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  1. Article ; Online: Hydrogen-Bonding Interactions from Nucleobase-Decorated Supramolecular Polymer: Synthesis, Self-Assembly and Biomedical Applications.

    Ilhami, Fasih Bintang / Birhan, Yihenew Simegniew / Cheng, Chih-Chia

    ACS biomaterials science & engineering

    2023  Volume 10, Issue 1, Page(s) 234–254

    Abstract: The fabrication of supramolecular materials for biomedical applications such as drug delivery, bioimaging, wound-dressing, adhesion materials, photodynamic/photothermal therapy, infection control (as antibacterial), etc. has grown tremendously, due to ... ...

    Abstract The fabrication of supramolecular materials for biomedical applications such as drug delivery, bioimaging, wound-dressing, adhesion materials, photodynamic/photothermal therapy, infection control (as antibacterial), etc. has grown tremendously, due to their unique properties, especially the formation of hydrogen bonding. Nevertheless, void space in the integration process, lack of feasibility in the construction of supramolecular materials of natural origin in living biological systems, potential toxicity, the need for complex synthesis protocols, and costly production process limits the actual application of nanomaterials for advanced biomedical applications. On the other hand, hydrogen bonding from nucleobases is one of the strategies that shed light on the blurred deployment of nanomaterials in medical applications, given the increasing reports of supramolecular polymers that promote advanced technologies. Herein, we review the extensive body of literature about supramolecular functional biomaterials based on nucleobase hydrogen bonding pertinent to different biomedical applications. It focuses on the fundamental understanding about the synthesis, nucleobase-decorated supramolecular architecture, and novel properties with special emphasis on the recent developments in the assembly of nanostructures via hydrogen-bonding interactions of nucleobase. Moreover, the challenges, plausible solutions, and prospects of the so-called hydrogen bonding interaction from nucleobase for the fabrication of functional biomaterials are outlined.
    MeSH term(s) Hydrogen Bonding ; Biocompatible Materials ; Nanostructures ; Polymers/chemistry ; Hydrogen
    Chemical Substances Biocompatible Materials ; Polymers ; Hydrogen (7YNJ3PO35Z)
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01097
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  2. Article ; Online: CO

    Hsiao, Yu-Nong / Ilhami, Fasih Bintang / Cheng, Chih-Chia

    Biomacromolecules

    2023  Volume 25, Issue 2, Page(s) 997–1008

    Abstract: We describe important progress in the synthesis and development of gas-responsive water-soluble conjugated polymers (WSCPs) with potential as multifunctional fluorescent materials for biomedical imaging and probes. A water-soluble WSCP (I-PT) composed of ...

    Abstract We describe important progress in the synthesis and development of gas-responsive water-soluble conjugated polymers (WSCPs) with potential as multifunctional fluorescent materials for biomedical imaging and probes. A water-soluble WSCP (I-PT) composed of a hydrophobic fluorescent polythiophene backbone and a hydrophilic imidazole side chain was successfully prepared through a facile and efficient two-step synthetic route. Owing to the repulsive force between the hydrophilic and hydrophobic segments and the highly sensitive carbon dioxide (CO
    MeSH term(s) Fluorescent Dyes/pharmacology ; Fluorescent Dyes/chemistry ; Carbon Dioxide/chemistry ; Water/chemistry ; Polymers/pharmacology ; Polymers/chemistry ; Imidazoles ; Nanoparticles/chemistry
    Chemical Substances Fluorescent Dyes ; Carbon Dioxide (142M471B3J) ; Water (059QF0KO0R) ; Polymers ; Imidazoles
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01078
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  3. Article ; Online: Fabrication of localized surface plasmon resonance sensors with scalable polyvinyltetrazole/copper cluster hybrid ring-array for Cu(II) detection.

    Chen, Jem-Kun / Zeng, Xiang-Yun / Cheng, Chih-Chia / Chen, Chih-Wei

    Talanta

    2023  Volume 256, Page(s) 124282

    Abstract: The bottom of a hole-array photoresist template deposited with a hydrophobic atom-transfer radical polymerization (ATRP) initiator was wetted by treatment with oxygen plasma. After the removal of the photoresist template, ring patterns of the ATRP ... ...

