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Article ; Online: Self-reinforced and self-healing dynamic covalent polymeric networks with shifting chemical structures.

Zhang, Ziwen / Cheng, Chong

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 47, Page(s) 7259–7262

Abstract: Dynamic covalent polymeric networks (DCPNs) with hindered urea bonds and free thiol groups were prepared. Due to the catalyst-free conversion of dynamic hindered urea bonds to dynamic thiourethane bonds, these materials showed enhanced mechanical ... ...

Abstract	Dynamic covalent polymeric networks (DCPNs) with hindered urea bonds and free thiol groups were prepared. Due to the catalyst-free conversion of dynamic hindered urea bonds to dynamic thiourethane bonds, these materials showed enhanced mechanical properties along with time or triggered by elevated temperature, and exhibited excellent self-healing performance.
MeSH term(s)	Polymers ; Sulfhydryl Compounds ; Urea
Chemical Substances	Polymers ; Sulfhydryl Compounds ; Urea (8W8T17847W)
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc01208e
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immobilization of carbonic anhydrase on modified PES membranes for artificial lungs.

Wang, Yi / Cheng, Chong / Li, Shuang / Sun, Shudong / Zhao, Changsheng

Journal of materials chemistry. B

2024 Volume 12, Issue 9, Page(s) 2364–2372

Abstract: The introduction of carbonic anhydrase (CA) onto an extracorporeal membrane oxygenation (ECMO) membrane can improve the permeability of carbon dioxide ( ... ...

Abstract	The introduction of carbonic anhydrase (CA) onto an extracorporeal membrane oxygenation (ECMO) membrane can improve the permeability of carbon dioxide (CO
MeSH term(s)	Carbonic Anhydrases/metabolism ; Carbon Dioxide ; Bicarbonates ; Membranes, Artificial ; Lung/metabolism ; Polymers ; Sulfones
Chemical Substances	polyether sulfone (25667-42-9) ; Carbonic Anhydrases (EC 4.2.1.1) ; Carbon Dioxide (142M471B3J) ; Bicarbonates ; Membranes, Artificial ; Polymers ; Sulfones
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb02553e
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Article ; Online: Metal-organic framework-based adsorbents for blood purification: progress, challenges, and prospects.

Wang, Jiemin / Cheng, Chong / Sun, Shudong / Zhao, Weifeng / Zhao, Changsheng

Journal of materials chemistry. B

2024 Volume 12, Issue 15, Page(s) 3594–3613

Abstract: Blood purification, such as hemodialysis (HD), plasma exchange (PE), and hemoperfusion (HP), is widely applied in patients with organ failure (such as kidney and liver failure). Among them, HP mainly relies on porous adsorbents to efficiently adsorb ... ...

Abstract	Blood purification, such as hemodialysis (HD), plasma exchange (PE), and hemoperfusion (HP), is widely applied in patients with organ failure (such as kidney and liver failure). Among them, HP mainly relies on porous adsorbents to efficiently adsorb accumulated metabolic wastes and toxins, thus improving purification efficiency. Metal-organic frameworks (MOFs), with a high porosity, large surface area, high loading capacity, and tailorable topology, are emerging as some of the most promising materials for HP. Compared with non-metal framework counterparts, the self-built metal centers of MOFs feature the intrinsic advantages of coordination with toxin molecules. However, research on MOFs in blood purification is insufficient, particularly in contrast to materials applied in other biomedical applications. Thus, to broaden this area, this review first discusses the essential characteristics, potential mechanisms, and structure-function relationship between MOFs and toxin adsorption based on porosity, topology, ligand functionalization, metal centers, and toxin types. Moreover, the stability, utilization safety, and hemocompatibility of MOFs are illustrated for adsorbent selection. The current development and progress in MOF composites for HD, HP, and extracorporeal membrane oxygenation (ECMO) are also summarized to highlight their practicability. Finally, we propose future opportunities and challenges from materials design and manufacture to the computational prediction of MOFs in blood purification. It is anticipated that our review will expand the interest of researchers for more impact in this area.
MeSH term(s)	Humans ; Metal-Organic Frameworks ; Adsorption ; Hemoperfusion ; Kidney ; Porosity
Chemical Substances	Metal-Organic Frameworks
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb03047d
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Article: Falling Mixed-Phase Ice Virga and their Liquid Parent Cloud Layers as Observed by Ground-Based Lidars

Cheng, Chong / Yi, Fan

Remote Sensing. 2020 June 30, v. 12, no. 13

2020

Abstract: Falling mixed-phase virga from a thin supercooled liquid layer cloud base were observed on 20 occasions at altitudes of 2.3–9.4 km with ground-based lidars at Wuhan (30.5 °N, 114.4 °E), China. Polarization lidar profile (3.75-m) analysis reveals some ... ...

