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  1. Article ; Online: Machine learning models for predicting unscheduled return visits to an emergency department: a scoping review.

    Lee, Yi-Chih / Ng, Chip-Jin / Hsu, Chun-Chuan / Cheng, Chien-Wei / Chen, Shou-Yen

    BMC emergency medicine

    2024  Volume 24, Issue 1, Page(s) 20

    Abstract: Background: Unscheduled return visits (URVs) to emergency departments (EDs) are used to assess the quality of care in EDs. Machine learning (ML) models can incorporate a wide range of complex predictors to identify high-risk patients and reduce errors ... ...

    Abstract Background: Unscheduled return visits (URVs) to emergency departments (EDs) are used to assess the quality of care in EDs. Machine learning (ML) models can incorporate a wide range of complex predictors to identify high-risk patients and reduce errors to save time and cost. However, the accuracy and practicality of such models are questionable. This review compares the predictive power of multiple ML models and examines the effects of multiple research factors on these models' performance in predicting URVs to EDs.
    Methods: We conducted the present scoping review by searching eight databases for data from 2010 to 2023. The criteria focused on eligible articles that used ML to predict ED return visits. The primary outcome was the predictive performances of the ML models, and results were analyzed on the basis of intervals of return visits, patient population, and research scale.
    Results: A total of 582 articles were identified through the database search, with 14 articles selected for detailed analysis. Logistic regression was the most widely used method; however, eXtreme Gradient Boosting generally exhibited superior performance. Variations in visit interval, target group, and research scale did not significantly affect the predictive power of the models.
    Conclusion: This is the first study to summarize the use of ML for predicting URVs in ED patients. The development of practical ML prediction models for ED URVs is feasible, but improving the accuracy of predicting ED URVs to beyond 0.75 remains a challenge. Including multiple data sources and dimensions is key for enabling ML models to achieve high accuracy; however, such inclusion could be challenging within a limited timeframe. The application of ML models for predicting ED URVs may improve patient safety and reduce medical costs by decreasing the frequency of URVs. Further research is necessary to explore the real-world efficacy of ML models.
    MeSH term(s) Humans ; Patient Readmission ; Machine Learning ; Emergency Service, Hospital ; Time Factors ; Logistic Models
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2050431-7
    ISSN 1471-227X ; 1471-227X
    ISSN (online) 1471-227X
    ISSN 1471-227X
    DOI 10.1186/s12873-024-00939-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Scientific publication trends of emergency department of International Federation for Emergency Medicine members, 2009 to 2018.

    Chou, Hsin-Hui / Cheng, Chien-Wei / Lee, Ching-Hsing

    The American journal of emergency medicine

    2021  Volume 50, Page(s) 85–92

    Abstract: Background: Emergency medicine (EM) is a rapidly developing specialty worldwide. The scientific publications trend is one of the parameters to evaluate national EM developmental milestones. This study was performed to analyze the publication trends from ...

    Abstract Background: Emergency medicine (EM) is a rapidly developing specialty worldwide. The scientific publications trend is one of the parameters to evaluate national EM developmental milestones. This study was performed to analyze the publication trends from emergency departments (EDs) of International Federation for Emergency Medicine (IFEM) full member countries from 2009 to 2018.
    Methods: All data were retrieved from the SciVerse Scopus database. IFEM full member countries where EM was recognized as a specialty before 2009 and annual publication numbers exceeded 12 in 2018 were included. The EM journals list was adopted from the 2017 Journal Citation Reports. Publications with the first author affiliated with EDs were divided into EM or non-EM journal groups according to the publishing journal. The slope (β) of the linear regression was used to assess the trends of publication numbers. The correlation between the 2009 publication number and the trend of publication between 2009 and 2018 was measured by Pearson's correlation coefficient (r). The correlation between funding numbers and publication numbers was analyzed by Spearman's rank correlation coefficient (r
    Results: We identified 30,130 publications with first authors from EDs in 19 countries. The numbers of publications in both EM and non-EM journals showed an increasing trend in 12 countries. Fifteen of the 19 countries had a greater increasing trend in non-EM journals than in EM journals. The 2009 publication numbers were positively correlated with the publication increasing trend between 2009 and 2018 in both EM and non-EM journals (r = 0.854 and 0.947, respectively, both p < 0.001). The funded publication number was positively correlated with the total national publication amount (r
    Conclusions: The research capacity of EDs has been increasingly recognized by other medical specialties. The national publication numbers from EDs may predict the academic publication increasing trends in the subsequent 10 years.
    MeSH term(s) Bibliometrics ; Emergency Medicine ; Humans ; Internationality ; Publishing/trends ; Societies, Medical
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2021.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of the COVID-19 Pandemic on Pediatric Emergency Medicine: A Systematic Review.

