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Article: The incidence and predictors of post transarterial chemoembolization variceal bleeding in hepatocellular carcinoma patients: Bystander rather than offender.

Cheng, Tzu-Hsuan / Wang, Chia-Chi

Journal of the Formosan Medical Association = Taiwan yi zhi

2020 Volume 119, Issue 10, Page(s) 1562–1563

MeSH term(s)	Carcinoma, Hepatocellular ; Chemoembolization, Therapeutic ; Criminals ; Esophageal and Gastric Varices ; Gastrointestinal Hemorrhage ; Humans ; Incidence ; Liver Neoplasms
Language	English
Publishing date	2020-06-06
Publishing country	Singapore
Document type	Letter ; Comment
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2020.05.037
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Article ; Online: Perioperative Management of Patients with Craniomaxillofacial Trauma.

Cheng, Tzu-Hsuan / Mendelsohn, Matthew / Patel, Radhika / Worah, Samrat / Butts, Sydney C

Otolaryngologic clinics of North America

2023 Volume 56, Issue 6, Page(s) 1069–1078

Abstract: Successful surgical management of patients with facial fractures requires a detailed preoperative evaluation and postoperative management that differs from elective surgical patients. This review presents evidence-based recommendations from the surgical ... ...

Abstract	Successful surgical management of patients with facial fractures requires a detailed preoperative evaluation and postoperative management that differs from elective surgical patients. This review presents evidence-based recommendations from the surgical and anesthesiology literature that address many of the clinical questions that arise during the perioperative management of this group of patients. Surgeons and anesthesiologists must work together at numerous points and make joint decisions, especially where airway and pain management challenges may arise. The multidisciplinary nature of the decision-making process is emphasized.
MeSH term(s)	Humans ; Preoperative Care ; Anesthesiology ; Anesthesiologists ; Pain Management ; Elective Surgical Procedures
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2023.05.015
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Article ; Online: Thyroid neoplasia associated with nutritional deficiency in cultured jade perch in Hong Kong.

Chan, Stephen C H / Lim, Zwok Zu / Leung, Aaron C F / Cheng, Tzu Hsuan / Cheng, Ka Po F / St-Hilaire, Sophie / Ferguson, Andrew M D

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2024 , Page(s) 10406387231218733

Abstract: Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We ...

Abstract	Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We diagnosed cases of thyroid neoplasia in a population of jade perch (
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231218733
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Article ; Online: Complement C3-α and C3-β Levels in Synovial Fluid But Not in Blood Correlate With the Severity of Osteoarthritis Research Society International Histopathological Grades in Primary Knee Osteoarthritis.

Cheng, Tzu Hsuan / Zeng, Jianying / Dehghani, Amir / Dimaculangan, Dennis / Zhang, Ming / Maheshwari, Aditya V

The Journal of arthroplasty

2022 Volume 37, Issue 8, Page(s) 1541–1548.e1

Abstract: Background: Primary osteoarthritis (OA) is the most common cause of knee arthritis worldwide. The knee synovial fluid complement C3-β chain levels have been shown to correlate with clinical symptoms of knee OA. It is not known whether the complement C3 ... ...

