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Article: [Studies on the methodology for quality control in Chinese medicine manufacturing process based on knowledge graph].

Zhong, Yi / Ru, Chen-Lei / Zhang, Bo-Li / Cheng, Yi-Yu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Volume 44, Issue 24, Page(s) 5269–5276

Abstract: According to the requirements for developing the quality control technology in Chinese medicine( CM) manufacturing process and the practical scenarios in applying a new generation of artificial intelligence to CM industry,we present a method of ... ...

Abstract	According to the requirements for developing the quality control technology in Chinese medicine( CM) manufacturing process and the practical scenarios in applying a new generation of artificial intelligence to CM industry,we present a method of constructing the knowledge graph( KG) for CM manufacture to solve key problems about quality control in CM manufacturing process.Based on the above,a " pharmaceutical industry brain" model for CM manufacture has been established. Further,we propose founding the KG-based methodology for quality control in CM manufacturing process,and briefly describe the design method,system architecture and main functions of the KG system. In this work,the KG for manufacturing Shuxuening Injection( SXNI) was developed as a demonstration study. The KG version 1. 0 platform for intelligent manufacturing SXNI has been built,which could realize technology leap of the quality control system in CM manufacturing process from perceptual intelligence to cognitive intelligence.
MeSH term(s)	Artificial Intelligence ; Drug Industry/standards ; Drugs, Chinese Herbal/standards ; Medicine, Chinese Traditional/standards ; Pattern Recognition, Automated ; Quality Control ; Technology, Pharmaceutical
Chemical Substances	Drugs, Chinese Herbal ; shuxuening
Language	Chinese
Publishing date	2020-04-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20191203.302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Design and Verification of an Interval Type-2 Fuzzy Neural Network Based on Improved Particle Swarm Optimization

Cheng-Jian Lin / Shiou-Yun Jeng / Hsueh-Yi Lin / Cheng-Yi Yu

Applied Sciences, Vol 10, Iss 3041, p

2020 Volume 3041

Abstract: In this study, we proposed an interval type-2 fuzzy neural network (IT2FNN) based on an improved particle swarm optimization (PSO) method for prediction and control applications. The noise-suppressing ability of the proposed IT2FNN was superior to that ... ...

Abstract	In this study, we proposed an interval type-2 fuzzy neural network (IT2FNN) based on an improved particle swarm optimization (PSO) method for prediction and control applications. The noise-suppressing ability of the proposed IT2FNN was superior to that of the traditional type-1 fuzzy neural network. We proposed dynamic group cooperative particle swarm optimization (DGCPSO) with superior local search ability to overcome the local optimum problem of traditional PSO. The proposed model and related algorithms were verified through the accuracy of prediction and wall-following control of a mobile robot. Supervised learning was used for prediction, and reinforcement learning was used to achieve wall-following control. The experimental results demonstrated that DGCPSO exhibited superior prediction and wall-following control.
Keywords	fuzzy neural network ; grouping ; mobile robot control ; particle swarm optimization ; time-series prediction ; type-2 fuzzy set ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	629 ; 620
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Theoretical innovation of component-based Chinese medicine and its exemplary practice: the study on creating Guanxinning Tablets].

Cheng, Yi-Yu / Wang, Yi / Liu, Li / Zhao, Xiao-Ping / Zhong, Yi / Huang, Ming / Zhang, Bo-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 17, Page(s) 4545–4550

Abstract: Upholding the wisdom of traditional Chinese medicine that the therapeutic principle, method, formula and medicine are coherent with each other, we propose the technical methodology for intelligent creation of component-based Chinese medicine by ... ...

Abstract	Upholding the wisdom of traditional Chinese medicine that the therapeutic principle, method, formula and medicine are coherent with each other, we propose the technical methodology for intelligent creation of component-based Chinese medicine by integrating multidisciplinary knowledge such as artificial intelligence, pharmaceutical informatics, system pharmacology and phytochemistry. Taking the creation of Guanxinning Tablets as an example, we expound the technical principle for creating component-based Chinese medicine and briefly describe the design method for optimizing the entity of Chinese medicine efficacy by rational combination of active components. Our research sought to "clarify and explain" the mechanism of its clinical treatment action through multi-modal and multi-scale systematic pharmacology studies. This work emphatically demonstrates the pilot workshop and engineering validation platform based on the intelligent simulation of whole production process, and outlines the design principles of the intelligent production line for innovative Chinese medicine. The results of industrial research show that the ourself established method for evaluating the process quality controllability and intelligent production line can be applied to manufacturing Guanxining Tablets with high quality. Through the innovative research of multidisciplinary cross-border integration, the present work explored a new way for the creation of modern Chinese medicine.
MeSH term(s)	Artificial Intelligence ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional ; Quality Control ; Tablets
Chemical Substances	Drugs, Chinese Herbal ; Tablets
Language	Chinese
Publishing date	2022-09-27
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220804.301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [A strategy of constructing the technological system for quality control of Chinese medicine based on process control and management].

