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  1. Article ; Online: Molecular Factors and Pathways of Hepatotoxicity Associated with HIV/SARS-CoV-2 Protease Inhibitors

    Cheng Ji

    International Journal of Molecular Sciences, Vol 24, Iss 7938, p

    2023  Volume 7938

    Abstract: Antiviral protease inhibitors are peptidomimetic molecules that block the active catalytic center of viral proteases and, thereby, prevent the cleavage of viral polyprotein precursors into maturation. They continue to be a key class of antiviral drugs ... ...

    Abstract Antiviral protease inhibitors are peptidomimetic molecules that block the active catalytic center of viral proteases and, thereby, prevent the cleavage of viral polyprotein precursors into maturation. They continue to be a key class of antiviral drugs that can be used either as boosters for other classes of antivirals or as major components of current regimens in therapies for the treatment of infections with human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, sustained/lifelong treatment with the drugs or drugs combined with other substance(s) often leads to severe hepatic side effects such as lipid abnormalities, insulin resistance, and hepatotoxicity. The underlying pathogenic mechanisms are not fully known and are under continuous investigation. This review focuses on the general as well as specific molecular mechanisms of the protease inhibitor-induced hepatotoxicity involving transporter proteins, apolipoprotein B, cytochrome P450 isozymes, insulin-receptor substrate 1, Akt/PKB signaling, lipogenic factors, UDP-glucuronosyltransferase, pregnane X receptor, hepatocyte nuclear factor 4α, reactive oxygen species, inflammatory cytokines, off-target proteases, and small GTPase Rab proteins related to ER-Golgi trafficking, organelle stress, and liver injury. Potential pharmaceutical/therapeutic solutions to antiviral drug-induced hepatic side effects are also discussed.
    Keywords anti-AIDS/COVID-19 drugs ; side effects ; substance use disorders (SUD) ; alcohol use disorder (AUD) ; ER/Golgi stress ; unfolded protein response ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: New "HOPE" laser for photoacoustic imaging of water.

    Cheng, Ji-Xin

    Light, science & applications

    2022  Volume 11, Issue 1, Page(s) 107

    Abstract: A hybrid optical parametrically-oscillating laser at 1930 nm enables photoacoustic mapping of water content in deep tissue with good sensitivity and high spatial resolution. ...

    Abstract A hybrid optical parametrically-oscillating laser at 1930 nm enables photoacoustic mapping of water content in deep tissue with good sensitivity and high spatial resolution.
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2662628-7
    ISSN 2047-7538 ; 2047-7538
    ISSN (online) 2047-7538
    ISSN 2047-7538
    DOI 10.1038/s41377-022-00805-9
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  3. Article ; Online: Glioblastoma U-87 cell electrotaxis is hindered by doxycycline with a concomitant reduction in the matrix metallopeptidase-9 expression.

    Chang, Hui-Fang / Cheng, Ji-Yen

    Biochemistry and biophysics reports

    2024  Volume 38, Page(s) 101690

    Abstract: Electric fields (EF) play an essential role in cancer cell migration. Numerous cancer cell types exhibit electrotaxis under direct current electric fields (dcEF) of physiological electric field strength (EFs). This study investigated the effects of ... ...

    Abstract Electric fields (EF) play an essential role in cancer cell migration. Numerous cancer cell types exhibit electrotaxis under direct current electric fields (dcEF) of physiological electric field strength (EFs). This study investigated the effects of doxycycline on the electrotactic responses of U87 cells. After EF stimulation, U87 cells migrated toward the cathode, whereas doxycycline-treated U87 cells exhibited enhanced cell mobility but hindered cathodal migration. We further investigated the expression of the metastasis-correlated proteins matrix metallopeptidase-2 (MMP-2) and MMP-9 in U87 cells. The levels of MMP-2 in the cells were not altered under EF or doxycycline stimulation. In contrast, the EF stimulation greatly enhanced the levels of MMP-9 and then repressed in doxycycline-cotreated cells, accompanied by reduced cathodal migration. Our results demonstrated that an antibiotic at a non-toxic concentration could suppress the enhanced cell migration accelerated by EF of physiological strength. This finding may be applied as an anti-metastatic treatment for cancers.
    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2024.101690
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  4. Article ; Online: Miniaturized bioluminescent whole-cell sensor systems.

    Belkin, Shimshon / Cheng, Ji-Yen

    Current opinion in biotechnology

    2023  Volume 82, Page(s) 102952

    Abstract: Relying on the biological responses and activity of living cells, bioluminescent whole-cell biosensors generate an optical signal in response to the presence of target compounds. The miniaturization of low-light detectors and their integration with ... ...