Abstract	Falling mixed-phase virga from a thin supercooled liquid layer cloud base were observed on 20 occasions at altitudes of 2.3–9.4 km with ground-based lidars at Wuhan (30.5 °N, 114.4 °E), China. Polarization lidar profile (3.75-m) analysis reveals some ubiquitous features of both falling mixed-phase virga and their liquid parent cloud layers. Each liquid parent cloud had a well-defined base height where the backscatter ratio R was ~7.0 and the R profile had a clear inflection point. At an altitude of ~34 m above the base height, the depolarization ratio reached its minimum value (~0.04), indicating a liquid-only level therein. The thin parent cloud layers tended to form on the top of a broad preexisting aerosol/liquid water layer. The falling virga below the base height showed firstly a significant depolarization ratio increase, suggesting that most supercooled liquid drops in the virga were rapidly frozen into ice crystals (via contact freezing). After reaching a local maximum value of the depolarization ratio, both the values of the backscatter ratio and depolarization ratio for the virga exhibited an overall decrease with decreasing height, indicating sublimated ice crystals. The diameters of the ice crystals in the virga were estimated based on an ice particle sublimation model along with the lidar and radiosonde observations. It was found that the ice crystal particles in these virga cases tended to have smaller mean diameters and narrower size distributions with increasing altitude. The mean diameter value is 350 ± 111 µm at altitudes of 4–8.5 km.
Keywords	aerosols ; altitude ; crystals ; freezing ; ice ; lidar ; models ; remote sensing ; sublimation ; China
Language	English
Dates of publication	2020-0630
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs12132094
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Conjugated Network Supporting Highly Surface-Exposed Ru Site-Based Artificial Antioxidase for Efficiently Modulating Microenvironment and Alleviating Solar Dermatitis.

Yang, Dongmei / Yuan, Minjia / Huang, Jianbo / Xiang, Xi / Pang, Houqing / Wei, Qiang / Luo, Xianglin / Cheng, Chong / Qiu, Li / Ma, Lang

ACS nano

2024 Volume 18, Issue 4, Page(s) 3424–3437

Abstract: Solar dermatitis, a form of acute radiation burn that affects the skin, results from overexposure to ultraviolet B (UVB) radiation in strong sunlight. Cell damage caused by the accumulation of reactive oxygen species (ROS) produced by UVB radiation plays ...

Abstract	Solar dermatitis, a form of acute radiation burn that affects the skin, results from overexposure to ultraviolet B (UVB) radiation in strong sunlight. Cell damage caused by the accumulation of reactive oxygen species (ROS) produced by UVB radiation plays an important role in UVB-induced inflammation in the skin. Here, for efficiently scavenging excess ROS, modulating the microenvironment, and alleviating solar dermatitis, a π-conjugated network polyphthalocyanine supporting a highly surface-exposed Ru active site-based artificial antioxidase (HSE-PPcRu) is designed and fabricated with excellent ROS-scavenging, antioxidant, and anti-inflammatory capabilities. In photodamaged human keratinocyte cells, HSE-PPcRu could modulate mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B signaling pathways, prevent DNA damage, suppress apoptosis, inhibit pro-inflammatory cytokine secretion, and alleviate cell damage.
MeSH term(s)	Animals ; Humans ; Antioxidants/pharmacology ; Reactive Oxygen Species/metabolism ; Skin/metabolism ; Ultraviolet Rays ; Anti-Inflammatory Agents/pharmacology ; Dermatitis/etiology ; Dermatitis/metabolism
Chemical Substances	Antioxidants ; Reactive Oxygen Species ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c10552
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Article ; Online: Well-Defined pH-Sensitive Self-Assembled Triblock Copolymer-Based Crosslinked Micelles for Efficient Cancer Chemotherapy.