    Cheng, Chien-Wei / Huang, Yan-Bo / Chao, Hsiao-Yun / Ng, Chip-Jin / Chen, Shou-Yen

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 8

    Abstract: 1) ...

    Abstract (1)
    MeSH term(s) COVID-19 ; Child ; Emergencies ; Emergency Service, Hospital ; Humans ; Pandemics ; Pediatric Emergency Medicine ; United States
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Systematic Review ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58081112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The effect of photolysis of sodium citrate treated with gold chloride using coloured light on the generation of gold nanoparticles and the repression of WiDr colon cancer cells.

    Cheng, Chien-Wei / Lee, Shwu-Yuan / Zhan, Shao-Qi / Huang, Cheng-Liang / Chen, Tang-Yu / Yuann, Jeu-Ming P / Huang, Shiuh-Tsuen / Chiu, Chi-Ming / Liang, Ji-Yuan

    Journal of photochemistry and photobiology. B, Biology

    2024  Volume 251, Page(s) 112844

    Abstract: Gold nanoparticles (GNPs) are usually formed via a wet chemical method using gold (III) chloride trihydrate (GC), which is treated with stable reducing agents such as sodium citrate (SC). This study determines the effect of coloured light on the ... ...

    Abstract Gold nanoparticles (GNPs) are usually formed via a wet chemical method using gold (III) chloride trihydrate (GC), which is treated with stable reducing agents such as sodium citrate (SC). This study determines the effect of coloured light on the formation of GNPs by irradiation of SC after the addition of GC (SCGC) and the effect of the SCGC photolytic procedure on the suppression of WiDr colon cancer cells by forming reactive oxygen species. The absorbance of surface plasmon resonance peaks at 523 nm are 0.069 and 0.219 for SCGC when treated with blue light illumination (BLI) and violet light irradiation (VLI), respectively, whereas green and red light treatments have little or no effect. Most GNPs have diameters ranging from 3 to 15 nm, with a mean of 6 nm, when SCGC is exposed to VLI for 1.5 h. Anionic superoxide radicals (O
    MeSH term(s) Humans ; Sodium Citrate ; Metal Nanoparticles/toxicity ; Gold/pharmacology ; Photolysis ; Propidium ; Colonic Neoplasms/drug therapy ; Gold Compounds
    Chemical Substances Sodium Citrate (1Q73Q2JULR) ; Gold (7440-57-5) ; gold chloride (11118-27-7) ; Propidium (36015-30-2) ; Gold Compounds
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2024.112844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5'-Phosphate.

    Cheng, Chien-Wei / Lee, Shwu-Yuan / Chen, Tang-Yu / Yuann, Jeu-Ming P / Chiu, Chi-Ming / Huang, Shiuh-Tsuen / Liang, Ji-Yuan

    Journal of visualized experiments : JoVE

    2022  , Issue 182

    Abstract: Riboflavin-5'-phosphate (or flavin mononucleotide; FMN) is sensitive to visible light. Various compounds, including reactive oxygen species (ROS), can be generated from FMN photolysis upon irradiation with visible light. The ROS generated from FMN ... ...

    Abstract Riboflavin-5'-phosphate (or flavin mononucleotide; FMN) is sensitive to visible light. Various compounds, including reactive oxygen species (ROS), can be generated from FMN photolysis upon irradiation with visible light. The ROS generated from FMN photolysis are harmful to microorganisms, including pathogenic bacteria such as Staphylococcus aureus (S. aureus). This article presents a protocol for deactivating S. aureus, as an example, via photochemical reactions involving FMN under visible light irradiation. The superoxide radical anion () generated during the FMN photolysis is evaluated via nitro blue tetrazolium (NBT) reduction. The microbial viability of S. aureus that is attributed to reactive species was used to determine the effectiveness of the process. The bacterial inactivation rate is proportional to FMN concentration. Violet light is more efficient in inactivating S. aureus than blue light irradiation, while the red or green light does not drive FMN photolysis. The present article demonstrates FMN photolysis as a simple and safe method for sanitary processes.
    MeSH term(s) Flavin Mononucleotide/chemistry ; Light ; Phosphates ; Photolysis ; Reactive Oxygen Species ; Staphylococcus aureus
    Chemical Substances Phosphates ; Reactive Oxygen Species ; Flavin Mononucleotide (7N464URE7E)
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/63531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain

