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Article ; Online: A neuropeptide code for itch.

Chen, Zhou-Feng

2021 Volume 22, Issue 12, Page(s) 758–776

Abstract: Itch is one of the most primal sensations, being both ubiquitous and important for the well-being of animals. For more than a century, a desire to understand how itch is encoded by the nervous system has prompted the advancement of many theories. Within ... ...

Abstract	Itch is one of the most primal sensations, being both ubiquitous and important for the well-being of animals. For more than a century, a desire to understand how itch is encoded by the nervous system has prompted the advancement of many theories. Within the past 15 years, our understanding of the molecular and neural mechanisms of itch has undergone a major transformation, and this remarkable progress continues today without any sign of abating. Here I describe accumulating evidence that indicates that itch is distinguished from pain through the actions of itch-specific neuropeptides that relay itch information to the spinal cord. According to this model, classical neurotransmitters transmit, inhibit and modulate itch information in a context-, space- and time-dependent manner but do not encode itch specificity. Gastrin-releasing peptide (GRP) is proposed to be a key itch-specific neuropeptide, with spinal neurons expressing GRP receptor (GRPR) functioning as a key part of a convergent circuit for the conveyance of peripheral itch information to the brain.
MeSH term(s)	Animals ; Gastrin-Releasing Peptide/metabolism ; Humans ; Neurons/metabolism ; Neuropeptides/metabolism ; Pruritus/metabolism ; Spinal Cord/metabolism
Chemical Substances	Neuropeptides ; Gastrin-Releasing Peptide (80043-53-4)
Language	English
Publishing date	2021-10-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2034150-7
ISSN	1471-0048 ; 1471-0048 ; 1471-003X
ISSN (online)	1471-0048
ISSN	1471-0048 ; 1471-003X
DOI	10.1038/s41583-021-00526-9
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Zs.A 5473: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Evolution of landscape dynamics in the Yangtze River Delta from 2000 to 2020

Zhe Chen Zhou / Jun Wang

Journal of Water and Climate Change, Vol 13, Iss 3, Pp 1241-

2022 Volume 1256

Abstract: Based on the 2000–2020 land cover data, the landscape dynamics and landscape pattern index are used to study the landscape pattern changes of the Yangtze River Delta. The results show that with the growth of built-in land area, the dominance of natural ... ...

Abstract	Based on the 2000–2020 land cover data, the landscape dynamics and landscape pattern index are used to study the landscape pattern changes of the Yangtze River Delta. The results show that with the growth of built-in land area, the dominance of natural landscape in the Yangtze River Delta is gradually weakened. From the perspective of the overall landscape pattern, the degree of landscape fragmentation in this area is increasing, and the degree of landscape connectivity and aggregation are decreasing in varying degrees. The regional landscape is developing toward homogeneous distribution and increasing complexity. At the same time, from the perspective of classified landscape, the spatial distribution of various landscapes shows a strong correlation between climate and landform. Through comparative analysis, this study puts forward that the development of the Yangtze River Delta needs to pay attention to maintaining the integrity of the regional dominant landscape and paying attention to the diversity and connectivity of the natural landscape with high ecological service value. HIGHLIGHTS From the perspective of overall landscape pattern, this paper studies landscape fragmentation, connectivity, and aggregation.; The study found that the spatial distribution of various landscapes showed a strong correlation between climate and landform.; The study found that the change degree of landscape structure such as forest land and wetland with high ecological service value.;
Keywords	landscape index ; landscape pattern ; spatial-temporal evolution ; yangtze river delta ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
Subject code	710 ; 550
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	IWA Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Observations of Ionospheric Disturbances Produced by a Powerful Very-Low-Frequency Radio Signal in the Magnetic Conjugated Region Respect the Transmitter

Ting Feng / Moran Liu / Chen Zhou

Remote Sensing, Vol 15, Iss 3307, p

2023 Volume 3307

Abstract: We investigate four observational cases over NWC magnetically conjugate region by DEMETER spacecraft and CSES satellite. The cases of DEMETER on 23 February 2008 and CSES on 22 March 2020 show the evident ionospheric heating effects, in which the ... ...