Mohamed, Mohamed Alaa / Singh, Ajay / Prasad, Paras N / Cheng, Chong

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 23

Abstract: Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, limited stability of micelles, premature drug release and off-target effect are the major obstacles that restrict the ... ...

Abstract	Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, limited stability of micelles, premature drug release and off-target effect are the major obstacles that restrict the utilization of polymeric micelles as effective drug delivery systems. In this work, we addressed these issues through the innovative design of targeted pH-sensitive crosslinked polymeric micelles for chemotherapeutic delivery. A well-defined triblock copolymer, poly(ethylene glycol)-
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27238153
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Article ; Online: Polymerized Network-Based Artificial Peroxisome Reprogramming Macrophages for Photoacoustic Imaging-Guided Treatment of Rheumatoid Arthritis.

Wang, Liyun / Zhang, Lingyan / Chen, Fan / Li, Qian / Zhu, Bihui / Tang, Yuanjiao / Yang, Zhengbao / Cheng, Chong / Qiu, Li / Ma, Lang

ACS applied materials & interfaces

2024

Abstract: Artificial peroxisomes (AP) with enzyme-mimetic catalytic activity and recruitment ability have drawn a great deal of attention in fabricating protocell systems for scavenging reactive oxygen species (ROS), modulating the inflammatory microenvironment, ... ...

Abstract	Artificial peroxisomes (AP) with enzyme-mimetic catalytic activity and recruitment ability have drawn a great deal of attention in fabricating protocell systems for scavenging reactive oxygen species (ROS), modulating the inflammatory microenvironment, and reprogramming macrophages, which is of great potential in treating inflammatory diseases such as rheumatoid arthritis (RA). Herein, a macrophage membrane-cloaked Cu-coordinated polyphthalocyanine-based AP (CuAP) is prepared with a macrocyclic conjugated polymerized network and embedded Cu-single atomic active center, which mimics the catalytic activity and coordination environment of natural superoxide dismutase and catalase, possesses the inflammatory recruitment ability of macrophages, and performs photoacoustic imaging (PAI)-guided treatment. The results of both
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c04000
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Article ; Online: Tunable Structured 2D Nanobiocatalysts: Synthesis, Catalytic Properties and New Horizons in Biomedical Applications.

Cui, Qiqi / Gao, Yang / Wen, Qinlong / Wang, Ting / Ren, Xiancheng / Cheng, Liang / Bai, Mingru / Cheng, Chong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2311584

Abstract: 2D materials have offered essential contributions to boosting biocatalytic efficiency in diverse biomedical applications due to the intrinsic enzyme-mimetic activity and massive specific surface area for loading metal catalytic centers. Since the ... ...

Abstract	2D materials have offered essential contributions to boosting biocatalytic efficiency in diverse biomedical applications due to the intrinsic enzyme-mimetic activity and massive specific surface area for loading metal catalytic centers. Since the difficulty of high-quality synthesis, the varied structure, and the tough choice of efficient surface loading sites with catalytic properties, the artificial building of 2D nanobiocatalysts still faces great challenges. Here, in this review, a timely and comprehensive summarization of the latest progress and future trends in the design and biotherapeutic applications of 2D nanobiocatalysts is provided, which is essential for their development. First, an overview of the synthesis-structure-fundamentals and structure-property relationships of 2D nanobiocatalysts, both metal-free and metal-based is provided. After that, the effective design of the active sites of nanobiocatalysts is discussed. Then, the progress of their applied research in recent years, including biomedical analysis, biomedical therapeutics, pharmacokinetics, and toxicology is systematically highlighted. Finally, future research directions of 2D nanobiocatalysts are prospected. Overall, this review to provide cutting-edge and multidisciplinary guidance for accelerating future developments and biomedical applications of 2D nanobiocatalysts is expected.
Language	English
Publishing date	2024-04-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202311584
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Article ; Online: Pyridine-Bridged Covalent Organic Frameworks with Adjustable Band Gaps as Intelligent Artificial Enzymes for Light-Augmented Biocatalytic Sensing.