Cheng, Yi-Yu / Qian, Zhong-Zhi / Zhang, Bo-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2017 Volume 42, Issue 1, Page(s) 1–5

Abstract: The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process ... ...

Abstract	The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process control in drug regulation, reverse the situation of neglecting the development of process control and management technology for pharmaceutical manufacture and reconstruct the technological system for quality control of CM products. The regulation and technology system based on process control and management for controlling CM quality should be established to solve weighty realistic problems of CM industry from the root causes, including backwardness of quality control technology, weakness of quality risk control measures, poor reputation of product quality and so on. By this way, the obstacles from poor controllability of CM product quality could be broken. Concentrating on those difficult problems and weak links in the technical field of CM quality control, it is proposed to build CMC (Chemistry, Manufacturing and Controls) regulation for CM products with Chinese characteristics and promote the regulation international recognition as soon as possible. The CMC technical framework, which is clinical efficacy-oriented, manufacturing manner-centered and process control-focused, was designed. To address the clinical characteristics of traditional Chinese medicine (TCM) and the production feature of CM manufacture, it is suggested to establish quality control engineering for CM manufacturing by integrating pharmaceutical analysis, TCM chemistry, TCM pharmacology, pharmaceutical engineering, control engineering, management engineering and other disciplines. Further, a theoretical model of quality control engineering for CM manufacturing and the methodology of digital pharmaceutical engineering are proposed. A technology pathway for promoting CM standard and realizing the strategic goal of CM internationalization is elaborated.
Language	Chinese
Publishing date	2017-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.2017.0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Chinese medicine industry 4.0：advancing digital pharmaceutical manufacture toward intelligent pharmaceutical manufacture].

Cheng, Yi-Yu / Qu, Hai-Bin / Zhang, Bo-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2016 Volume 41, Issue 1, Page(s) 1–5

Abstract: A perspective analysis on the technological innovation in pharmaceutical engineering of Chinese medicine unveils a vision on "Future Factory" of Chinese medicine industry in mind. The strategy as well as the technical roadmap of "Chinese medicine ... ...

Abstract	A perspective analysis on the technological innovation in pharmaceutical engineering of Chinese medicine unveils a vision on "Future Factory" of Chinese medicine industry in mind. The strategy as well as the technical roadmap of "Chinese medicine industry 4.0" is proposed, with the projection of related core technology system. It is clarified that the technical development path of Chinese medicine industry from digital manufacture to intelligent manufacture. On the basis of precisely defining technical terms such as process control, on-line detection and process quality monitoring for Chinese medicine manufacture, the technical concepts and characteristics of intelligent pharmaceutical manufacture as well as digital pharmaceutical manufacture are elaborated. Promoting wide applications of digital manufacturing technology of Chinese medicine is strongly recommended. Through completely informationized manufacturing processes and multi-discipline cluster innovation, intelligent manufacturing technology of Chinese medicine should be developed, which would provide a new driving force for Chinese medicine industry in technology upgrade, product quality enhancement and efficiency improvement.
MeSH term(s)	Drug Industry/economics ; Drug Industry/standards ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Medicine, Chinese Traditional ; Quality Control ; Technology, Pharmaceutical/economics ; Technology, Pharmaceutical/standards ; Technology, Pharmaceutical/trends
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2016-01
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.4268/cjcmm20160101
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Research frontiers and trends of the analytical technology for Chinese medicine].

Wang, Shu-fang / Cheng, Yi-yu

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2012 Volume 41, Issue 1, Page(s) 1–5

MeSH term(s)	Chromatography/methods ; DNA Fingerprinting ; Drugs, Chinese Herbal/analysis ; Magnetic Resonance Spectroscopy ; Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2012-01
Publishing country	China
Document type	Journal Article ; Review
ISSN	1008-9292
ISSN	1008-9292
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Network formulaology: a new strategy for modern research of traditional Chinese medicine formulae].

Fan, Xiao-Hui / Cheng, Yi-Yu / Zhang, Bo-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Volume 40, Issue 1, Page(s) 1–6

Abstract: This paper briefly analyzed and discussed the current status and major scientific challenges of traditional Chinese medicine (TCM) formulaology research. To promote formulaology research, a new strategy and corresponding technology, network formulaology, ...