    Abstract Relying on the biological responses and activity of living cells, bioluminescent whole-cell biosensors generate an optical signal in response to the presence of target compounds. The miniaturization of low-light detectors and their integration with microfluidics have allowed the realization of portable devices for sensitive imaging and quantification of these signals. This review thus focuses on bioluminescence-based whole-cell biosensors, integrated with handheld optical detectors, with an emphasis on the use of the low-light imaging capability of modern smartphones. We highlight state-of-the-art miniaturization techniques applied to the incorporation of living cells into diverse hardware platforms, and to the sensitive recording of the biologically generated photons. The integration of sample introduction, host-cell activity maintenance, luminescence acquisition, data processing/presentation, and portability are also discussed.
    MeSH term(s) Microfluidics/methods ; Biosensing Techniques/methods ; Luminescence
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2023.102952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Medical and interventional therapy of Kasabach-Merritt phenomenon associated with Kaposiform hemangioendothelioma: A case report.

    Zhao, Yan / Cheng, Ji

    Journal of interventional medicine

    2023  Volume 6, Issue 3, Page(s) 130–133

    Abstract: An infant with Kasabach-Merritt Phenomenon (KMP) presented with a giant subcutaneous mass in the right lower limb, severe hypofibrinogenemia, and thrombocytopenia. Glucocorticoids, along with supportive treatments including transfusion of blood products ... ...

    Abstract An infant with Kasabach-Merritt Phenomenon (KMP) presented with a giant subcutaneous mass in the right lower limb, severe hypofibrinogenemia, and thrombocytopenia. Glucocorticoids, along with supportive treatments including transfusion of blood products and clotting factors, were administered to reverse fatal disseminated intravascular coagulation and acute hemolysis. The glucocorticoid dose was tapered slowly, and sirolimus was added to treat the hemangiomas. The patient subsequently underwent interventional therapy. After 6 months of medical and interventional therapy, the patient was doing well with a normal platelet count, the tumor volume was markedly reduced, and the primary cutaneous lesion became pale pink. Currently, the patient remains on sirolimus, and no recurrence of thrombocytopenia or further growth of the mass was observed after six months of follow-up.
    Language English
    Publishing date 2023-07-31
    Publishing country China
    Document type Case Reports
    ZDB-ID 3008114-2
    ISSN 2590-0293 ; 2096-3602
    ISSN (online) 2590-0293
    ISSN 2096-3602
    DOI 10.1016/j.jimed.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blue Light Improves Antimicrobial Efficiency of Silver Sulfadiazine Via Catalase Inactivation.

    Jusuf, Sebastian / Cheng, Ji-Xin

    Photobiomodulation, photomedicine, and laser surgery

    2023  Volume 41, Issue 2, Page(s) 80–87

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Animals ; Mice ; Anti-Infective Agents/pharmacology ; Catalase ; Hydrogen Peroxide/pharmacology ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Reactive Oxygen Species ; Silver Sulfadiazine/pharmacology ; Light
    Chemical Substances Anti-Infective Agents ; Catalase (EC 1.11.1.6) ; Hydrogen Peroxide (BBX060AN9V) ; Reactive Oxygen Species ; Silver Sulfadiazine (W46JY43EJR)
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5478
    ISSN (online) 2578-5478
    DOI 10.1089/photob.2022.0107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nanoscale bond-selective imaging by computational fusion of atomic force microscopy and coherent anti-Stokes Raman scattering microscopy.

    Wang, Le / Cheng, Ji-Xin

    The Analyst

    2023  Volume 148, Issue 13, Page(s) 2975–2982

    Abstract: Vibrational microscopy based on coherent Raman scattering is a powerful tool for high-speed chemical imaging, but its lateral resolution is bound to the optical diffraction limit. On the other hand, atomic force microscopy (AFM) provides nano-scale ... ...

    Abstract Vibrational microscopy based on coherent Raman scattering is a powerful tool for high-speed chemical imaging, but its lateral resolution is bound to the optical diffraction limit. On the other hand, atomic force microscopy (AFM) provides nano-scale spatial resolution, yet with lower chemical specificity. In this study, we leverage a computational approach called pan-sharpening to merge AFM topography images and coherent anti-Stokes Raman scattering (CARS) images. The hybrid system combines the advantages of both modalities, providing informative chemical mapping with ∼20 nm spatial resolution. CARS and AFM images were sequentially acquired on a single multimodal platform, which facilitates image co-localization. Our image fusion approach allowed for discerning merged neighboring features previously invisible due to the diffraction limit and identifying subtle unobservable structures with the input from AFM images. Compared to tip-enhanced CARS measurement, sequential acquisition of CARS and AFM images enables higher laser power to be used and avoids any tip damage caused by the incident laser beams, resulting in a significantly improved CARS image quality. Together, our work suggests a new direction for achieving super-resolution coherent Raman scattering imaging of materials through a computational approach.
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d3an00662j
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: How Does Digital Finance Affect People’s Income

    Tingting Wang / Cheng Ji

    Security and Communication Networks, Vol

    Evidence from China

    2022  Volume 2022

    Abstract: Using data from the China Family Panel Studies (CFPS) from 2010 to 2018 and the Peking University Digital Financial Inclusion Index from 2011 to 2018, this research explores the effect of digital financial development on residents’ income and the ... ...