Abstract	Background: Primary osteoarthritis (OA) is the most common cause of knee arthritis worldwide. The knee synovial fluid complement C3-β chain levels have been shown to correlate with clinical symptoms of knee OA. It is not known whether the complement C3 in the synovial fluid is derived from the circulation or is produced locally in the knee. Methods: Fifty primary OA patients undergoing a total knee arthroplasty procedure were evaluated for biochemical analyses of C3-α and C3-β chains in the synovial fluid and blood plasma. These levels were corelated with the severity of corresponding knee OA based on the Osteoarthritis Research Society International (OARSI) grade. Results: Both synovial C3-α and C3-β levels correlated significantly with the severity of OA. Neither plasma C3-α levels nor C3-β levels significantly correlated with OARSI grading. Neither synovial C3-α levels nor C3-β correlated significantly with plasma C3-α or C3-β levels, respectively. Synovial C3-α chain and C3-β chain levels were significantly higher in the grade >6 group. In plasma, neither C3-α chain levels nor C3-β chain levels were significantly different between the groups. Neither synovial C3-α nor C3-β levels significantly correlated with plasma erythrocyte sedimentation rate or C-reactive protein levels. Conclusion: In knee primary OA, C3 seems to be produced and released locally into the synovial fluid instead of being derived from blood in the circulation. Synovial C3 levels, but not blood plasma C3, correlate with the histopathological severity of primary OA in the knee. Synovial C3 may be an important factor in the pathogenesis of primary OA clinical symptoms and a potential target for therapeutic intervention.
MeSH term(s)	Biomarkers ; Complement C3/metabolism ; Humans ; Osteoarthritis, Knee/diagnostic imaging ; Radiography ; Severity of Illness Index ; Synovial Fluid/metabolism
Chemical Substances	Biomarkers ; Complement C3
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.03.076
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Article ; Online: Knee synovial fluid complement C3-β chain levels correlate with clinical symptoms of knee osteoarthritis.

Cheng, Tzu Hsuan / Yoon, Seung Ho / Lee, Philip / Dimaculangan, Dennis / Vikram Maheshwari, Aditya / Zhang, Ming

International journal of rheumatic diseases

2020 Volume 23, Issue 4, Page(s) 569–575

Abstract: Aim: Early research found innate immune factor complement C3 in the synovial fluid (SF) and activated in serum of osteoarthritis (OA) patients. Whether synovial C3 comes from circulation, or is produced locally, is still unknown. It is also unclear ... ...

Abstract	Aim: Early research found innate immune factor complement C3 in the synovial fluid (SF) and activated in serum of osteoarthritis (OA) patients. Whether synovial C3 comes from circulation, or is produced locally, is still unknown. It is also unclear whether synovial and circulating C3 is responsible to OA symptoms. A native C3 molecule consists of two chains, C3-α and C3-β. Small fragments breaking down from C3-α chain in serum and SF were reported to be related to OA severity. Little is known if C3-β chain is involved in the pathogenesis. Method: In this study, we evaluated these important areas by biochemical analyses of C3-α and C3-β chains in both the SF and plasma of OA patients. Results: Our results showed that C3-α and C3-β levels in SF did not correlate with those in plasma, suggesting that synovial C3 is independently and locally produced, rather than being "leaked" from circulation. Synovial C3-β but not C3-α levels correlated with pain, other OA symptoms, function in daily living, and sports/recreational activities. Plasma C3-β levels only marginally correlated with pain, and plasma C3-α levels did not correlate with any of these OA symptoms. Conclusion: We present first-hand evidence that the clinical symptoms of OA are mainly associated with C3 in the local SF rather than systemic circulation, suggesting local factors in the etiopathogenesis. Future local targeted therapies for pain management may be more effective and safer.
MeSH term(s)	Aged ; Biomarkers/analysis ; Complement C3/analysis ; Female ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/metabolism ; Prospective Studies ; Synovial Fluid/chemistry
Chemical Substances	Biomarkers ; C3 protein, human ; Complement C3
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.13794
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Article ; Online: Subsidized veterinary extension services may reduce antimicrobial resistance in aquaculture.

St-Hilaire, Sophie / Chan, Stephen Chi Ho / Lim, Kwok Zu / MacKinnon, Brett / Cheng, Tzu Hsuan / Cheng, Ka Po Fiona / Leung, Aaron Chi Fai / Lam, Sabrina Hei Yuet / Bhardwaj, Vidya / Chan, Olivia Sinn Kay

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10118

Abstract: Antibiotic use in aquaculture has become very controversial vis-à-vis driving antimicrobial resistance (AMR) in aquatic bacterial populations. The AMR trends in fish pathogens in Hong Kong over a four-year period suggests that providing small stakeholder ...

