Article ; Online: Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.
Colloids and surfaces. B, Biointerfaces
2017 Volume 158, Page(s) 578–588
Abstract: Magnetic resonance contrast agents that can be activated in response to specific triggers hold potential as molecular biosensors that may be of great utility in non-invasive disease diagnosis. We developed an activatable agent based on superparamagnetic ... ...
| Abstract | Magnetic resonance contrast agents that can be activated in response to specific triggers hold potential as molecular biosensors that may be of great utility in non-invasive disease diagnosis. We developed an activatable agent based on superparamagnetic iron oxide nanoparticles (SPIOs) that is sensitive to oxidative stress, a factor in the pathophysiology of numerous diseases. SPIOs were coated with poly(ethylene glycol) (PEG) and complexed with poly(gallol), a synthetic tannin. Hydrogen bonding between PEG and poly(gallol) creates a complexed layer around the SPIO that decreases the interaction of solute water with the SPIO, attenuating its magnetic resonance relaxivity. The complexed interpolymer nanoparticle is in an OFF state (decreased T |
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| MeSH term(s) | Contrast Media/chemistry ; Ferric Compounds/chemistry ; Magnetic Resonance Imaging ; Magnetite Nanoparticles/chemistry ; Nanoparticles/chemistry ; Oxidative Stress ; Polyethylene Glycols/chemistry |
| Chemical Substances | Contrast Media ; Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide (1K09F3G675) ; Polyethylene Glycols (3WJQ0SDW1A) |
| Language | English |
| Publishing date | 2017-07-18 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 1500523-9 |
| ISSN | 1873-4367 ; 0927-7765 |
| ISSN (online) | 1873-4367 |
| ISSN | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2017.07.025 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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