Cui, Qiqi / Zhou, Mi / Wen, Qinlong / Li, Lin / Xiong, Chao / Adeli, Mohsen / Cheng, Liang / Xu, Xiaohui / Ren, Xiancheng / Cheng, Chong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2401673

Abstract: One of the biggest challenges in biotechnology and medical diagnostics is finding extremely sensitive and adaptable biosensors. Since metal-based enzyme-mimetic biocatalysts may lead to biosafety concerns on accumulative toxicity, it is essential to ... ...

Abstract	One of the biggest challenges in biotechnology and medical diagnostics is finding extremely sensitive and adaptable biosensors. Since metal-based enzyme-mimetic biocatalysts may lead to biosafety concerns on accumulative toxicity, it is essential to synthesize metal-free enzyme-mimics with optimal biocatalytic activity and superior selectivity. Here, the pyridine-bridged covalent organic frameworks (COFs) with specific oxidase-like (OXD-like) activities as intelligent artificial enzymes for light-augmented biocatalytic sensing of biomarkers are disclosed. Because of the adjustable bandgaps of pyridine structures on the photocatalytic properties of the pristine COF structures, the pyridine-bridged COF exhibit efficient, selective, and light-responsive OXD-like biocatalytic activity. Moreover, the pyridine-bridged COF structures show tunable and light-augmented biocatalytic detection capabilities, which outperform the recently reported state-of-the-art OXD-mimics regarding biosensing efficiency. Notably, the pyridine-bridged COF exhibits efficient and multifaceted diagnostic activity, including the extremely low limit of detection (LOD), which enables visual assays for abundant reducibility biomarkers. It is believed that this design will offer unique metal-free biocatalysts for high-sensitive and low-cost colorimetric detection and also provide new insights to create highly efficient enzyme-like COF materials via linkage-modulation strategies for future biocatalytic applications.
Language	English
Publishing date	2024-05-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202401673
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Article ; Online: Delocalization Engineering of Heme-Mimetic Artificial Enzymes for Augmented Reactive Oxygen Catalysis.

Li, Qian / Zhao, Zhenyang / Chen, Fan / Xu, Xiaohui / Xu, Lizhi / Cheng, Liang / Adeli, Mohsen / Luo, Xianglin / Cheng, Chong

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 15, Page(s) e202400838

Abstract: Developing artificial enzymes based on organic molecules or polymers for reactive oxygen species (ROS)-related catalysis has broad applicability. Herein, inspired by porphyrin-based heme mimics, we report the synthesis of polyphthalocyanine-based ... ...

Abstract	Developing artificial enzymes based on organic molecules or polymers for reactive oxygen species (ROS)-related catalysis has broad applicability. Herein, inspired by porphyrin-based heme mimics, we report the synthesis of polyphthalocyanine-based conjugated polymers (Fe-PPc-AE) as a new porphyrin-evolving structure to serve as efficient and versatile artificial enzymes for augmented reactive oxygen catalysis. Owing to the structural advantages, such as enhanced π-conjugation networks and π-electron delocalization, promoted electron transfer, and unique Fe-N coordination centers, Fe-PPc-AE showed more efficient ROS-production activity in terms of Vmax and turnover numbers as compared with porphyrin-based conjugated polymers (Fe-PPor-AE), which also surpassed reported state-of-the-art artificial enzymes in their activity. More interestingly, by changing the reaction medium and substrates, Fe-PPc-AE also revealed significantly improved activity and environmental adaptivity in many other ROS-related biocatalytic processes, validating the potential of Fe-PPc-AE to replace conventional (poly)porphyrin-based heme mimics for ROS-related catalysis, biosensors, or biotherapeutics. It is suggested that this study will offer essential guidance for designing artificial enzymes based on organic molecules or polymers.
MeSH term(s)	Heme/chemistry ; Oxygen/chemistry ; Reactive Oxygen Species ; Porphyrins/chemistry ; Catalysis ; Polymers
Chemical Substances	Heme (42VZT0U6YR) ; Oxygen (S88TT14065) ; Reactive Oxygen Species ; Porphyrins ; Polymers
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202400838
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