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  1. Article ; Online: Detection of Outdated Structural Priors in the Discrete Cosine Transformation-based Electrical Impedance Tomography Algorithm

    Chen Rongqing / Moeller Knut

    Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 676-

    2021  Volume 679

    Abstract: Morphological prior information incorporated with the discrete cosine transformation (DCT) based electrical impedance tomography (EIT) algorithm can improve the interpretability of EIT reconstructions in clinical applications. However, an outdated ... ...

    Abstract Morphological prior information incorporated with the discrete cosine transformation (DCT) based electrical impedance tomography (EIT) algorithm can improve the interpretability of EIT reconstructions in clinical applications. However, an outdated structural prior can yield a misleading reconstruction compromising the accuracy of the clinical diagnosis and the appropriate treatment decision. In this contribution, we propose a redistribution index scaled between 0 and 1 to quantify the possible error in a DCT-based EIT reconstruction influenced by structural prior information. Two simulation models of different tissue atelectasis and collapsed ratios were investigated. Outdated and updated structural prior information were applied to obtain different EIT reconstructions using this simulated data, with which the redistribution index was calculated and compared. When the difference between prior and reality (the redistribution index) became larger and exceeded a threshold, this was considered as an indicator of an outdated prior information. The evaluation result shows the potential of the redistribution index to detect outdated prior information in a DCT-based EIT algorithm.
    Keywords electrical impedance tomography ; simulation ; prior information ; redistribution index ; Medicine ; R
    Subject code 518
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Quantitative proteomics analysis identified new interacting proteins of JAL30 in Arabidopsis.

    Bian, Jianghu / Chen, Rongqing / Gu, Shiting / Wang, Wenfei / Yang, Xuelian

    Journal of proteomics

    2024  Volume 297, Page(s) 105127

    Abstract: Jacalin-related lectins (JALs) are a unique group of plant lectins derived from the jacalin protein family, which play important roles in plant defense responses. JAL30/PBP1 (PYK10 binding protein 1) interacts with inactive PYK10, exerting negative ... ...

    Abstract Jacalin-related lectins (JALs) are a unique group of plant lectins derived from the jacalin protein family, which play important roles in plant defense responses. JAL30/PBP1 (PYK10 binding protein 1) interacts with inactive PYK10, exerting negative regulatory control over the size of the PYK10 complex, which is formed and activated upon insect or pathogen invasion. However, the precise interplay between JAL30 and other components remains elusive. In this study, we found JAL30 as a nucleocytoplasmic protein, but no obvious phenotype was observed in jal30-1 single mutant. Through immunoprecipitation (IP) enrichment combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), dozens of new JAL30 interacting proteins were found in addition to several reported ones. Gene Ontology (GO) analysis revealed that these interacting proteins were highly related to the wounding and bacterial stimuli, suggesting their potential involvement in the jasmonate (JA) response. Importantly, the expression of JAL30 was induced by MeJA treatment, further highlighting its relevance in plant defense mechanisms. A novel JAL30 interacting protein, ESM1, was identified and its interaction with JAL30 was confirmed by Co-immunoprecipitation. Moreover, ESM1 was found as an O-GlcNAcylated protein, suggesting that JAL30 may possess glycosylated protein binding ability, particularly in O-GlcNAcylated protein and peptide recognition. Overall, our study provides valuable insights into the interacting protein network and biological function of JAL30, demonstrates the interaction between JAL30 and ESM1, and uncovers the potential significance of JAL30 in plant defense system, potentially through its association with PYK10 complex or JA response. SIGNIFICANCE: The biological functions of lectin proteins, including defense responses, immunity responses, signal transduction, have been well studied. Lectin proteins were also utilized to enrich glycosylated proteins for their specific carbohydrates binding capability. Jacalin-related lectins (JALs) were found to involve in plant defense mechanism. However, it is not yet clear whether JALs could use for enrichment of glycosylated proteins. In this study, we used label-free quantification method to identify interacting proteins of JAL30. A novel interacting protein, ESM1, as an O-GlcNAcylated protein was found. ESM1 has been reported to take part in defense against insect herbivory. Therefore, our findings provided experimental evidence to confirm that JALs have potential to be developed as the bio-tools to enrich glycosylated proteins. Finally, our data not only illustrated the vital biological role of JALs in plants, but also verified unique function of JAL30 in recognizing O-GlcNAcylated proteins.
    MeSH term(s) Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Chromatography, Liquid ; Gene Expression Regulation, Plant ; Glycoproteins/metabolism ; Proteomics ; Tandem Mass Spectrometry ; Protein Interaction Maps
    Chemical Substances Arabidopsis Proteins ; Glycoproteins
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2400835-7
    ISSN 1876-7737 ; 1874-3919
    ISSN (online) 1876-7737
    ISSN 1874-3919
    DOI 10.1016/j.jprot.2024.105127
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  3. Article: Editorial: Modulation of neuronal excitability by non-neuronal cells in physiological and pathophysiological conditions.