    Abstract Using data from the China Family Panel Studies (CFPS) from 2010 to 2018 and the Peking University Digital Financial Inclusion Index from 2011 to 2018, this research explores the effect of digital financial development on residents’ income and the channels of influence. The findings suggest that the growth of digital financial services has a significant and favourable influence on citizens’ income. Furthermore, digital financial development benefits rural populations, low-skilled workers, and individuals working in basic industries the most. The extension of inhabitants’ employment space, better access to credit, and ease of access to information online are the major ways that digital financial development influences their income. In particular, the expansion of employment space has a greater positive impact on the low-skilled labor force, rural residents, and those in primary and secondary industries, while access to information is more likely to explain the increase in income of urban residents, and credit has an advantage in promoting income growth for the low-skilled laborers and those in traditional industries.
    Keywords Technology (General) ; T1-995 ; Science (General) ; Q1-390
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: A Review on Data-Driven Process Monitoring Methods

    Cheng Ji / Wei Sun

    Processes, Vol 10, Iss 335, p

    Characterization and Mining of Industrial Data

    2022  Volume 335

    Abstract: Safe and stable operation plays an important role in the chemical industry. Fault detection and diagnosis (FDD) make it possible to identify abnormal process deviations early and assist operators in taking proper action against fault propagation. After ... ...

    Abstract Safe and stable operation plays an important role in the chemical industry. Fault detection and diagnosis (FDD) make it possible to identify abnormal process deviations early and assist operators in taking proper action against fault propagation. After decades of development, data-driven process monitoring technologies have gradually attracted attention from process industries. Although many promising FDD methods have been proposed from both academia and industry, challenges remain due to the complex characteristics of industrial data. In this work, classical and recent research on data-driven process monitoring methods is reviewed from the perspective of characterizing and mining industrial data. The implementation framework of data-driven process monitoring methods is first introduced. State of art of process monitoring methods corresponding to common industrial data characteristics are then reviewed. Finally, the challenges and possible solutions for actual industrial applications are discussed.
    Keywords chemical industrial process ; fault detection and diagnosis ; feature extraction ; machine learning ; multivariate statistical methods ; deep learning ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 670 ; 006
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Clinical analysis of temporary pacemaker implantation in 13 children.

    Li, Ting-Ting / Cheng, Ji

    Translational pediatrics

    2022  Volume 11, Issue 2, Page(s) 174–182

    Abstract: Background: At present, temporary pacemaker implantation is very common in the treatment of cardiovascular diseases in adults. However, the number of pediatric pacemakers implanted is still relatively small, and relevant research is also far less than ... ...

    Abstract Background: At present, temporary pacemaker implantation is very common in the treatment of cardiovascular diseases in adults. However, the number of pediatric pacemakers implanted is still relatively small, and relevant research is also far less than that of adults. This study aimed to explore the application of temporary pacemakers in children with acute and critical cardiovascular diseases.
    Methods: The clinical data of children with cardiovascular diseases who were treated with temporary pacemakers in Tianjin Children's Hospital from October 2017 to February 2021 were analyzed retrospectively.
    Results: A total of 13 children with cardiovascular diseases were included in this study, including 4 males and 9 females, mean age of 71.2±56.3 months, and median body weight of 15.5 kg. There were 9 children with endocardial pacing and 4 children with epicardial pacing. The types of diseases included fulminant myocarditis (n=8), complete atrioventricular block (CAVB; n=1), and arrhythmias after open heart surgery (n=4). The median time from onset to admission was 1.0 days in children with endocardial pacing and there was cardiac arrest in 2 children, heart failure in 9 children, cardiogenic shock in 8 children, and Adams-Stokes attack in 7 children. The median time from admission to implantation of temporary pacemakers was 3.0 h and the operation time was 55.0±19.4 min. All 4 children with epicardial pacing had pacemakers implanted during operation because of CAVB. The pacing mode was VVI mode. The initial perceptual voltage was 1-2 mv, the output voltage was 5v, and the pacing frequency was 70-145 bpm. A total of 11 children reverted to sinus rhythm within 5.0 (1.8-34.0) h and the working time of temporary pacemakers was 134.0 (15.0-191.0) h. There was poor pacing in 2 children and catheter displacement in 1 child during pacing. A total of 12 children were followed up for 20.0±12.5 months and 1 was lost to follow-up. During the follow-up period, the cardiac functions were basically normal and no new arrhythmia appeared.
    Conclusions: Temporary pacemakers have the advantage of simple operation, definite effect, and safety which has a remarkable effect in the treatment of acute and critical cardiovascular diseases in children.
    Language English
    Publishing date 2022-01-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-21-586
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