Abstract	Antibiotic use in aquaculture has become very controversial vis-à-vis driving antimicrobial resistance (AMR) in aquatic bacterial populations. The AMR trends in fish pathogens in Hong Kong over a four-year period suggests that providing small stakeholder farmers with free veterinary advice on fish health issues and treatments, as well as subsidized quality-assured medicines, likely reduced AMR. We observed a dramatic reduction in the proportion of bacteria resistant to oxolinic acid, oxytetracycline, and florfenicol on local aquaculture farms between 2018 and 2021. These decreases coincided with either a change in antibiotic use practices on farms (i.e. with oxytetracycline), or the reduction in the use of specific drugs (i.e. oxolinic acid and florfenicol). We did not observe a similar decline in the resistance pattern to commonly used antibiotics in human medicine in the same fish bacteria. Resistance to these products, which were unlikely to be used by the farmers in our study, was very high. Our finding suggests that both human and veterinary use of antibiotics in Hong Kong may have an influence on the AMR of bacteria in the aquatic environment.
MeSH term(s)	Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Oxytetracycline/pharmacology ; Oxytetracycline/therapeutic use ; Oxolinic Acid ; Drug Resistance, Bacterial ; Aquaculture ; Bacteria ; Fishes
Chemical Substances	Anti-Bacterial Agents ; florfenicol (9J97307Y1H) ; Oxytetracycline (X20I9EN955) ; Oxolinic Acid (L0A22B22FT)
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37262-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hydrogen peroxide as a mitigation against

Ng, Pok Him / Cheng, Tzu Hsuan / Man, Ka Yan / Huang, Liqing / Cheng, Ka Po / Lim, Kwok Zu / Chan, Chi Ho / Kam, Maximilian Ho Yat / Zhang, Ju / Marques, Ana Rita Pinheiro / St-Hilaire, Sophie

Aquaculture (Amsterdam, Netherlands)

2023 Volume 577, Page(s) 739932

Abstract: ... ...

Abstract	Microcystis
Language	English
Publishing date	2023-12-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2023.739932
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Article ; Online: Preeclampsia Among African American Pregnant Women: An Update on Prevalence, Complications, Etiology, and Biomarkers.

Zhang, Ming / Wan, Philip / Ng, Kenneth / Singh, Kurnvir / Cheng, Tzu Hsuan / Velickovic, Ivan / Dalloul, Mudar / Wlody, David

Obstetrical & gynecological survey

2020 Volume 75, Issue 2, Page(s) 111–120

Abstract: Importance: Preeclampsia is a devastating disease of pregnancy associated with increased risk of fetal and maternal complications. African American pregnant women have a high prevalence of preeclampsia, but there is a need of systemic analyses of this ... ...

Abstract	Importance: Preeclampsia is a devastating disease of pregnancy associated with increased risk of fetal and maternal complications. African American pregnant women have a high prevalence of preeclampsia, but there is a need of systemic analyses of this high-risk group regarding complications, etiology, and biomarkers. Objective: The aim of this study was to provide a synopsis of current research of preeclampsia specifically related to African American women. Evidence acquisition: A comprehensive search was performed in the bibliographic database PubMed with keywords "preeclampsia" and "African American." Results: African American women with preeclampsia were at an increased risk of preterm birth, which resulted in low-birth-weight infants. Intrauterine fetal death among African American preeclamptic patients occurs at twice the rate as in other races. On the maternal side, African American mothers with preeclampsia have more severe hypertension, antepartum hemorrhage, and increased mortality. Those who survive preeclampsia have a high risk of postpartum cardiometabolic disease. Preexisting conditions (eg, systemic lupus erythematosus) and genetic mutations (eg, sickle cell disease in the mother, FVL or APOL1 mutations in the fetus) may contribute to the higher prevalence and worse outcomes in African American women. Many blood factors, for example, the ratio of proteins sFlt/PlGF, hormones, and inflammatory factors, have been studied as potential biomarkers for preeclampsia, but their specificity needs further investigation. Conclusions: Further studies of preeclampsia among African American women addressing underlying risk factors and etiologies, coupled with identification of preeclampsia-specific biomarkers allowing early detection and intervention, will significantly improve the clinical management of this devastating disease.
MeSH term(s)	African Americans/statistics & numerical data ; Biomarkers/analysis ; Female ; Humans ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pre-Eclampsia/etiology ; Pregnancy ; Premature Birth/epidemiology ; Prevalence ; Risk Factors ; Stillbirth/epidemiology ; United States
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-02-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391345-4
ISSN	1533-9866 ; 0029-7828
ISSN (online)	1533-9866
ISSN	0029-7828
DOI	10.1097/OGX.0000000000000747
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Article ; Online: Effect of ozone nanobubbles on the microbial ecology of pond water and safety for jade perch (Scortum barcoo)

