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  1. Article ; Online: Data-driven detection of age-related arbitrary monotonic changes in single-cell gene expression distributions.

    Cheng, Jian Hao / Okada, Daigo

    PeerJ

    2024  Volume 12, Page(s) e16851

    Abstract: Identification of genes whose expression increases or decreases with age is central to understanding the mechanisms behind aging. Recent scRNA-seq studies have shown that changes in single-cell expression profiles with aging are complex and diverse. In ... ...

    Abstract Identification of genes whose expression increases or decreases with age is central to understanding the mechanisms behind aging. Recent scRNA-seq studies have shown that changes in single-cell expression profiles with aging are complex and diverse. In this study, we introduce a novel workflow to detect changes in the distribution of arbitrary monotonic age-related changes in single-cell expression profiles. Since single-cell gene expression profiles can be analyzed as probability distributions, our approach uses information theory to quantify the differences between distributions and employs distance matrices for association analysis. We tested this technique on simulated data and confirmed that potential parameter changes could be detected in a set of probability distributions. Application of the technique to a public scRNA-seq dataset demonstrated its potential utility as a straightforward screening method for identifying aging-related cellular features.
    MeSH term(s) Gene Expression/genetics ; Single-Cell Analysis ; Cellular Senescence
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16851
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  2. Article ; Online: ASO Author Reflections: Innovative Techniques for Laparoscopic Duodenum-Preserving Pancreatic Head Resection.

    Cheng, Jian

    Annals of surgical oncology

    2020  Volume 28, Issue 6, Page(s) 3217–3218

    MeSH term(s) Duodenum/surgery ; Humans ; Laparoscopy ; Pancreatectomy ; Pancreatic Neoplasms/surgery
    Language English
    Publishing date 2020-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-09256-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  3. Article ; Online: The government subsidy design considering the reference price effect in a green supply chain.

    Huang, Shuai / Du, Bingzhi / Chen, Zhongwei / Cheng, Jian

    Environmental science and pollution research international

    2024  Volume 31, Issue 15, Page(s) 22645–22662

    Abstract: This paper constructs a green supply chain with a manufacturer and a retailer. Taking into account the reference price effect of consumers based on the mental accounting theory, we investigate the following government incentive policies: R&D (research ... ...

    Abstract This paper constructs a green supply chain with a manufacturer and a retailer. Taking into account the reference price effect of consumers based on the mental accounting theory, we investigate the following government incentive policies: R&D (research and development) subsidy, consumption subsidy, and dual subsidy. For manufacturer-led (M-led) and retailer-led (R-led) supply chains, we evaluate the optimal wholesale price, sales price, green degree of product, and the optimal subsidy of the government aiming to improve the environmental benefit or social welfare. We find that the government goal, power structure and reference price effect impact the design of subsidy mechanisms significantly. First, for M-led supply chain, the government concerned with the environmental benefit goal should only provide R&D subsidy for the manufacturer when the reference price effect is low; otherwise, the government would offer subsidy both for the manufacturer and consumers. However, the government will only offer R&D subsidy when the social welfare goal is adopted. Second, for R-led supply chain, the government aiming to improve the environmental benefit prefers dual subsidy when the reference price effect is low; otherwise, consumption subsidy is preferable. Surprisingly, under the social welfare goal, no subsidy for R-led supply chain tends to be the best option. Intriguingly, embracing the social welfare goal can result in more economic and environmental benefits for M-led supply chain, although the subsidy strategy is less effective than the environmental benefit goal. Our research can provide inspirations and references for designing government subsidy mechanisms in practice.
    MeSH term(s) Commerce ; Costs and Cost Analysis ; Government ; Financing, Government ; Policy ; Consumer Behavior
    Language English
    Publishing date 2024-02-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32488-7
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  4. Article ; Online: Efficient second harmonic generation in a high-Q Fabry-Perot microresonator on x-cut thin film lithium niobate.

    Cheng, Jian / Gao, Dingshan / Dong, Jianji / Zhang, Xinliang

    Optics express

    2024  Volume 32, Issue 7, Page(s) 12118–12126

    Abstract: Microresonators facilitate enhanced light-matter interactions within a limited space, showing great promise for nonlinear optics. Here, we demonstrate a high-quality (Q) factor Fabry-Perot microresonator (FPR) for second harmonic generation (SHG) on an x- ...