    Yuann, Jeu-Ming P. / Lee, Shwu-Yuan / He, Sin / Wong, Tak-Wah / Yang, Meei-Ju / Cheng, Chien-Wei / Huang, Shiuh-Tsuen / Liang, Ji-Yuan

    Journal of photochemistry and photobiology. 2022 Jan., v. 226

    2022  

    Abstract: Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. ... ...

    Abstract Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. Deactivation caused by superoxide anion radical (O₂•⁻) and deactivation from DCH and MH during photolysis on Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA), were studied. DCH is relatively unstable compared to MH under BLIA. The level of O₂•⁻ generated from the MH-treated photoreaction is lower than that from DCH photolysis, and the DCH-treated photoreaction is more efficient at inactivating S. aureus and MRSA at the same radiant intensity. DCH subjected to BLIA decreased the viability of S. aureus and MRSA by 3.84 and 5.15 log, respectively. Two photolytic products of DCH (PPDs) were generated under BLIA. The mass spectra of the PPDs featured molecular ions at m/z 460.8 and 458.8. The molecular formulas of the PPDs were C₂₁H₂₂N₂O₁₀ and C₂₂H₂₄N₂O₉, and their exact masses were 462.44 and 460.44 g/mol, respectively. These results bolster the photolytic oxidation that leads to DCH-enhanced deactivation of S. aureus and MRSA. Photochemical treatment of DCH could be applied as a supplement in hygienic processes.
    Keywords blue light ; doxycycline ; hygiene ; irradiation ; light intensity ; methicillin-resistant Staphylococcus aureus ; minocycline ; oxidation ; photobiology ; photolysis ; superoxide anion ; tetracycline ; viability
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2021.112370
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: An investigation of the influence of reactive oxygen species produced from riboflavin-5'-phosphate by blue or violet light on the inhibition of WiDr colon cancer cells.

    Chiu, Chi-Ming / Lee, Shwu-Yuan / Chen, Pin-Rong / Zhan, Shao-Qi / Yuann, Jeu-Ming P / Huang, Shiuh-Tsuen / Wu, Ming-Fang / Cheng, Chien-Wei / Chang, Yu-Chung / Liang, Ji-Yuan

    Photodiagnosis and photodynamic therapy

    2023  Volume 44, Page(s) 103810

    Abstract: Riboflavin-5'-phosphate (FMN), an innocuous product of riboflavin (RF) phosphorylation, is vital for humans. FMN is sensitive to light illumination, as indicated by reactive oxygen species (ROS) formation. This investigation was undertaken to evaluate ... ...

    Abstract Riboflavin-5'-phosphate (FMN), an innocuous product of riboflavin (RF) phosphorylation, is vital for humans. FMN is sensitive to light illumination, as indicated by reactive oxygen species (ROS) formation. This investigation was undertaken to evaluate the influence of blue light illumination (BLI) and violet light illumination (VLI) upon FMN to develop a method to inhibit WiDr colon cancer cells by FMN photolysis. When FMN is subjected to BLI and VLI, it inhibits WiDr colon cancer cells by generating superoxide radical anions (O
    MeSH term(s) Humans ; Reactive Oxygen Species/metabolism ; Light ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Riboflavin/pharmacology ; Colonic Neoplasms/drug therapy ; Phosphates
    Chemical Substances Reactive Oxygen Species ; Photosensitizing Agents ; Riboflavin (TLM2976OFR) ; Phosphates
    Language English
    Publishing date 2023-09-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2023.103810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain.

    Yuann, Jeu-Ming P / Lee, Shwu-Yuan / He, Sin / Wong, Tak-Wah / Yang, Meei-Ju / Cheng, Chien-Wei / Huang, Shiuh-Tsuen / Liang, Ji-Yuan

    Journal of photochemistry and photobiology. B, Biology

    2021  Volume 226, Page(s) 112370

    Abstract: Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. ... ...

