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  1. Article ; Online: Immunosensor for Rapid and Sensitive Detection of Digoxin.

    Zhao, Shuyang / Zhang, Ruxue / Gao, Yujie / Cheng, Yueqing / Zhao, Shouzhen / Li, Mei / Li, Haimei / Dong, Jinhua

    ACS omega

    2023  Volume 8, Issue 17, Page(s) 15341–15349

    Abstract: Digoxin is a cardiac glycosylated steroid-like drug with a positive inotropic effect and has been widely used in treating congestive heart failure, atrial fibrillation, atrial flutter, and other heart diseases. Digoxin is also a dangerous drug, which can ...

    Abstract Digoxin is a cardiac glycosylated steroid-like drug with a positive inotropic effect and has been widely used in treating congestive heart failure, atrial fibrillation, atrial flutter, and other heart diseases. Digoxin is also a dangerous drug, which can cause drug poisoning at a low blood drug concentration (2.73-3.9 nmol/L, i.e., 2.14-3.05 ng/mL). Therefore, the timely detection of a patient's blood drug concentration plays a significant role in controlling blood drug concentration, reducing the occurrence of drug poisoning events, and maximizing the role of drug therapy. In this study, a DNA vector for the expression of the antidigoxin antibody Fab fragment was constructed. With the vector, Fab was expressed in
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Fluorescence quenching-based immunological probe for ticagrelor monitoring.

    Zhang, Shengshuo / Cheng, Yueqing / Gao, Yujie / Zou, Yujie / Xiao, Weiling / Li, Tianyi / Li, Mei / Yu, Bowen / Dong, Jinhua

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1295406

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1295406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Ultrastructure of the Olfactory Sensilla across the Antennae and Maxillary Palps of Bactrocera dorsalis (Diptera: Tephritidae)

    Liu, Zhao / Hu, Ting / Guo, Huai-Wang / Liang, Xiao-Fei / Cheng, Yue-Qing

    Insects. 2021 Mar. 26, v. 12, no. 4

    2021  

    Abstract: The sensilla on the antennae and maxillary palps are the most important olfactory organs, via which the insect can perceive the semiochemicals to adjust their host seeking and oviposition behaviors. The oriental fruit fly, Bactrocera dorsalis (Hendel) ( ... ...

    Abstract The sensilla on the antennae and maxillary palps are the most important olfactory organs, via which the insect can perceive the semiochemicals to adjust their host seeking and oviposition behaviors. The oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), is a major agricultural quarantine pest infesting more than 250 different fruits and vegetables. However, the sensilla involved in olfaction have not been well documented even though a variety of control practices based on chemical communication have already been developed. In this study, the ultrastructure of the sensilla, especially the olfactory sensilla on the antennae and maxillary palps of both males and females, were investigated with field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). Three types of olfactory sensillum types including trichodea, basiconica, and coeloconica, and two non-olfactory sensilla including both chaetica and microtrichia, were observed. Each of these three types of olfactory sensilla on the antennae of B. dorsalis were further classified into two subtypes according to the morphology and number of receptor cells. For the first time, the pores on the sensilla trichodea and basiconica cuticular wall were observed in this species, suggesting they are involved in semiochemical perception. This study provides new information on B. dorsalis olfaction, which can be connected to other molecular, genetic, and behavioral research to construct an integral olfactory system model for this species.
    Keywords Bactrocera dorsalis ; chemical communication ; insects ; models ; oviposition ; palps ; pests ; quarantine ; semiochemicals ; sensilla ; smell ; transmission electron microscopy ; ultrastructure
    Language English
    Dates of publication 2021-0326
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ISSN 2075-4450
    DOI 10.3390/insects12040289
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Transcriptome analysis reveals the molecular mechanisms of response to an emergent yellow-flower disease in green Chinese prickly ash (Zanthoxylum schinifolium).