    Abstract Microresonators facilitate enhanced light-matter interactions within a limited space, showing great promise for nonlinear optics. Here, we demonstrate a high-quality (Q) factor Fabry-Perot microresonator (FPR) for second harmonic generation (SHG) on an x-cut thin film lithium niobate (TFLN) platform. The FPR exhibits Q factors of Q
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.521331
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  5. Article ; Online: A new era for paclitaxel biosynthesis is coming.

    Liu, Xiaonan / Zhu, Xiaoxi / Cheng, Jian / Jiang, Huifeng

    Molecular plant

    2024  Volume 17, Issue 3, Page(s) 370–371

    MeSH term(s) Paclitaxel ; Taxus
    Chemical Substances Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.01.005
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  6. Article ; Online: The effect of serum triglyceride levels and different lipid-lowering methods on the prognosis of hypertriglyceridemic acute pancreatitis: a single-center 12-year retrospective study by propensity score matching.

    Liu, Yang / Cheng, Jian-Ping / Zhao, Xiao-Lin

    Scandinavian journal of gastroenterology

    2024  , Page(s) 1–9

    Abstract: Aim: To investigate the impact of triglyceride on hypertriglyceridemic acute pancreatitis (HTG-AP) and different lipid-lowering methods on triglyceride-lowering efficiency and HTG-AP.: Methods: The patients with HTG-AP from January 2012 to December ... ...

    Abstract Aim: To investigate the impact of triglyceride on hypertriglyceridemic acute pancreatitis (HTG-AP) and different lipid-lowering methods on triglyceride-lowering efficiency and HTG-AP.
    Methods: The patients with HTG-AP from January 2012 to December 2023 in Civil Aviation General Hospital were analyzed, retrospectively. Patients were divided and compared according to whether their triglycerides were below 5.56 mmol/L at 48 and 72 h of admission. The patients were divided into control group, insulin group, and low molecular weight heparin (LMWH)+bezafibrate group based on the different methods of lipid-lowering. Propensity score matching (PSM) was employed to balance the baseline characteristics.
    Results: There was no correlation between the severity of HTG-AP and the triglyceride at admission. The incidence of severity, local complications, and persistent organ failure (POF) were significantly decreased in patients with 48-h and 72-h triglyceride attainment. Following PSM, the incidence of infectious pancreatic necrosis (IPN) (3.3% vs. 13.3%) was significantly reduced in insulin group compared with control group (
    Conclusion: The severity of HTG-AP is not associated with the triglyceride levels at admission. However, rapid reduction of triglyceride levels can lower the incidence of local complications and respiratory failure. Compared with conservative treatment, insulin and LMWH + bezafibrate can both reduce the incidence of IPN in patients with HTG-AP.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.1080/00365521.2024.2342406
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 567: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Bearing Fault Diagnosis Using a Vector-Based Convolutional Fuzzy Neural Network

    Cheng-Jian Lin / Chun-Hui Lin / Frank Lin

    Applied Sciences, Vol 13, Iss 3337, p

    2023  Volume 3337

    Abstract: The spindle of a machine tool plays a key role in machining because the wear of a spindle might result in inaccurate production and decreased productivity. To understand the condition of a machine tool, a vector-based convolutional fuzzy neural network ( ... ...

    Abstract The spindle of a machine tool plays a key role in machining because the wear of a spindle might result in inaccurate production and decreased productivity. To understand the condition of a machine tool, a vector-based convolutional fuzzy neural network (vector-CFNN) was developed in this study to diagnose faults from signals. The developed vector-CFNN mainly comprises a feature extraction part and a classification part. The feature extraction phase encompasses the use of convolutional layers and pooling layers, while the classification phase is facilitated through the deployment of a fuzzy neural network. The fusion layer plays an important role by being placed between the feature extraction and classification parts. It combines the characteristics and then passes the feature information to the classification part to improve the model’s performance. The developed vector-CFNN was experimentally evaluated against existing fusion methods; vector-CFNN required fewer parameters and achieved the highest average accuracy (99.84%) in fault diagnosis relative to conventional neural networks, fuzzy neural networks, and convolutional neural networks. Moreover, vector-CFNN achieved superior fault diagnosis using spindle vibration signals and required fewer parameters relative to its counterparts, indicating its feasibility for online spindle vibration monitoring.
    Keywords spindle vibration ; vector convolutional neural network ; feature fusion ; fault diagnosis ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Red light-triggered release of ROS and carbon monoxide for combinational antibacterial application.