    Abstract Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. Deactivation caused by superoxide anion radical (O
    MeSH term(s) Staphylococcus aureus
    Language English
    Publishing date 2021-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2021.112370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of blue or violet light on the inactivation of Staphylococcus aureus by riboflavin-5'-phosphate photolysis.

    Wong, Tak-Wah / Cheng, Chien-Wei / Hsieh, Zong-Jhe / Liang, Ji-Yuan

    Journal of photochemistry and photobiology. B, Biology

    2017  Volume 173, Page(s) 672–680

    Abstract: The light sensitive compound riboflavin-5'-phosphate (or flavin mononucleotide, FMN) generates reactive oxygen species (ROS) upon photo-irradiation. FMN is required by all flavoproteins because it is a cofactor of biological blue-light receptors. The ... ...

    Abstract The light sensitive compound riboflavin-5'-phosphate (or flavin mononucleotide, FMN) generates reactive oxygen species (ROS) upon photo-irradiation. FMN is required by all flavoproteins because it is a cofactor of biological blue-light receptors. The photochemical effects of FMN after irradiation by blue or violet light on the inactivation of Staphylococcus aureus strains, including a methicillin-resistant strain (MRSA), were investigated in this study. Upon blue- or violet-light photo-treatment, FMN was shown to inactivate S. aureus due to the generated ROS. Effective bacterial inactivation can be achieved by FMN photolysis without an exogenous electron provider. Inactivation rates of 94.9 and 95.2% in S. aureus and MRSA, respectively, can be reached by blue light irradiation (2.0mW/cm
    MeSH term(s) DNA/chemistry ; DNA/metabolism ; DNA Cleavage/drug effects ; DNA Cleavage/radiation effects ; Flavin Mononucleotide/chemistry ; Flavin Mononucleotide/pharmacology ; Light ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/radiation effects ; Methionine/chemistry ; Methionine/pharmacology ; Photolysis/radiation effects ; Reactive Oxygen Species/metabolism ; Spectrophotometry ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/genetics ; Staphylococcus aureus/radiation effects
    Chemical Substances Reactive Oxygen Species ; Flavin Mononucleotide (7N464URE7E) ; DNA (9007-49-2) ; Methionine (AE28F7PNPL)
    Language English
    Publishing date 2017-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2017.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A study of the effect of reactive oxygen species induced by violet and blue light from oxytetracycline on the deactivation of Escherichia coli.

    Cheng, Chien-Wei / Lee, Shwu-Yuan / Chen, Tang-Yu / Yang, Meei-Ju / Yuann, Jeu-Ming P / Chiu, Chi-Ming / Huang, Shiuh-Tsuen / Liang, Ji-Yuan

    Photodiagnosis and photodynamic therapy

    2022  Volume 39, Page(s) 102917

    Abstract: Oxytetracycline (OTC), a tetracycline antibiotic, is a broad-spectrum antibacterial agent. In this investigation, liquid chromatography-mass spectrometry (LC-MS) is utilized to determine the effects of blue light (λ = 448 nm) illumination (BLIA) and ... ...

    Abstract Oxytetracycline (OTC), a tetracycline antibiotic, is a broad-spectrum antibacterial agent. In this investigation, liquid chromatography-mass spectrometry (LC-MS) is utilized to determine the effects of blue light (λ = 448 nm) illumination (BLIA) and violet light (λ = 403 nm) illumination (VLIA) on conformational changes in OTC at pH 7.8. The photochemical effect of OTC that is exposed to BLIA and VLIA on the deactivation of Escherichia coli (E. coli) is studied. The deactivation of E. coli has an insignificant effect on treatment with OTC alone. OTC is relatively unstable under BLIA and VLIA illumination in an alkaline solution, and OTC has been shown to inactivate E. coli by generating reactive oxygen species (ROS). Less anionic superoxide radicals (O
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Light ; Oxytetracycline/analysis ; Oxytetracycline/chemistry ; Oxytetracycline/pharmacology ; Photochemotherapy/methods ; Reactive Oxygen Species
    Chemical Substances Anti-Bacterial Agents ; Reactive Oxygen Species ; Oxytetracycline (X20I9EN955)
    Language English
    Publishing date 2022-05-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2022.102917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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