndrome and compared the outcomes of laparoscopic and open hepatectomy. Here, we describe surgical techniques for giant hepatic hemangioma and report on two meaningful cases. Results: Most (63.8%) patients with hepatic hemangioma were asymptomatic. Most (86.4%) tumors from patients with Kasabach-Merritt syndrome were larger than 15 cm. Enucleation (30.9%), sectionectomy (28.9%), hemihepatectomy (25.7%), and the removal of more than half of the liver (14.5%) were performed through open (87.5%) and laparoscopic (12.5%) approaches. Laparoscopic hepatectomy is associated with an operative time, estimated blood loss, and major morbidity and mortality rate similar to those of open hepatectomy, but a shorter length of stay. 3D image reconstruction is an alternative for diagnosis and surgical planning for partial hepatectomy. Conclusion: The main indication for surgery is giant (> 10 cm) liver hemangioma, with or without symptoms. Laparoscopic hepatectomy was an effective option for hepatic hemangioma treatment. For extremely giant hemangiomas, 3D image reconstruction was indispensable. Hepatectomy should be performed by experienced hepatic surgeons.
MeSH term(s)	Hemangioma/surgery ; Hepatectomy/methods ; Humans ; Laparoscopy ; Liver Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-021-01185-4
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Article ; Online: Comparison of Conduits Fabricated by Fresh and Predegenerated Skeletal Muscles for Peripheral Nerve Repairing.

Chen, Zi-Xiang / Yi, Zhen / Lu, Hai-Bin / Chen, Lu-Lu / Yang, Xiao-Nan / Qi, Zuo-Liang

The Journal of craniofacial surgery

2021 Volume 33, Issue 1, Page(s) 354–359

Abstract: Abstract: Reconstruction of peripheral nerve injury remains a challenge for clinical medicine. Previous reports have confirmed that external oblique muscle-fabricated nerve conduit (EMC) could effectively be used to promote peripheral nerve regeneration. ...

Abstract	Abstract: Reconstruction of peripheral nerve injury remains a challenge for clinical medicine. Previous reports have confirmed that external oblique muscle-fabricated nerve conduit (EMC) could effectively be used to promote peripheral nerve regeneration. In this study, we compared between conduits fabricated from fresh muscle and conduits fabricated from predegenerated muscle for the repair of peripheral nerve defects in a mouse sciatic nerve transection model. We found that the number, diameter, and myelin sheath thickness of the myelinated nerve fibers of the regenerative nerve in the EMC group were larger than those of the predegenerated-EMC (P-EMC) group eight weeks after surgery. The sciatic function index and gastrocnemius wet-weight mass ratio in the EMC group were higher than those in the P-EMC group. The Bcl-2/Bax ratio and the number of Schwann cell nucleus in the proximal nerve stumps in the EMC group were greater than those in the P-EMC group. In conclusion, our results confirmed that the use of fresh skeletal muscle nerve conduit increased the Bcl-2/Bax ratio and promoted the survival of Schwann cells of the proximal nerve stump compared with that of predegenerated skeletal muscle nerve conduits, thus achieving better functional recovery after sciatic nerve defect.
MeSH term(s)	Animals ; Dental Implants ; Mice ; Muscle, Skeletal ; Nerve Regeneration ; Peripheral Nerve Injuries/surgery ; Schwann Cells ; Sciatic Nerve/surgery
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000007882
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Nomogram based on inflammation-related markers for predicting survival of patients undergoing hepatectomy for hepatocellular carcinoma.

Pu, Tian / Li, Zi-Han / Jiang, Dong / Chen, Jiang-Ming / Guo, Qi / Cai, Ming / Chen, Zi-Xiang / Xie, Kun / Zhao, Yi-Jun / Liu, Fu-Bao

World journal of clinical cases

2022 Volume 9, Issue 36, Page(s) 11193–11207

Abstract: Background: Previous nomograms for hepatocellular carcinoma (HCC) did not include the neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR). This study aimed to establish an effective nomogram capable of estimating the association ... ...

