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Book: Structure based study of viral replication

Cheng, R. Holland

2008

Title variant	Structure-based study of viral replication
Author's details	ed. R. Holland Cheng
Keywords	Virus Replication ; Cellular Structures ; Morphogenesis
Language	English
Size	XXIV, 638 S. : Ill., graph. Darst.
Publisher	World Scientific
Publishing place	Singapore u.a.
Publishing country	Singapore
Document type	Book
Accompanying material	1 CD-ROM (12 cm)
HBZ-ID	HT015229910
ISBN	981-270-405-1 ; 978-981-270-405-4 ; 981-270-406-X ; 978-981-270-406-1
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2007 MO 984 <<[Begleitmaterial]>>	order for loan	Magazin
2008 A 2029	order for loan	Magazin

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Article ; Online: Protein-based nanoplatform for detection of tumorigenic polyps in the colon via noninvasive mucosal routes.

Chen, Chun-Chieh / Baikoghli, Mo A / Cheng, R Holland

Pharmaceutical patent analyst

2021

Abstract: The use of nanoparticulate systems to diagnose and treat tumors has gained momentum with the rapid development of nanomedicine. Many nanotheranostics fail due to insufficient bioavailability and low accumulation at the tumor site, resulting in ... ...

Abstract	The use of nanoparticulate systems to diagnose and treat tumors has gained momentum with the rapid development of nanomedicine. Many nanotheranostics fail due to insufficient bioavailability and low accumulation at the tumor site, resulting in undesirable side effects. We describe the use of an engineered hepatitis E viral nanoparticle (HEVNP) with enhanced bioavailability, tissue retention and mucosal penetration capacities. HEVNP is a modular nanocapsule that can encapsulate heterologous nucleotides, proteins and inorganic metals, such as ferrite oxide nanoparticles. Additionally, the exterior protruding arms of HEVNP is composed of loops that are used for chemical coupling of targeting and therapeutic peptides. We propose the use of HEVNP to target colorectal cancer (i.e., polyps) with imaging-guided delivery using colonoscopy.
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article
ISSN	2046-8962
ISSN (online)	2046-8962
DOI	10.4155/ppa-2020-0034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surface modulatable nanocapsids for targeting and tracking toward nanotheranostic delivery.

Stark, Marie / Cheng, R Holland

Pharmaceutical patent analyst

2016 Volume 5, Issue 5, Page(s) 307–317

Abstract: Nanoparticle diagnostics and therapeutics (nanotheranostics) have significantly advanced cancer detection and treatment. However, many nanotheranostics are ineffective due to defects in tumor localization and bioavailability. An engineered Hepatitis E ... ...

Abstract	Nanoparticle diagnostics and therapeutics (nanotheranostics) have significantly advanced cancer detection and treatment. However, many nanotheranostics are ineffective due to defects in tumor localization and bioavailability. An engineered Hepatitis E Virus (HEV) nanocapsid is a proposed platform for targeted cancer-cell delivery. Self-assembling from HEV capsid subunits, nanocapsids retain the capacity to enter cells and resist proteolytic/acidic conditions, but lack infectious viral elements. The nanocapsid surface was modified for chemical activation to confer tumor-specific targeting and detection, immune-response manipulation and controlled theranostic delivery. Nanotheranostic molecules can be packaged in the hollow nanocapsid shell during in vitro assembly. Complementing the adapted stability and cell-entry characteristics of the HEV capsid, a modified nanocapsid serves as a tunable tumor-targeting platform for nanotheronostic delivery.
MeSH term(s)	Animals ; Capsid Proteins/administration & dosage ; Capsid Proteins/chemistry ; Capsid Proteins/genetics ; Gene Transfer Techniques/trends ; Genetic Therapy/methods ; Genetic Therapy/trends ; Hepatitis E virus/genetics ; Humans ; Immunotherapy/methods ; Immunotherapy/trends ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Neoplasms/genetics ; Neoplasms/therapy
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article ; Review
ISSN	2046-8962
ISSN (online)	2046-8962
DOI	10.4155/ppa-2016-0021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Soluble CD40L activates soluble and cell-surface integrin αvβ3, α5β1, and α4β1 by binding to the allosteric ligand-binding site (site 2).