    Abstract The bottom of a hole-array photoresist template deposited with a hydrophobic atom-transfer radical polymerization (ATRP) initiator was wetted by treatment with oxygen plasma. After the removal of the photoresist template, ring patterns of the ATRP initiator were formed at the interface between the hydrophobic and wetting regions. Polyacrylonitrile (PAN) was grafted from the initiator ring array to covert to polyvinyltetrazole (PVT) rings via a cyano-to-tetrazole reaction, which could adsorb Cu(II) at various concentrations. The Cu(II) ions within the PVT rings were reduced to form a PVT-copper hybrid ring (VCHR), resulting in a blue-shift of the localized surface plasmon resonance (LSPR) peak as the Cu(II) was adsorbed by the PVT rings. The blue-shift and Cu(II) concentration were linearly correlated, with a detection limit of ∼25 pg mL
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124282
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  4. Article ; Online: Multi-Biofunctional Silver-Containing Metallosupramolecular Nanogels for Efficient Antibacterial Treatment and Selective Anticancer Therapy.

    Ilhami, Fasih Bintang / Huang, Sin-Yu / Cheng, Chih-Chia

    Acta biomaterialia

    2022  Volume 151, Page(s) 576–587

    Abstract: We develop a simple and efficient route for the fabrication of water-soluble metallosupramolecular polymers. We demonstrate that the introduction of environment-responsive metal-organic complexes within supramolecular polymers endows the resulting self- ... ...

    Abstract We develop a simple and efficient route for the fabrication of water-soluble metallosupramolecular polymers. We demonstrate that the introduction of environment-responsive metal-organic complexes within supramolecular polymers endows the resulting self-assembled nano-objects with outstanding antibacterial activity and may significantly improve the efficacy and safety of selective cancer therapy. Herein, we successfully developed a silver-containing supramolecular polymer (Ag-Cy-J) possessing a hydrophilic Jeffamine backbone and highly sensitive pH-responsive cytosine-silver-cytosine (Cy-Ag-Cy) linkages, which spontaneously self-assemble to produce sterically stabilized spherical nanogels in water. The resulting nanogels exhibit several attractive features such as unique fluorescence behavior in water, highly stable self-assembled structures in biological media, significant antihemolytic capability, highly sensitive pH-responsiveness and broad-spectrum antibacterial activity against various bacteria strains. Importantly, in vitro cellular assays clearly demonstrated Ag-Cy-J nanogels highly selectively target and induce cytotoxicity in cancer cells, without affecting normal cells. The selective cytotoxic activity in cancer cells is attributed to rapid dissociation of the Cy-Ag-Cy complexes within the nanogels in the cancer cell microenvironment, followed by the intracellular release of silver ions and induction of rapid, massive apoptosis. Overall, the pH-sensitive Cy-Ag-Cy complexes within this supramolecular nanogel system may provide a route to remarkably improve the efficacy of both antibacterial and cancer drug therapies. STATEMENT OF SIGNIFICANCE: We present a significant breakthrough in the development of a water-soluble silver-containing metallosupramolecular polymer (Ag-Cy-J) that spontaneously self-assembles in water into a spherical nanogel with unique physical characteristics due to the existence of highly sensitive pH-responsive cytosine-silver-cytosine (Cy-Ag-Cy) linkages within the nanogels. Importantly, a series of in vitro antibacterial and anticancer assays demonstrated the Ag-Cy-J nanogels not only exert strong antibacterial activity against various bacterial strains, but also exhibit a high degree of selective uptake and rapidly induce massive apoptosis in cancer cells without harming normal cells. Thus, this newly discovered supramolecular system may potentially provide a multi-biofunctional soft nanomaterial for efficient and safe antibacterial and cancer therapies.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cytosine ; Hydrogen-Ion Concentration ; Nanogels ; Polyethylene Glycols ; Polyethyleneimine ; Polymers ; Silver/pharmacology ; Water
    Chemical Substances Anti-Bacterial Agents ; Nanogels ; Polymers ; polyethylene glycol polyethyleneimine nanogel ; Water (059QF0KO0R) ; Silver (3M4G523W1G) ; Polyethylene Glycols (3WJQ0SDW1A) ; Cytosine (8J337D1HZY) ; Polyethyleneimine (9002-98-6)
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2022.07.065
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  5. Article: Spontaneous Self-Assembly of Single-Chain Amphiphilic Polymeric Nanoparticles in Water.