Abstract	We investigate four observational cases over NWC magnetically conjugate region by DEMETER spacecraft and CSES satellite. The cases of DEMETER on 23 February 2008 and CSES on 22 March 2020 show the evident ionospheric heating effects, in which the electron density and electron temperature suggest simultaneous enhancements associated with the intense spectra of the VLF electric and magnetic field above the conjugate region. This indicates that the heating effects associated with ionospheric modification are indeed triggered by the VLF signal transmitted by the NWC transmitter. In other words, the strong disturbances induced directly above the transmitter propagate along the magnetic field lines and extend into the magnetic conjugated region. Differently, the cases on 11 February 2010 (DEMETER) and 15 February 2019 (CSES) show obvious increases in electron densities while having no significant elevation in electron temperatures. The presence of enhanced energetic electron spectra at higher L-values, rather than directly above the conjugate region, suggests precipitation events induced by the VLF transmitter.
Keywords	conjugate ; heating effect ; precipitation ; DEMETER ; CSES ; Science ; Q
Subject code	530
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assimilation and Inversion of Ionospheric Electron Density Data Using Lightning Whistlers

Tian Xiang / Moran Liu / Shimin He / Chen Zhou

Remote Sensing, Vol 15, Iss 3037, p

2023 Volume 3037

Abstract: The data assimilation algorithm is a common algorithm in space weather research. In this paper, the time-frequency information in the dispersion spectrum of lightning whistlers received by the ZH-1 satellite is used as the observed value, and the ... ...

Abstract	The data assimilation algorithm is a common algorithm in space weather research. In this paper, the time-frequency information in the dispersion spectrum of lightning whistlers received by the ZH-1 satellite is used as the observed value, and the international reference ionospheric model serves as the background model to construct the calculation model of the propagation time of lightning whistlers in the ionosphere. Kalman filtering is adopted to assimilate the electron density distribution along the propagation path of lightning whistlers. The results show that the situation where the electron density of the background model deviates greatly from the true value is significantly improved through data assimilation. The electron density after assimilation is in good agreement with the true value, which effectively helps realize the process of using observed values to correct the background value. On this basis, the influence of the frequency difference on the assimilation inversion effect is studied, and the results show that the assimilation effect is worse when the frequency difference between frequency points is less than 1 kHz.
Keywords	data assimilation ; electron density ; lightning whistlers ; dispersion spectrum ; Science ; Q
Subject code	541
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploration of Key Genes Combining with Immune Infiltration Level and Tumor Mutational Burden in Hepatocellular Carcinoma.

Chen, Jing / Zhang, Lu / Lu, Cui-Hua / Xu, Chen-Zhou

Combinatorial chemistry & high throughput screening

2024

Language	English
Publishing date	2024-01-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073239916231023053142
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A Strategy for Rapid Acquisition of the β-D-Fructofuranosidase Gene through Chemical Synthesis and New Function of Its Encoded Enzyme to Improve Gel Properties during Yogurt Processing

Chen, Zhou / Shen, Yimei / Xu, Jiangqi

Foods. 2023 Apr. 19, v. 12, no. 8

2023

Abstract: A chemical gene synthesis strategy was developed in order to obtain β-D-fructofuranosidase, and a novel gene, AlFFase3, was characterized from Aspergillus luchuensis and expressed in Escherichia coli. The recombinant protein was purified, showing a ... ...