    Chen, Rongqing / Peng, Biwen / Zhu, Peimin / Wang, Yun

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1133445

    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1133445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Separating Respiration and Perfusion in EIT

    Stein Erik / Chen Rongqing / Battistel Alberto / Moeller Knut

    Current Directions in Biomedical Engineering, Vol 8, Iss 2, Pp 785-

    Harmonic Analysis on 2D-Thorax Simulation

    2022  Volume 788

    Abstract: Electrical impedance tomography (EIT) has the potential for monitoring perfusion in addition to respiration on the bedside. Several separation methods were reported, e.g. Filtering, ECG-gating and PCA. However, the separation is not trivial, which is why ...

    Abstract Electrical impedance tomography (EIT) has the potential for monitoring perfusion in addition to respiration on the bedside. Several separation methods were reported, e.g. Filtering, ECG-gating and PCA. However, the separation is not trivial, which is why harmonic analysis was introduced in EIT data analysis. It is based on several assumptions and therefore prove of plausibility is necessary. In this contribution a two-dimensional thorax simulation is introduced, which includes simplified lungs and heart with changing shapes and conductivities due to volume variations and lung perfusion. Harmonic analysis was applied on the simulated data. The separation results are in good agreement with the simulation settings. Further investigations will be required due to limitations of the simulation. Nevertheless, harmonic analysis delivered precise results in ideal and strictly defined conditions.
    Keywords electrical impedance tomography ; harmonic analysis ; separation of respiration and perfusion ; simulation ; Medicine ; R
    Subject code 600
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: COVID-19 Pneumonia Phenotypes Detection with Electrical Impedance Tomography

    Chen Rongqing / Lovas András / Benyó Balázs / Moeller Knut

    Current Directions in Biomedical Engineering, Vol 8, Iss 2, Pp 707-

    2022  Volume 710

    Keywords Medicine ; R
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Global Inhomogeneity Index Evaluation of a DCT-based EIT Lung Imaging

    Chen Rongqing / Möller Knut

    Current Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 36-

    2020  Volume 39

    Abstract: Purpose: To evaluate a novel structural-functional DCT-based EIT lung imaging method against the classical EIT reconstruction. Method: Taken retrospectively from a former study, EIT data was evaluated using both reconstruction methods. For different ... ...

    Abstract Purpose: To evaluate a novel structural-functional DCT-based EIT lung imaging method against the classical EIT reconstruction. Method: Taken retrospectively from a former study, EIT data was evaluated using both reconstruction methods. For different phases of ventilation, EIT images are analyzed with respect to the global inhomogeneity (GI) index for comparison. Results: A significant less variant GI index was observed in the DCTbased method, compared to the index from classical method. Conclusion: The DCT-based method generates more accurate lung contour yet decreasing the essential information in the image which affects the GI index. These preliminary results must be consolidated with more patient data in different breathing states.
    Keywords eit ; lung imaging ; dct ; gi ; Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Redistribution Index - Detection of an Outdated Prior Information in the Discrete Cosine Transformation-based EIT Algorithm.

    Chen, Rongqing / Moeller, Knut

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Volume 2021, Page(s) 3693–3696

    Abstract: The morphological prior information incorporated with the discrete cosine transformation (DCT) based electrical impedance tomography (EIT) algorithm can improve the interpretability of the EIT results in clinical settings. However, an outdated prior ... ...

    Abstract The morphological prior information incorporated with the discrete cosine transformation (DCT) based electrical impedance tomography (EIT) algorithm can improve the interpretability of the EIT results in clinical settings. However, an outdated prior information can yield a misleading result compromising the accuracy of the clinical decisions. Detection of the outdated prior information is critical in the DCT-based EIT algorithm. In this contribution, a redistribution index calculated from the DCT approach result was proposed to quantify the possible error induced by the morphological prior information. Two simulations in terms of different atelectasis and collapse scales were conducted to evaluate the plausibility of the redistribution index. Thus, an experiential threshold for redistribution index was adopt as an indicator to the outdated prior in DCT-based EIT approach. A retrospective research was conducted with the seven-day patient monitor data as a proof-of-concept to verify plausibility and comparability of the redistribution index. From the evaluation, the redistribution index qualifies the function as an indicator for the outdated prior in the DCT-based EIT approach.Clinical relevance- This establishes an indicator to advice an update to the morphological prior information embedded in EIT approach, which lower the risk misleading interpretation of EIT results in mechanical ventilation monitoring.
    MeSH term(s) Algorithms ; Electric Impedance ; Humans ; Pulmonary Ventilation ; Retrospective Studies ; Tomography
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9630567
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  8. Article ; Online: Electrical Impedance Tomography might be a Practical Tool to Provide Information about COVID-19 Pneumonia Progression

    Chen Rongqing / Lovas András / Benyó Balázs / Moeller Knut

    Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 276-

    2021  Volume 278

    Abstract: COVID-19 induced acute respiratory distress syndrome (ARDS) could have two different phenotypes, which might have different response and outcome to the traditional ARDS positive end-expiration pressure (PEEP) treatment. The identification of the ... ...