Takada, Yoko K / Shimoda, Michiko / Maverakis, Emanual / Felding, Brunie H / Cheng, R Holland / Takada, Yoshikazu

The Journal of biological chemistry

2021 Volume 296, Page(s) 100399

Abstract: CD40L is a member of the TNF superfamily that participates in immune cell activation. It binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. We previously showed that several integrin ... ...

Abstract	CD40L is a member of the TNF superfamily that participates in immune cell activation. It binds to and signals through several integrins, including αvβ3 and α5β1, which bind to the trimeric interface of CD40L. We previously showed that several integrin ligands can bind to the allosteric site (site 2), which is distinct from the classical ligand-binding site (site 1), raising the question of if CD40L activates integrins. In our explorations of this question, we determined that integrin α4β1, which is prevalently expressed on the same CD4+ T cells as CD40L, is another receptor for CD40L. Soluble (s)CD40L activated soluble integrins αvβ3, α5β1, and α4β1 in cell-free conditions, indicating that this activation does not require inside-out signaling. Moreover, sCD40L activated cell-surface integrins in CHO cells that do not express CD40. To learn more about the mechanism of binding, we determined that sCD40L bound to a cyclic peptide from site 2. Docking simulations predicted that the residues of CD40L that bind to site 2 are located outside of the CD40L trimer interface, at a site where four HIGM1 (hyper-IgM syndrome type 1) mutations are clustered. We tested the effect of these mutations, finding that the K143T and G144E mutants were the most defective in integrin activation, providing support that this region interacts with site 2. We propose that allosteric integrin activation by CD40L also plays a role in CD40L signaling, and defective site 2 binding may be related to the impaired CD40L signaling functions of these HIGM1 mutants.
MeSH term(s)	Allosteric Site ; Animals ; CD40 Ligand/immunology ; CD40 Ligand/metabolism ; Cell Line ; Cricetinae ; Humans ; Integrin alpha4beta1/immunology ; Integrin alpha4beta1/metabolism ; Integrin alpha5beta1/immunology ; Integrin alpha5beta1/metabolism ; Integrin alphaVbeta3/immunology ; Integrin alphaVbeta3/metabolism ; Molecular Docking Simulation ; Protein Binding ; Receptors, Cell Surface/chemistry ; Receptors, Cell Surface/metabolism ; Signal Transduction ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Integrin alpha4beta1 ; Integrin alpha5beta1 ; Integrin alphaVbeta3 ; Receptors, Cell Surface ; CD40 Ligand (147205-72-9)
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tissue targeted nanocapsids for oral insulin delivery via drink.

Chen, Chun C / Baikoghli, Mo A / Cheng, R Holland

Pharmaceutical patent analyst

2018 Volume 7, Issue 3, Page(s) 121–127

Abstract: For the past eight decades, subcutaneous injection has been the main route used for supplementing the suboptimal insulin secretion for administering insulin as a treatment for diabetes mellitus. Although this method is effective, subcutaneous injections ... ...

Abstract	For the past eight decades, subcutaneous injection has been the main route used for supplementing the suboptimal insulin secretion for administering insulin as a treatment for diabetes mellitus. Although this method is effective, subcutaneous injections are painful, inconvenient and carry a high risk of infections leading to poor patient compliance. The insulin-encapsulated hepatitis E virus nanoparticle, composed of the noninfectious hepatitis E viral capsid, is expected to deliver insulin from the GI tract to the liver after ingestion. Hepatitis E virus nanoparticle could be the answer to the long search of effective and efficient means to administer insulin orally and the most preferred route of drug delivery with highest patient compliance.
MeSH term(s)	Administration, Oral ; Animals ; Capsid Proteins ; Diabetes Mellitus/drug therapy ; Drinking ; Drug Delivery Systems ; Hepatitis E virus ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage ; Nanocapsules/administration & dosage ; Patents as Topic
Chemical Substances	Capsid Proteins ; Hypoglycemic Agents ; Insulin ; Nanocapsules
Language	English
Publishing date	2018-04-20
Publishing country	England
Document type	Journal Article
ISSN	2046-8962
ISSN (online)	2046-8962
DOI	10.4155/ppa-2017-0041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of