Abstract	A chemical gene synthesis strategy was developed in order to obtain β-D-fructofuranosidase, and a novel gene, AlFFase3, was characterized from Aspergillus luchuensis and expressed in Escherichia coli. The recombinant protein was purified, showing a molecular mass of 68.0 kDa on SDS-PAGE, and displaying a specific activity towards sucrose of up to 771.2 U mg⁻¹, indicating its exceptional enzymatic capacity. AlFFase3 exhibited stability between pH 5.5 and 7.5, with maximal activity at pH 6.5 and 40 °C. Impressively, AlFFase3, as a soluble protein, was resistant to digestion by various common proteases, including Flavourzyme, acidic protease, pepsin, neutral protease, Proteinase K, alkaline proteinase, and trypsin. AlFFase3 also demonstrated significant transfructosylation activity, with a yield of various fructooligosaccharides up to 67%, higher than almost all other reports. Furthermore, we demonstrated that the addition of AlFFase3 enhanced the growth of probiotics in yogurt, thereby increasing its nutritional value. AlFFase3 also improved the formation of yogurt gel, reducing the gel formation time and lowering the elasticity while increasing its viscosity, thereby improving the palatability of yogurt and reducing production costs.
Keywords	Aspergillus ; Escherichia coli ; digestion ; fructooligosaccharides ; gels ; genes ; molecular weight ; nutritive value ; pH ; palatability ; pepsin ; peptidase K ; polyacrylamide gel electrophoresis ; probiotics ; recombinant proteins ; sucrose ; synthesis ; trypsin ; viscosity ; yogurt
Language	English
Dates of publication	2023-0419
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12081704
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Highly Efficient Synthesis of Rare Sugars from Glycerol in Endotoxin-Free ClearColi by Fermentation

Gao, Yahui / Chen, Zhou / Nakanishi, Hideki / Li, Zijie

Foods. 2023 Aug. 16, v. 12, no. 16

2023

Abstract: Rare sugars possess potential applications as low-calorie sweeteners, especially for anti-obesity and anti-diabetes. In this study, a fermentation biosystem based on the “DHAP-dependent aldolases strategy” was established for D-allulose and D-sorbose ... ...

Abstract	Rare sugars possess potential applications as low-calorie sweeteners, especially for anti-obesity and anti-diabetes. In this study, a fermentation biosystem based on the “DHAP-dependent aldolases strategy” was established for D-allulose and D-sorbose production from glycerol in endotoxin-free ClearColi BL21 (DE3). Several engineering strategies were adopted to enhance rare sugar production. Firstly, the combination of different plasmids for aldO, rhaD, and yqaB expression was optimized. Then, the artificially constructed ribosomal binding site (RBS) libraries of aldO, rhaD, and yqaB genes were assembled individually and combinatorially. In addition, a peroxidase was overexpressed to eliminate the damage or toxicity from hydrogen peroxide generated by alditol oxidase (AldO). Finally, stepwise improvements in rare sugar synthesis were elevated to 15.01 g/L with a high yield of 0.75 g/g glycerol in a 3 L fermenter. This research enables the effective production of rare sugars from raw glycerol in high yields.
Keywords	fermentation ; fermenters ; glycerol ; hydrogen peroxide ; peroxidase ; plasmids ; psicose ; sorbose ; toxicity
Language	English
Dates of publication	2023-0816
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12163078
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Novel Property Cytotoxicity and Mechanism of Food Preservative Brevilaterins against Human Gastric Cancer Cells

Chen, Zhou / Hong, Dan / Li, Siting / Jia, Yingmin

Foods. 2023 Apr. 21, v. 12, no. 8

2023

Abstract: Brevilaterins, antimicrobial peptides produced by Brevibacillus laterosporus, are regarded as excellent food preservatives and are popular as antimicrobial applications. Recent research has uncovered their potent cytotoxic effects against diverse cancer ... ...