Aquaculture. 2023 Nov., v. 576 p.739866-

2023

Abstract: The microbial composition and diversity in aquaculture pond ecosystems are closely related to animal productivity and disease outbreaks. Interventions that alter the bacteria found in pond water can therefore affect the productivity of these systems. ... ...

Abstract	The microbial composition and diversity in aquaculture pond ecosystems are closely related to animal productivity and disease outbreaks. Interventions that alter the bacteria found in pond water can therefore affect the productivity of these systems. Ozone nanobubbles have recently been shown to reduce pathogens, improve dissolved oxygen, and influence fish innate immunity. However, little is known about the effect of nanobubble treatment on the microbial community of aquaculture ponds. This study investigated the impact of ozone macrobubbles (O3MB) and nanobubbles (O3NB) on the microbial ecology of pond water and fish health. We successfully eliminated between 90.9 and 99.4% of the heterotrophic bacteria and 90.1 to 95.2% of the bacterial DNA in our small pond water ecosystems after treatment with 0.15 mg/L ozone. According to the shotgun metagenomic sequencing, ozone macro- and nanobbuble treatments reduced the relative abundance of all bacteria in our water sample, including the dominant bacterial species, as well as Cyanobacteria. The top ten bacterial species in the community changed and were more evenly distributed within the water sample. The bacterial richness of the ozone-treated water samples declined slightly, but over 6000 species were still identified 24 h after the treatment. We also observed a rebound in the bacterial community 24 h after the ozone treatments. The advantage of the nanobubble delivery of ozone over macrobubble delivery of this gas was that the former took significantly less time to deliver the desired quantity of gas while it also greatly increased the dissolved oxygen in the water. Further, we assessed the impact of ozone nanobubbles on jade perch, and no effects were found on the fish at an exposure dose of 0.15 mg/L. This study provides preliminary information on potential applications of nanobubble technology for “resetting” microbial communities, which may be useful during disease outbreaks.
Keywords	Cyanobacteria ; DNA ; Scortum barcoo ; aquaculture ; bacterial communities ; dissolved oxygen ; fish ; fish health ; innate immunity ; metagenomics ; nanobubbles ; ozone ; Pond microbial community ; Bacterial species ; Jade perch
Language	English
Dates of publication	2023-11
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	185380-6
ISSN	0044-8486 ; 0044-8516
ISSN	0044-8486 ; 0044-8516
DOI	10.1016/j.aquaculture.2023.739866
Database	NAL-Catalogue (AGRICOLA)

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Article: Emamectin Benzoate Treatment of Hybrid Grouper Infected With Sea Lice in Hong Kong.

St-Hilaire, Sophie / Cheng, Tzu Hsuan / Chan, Stephen Chi Ho / Leung, Chi Fai / Chan, Ka Man / Lim, Kwok Zu / Furtado, William / Bastos Gomes, Giana

Frontiers in veterinary science

2021 Volume 8, Page(s) 646652

Abstract: Sea lice (Copepoda: Caligidae) are ectoparasites which negatively impact marine aquaculture species around the world. There are a limited number of treatments licensed for use against sea lice in tropical and semi-tropical farmed fish species. Emamectin ... ...

Abstract	Sea lice (Copepoda: Caligidae) are ectoparasites which negatively impact marine aquaculture species around the world. There are a limited number of treatments licensed for use against sea lice in tropical and semi-tropical farmed fish species. Emamectin benzoate (EB) was an effective pharmaceutical drug against sea lice infestations in several salmon industries before resistance to the product developed. This drug has not been extensively tested in marine fish within Asia. The objective of this study was to determine whether this drug could be used to treat oral infections with sea lice in hybrid grouper (
Language	English
Publishing date	2021-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.646652
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