Lambidis, Elisavet / Chen, Chun-Chieh / Baikoghli, Mo / Imlimthan, Surachet / Khng, You Cheng / Sarparanta, Mirkka / Cheng, R Holland / Airaksinen, Anu J

Molecular pharmaceutics

2022 Volume 19, Issue 8, Page(s) 2971–2979

Abstract: Targeted delivery of diagnostics and therapeutics offers essential advantages over nontargeted systemic delivery. These include the reduction of toxicity, the ability to reach sites beyond biological barriers, and the delivery of higher cargo ... ...

Abstract	Targeted delivery of diagnostics and therapeutics offers essential advantages over nontargeted systemic delivery. These include the reduction of toxicity, the ability to reach sites beyond biological barriers, and the delivery of higher cargo concentrations to diseased sites. Virus-like particles (VLPs) can efficiently be used for targeted delivery purposes. VLPs are derived from the coat proteins of viral capsids. They are self-assembled, biodegradable, and homogeneously distributed. In this study, hepatitis E virus (HEV) VLP derivatives, hepatitis E virus nanoparticles (HEVNPs), were radiolabeled with gallium-68, and consequently, the biodistribution of the labeled [
MeSH term(s)	Animals ; Gallium Radioisotopes ; Hepatitis E virus ; Mice ; Nanoparticles ; Positron-Emission Tomography/methods ; Tissue Distribution
Chemical Substances	Gallium Radioisotopes
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c00359
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Article ; Online: Biological evaluation of integrin α

Lambidis, Elisavet / Chen, Chun-Chieh / Lumen, Dave / Sánchez, Ana Isabel Fraguas / Sarparanta, Mirkka / Cheng, R Holland / Airaksinen, Anu J

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2022 Volume 180, Page(s) 106336

Abstract: Integrins are cell surface receptors involved in multiple functions vital for cellular proliferation. Various tumor cells overexpress αβ-integrins, making them ideal biomarkers for diagnostic imaging and tumor-targeted drug delivery. LXY30 is a peptide ... ...

Abstract	Integrins are cell surface receptors involved in multiple functions vital for cellular proliferation. Various tumor cells overexpress αβ-integrins, making them ideal biomarkers for diagnostic imaging and tumor-targeted drug delivery. LXY30 is a peptide that can specifically recognize and interact with the integrin α
Language	English
Publishing date	2022-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2022.106336
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Article ; Online: Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods.

Chen, Chun Chieh / Stark, Marie / Baikoghli, Mo / Cheng, R Holland

Journal of visualized experiments : JoVE

2018 , Issue 135

Abstract: Virus-like particles (VLPs) have been used as nanocarriers to display foreign epitopes and/or deliver small molecules in the detection and treatment of various diseases. This application relies on genetic modification, self-assembly, and cysteine ... ...

Abstract	Virus-like particles (VLPs) have been used as nanocarriers to display foreign epitopes and/or deliver small molecules in the detection and treatment of various diseases. This application relies on genetic modification, self-assembly, and cysteine conjugation to fulfill the tumor-targeting application of recombinant VLPs. Compared with genetic modification alone, chemical conjugation of foreign peptides to VLPs offers a significant advantage because it allows a variety of entities, such as synthetic peptides or oligosaccharides, to be conjugated to the surface of VLPs in a modulated and flexible manner without alteration of the VLP assembly. Here, we demonstrate how to use the hepatitis E virus nanoparticle (HEVNP), a modularized theranostic capsule, as a multifunctional delivery carrier. Functions of HEVNPs include tissue-targeting, imaging, and therapeutic delivery. Based on the well-established structural research of HEVNP, the structurally independent and surface-exposed residues were selected for cysteine replacement as conjugation sites for maleimide-linked chemical groups via thiol-selective linkages. One particular cysteine-modified HEVNP (a Cys replacement of the asparagine at 573 aa (HEVNP-573C)) was conjugated to a breast cancer cell-specific ligand, LXY30 and labeled with near-infrared (NIR) fluorescence dye (Cy5.5), rendering the tumor-targeted HEVNPs as effective diagnostic capsules (LXY30-HEVNP-Cy5.5). Similar engineering strategies can be employed with other macromolecular complexes with well-known atomic structures to explore potential applications in theranostic delivery.
MeSH term(s)	Animals ; Hepatitis E virus/chemistry ; Humans ; Insecta/virology ; Nanoparticles/chemistry
Language	English
Publishing date	2018-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ISSN	1940-087X
ISSN (online)	1940-087X
DOI	10.3791/57020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surface functionalization of hepatitis e virus nanoparticles using chemical conjugation methods