    Huang, Shan-You / Cheng, Chih-Chia

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 10

    Abstract: Single-chain polymeric nanoparticles (SCPNs) have great potential as functional nanocarriers for drug delivery and bioimaging, but synthetic challenges in terms of final yield and purification procedures limit their use. A new concept to modify and ... ...

    Abstract Single-chain polymeric nanoparticles (SCPNs) have great potential as functional nanocarriers for drug delivery and bioimaging, but synthetic challenges in terms of final yield and purification procedures limit their use. A new concept to modify and improve the synthetic procedures used to generate water-soluble SCPNs through amphiphilic interactions has been successfully exploited. We developed a new ultrahigh molecular weight amphiphilic polymer containing a hydrophobic poly(epichlorohydrin) backbone and hydrophilic poly(ethylene glycol) side chains. The polymer spontaneously self-assembles into SCPNs in aqueous solution and does not require subsequent purification. The resulting SCPNs possess a number of distinct physical properties, including a uniform hydrodynamic nanoparticle diameter of 10-15 nm, extremely low viscosity and a desirable spherical-like morphology. Concentration-dependent studies demonstrated that stable SCPNs were formed at high concentrations up to 10 mg/mL in aqueous solution, with no significant increase in solution viscosity. Importantly, the SCPNs exhibited high structural stability in media containing serum or phosphate-buffered saline and showed almost no change in hydrodynamic diameter. The combination of these characteristics within a water-soluble SCPN is highly desirable and could potentially be applied in a wide range of biomedical fields. Thus, these findings provide a path towards a new, innovative route for the development of water-soluble SCPNs.
    Language English
    Publishing date 2020-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10102006
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  6. Article: Complementary Nucleobase Interactions Drive Co-Assembly of Drugs and Nanocarriers for Selective Cancer Chemotherapy.

    Ilhami, Fasih Bintang / Bayle, Enyew Alemayehu / Cheng, Chih-Chia

    Pharmaceutics

    2021  Volume 13, Issue 11

    Abstract: A new concept in cooperative adenine-uracil (A-U) hydrogen bonding interactions between anticancer drugs and nanocarrier complexes was successfully demonstrated by invoking the co-assembly of water soluble, uracil end-capped polyethylene glycol polymer ( ... ...

    Abstract A new concept in cooperative adenine-uracil (A-U) hydrogen bonding interactions between anticancer drugs and nanocarrier complexes was successfully demonstrated by invoking the co-assembly of water soluble, uracil end-capped polyethylene glycol polymer (BU-PEG) upon association with the hydrophobic drug adenine-modified rhodamine (A-R6G). This concept holds promise as a smart and versatile drug delivery system for the achievement of targeted, more efficient cancer chemotherapy. Due to A-U base pairing between BU-PEG and A-R6G, BU-PEG has high tendency to interact with A-R6G, which leads to the formation of self-assembled A-R6G/BU-PEG nanogels in aqueous solution. The resulting nanogels exhibit a number of unique physical properties, including extremely high A-R6G-loading capacity, well-controlled, pH-triggered A-R6G release behavior, and excellent structural stability in biological media. Importantly, a series of in vitro cellular experiments clearly demonstrated that A-R6G/BU-PEG nanogels improved the selective uptake of A-R6G by cancer cells via endocytosis and promoted the intracellular release of A-R6G to subsequently induce apoptotic cell death, while control rhodamine/BU-PEG nanogels did not exert selective toxicity in cancer or normal cell lines. Overall, these results indicate that cooperative A-U base pairing within nanogels is a critical factor that improves selective drug uptake and effectively promotes apoptotic programmed cell death in cancer cells.
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13111929
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  7. Article ; Online: Hydrogen-bonded cytosine-endowed supramolecular polymeric nanogels: Highly efficient cancer cell targeting and enhanced therapeutic efficacy.

    Fan, Wen-Lu / Huang, Shan-You / Yang, Xiu-Jing / Bintang Ilhami, Fasih / Chen, Jem-Kun / Cheng, Chih-Chia

    Journal of colloid and interface science

    2024  Volume 665, Page(s) 329–344

    Abstract: We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy- ... ...