    Xu, Fan / Meng, Qian / Suo, Xiaodong / Xie, Yonghong / Cheng, Yueqing / Luo, Ming

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 18886

    Abstract: Chinese prickly ash (Zanthoxylum) is extensively used as spice and traditional medicine in eastern Asian countries. Recently, an emergent yellow-flower disease (YFD) break out in green Chinese prickly ash (Zanthoxylum schinifolium, Qinghuajiao in Chinese) ...

    Abstract Chinese prickly ash (Zanthoxylum) is extensively used as spice and traditional medicine in eastern Asian countries. Recently, an emergent yellow-flower disease (YFD) break out in green Chinese prickly ash (Zanthoxylum schinifolium, Qinghuajiao in Chinese) at Chongqing municipality, and then leads to a sharp reduction in the yield of Qinghuajiao, and thus results in great economic losses for farmers. To address the molecular response for the emergent YFD of Qinghuajiao, we analyzed the transcriptome of 12 samples including the leaves and inflorescences of asymptomatic and symptomatic plants from three different towns at Chongqing by high-throughput RNA-Seq technique. A total of 126,550 genes and 229,643 transcripts were obtained, and 21,054 unigenes were expressed in all 12 samples. There were 56 and 164 different expressed genes (DEGs) for the AL_vs_SL (asymptomatic leaf vs symptomatic leaf) and AF_vs_SF (asymptomatic flower vs symptomatic flower) groups, respectively. The results of KEGG analysis showed that the "phenylpropanoid biosynthesis" pathway that related to plant-pathogen interaction were found in AL_vs_SL and AF_vs_SF groups, and the "Plant-pathogen interaction" found in AF_vs_SF group, implying that this Qinghuajiao YFD might cause by plant pathogen. Interestingly, we detected 33 common unigenes for the 2 groups, and almost these unigenes were up-regulated in the symptomatic plants. Moreover, most of which were homologs to virus RNA, the components of viruses, implying that this YFD was related to virus. Our results provided a primary molecular basis for the prevention and treatment of YFD of Qinghuajiao trees.
    MeSH term(s) Color ; Flowers/metabolism ; Gene Expression Regulation, Plant ; Host-Pathogen Interactions/genetics ; Plant Diseases/genetics ; Plant Diseases/therapy ; Plant Leaves/metabolism ; RNA, Viral/genetics ; RNA-Seq ; Secondary Metabolism/genetics ; Sequence Homology, Nucleic Acid ; Zanthoxylum/genetics ; Zanthoxylum/metabolism ; Zanthoxylum/virology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98427-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ultrastructure of the Olfactory Sensilla across the Antennae and Maxillary Palps of

    Liu, Zhao / Hu, Ting / Guo, Huai-Wang / Liang, Xiao-Fei / Cheng, Yue-Qing

    Insects

    2021  Volume 12, Issue 4

    Abstract: The sensilla on the antennae and maxillary palps are the most important olfactory organs, via which the insect can perceive the semiochemicals to adjust their host seeking and oviposition behaviors. The oriental fruit fly, ...

    Abstract The sensilla on the antennae and maxillary palps are the most important olfactory organs, via which the insect can perceive the semiochemicals to adjust their host seeking and oviposition behaviors. The oriental fruit fly,
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects12040289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New Perspectives on Difficult Asthma; Sex and Age of Asthma-Onset Based Phenotypes.

    Azim, Adnan / Freeman, Anna / Lavenu, Audrey / Mistry, Heena / Haitchi, Hans Michael / Newell, Colin / Cheng, Yueqing / Thirlwall, Yvette / Harvey, Matthew / Barber, Clair / Pontoppidan, Katarina / Dennison, Paddy / Arshad, S Hasan / Djukanovic, Ratko / Howarth, Peter / Kurukulaaratchy, Ramesh J

    The journal of allergy and clinical immunology. In practice

    2020  Volume 8, Issue 10, Page(s) 3396–3406.e4

    Abstract: Background: Asthma is a diverse condition that differs with age and sex. However, it remains unclear how sex, age of asthma onset, and/or their interaction influence clinical expression of more problematic adult "difficult" asthma.: Objectives: To ... ...