Chen, Chun Chieh / Stark, Marie / Baikoghli, Mo / Cheng, R. Holland

Journal of visualized experiments. 2018 May 11, , no. 135

2018

Abstract	Virus-like particles (VLPs) have been used as nanocarriers to display foreign epitopes and/or deliver small molecules in the detection and treatment of various diseases. This application relies on genetic modification, self-assembly, and cysteine conjugation to fulfill the tumor-targeting application of recombinant VLPs. Compared with genetic modification alone, chemical conjugation of foreign peptides to VLPs offers a significant advantage because it allows a variety of entities, such as synthetic peptides or oligosaccharides, to be conjugated to the surface of VLPs in a modulated and flexible manner without alteration of the VLP assembly. Here, we demonstrate how to use the hepatitis E virus nanoparticle (HEVNP), a modularized theranostic capsule, as a multifunctional delivery carrier. Functions of HEVNPs include tissue-targeting, imaging, and therapeutic delivery. Based on the well-established structural research of HEVNP, the structurally independent and surface-exposed residues were selected for cysteine replacement as conjugation sites for maleimide-linked chemical groups via thiol-selective linkages. One particular cysteine-modified HEVNP (a Cys replacement of the asparagine at 573 aa (HEVNP-573C)) was conjugated to a breast cancer cell-specific ligand, LXY30 and labeled with near-infrared (NIR) fluorescence dye (Cy5.5), rendering the tumor-targeted HEVNPs as effective diagnostic capsules (LXY30-HEVNP-Cy5.5). Similar engineering strategies can be employed with other macromolecular complexes with well-known atomic structures to explore potential applications in theranostic delivery.
Keywords	epitopes ; Orthohepevirus A ; engineering ; asparagine ; image analysis ; nanoparticles ; synthetic peptides ; ligands ; virus-like particles ; near-infrared spectroscopy ; nanocarriers ; genetic engineering ; fluorescent dyes ; oligosaccharides ; cysteine ; breast neoplasms
Language	English
Dates of publication	2018-0511
Size	p. e57020.
Publishing place	Journal of Visualized Experiments
Document type	Article
Note	2019-12-06
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/57020
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Toxicologic Concerns with Current Medical Nanoparticles.

Cheng, Tsai-Mu / Chu, Hsiu-Yi / Huang, Haw-Ming / Li, Zi-Lin / Chen, Chiang-Ying / Shih, Ya-Jung / Whang-Peng, Jacqueline / Cheng, R Holland / Mo, Ju-Ku / Lin, Hung-Yun / Wang, Kuan

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles changes, the physiological response of the cells can be very different. Several ...

Abstract	Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles changes, the physiological response of the cells can be very different. Several characteristics of NPs such as the composition, surface chemistry, surface charge, and shape are also important parameters affecting the toxicity of nanomaterials. This review covered specific topics that address the effects of NPs on nanomedicine. Furthermore, mechanisms of different types of nanomaterial-induced cytotoxicities were described. The distributions of different NPs in organs and their adverse effects were also emphasized. This review provides insight into the scientific community interested in nano(bio)technology, nanomedicine, and nanotoxicology. The content may also be of interest to a broad range of scientists.
MeSH term(s)	Nanomedicine ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Nanotechnology
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147597
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