Abstract	Background: Previous nomograms for hepatocellular carcinoma (HCC) did not include the neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR). This study aimed to establish an effective nomogram capable of estimating the association between preoperative inflammatory factors and overall survival (OS) of HCC patients after hepatectomy. Aim: To analyse the factors affecting the prognosis of HCC and establish a nomogram. Methods: A total of 626 HCC patients (410 training set patients from the First Affiliated Hospital of Anhui Medical University and 216 validation set patients from the First Affiliated Hospital of University of Science and Technology of China) underwent hepatectomy from January 2014 to December 2017 and were followed up every 3-6 mo. The nomogram was based on OS-related independent risk factors identified by Cox regression analysis. The C-index, calibration curve, and area under the curve (AUC) were used to evaluate the nomogram's accuracy. Results: The 1-, 2- and 3-year OS rates were 79.0%, 68.0% and 45.4% in the training cohort (median OS = 34 mo) and 92.1%, 73.9% and 51.2% in the validation cohort (median OS = 38 mo). Higher α-fetoprotein [hazard ratio (HR) = 1.812, 95% confidence interval (CI): 1.343-2.444], NLR (HR = 2.480, 95%CI: 1.856-3.312) and PLR (HR = 1.974, 95%CI: 1.490-2.616), tumour size ≥ 5 cm (HR = 1.323, 95%CI: 1.002-1.747), and poor differentiation (HR = 3.207, 95%CI: 1.944-5.290) were significantly associated with shortened OS. The developed nomogram integrating these variables showed good reliability in both the training (C-index = 0.71) and validation cohorts (C-index = 0.75). For predicting 1-, 2- and 3-year OS, the nomogram had AUCs of 0.781, 0.743 and 0.706 in the training cohort and 0.789, 0.815 and 0.813 in the validation cohort. The nomogram was more accurate in predicting prognosis than the AJCC TNM staging system. Conclusion: The prognostic nomogram combining pathological characteristics and inflammation indicators could provide a more accurate individualized risk estimate for the OS of HCC patients with hepatectomy.
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i36.11193
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Article ; Online: Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study.

Jiang, Dong / Chen, Zi-Xiang / Ma, Fu-Xiao / Gong, Yu-Yong / Pu, Tian / Chen, Jiang-Ming / Liu, Xue-Qian / Zhao, Yi-Jun / Xie, Kun / Hou, Hui / Wang, Cheng / Geng, Xiao-Ping / Liu, Fu-Bao

World journal of gastroenterology

2022 Volume 28, Issue 37, Page(s) 5469–5482

Abstract: Background: Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms (PCNs) are lacking.: Aim: To establish a nomogram-based online calculator for predicting the risk of malignancy in patients ...

Abstract	Background: Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms (PCNs) are lacking. Aim: To establish a nomogram-based online calculator for predicting the risk of malignancy in patients with PCNs. Methods: In this study, the clinicopathological data of target patients in three medical centers were analyzed. The independent sample t-test, Mann-Whitney U test or chi-squared test were used as appropriate for statistical analysis. After univariable and multivariable logistic regression analysis, five independent factors were screened and incorporated to develop a calculator for predicting the risk of malignancy. Finally, the concordance index (C-index), calibration, area under the curve, decision curve analysis and clinical impact curves were used to evaluate the performance of the calculator. Results: Enhanced mural nodules [odds ratio (OR): 4.314; 95% confidence interval (CI): 1.618-11.503, Conclusion: The calculator demonstrates optimal predictive performance for identifying the risk of malignancy, potentially yielding a personalized method for patient selection and decision-making in clinical practice.
MeSH term(s)	Humans ; Retrospective Studies ; Pancreatic Neoplasms/pathology ; CA-19-9 Antigen ; Nomograms ; Risk Factors
Chemical Substances	CA-19-9 Antigen
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i37.5469
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Zs.A 6039: Show issues

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Article: Mechanical characteristics of antibacterial epoxy resin adhesive wood biocomposites against skin disease.

Chen, Zi-Xiang / Zhang, Zhong-Feng / Aqma, Wan Syaidatul

Saudi journal of biological sciences

2015 Volume 23, Issue 1, Page(s) S126–36

Abstract: Moldy wood can cause some skin disease. However epoxy resin adhesive (EP) can inhibit mold growth. Therefore, antibacterial EP/wood biocomposites were reinforced and analyzed by the nonlinear finite element. Results show that glass fiber cloth and ... ...

Abstract	Moldy wood can cause some skin disease. However epoxy resin adhesive (EP) can inhibit mold growth. Therefore, antibacterial EP/wood biocomposites were reinforced and analyzed by the nonlinear finite element. Results show that glass fiber cloth and aluminum foil have the obvious reinforced effect under flat pressure, but this was not the case under side pressure. And when the assemble pattern was presented in 5A way, the strengthening effect was better. The nonlinear finite element showed that the aluminum foil and glass fiber cloth have the obvious reinforced effect. The mutual influence and effect of span, thickness and length on the ultimate bearing capacity of specimen were studied. And the simulation results agreed with the test. It provided a theoretical basis on the preparation of antibacterial EP/wood biocomposites against skin disease.
Language	English
Publishing date	2015-10-09
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2015.09.026
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