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  1. Article ; Online: Influences: Experimenting with multidisciplinary training.

    Cheng, Heping Peace

    The Journal of general physiology

    2018  Volume 150, Issue 10, Page(s) 1350–1351

    MeSH term(s) Biomedical Engineering/history ; China ; History, 20th Century ; History, 21st Century ; Interdisciplinary Research ; Universities/history
    Language English
    Publishing date 2018-08-27
    Publishing country United States
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201812156
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  2. Article ; Online: Pattern recognition of microcirculation with super-resolution ultrasound imaging provides markers for early tumor response to anti-angiogenic therapy.

    Yin, Jingyi / Dong, Feihong / An, Jian / Guo, Tianyu / Cheng, Heping / Zhang, Jiabin / Zhang, Jue

    Theranostics

    2024  Volume 14, Issue 3, Page(s) 1312–1324

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Microcirculation ; Neoplasms/blood supply ; Ultrasonography/methods ; Treatment Outcome ; Immunotherapy ; Microvessels/diagnostic imaging ; Microbubbles
    Language English
    Publishing date 2024-01-20
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.89306
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  3. Article ; Online: New imaging instrument in animal models: Two-photon miniature microscope and large field of view miniature microscope for freely behaving animals.

    Guo, Changliang / Wang, Aimin / Cheng, Heping / Chen, Liangyi

    Journal of neurochemistry

    2022  Volume 164, Issue 3, Page(s) 270–283

    Abstract: Over the past decade, novel optical imaging tools have been developed for imaging neuronal activities along with the evolution of fluorescence indicators with brighter expression and higher sensitivity. Miniature microscopes, as revolutionary approaches, ...

    Abstract Over the past decade, novel optical imaging tools have been developed for imaging neuronal activities along with the evolution of fluorescence indicators with brighter expression and higher sensitivity. Miniature microscopes, as revolutionary approaches, enable the imaging of large populations of neuron ensembles in freely behaving rodents and mammals, which allows exploring the neural basis of behaviors. Recent progress in two-photon miniature microscopes and mesoscale single-photon miniature microscopes further expand those affordable methods to navigate neural activities during naturalistic behaviors. In this review article, two-photon miniature microscopy techniques are summarized historically from the first documented attempt to the latest ones, and comparisons are made. The driving force behind and their potential for neuroscientific inquiries are also discussed. Current progress in terms of the mesoscale, i.e., the large field-of-view miniature microscopy technique, is addressed as well. Then, pipelines for registering single cells from the data of two-photon and large field-of-view miniature microscopes are discussed. Finally, we present the potential evolution of the techniques.
    MeSH term(s) Animals ; Microscopy ; Optical Imaging/methods ; Mammals ; Neurons/metabolism ; Behavior, Animal/physiology
    Language English
    Publishing date 2022-11-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80158-6
    ISSN 1471-4159 ; 0022-3042 ; 1474-1644
    ISSN (online) 1471-4159
    ISSN 0022-3042 ; 1474-1644
    DOI 10.1111/jnc.15711
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    Ui II Zs.170: Show issues Location:
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  4. Article ; Online: Genome wide association study for the identification of genes associated with tail fat deposition in Chinese sheep breeds.

    Zhu, Caiye / Li, Na / Cheng, Heping / Ma, Youji

    Biology open

    2021  Volume 10, Issue 5

    Abstract: Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han sheep, Altay sheep, and Tibetan sheep, respectively. To unravel the ... ...