    Abstract We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy-and thus hold significant potential as a new perspective for development of drug delivery systems. Herein, we successfully developed physically cross-linked supramolecular polymers (PECH-PEG-Cy) comprised of hydrogen-bonding cytosine pendant groups, hydrophilic poly(ethylene glycol) side chains, and a hydrophobic poly(epichlorohydrin) main chain. The polymers spontaneously self-assemble into a reversibly hydrogen-bonded network structure induced by cytosine and directly form spherical nanogels in aqueous solution. Nanogels with a high hydrogen-bond network density (i.e., a higher content of cytosine moieties) exhibit outstanding long-term structural stability in cell culture substrates containing serum, whereas nanogels with a relatively low hydrogen-bond network density cannot preserve their structural integrity. The nanogels also exhibit numerous unique physicochemical characteristics in aqueous solution, such as a desirable spherical size, high biocompatibility with normal and cancer cells, excellent drug encapsulation capacity, and controlled pH-responsive drug release properties. More importantly, in vitro experiments conclusively indicate the drug-loaded PECH-PEG-Cy nanogels can selectively induce cancer cell-specific apoptosis and cell death via cytosine receptor-mediated endocytosis, without significantly harming normal cells. In contrast, control drug-loaded PECH-PEG nanogels, which lack cytosine moieties in their structure, can only induce cell death in cancer cells through non-specific pathways, which significantly inhibits the induction of apoptosis. This work clearly demonstrates that the cytosine moieties in PECH-PEG-Cy nanogels confer selective affinity for the surface of cancer cells, which enhances their targeted cellular uptake, cytotoxicity, and subsequent induction of programmed cell death in cancer cells.
    MeSH term(s) Nanogels ; Polymers/chemistry ; Drug Delivery Systems ; Polyethylene Glycols/chemistry ; Apoptosis ; Drug Carriers/chemistry ; Doxorubicin/pharmacology ; Neoplasms/drug therapy
    Chemical Substances Nanogels ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Drug Carriers ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.03.154
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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  8. Article ; Online: Two-Way CO

    Shieh, Yeong-Tarng / Yeh, Yao-Chuan / Cheng, Chih-Chia

    ACS omega

    2020  Volume 5, Issue 4, Page(s) 1862–1869

    Abstract: Multiple stimuli-responsive amphiphilic block copolymers of poly(methacrylic acid) (PMAA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were used as emulsifiers to prepare two-way ... ...

    Abstract Multiple stimuli-responsive amphiphilic block copolymers of poly(methacrylic acid) (PMAA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were used as emulsifiers to prepare two-way CO
    Language English
    Publishing date 2020-01-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b03319
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  9. Article ; Online: Excess adsorption of phosphoric acid from extremely acidic solutions by covalent organic framework EB-COF:Br.

    Yang, Cheng-Hao / Cheng, Chih-Chia / Lee, Duu-Jong

    Chemosphere

    2020  Volume 257, Page(s) 127244

    Abstract: The industrial waste streams with excess phosphorus acid ( ... ...

    Abstract The industrial waste streams with excess phosphorus acid (H
    MeSH term(s) Adsorption ; Industrial Waste ; Metal-Organic Frameworks ; Phosphoric Acids/chemistry ; Water ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/chemistry
    Chemical Substances Industrial Waste ; Metal-Organic Frameworks ; Phosphoric Acids ; Water Pollutants, Chemical ; Water (059QF0KO0R) ; phosphoric acid (E4GA8884NN)
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.127244
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Piezoelectric Property Enhancement of PZT/Poly(vinylidenefluoride-

    Chen, Jian-Xun / Li, Jia-Wun / Cheng, Chih-Chia / Chiu, Chih-Wei

    ACS omega

    2021  Volume 7, Issue 1, Page(s) 793–803

    Abstract: In this study, lead zirconate titanate (PZT) ceramic particles were added for further improvement. PZT belongs to the perovskite family and exhibits good piezoelectricity. Thus, it was added in this experiment to enhance the piezoelectric response of the ...

    Abstract In this study, lead zirconate titanate (PZT) ceramic particles were added for further improvement. PZT belongs to the perovskite family and exhibits good piezoelectricity. Thus, it was added in this experiment to enhance the piezoelectric response of the poly(vinylidenefluoride-
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c05451
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