    Abstract Background: Asthma is a diverse condition that differs with age and sex. However, it remains unclear how sex, age of asthma onset, and/or their interaction influence clinical expression of more problematic adult "difficult" asthma.
    Objectives: To better understand the clinical features of difficult asthma within a real-world clinical setting using novel phenotypic classification, stratifying subjects by sex and age of asthma onset.
    Methods: Participants in a longitudinal difficult asthma clinical cohort study (Wessex AsThma CoHort of difficult asthma; WATCH), United Kingdom (n = 501), were stratified into 4 difficult asthma phenotypes based on sex and age of asthma onset (early <18 years or adult ≥18 years) and characterized in relation to clinical and pathophysiological features.
    Results: The cohort had more female participants (65%) but had similar proportions of participants with early- or adult-onset disease. Early-onset female disease was commonest (35%), highly atopic, with good spirometry and strong associations with some physical comorbidities but highest psychophysiologic comorbidities. Adult-onset females also had considerable psychophysiologic comorbidities and highest obesity, and were least atopic. Amongst male subjects, proportionately more had adult-onset disease. Early-onset male disease was rarest (14%) but associated with worst lung function, high smoking, atopy, and fungal sensitization. Despite shortest disease duration, adult-onset males had highest use of maintenance oral corticosteroid, poor lung function, and highest fractional exhaled nitrogen oxide in spite of highest smoking prevalence.
    Conclusions: This study shows that sex, age of asthma onset, and their interactions influence different clinical manifestations of difficult asthma and identifies a greater risk for lung function loss and oral corticosteroid dependence associated with smoking in adult-onset male subjects.
    MeSH term(s) Adolescent ; Adult ; Asthma/epidemiology ; Cohort Studies ; Female ; Humans ; Male ; Phenotype ; Spirometry ; United Kingdom/epidemiology
    Language English
    Publishing date 2020-06-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.05.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic.

    Azim, Adnan / Mistry, Heena / Freeman, Anna / Barber, Clair / Newell, Colin / Gove, Kerry / Thirlwall, Yvette / Harvey, Matt / Bentley, Kimberley / Knight, Deborah / Long, Karen / Mitchell, Frances / Cheng, Yueqing / Varkonyi-Sepp, Judit / Grabau, Wolfgang / Dennison, Paddy / Haitchi, Hans Michael / Arshad, S Hasan / Djukanovic, Ratko /
    Wilkinson, Tom / Howarth, Peter / Kurukulaaratchy, Ramesh J

    BMC pulmonary medicine

    2019  Volume 19, Issue 1, Page(s) 99

    Abstract: Background: Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a ... ...

    Abstract Background: Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. Why some individuals should continue to suffer remains unclear.
    Methods: The Wessex Asthma Cohort of Difficult Asthma (WATCH) is an ongoing 'real-life', prospective study of patients in the University Hospital Southampton Foundation Trust (UHSFT) Difficult Asthma service. Research data capture is aligned with the extensive clinical characterisation required of a commissioned National Health Service (NHS) Specialist Centre for Severe Asthma. Data acquisition includes detailed clinical, health and disease-related questionnaires, anthropometry, allergy and lung function testing, radiological imaging (in a small subset) and collection of biological samples (blood, urine and sputum). Prospective data are captured in parallel to clinical follow up appointments, with data entered into a bespoke database.
    Discussion: The pragmatic ongoing nature of the WATCH study allows comprehensive assessment of the real world clinical spectrum seen in a Specialist Asthma Centre and allows a longitudinal perspective of deeply phenotyped patients. It is anticipated that the WATCH cohort would act as a vehicle for potential collaborative asthma studies and will build upon our understanding of mechanisms underlying difficult asthma.
    MeSH term(s) Asthma/physiopathology ; Asthma/therapy ; Disease Progression ; Humans ; Longitudinal Studies ; Lung/physiopathology ; Phenotype ; Prospective Studies ; Research Design ; Respiratory Function Tests ; Surveys and Questionnaires
    Language English
    Publishing date 2019-05-24
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-019-0862-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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