Abstract	Brevilaterins, antimicrobial peptides produced by Brevibacillus laterosporus, are regarded as excellent food preservatives and are popular as antimicrobial applications. Recent research has uncovered their potent cytotoxic effects against diverse cancer cells, thereby underscoring the pressing need for more extensive and intensive investigations into this use. In this study, we explored their novel function in inducing cytotoxicity to cancer cells and systematically investigated the mechanism of action of Brevilaterin B/C (BB/BC) in vivo. Proliferation, membrane permeability, and apoptotic rate were evaluated using CCK-8 assay, LDH assay, and Annexin V-FITC/PI kits. ROS levels and mitochondrial membrane potential were detected using the fluorescent probe DCFH-DA and JC-1. Our results demonstrated that both BB and BC at concentrations of 4–6 µg/mL significantly inhibited the proliferation and migration of gastric cancer cells BGC-823. Treatment with 4 µg/mL of BB/BC rapidly increased LDH levels in the supernatant of BGC-823 cells, leading to further investigation of the mechanism of apoptosis. We found that the apoptotic rate of BGC-823 cells significantly increased upon treatment with BB/BC, demonstrating their potent induction of apoptosis. BB/BC-induced ROS production in BGC-823 cells impaired their growth and induced apoptosis, indicating a close association between apoptosis and ROS elevation. Additionally, JC-1 aggregates rapidly accumulated after treatment with 4 µg/mL of BB/BC, suggesting changes in mitochondrial membrane potential and early apoptosis. Taken together, our findings revealed that BB and BC exhibit significant anticancer effects against gastric cancer cells, highlighting the promising potential of Brevilaterins as anticancer agents.
Keywords	Brevibacillus laterosporus ; antimicrobial peptides ; apoptosis ; cytotoxicity ; fluorescent dyes ; food preservatives ; humans ; mechanism of action ; membrane permeability ; membrane potential ; mitochondrial membrane ; stomach neoplasms
Language	English
Dates of publication	2023-0421
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12081732
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Simulation of Electron Density Disturbance in the Lower Ionosphere Caused by Thundercloud Electrostatic Fields

Xubo Yang / Yi Liu / Youzhi Lin / Chen Zhou / Zhengyu Zhao

Atmosphere, Vol 14, Iss 444, p

2023 Volume 444

Abstract: In this study, we simulated the electron density disturbance at night in the bottom of the ionosphere caused by the electrostatic field in a thundercloud. The simulation was conducted using the charge of the thundercloud as the source, by incorporating a ...

Abstract	In this study, we simulated the electron density disturbance at night in the bottom of the ionosphere caused by the electrostatic field in a thundercloud. The simulation was conducted using the charge of the thundercloud as the source, by incorporating a more up-to-date conductivity profile, and using the ion chemistry model for the lower ionosphere. The results revealed that a thundercloud charge of 30–100 C can cause a disturbance in the electron density in the lower ionosphere, decreasing to 40% of the original value or increasing to 160% of the original value. The electron density disturbance occurs mainly below an altitude of 80 km, and its peak is located at an altitude of 70 km, with a regional horizontal radius of about 50–75 km. The simulation results of this study improve the theory of Salem et al and extend the original one-dimensional model to three-dimensional space.
Keywords	thundercloud ; electrostatic field ; electron density disturbance ; lower ionosphere ; ion chemistry model ; Meteorology. Climatology ; QC851-999
Subject code	541
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biochar-Based Photothermal Hydrogel for Efficient Solar Water Purification

Liang Wang / Jilei Wei / Kun Fang / Chen Zhou / Shengyang Yang

Molecules, Vol 28, Iss 1157, p

2023 Volume 1157

Abstract: The development of technology for solar interface evaporation has a significant meaning for the sustainable use of water resources in remote regions. However, establishing a solar evaporator with a high evaporation rate and favorable water treatment ... ...

Abstract	The development of technology for solar interface evaporation has a significant meaning for the sustainable use of water resources in remote regions. However, establishing a solar evaporator with a high evaporation rate and favorable water treatment capabilities remains challenging. In this work, we reported a silver nanoparticle (AgNP)@carbonized cattail (CC)/polyvinyl alcohol (PVA) composite hydrogel (ACPH) membrane. Because of the successfully loaded AgNPs, which have a photothermal synergy with the CC, the ACPH-10 membrane obtained an excellent photothermal conversion performance. Additionally, the hydrophilicity of the ACPH-10 membrane ensures a sustainable water supply which is necessary for the improvement of the evaporation rate. Therefore, the ACPH-10 membrane achieves an evaporation rate of 1.66 kg m −2 h −1 and an efficiency of 88.0%, attributed to the remarkable photothermal conversion and water transmission. More importantly, the membrane exhibits superior purification ability in a variety of sewage. Pollutant removal rates in heavy metal and organic dye sewage have exceeded 99.8%. As a result, the ACPH membrane holds great promise for wastewater recovery and seawater desalination, which can aid in resolving the water crisis issue.
Keywords	solar interface evaporation ; seawater desalination ; wastewater purification ; AgNP@CC hybrid ; ACPH membrane ; Organic chemistry ; QD241-441
Subject code	660
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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