    Abstract Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han sheep, Altay sheep, and Tibetan sheep, respectively. To unravel the molecular genetic basis underlying the phenotypic differences among Chinese indigenous sheep with these three different tail types, we used ovine high-density 600K single nucleotide polymorphism (SNP) arrays to detect genome-wide associations, and performed general linear model analysis to identify candidate genes, using genotyping technology to validate the candidate genes. Tail type is an important economic trait in sheep. However, the candidate genes associated with tail type are not known. The objective of this study was to identify SNP markers, genes, and chromosomal regions related to tail traits. We performed a genome-wide association study (GWAS) using data from 40 large-tailed Han sheep, 40 Altay sheep (cases) and 40 Tibetan sheep (controls). A total of 31 significant (P<0.05) SNPs associated with tail-type traits were detected. For significant SNPs' loci, we determined their physical location and performed a screening of candidate genes within each region. By combining information from previously reported and annotated biological functional genes, we identified SPAG17, Tbx15, VRTN, NPC2, BMP2 and PDGFD as the most promising candidate genes for tail-type traits. Based on the above identified candidate genes for tail-type traits, BMP2 and PDGFD genes were selected to investigate the relationship between SNPs within the tails in the Altay and Tibetan populations. rs119 T>C in exon1 of the BMP2 gene and one SNP in exon4 (rs69 C>A) of the PDGFD gene were detected. rs119 was of the TT genotype in Altay sheep, while it was of the CC genotype in Tibetan sheep. On rs69 of the PDGFD gene, Altay sheep presented with the CC genotype; however, Tibetan sheep presented with the AA genotype.
    MeSH term(s) Adiposity/genetics ; Animals ; China ; Computational Biology/methods ; Gene Ontology ; Genetic Markers ; Genome ; Genome-Wide Association Study/methods ; Genotype ; Humans ; Organ Specificity ; Polymorphism, Single Nucleotide ; Sheep/classification ; Sheep/genetics ; Sheep, Domestic/classification ; Sheep, Domestic/genetics ; Tail
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.054932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Isobaric Tags for Relative and Absolute Quantification-Based Proteomics Reveals Candidate Proteins of Fat Deposition in Chinese Indigenous Sheep With Morphologically Different Tails.

    Zhu, Caiye / Cheng, Heping / Li, Na / Liu, Tiaoguo / Ma, Youji

    Frontiers in genetics

    2021  Volume 12, Page(s) 710449

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2021.710449
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  6. Article ; Online: Spatiotemporal regulation of store-operated calcium entry in cancer metastasis.

    Lu, Fujian / Li, Yunzhan / Lin, Shengchen / Cheng, Heping / Yang, Shengyu

    Biochemical Society transactions

    2021  Volume 49, Issue 6, Page(s) 2581–2589

    Abstract: The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by ... ...

    Abstract The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.
    MeSH term(s) Calcium/metabolism ; Calcium Signaling ; Humans ; Ion Transport ; Neoplasm Metastasis ; Neoplasms/metabolism ; Neoplasms/pathology
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20210307
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    Zs.A 944: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: A neural circuit for regulating a behavioral switch in response to prolonged uncontrollability in mice.

    Li, Chaoqun / Sun, Tianping / Zhang, Yimu / Gao, Yan / Sun, Zhou / Li, Wei / Cheng, Heping / Gu, Yu / Abumaria, Nashat

    Neuron

    2023  Volume 111, Issue 17, Page(s) 2727–2741.e7

    Abstract: Persistence in the face of failure helps to overcome challenges. But the ability to adjust behavior or even give up when the task is uncontrollable has advantages. How the mammalian brain switches behavior when facing uncontrollability remains an open ... ...

    Abstract Persistence in the face of failure helps to overcome challenges. But the ability to adjust behavior or even give up when the task is uncontrollable has advantages. How the mammalian brain switches behavior when facing uncontrollability remains an open question. We generated two mouse models of behavioral transition from action to no-action during exposure to a prolonged experience with an uncontrollable outcome. The transition was not caused by pain desensitization or muscle fatigue and was not a depression-/learned-helplessness-like behavior. Noradrenergic neurons projecting to GABAergic neurons within the orbitofrontal cortex (OFC) are key regulators of this behavior. Fiber photometry, microdialysis, mini-two-photon microscopy, and tetrode/optrode in vivo recording in freely behaving mice revealed that the reduction of norepinephrine and downregulation of alpha 1 receptor in the OFC reduced the number and activity of GABAergic neurons necessary for driving action behavior resulting in behavioral transition. These findings define a circuit governing behavioral switch in response to prolonged uncontrollability.
    MeSH term(s) Mice ; Animals ; Brain ; Helplessness, Learned ; Prefrontal Cortex/physiology ; Mammals
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.05.023
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    Zs.A 2496: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 92: Show issues

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  8. Article ; Online: Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts.

    Li, Wenwen / Quan, Li / Peng, Kun / Wang, Yanru / Wang, Xianhua / Chen, Quan / Cheng, Heping / Ma, Qi

    Basic research in cardiology

    2023  Volume 118, Issue 1, Page(s) 45

    Abstract: A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we show that succinate dehydrogenase (SDH) is required for maintenance of myocardial homeostasis of FAO/glycolysis. Mice with cardiomyocyte- ... ...