    Zhang, Mengdan / Cheng, Jian / Shen, Zhiqiang / He, Kewu / Zheng, Bin

    Journal of materials chemistry. B

    2024  Volume 12, Issue 4, Page(s) 1077–1086

    Abstract: The abuse of antibiotics has led to the emergence of a wide range of drug-resistant bacteria. To address the challenge of drug-resistant bacterial infections and related infectious diseases, several effective antibacterial strategies have been developed. ...

    Abstract The abuse of antibiotics has led to the emergence of a wide range of drug-resistant bacteria. To address the challenge of drug-resistant bacterial infections and related infectious diseases, several effective antibacterial strategies have been developed. To achieve enhanced therapeutic effects, combinational treatment approaches should be employed. With this in mind, a metal-organic framework (MOF) based nanoreactor with integrated photodynamic therapy (PDT) and gas therapy which can release reactive oxygen species (ROS) and carbon monoxide (CO) under red light irradiation has been developed. The release of ROS and CO under red light irradiation exerts a preferential antibacterial effect on Gram-positive/Gram-negative bacteria. The bactericidal effects of ROS and CO on
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Reactive Oxygen Species ; Carbon Monoxide/pharmacology ; Red Light ; Anti-Bacterial Agents/pharmacology ; Penicillins/pharmacology
    Chemical Substances Reactive Oxygen Species ; Carbon Monoxide (7U1EE4V452) ; Anti-Bacterial Agents ; Penicillins
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb01829f
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  9. Article ; Online: Robust and high-efficiency dynamical method of enantio-specific state transfer.

    Cheng, Jian-Jian / Du, Lei / Li, Yong / Zhao, Nan

    Optics express

    2024  Volume 32, Issue 6, Page(s) 8684–8696

    Abstract: We propose a simple dynamical method to realize fast enantio-specific state transfer (ESST) of chiral molecules. Driven by three external electromagenetic fields, the chiral molecules are modeled as cyclic three-level systems, where the overall phase ... ...

    Abstract We propose a simple dynamical method to realize fast enantio-specific state transfer (ESST) of chiral molecules. Driven by three external electromagenetic fields, the chiral molecules are modeled as cyclic three-level systems, where the overall phase differs by π for the left- and right-handed chiral molecules. We unveil that the ESST is allowed when the amplitudes of three Rabi frequencies in the cyclic three-level systems are equal. Our method is robust and highly efficient in the sense that the external fields can have arbitrary waveforms. This thus provides the opportunity of simplifying the experimental implementations of ESST through pulse design.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.502410
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  10. Article: [Spatial-temporal Variation in Water Quality of Rain-source Rivers in Shenzhen from 2015 to 2021 and Its Response to Rainfall].

    Wei, Bi-Ying / Cheng, Jian-Mei / Su, Xiao-Yu / Cheng, Tian-Shun

    Huan jing ke xue= Huanjing kexue

    2024  Volume 45, Issue 2, Page(s) 780–791

    Abstract: Rain-source urban rivers have the characteristics of small water capacity， lack of dynamic water supply， and being easily polluted. This study analyzed the spatial and temporal distribution characteristics of river water quality and the response of ... ...

    Abstract Rain-source urban rivers have the characteristics of small water capacity， lack of dynamic water supply， and being easily polluted. This study analyzed the spatial and temporal distribution characteristics of river water quality and the response of characteristic pollutants to rainfall based on daily rainfall data and 21 water quality indicators of nine major river basins in Shenzhen （excluding Shenzhen-Shantou） from 2015 to 2021 by using the single-factor assessment method， comprehensive pollution index method， hierarchical cluster analysis， and Pearson correlation. The results showed that： ① in 2015， the water quality of most sections in the whole region was inferior Class V water. After October 2018， the overall water quality of rivers was greatly improved， which was consistent with the background of Shenzhen's special water control activities in 2018. By 2021， the water quality of approximately 62% of sections reached Class Ⅰ-Ⅲ water standards. ② The water pollution in the densely populated western part of Shenzhen was more serious than that in the eastern part， and the water pollution in the lower reaches of the estuaries and tributaries was more serious than that in the upper reaches. ③ The water quality of the Pingshan River， Guanlan River， Longgang River， and Maozhou River was significantly affected by rainfall. ④ The main characteristic pollution indexes of the Shenzhen River were DO， permanganate index， COD， BOD
    Language Chinese
    Publishing date 2024-03-12
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202303052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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