Abstract	This paper briefly analyzed and discussed the current status and major scientific challenges of traditional Chinese medicine (TCM) formulaology research. To promote formulaology research, a new strategy and corresponding technology, network formulaology, were proposed to reveal the complex interaction between functional chemome and biological responses network. The research framework and directions of network formulaology were also summarized and prospected.
MeSH term(s)	Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/standards ; Drugs, Chinese Herbal/chemistry ; Internet ; Medicine, Chinese Traditional/standards
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2015-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [The technological innovation strategy for quality control of Chinese medicine based on Big Data].

Li, Zhen-hao / Qian, Zhong-zhi / Cheng, Yi-yu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Volume 40, Issue 17, Page(s) 3374–3378

Abstract: The evolution of the quality control concepts of medical products within the global context and the development of the quality control technology of Chinese medicine are briefly described. Aimed at the bottlenecks in the regulation and quality control of ...

Abstract	The evolution of the quality control concepts of medical products within the global context and the development of the quality control technology of Chinese medicine are briefly described. Aimed at the bottlenecks in the regulation and quality control of Chinese medicine, using Big Data technology to address the significant challenges in Chinese medicine industry is proposed. For quality standard refinements and internationalization of Chinese medicine, a technological innovation strategy encompassing its methodology, and the R&D direction of the subsequent core technology are also presented.
MeSH term(s)	Data Mining ; Databases, Factual ; Drug Industry/organization & administration ; Drug Industry/standards ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/standards ; Humans ; Quality Control
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2015-09
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A multiple biomarker assay for quality assessment of botanical drugs using a versatile microfluidic chip.

Li, Zhen-Hao / Ai, Ni / Yu, Lawrence X / Qian, Zhong-Zhi / Cheng, Yi-Yu

Scientific reports

2017 Volume 7, Issue 1, Page(s) 12243

Abstract: Quality control is critical for ensuring the safety and effectiveness of drugs. Current quality control method for botanical drugs is mainly based on chemical testing. However, chemical testing alone may not be sufficient as it may not capture all ... ...

Abstract	Quality control is critical for ensuring the safety and effectiveness of drugs. Current quality control method for botanical drugs is mainly based on chemical testing. However, chemical testing alone may not be sufficient as it may not capture all constituents of botanical drugs. Therefore, it is necessary to establish a bioassay correlating with the drug's known mechanism of action to ensure its potency and activity. Herein we developed a multiple biomarker assay to assess the quality of botanicals using microfluidics, where enzyme inhibition was employed to indicate the drug's activity and thereby evaluate biological consistency. This approach was exemplified on QiShenYiQi Pills using thrombin and angiotensin converting enzyme as "quality biomarkers". Our results demonstrated that there existed variations in potency across different batches of the intermediates and preparations. Compared with chromatographic fingerprinting, the bioassay provided better discrimination ability for some abnormal samples. Moreover, the chip could function as "affinity chromatography" to identify bioactive phytochemicals bound to the enzymes. This work proposed a multiple-biomarker strategy for quality assessment of botanical drugs, while demonstrating for the first time the feasibility of microfluidics in this field.
MeSH term(s)	Biological Assay/methods ; Drugs, Chinese Herbal/pharmacology ; Enzyme Inhibitors/analysis ; Microfluidics/methods ; Quality Control ; Technology, Pharmaceutical/methods
Chemical Substances	Drugs, Chinese Herbal ; Enzyme Inhibitors ; qishen yiqi
Language	English
Publishing date	2017-09-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-12453-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Innovation guidelines and strategies for pharmaceutical engineering of Chinese medicine and their industrial translation].

Cheng, Yi-Yu / Qu, Hai-Bin / Zhang, Bo-Li

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2013 Volume 38, Issue 1, Page(s) 3–5

Abstract: This paper briefly analyzes the bottlenecks and major technical requirements for pharmaceutical industry of Chinese medicine, providing current status of pharmaceutical engineering of Chinese medicine. The innovation directions and strategies of the ... ...

Abstract	This paper briefly analyzes the bottlenecks and major technical requirements for pharmaceutical industry of Chinese medicine, providing current status of pharmaceutical engineering of Chinese medicine. The innovation directions and strategies of the pharmaceutical engineering for manufacturing Chinese medicine are proposed along with the framework of their core technology. As a consequence, the development of the third-generation pharmaceutical technology for Chinese medicine, featured as "precision, digital and intelligent", is recommended. The prospects of the pharmaceutical technology are also forecasted.
MeSH term(s)	China ; Drug Industry/methods ; Drug Industry/standards ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/standards ; Medicine, Chinese Traditional/methods ; Medicine, Chinese Traditional/standards ; Quality Control
Chemical Substances	Drugs, Chinese Herbal
Language	Chinese
Publishing date	2013-01
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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