    Abstract A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we show that succinate dehydrogenase (SDH) is required for maintenance of myocardial homeostasis of FAO/glycolysis. Mice with cardiomyocyte-restricted deletion of subunit b or c of SDH developed a dilated cardiomyopathy and heart failure. Hypertrophied hearts displayed a decrease in FAO, while glucose uptake and glycolysis were augmented, which was reversed by enforcing FAO fuels via a high-fat diet, which also improved heart failure of mutant mice. SDH-deficient hearts exhibited an increase in genome-wide DNA methylation associated with accumulation of succinate, a metabolite known to inhibit DNA demethylases, resulting in changes of myocardial transcriptomic landscape. Succinate induced DNA hypermethylation and depressed the expression of FAO genes in myocardium, leading to imbalanced FAO/glycolysis. Inhibition of succinate by α-ketoglutarate restored transcriptional profiles and metabolic disorders in SDH-deficient cardiomyocytes. Thus, our findings reveal the essential role for SDH in metabolic remodeling of failing hearts, and highlight the potential of therapeutic strategies to prevent cardiac dysfunction in the setting of SDH deficiency.
    MeSH term(s) Mice ; Animals ; Succinate Dehydrogenase/genetics ; Succinate Dehydrogenase/metabolism ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Heart Failure/genetics ; Heart Failure/metabolism ; Homeostasis ; Succinates/metabolism ; DNA/metabolism ; Epigenesis, Genetic
    Chemical Substances Succinate Dehydrogenase (EC 1.3.99.1) ; Succinates ; DNA (9007-49-2)
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-023-01015-z
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    Ui IV Zs.30: Show issues Location:
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  9. Article ; Online: Author Correction: BacFlash signals acid-resistance gene expression in bacteria.

    Wu, Di / Qi, Wenfeng / Nie, Wei / Lu, Zhengyuan / Ye, Yongxin / Li, Jinghang / Sun, Tao / Zhu, Yufei / Cheng, Heping / Wang, Xianhua

    Cell research

    2023  Volume 34, Issue 1, Page(s) 88

    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00900-5
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    Zs.A 5283: Show issues Location:
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  10. Article ; Online: C17orf80 binds the mitochondrial genome to promote its replication.

    Wu, Hao / Zhang, Wenshuo / Xu, Fengli / Peng, Kun / Liu, Xiaoyu / Ding, Wanqiu / Ma, Qi / Cheng, Heping / Wang, Xianhua

    The Journal of cell biology

    2023  Volume 222, Issue 10

    Abstract: Serving as the power plant and signaling hub of a cell, mitochondria contain their own genome which encodes proteins essential for energy metabolism and forms DNA-protein assemblies called nucleoids. Mitochondrial DNA (mtDNA) exists in multiple copies ... ...

    Abstract Serving as the power plant and signaling hub of a cell, mitochondria contain their own genome which encodes proteins essential for energy metabolism and forms DNA-protein assemblies called nucleoids. Mitochondrial DNA (mtDNA) exists in multiple copies within each cell ranging from hundreds to tens of thousands. Maintaining mtDNA homeostasis is vital for healthy cells, and its dysregulation causes multiple human diseases. However, the players involved in regulating mtDNA maintenance are largely unknown though the core components of its replication machinery have been characterized. Here, we identify C17orf80, a functionally uncharacterized protein, as a critical player in maintaining mtDNA homeostasis. C17orf80 primarily localizes to mitochondrial nucleoid foci and exhibits robust double-stranded DNA binding activity throughout the mitochondrial genome, thus constituting a bona fide new mitochondrial nucleoid protein. It controls mtDNA levels by promoting mtDNA replication and plays important roles in mitochondrial metabolism and cell proliferation. Our findings provide a potential target for therapeutics of human diseases associated with defective mtDNA control.
    MeSH term(s) Humans ; Cell Proliferation ; DNA Replication ; DNA, Mitochondrial/genetics ; Genome, Mitochondrial ; Mitochondria/genetics ; Mitochondrial Proteins/genetics
    Chemical Substances DNA, Mitochondrial ; Mitochondrial Proteins
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202302037
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