    Abstract COVID-19 induced acute respiratory distress syndrome (ARDS) could have two different phenotypes, which might have different response and outcome to the traditional ARDS positive end-expiration pressure (PEEP) treatment. The identification of the different phenotypes in terms of the PEEP recruitment can help improve the patients’ outcome. In this contribution we reported a COVID-19 patient with seven-day electrical impedance tomography monitoring. From the conductivity distribution difference image analysis of the data, a clear course developing trend can be observed in addition to the phenotype identification. This case might suggest that EIT can be a practical tool to identify phenotypes and to provide progressive information of COVID-19 pneumonia.
    Keywords electrical impedance tomography ; covid-19 pneumonia ; progressive information ; monitoring ; ards ; Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Influence of hyperparameter on the Untrue Prior Detection in Discrete Transformation-based EIT Algorithm.

    Chen, Rongqing / Rupitsch, Stefan J / Moeller, Knut

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2022  Volume 2022, Page(s) 580–583

    Abstract: Incorporated with a structural prior, discrete cosine transformation (DCT) based electrical impedance tomog-raphy (EIT) algorithm can improve the interpretability of EIT images in clinical settings. However, this benefit comes with a risk of the untrue ... ...

    Abstract Incorporated with a structural prior, discrete cosine transformation (DCT) based electrical impedance tomog-raphy (EIT) algorithm can improve the interpretability of EIT images in clinical settings. However, this benefit comes with a risk of the untrue prior which yields a misleading result compromising clinical decision. The redistribution index is able to detect an untrue prior by analysing EIT reconstructions. In addition to structural priors, EIT reconstruction is also affected by the choice of hyperparameter A in DCT-based EIT algorithm. In this research, influence of hyperparameter on untrue prior detection is investigated in terms of simulation experiment. A series of simulation settings consisting of 30 different atelectasis scales was conducted, then reconstructed with 20 different hyperparameters, to investigate the behavior of redistribution index. The result shows, despite the fact that redistribution index is indeed influenced by the choice of the hyperparameter A, the detection of an untrue prior is not significantly affected. The untrue prior detection is rather stable regardless of the optimal hyperparameter. Clinical Relevance - Optimal hyperparameter is not always guaranteed in clinical settings. This research confirms that the untrue prior detection is not strongly influenced by the hyperparameter. An update of untrue priors incorporated into EIT approach will facilitate a better interpretation of EIT results and an accurate clinical decision.
    MeSH term(s) Algorithms ; Computer Simulation ; Electric Impedance ; Tomography/methods
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC48229.2022.9871293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Acid-sensing ion channels differentially affect ictal-like and non-ictal-like epileptic activities of mouse hippocampal pyramidal neurons in acidotic extracellular pH].

    Liu, Shuai / Chen, Rongqing

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2020  Volume 40, Issue 7, Page(s) 972–980

    Abstract: Objective: To investigate the effects of acid-sensing ion channels (ASICs) on electrophysiological epileptic activities of mouse hippocampal pyramidal neurons in the extracellular acidotic condition.: Methods: We investigated effects of extracellular ...

    Abstract Objective: To investigate the effects of acid-sensing ion channels (ASICs) on electrophysiological epileptic activities of mouse hippocampal pyramidal neurons in the extracellular acidotic condition.
    Methods: We investigated effects of extracellular acidosis on epileptic activities induced by elevated extracellular K
    Results: Extracellular acidosis significantly suppressed epileptic activities of the hippocampal neurons by converting ictal-like epileptic activities to non-ictal-like epileptic activities in both high [K
    Conclusions: ASICs can differentially modulate ictal-like and non-ictallike epileptic activities via its direct actions on excitatory neurons.
    MeSH term(s) Acid Sensing Ion Channels ; Acidosis ; Animals ; Hippocampus ; Hydrogen-Ion Concentration ; Mice ; Pyramidal Cells
    Chemical Substances Acid Sensing Ion Channels
    Language Chinese
    Publishing date 2020-09-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2020.07.09
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