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  1. Article ; Online: Therapeutic plasma exchange for refractory vaccine‐induced immune thrombotic thrombocytopenia

    Sheng‐Bin Fan / Ming‐Ju Tsai / Mei‐Chuan Kuo / Cheng‐Hao Chuang

    Kaohsiung Journal of Medical Sciences, Vol 38, Iss 8, Pp 804-

    2022  Volume 805

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Emergent bronchoscopic cryotherapy may safely cease invasive lung cancer induced massive endobronchial hemorrhaging in patients with high oxygen supply

    Feng‐Ching Shen / Cheng‐Hao Chuang / Ying‐Ming Tsai / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 37, Iss 9, Pp 833-

    2021  Volume 834

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: FAK in Cancer

    Hsiang-Hao Chuang / Yen-Yi Zhen / Yu-Chen Tsai / Cheng-Hao Chuang / Michael Hsiao / Ming-Shyan Huang / Chih-Jen Yang

    International Journal of Molecular Sciences, Vol 23, Iss 1726, p

    From Mechanisms to Therapeutic Strategies

    2022  Volume 1726

    Abstract: Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, ... ...

    Abstract Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and activated in many cancer types. FAK regulates diverse cellular processes, including growth factor signaling, cell cycle progression, cell survival, cell motility, angiogenesis, and the establishment of immunosuppressive tumor microenvironments through kinase-dependent and kinase-independent scaffolding functions in the cytoplasm and nucleus. Mounting evidence has indicated that targeting FAK, either alone or in combination with other agents, may represent a promising therapeutic strategy for various cancers. In this review, we summarize the mechanisms underlying FAK-mediated signaling networks during tumor development. We also summarize the recent progress of FAK-targeted small-molecule compounds for anticancer activity from preclinical and clinical evidence.
    Keywords focal adhesion kinase ; metastasis ; drug resistance ; combination therapy ; tumor microenvironment ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: FAK Executes Anti-Senescence via Regulating EZH2 Signaling in Non-Small Cell Lung Cancer Cells

    Hsiang-Hao Chuang / Ming-Shyan Huang / Yen-Yi Zhen / Cheng-Hao Chuang / Ying-Ray Lee / Michael Hsiao / Chih-Jen Yang

    Biomedicines, Vol 10, Iss 8, p

    2022  Volume 1937

    Abstract: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase overexpressed in various cancer types that plays a critical role in tumor progression. Accumulating evidence suggests that targeting FAK, either alone or in combination with other agents, may ... ...

    Abstract Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase overexpressed in various cancer types that plays a critical role in tumor progression. Accumulating evidence suggests that targeting FAK, either alone or in combination with other agents, may serve as an effective therapeutic strategy for numerous cancers. In addition to retarding proliferation, metastasis, and angiogenesis, FAK inhibition triggers cellular senescence in lung cancer cells. However, the detailed mechanism remains enigmatic. In the present study, we found that FAK inhibition not only elicits DNA-damage signaling but also downregulates enhancer of zeste homolog 2 (EZH2) expression. The manipulation of FAK expression influences EZH2 expression and corresponding signaling in vitro. Immunohistochemistry shows that active FAK signaling corresponds with the activation of the EZH2-mediated signaling cascade in lung-cancer-cells-derived tumor tissues. We also found that ectopic EZH2 expression attenuates FAK-inhibition-induced cellular senescence in lung cancer cells. Our results identify EZH2 as a critical downstream effector of the FAK-mediated anti-senescence pathway. Targeting FAK-EZH2 axis-induced cellular senescence may represent a promising therapeutic strategy for restraining tumor growth.
    Keywords FAK ; EZH2 ; senescence ; lamin A/C ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy

    Hsiang-Hao Chuang / Yen-Yi Zhen / Yu-Chen Tsai / Cheng-Hao Chuang / Ming-Shyan Huang / Michael Hsiao / Chih-Jen Yang

    Biomedicines, Vol 9, Iss 359, p

    2021  Volume 359

    Abstract: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in ...

    Abstract Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting Pin1 is a potential therapeutic approach for various cancers by inhibiting cell proliferation, reducing metastasis, and maintaining genome stability. In this review, we summarize the underlying mechanisms of Pin1-mediated upregulation of oncogenes and downregulation of tumor suppressors in cancer development. Furthermore, we also discuss the multiple roles of Pin1 in cancer hallmarks and examine Pin1 as a desirable pharmaceutical target for cancer therapy. We also summarize the recent progress of Pin1-targeted small-molecule compounds for anticancer activity.
    Keywords Pin1 ; cis - trans isomerization ; tumorigenesis ; cell motility ; metastasis ; cancer therapeutics ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Cysteinyl Leukotriene Pathway and Cancer

    Ming-Ju Tsai / Wei-An Chang / Cheng-Hao Chuang / Kuan-Li Wu / Chih-Hung Cheng / Chau-Chyun Sheu / Ya-Ling Hsu / Jen-Yu Hung

    International Journal of Molecular Sciences, Vol 23, Iss 120, p

    2022  Volume 120

    Abstract: Cancer remains a leading cause of death worldwide, despite many advances being made in recent decades. Changes in the tumor microenvironment, including dysregulated immunity, may contribute to carcinogenesis and cancer progression. The cysteinyl ... ...

    Abstract Cancer remains a leading cause of death worldwide, despite many advances being made in recent decades. Changes in the tumor microenvironment, including dysregulated immunity, may contribute to carcinogenesis and cancer progression. The cysteinyl leukotriene (CysLT) pathway is involved in several signal pathways, having various functions in different tissues. We summarized major findings of studies about the roles of the CysLT pathway in cancer. Many in vitro studies suggested the roles of CysLTs in cell survival/proliferation via CysLT 1 receptor (CysLT 1 R). CysLT 1 R antagonism decreased cell vitality and induced cell death in several types of cancer cells, such as colorectal, urological, breast, lung and neurological malignancies. CysLTs were also associated with multidrug resistance of cancer, and CysLT 1 R antagonism might reverse chemoresistance. Some animal studies demonstrated the beneficial effects of CysLT 1 R antagonist in inhibiting tumorigenesis and progression of some cancer types, particularly colorectal cancer and lung cancer. The expression of CysLT 1 R was shown in various cancer tissues, particularly colorectal cancer and urological malignancies, and higher expression was associated with a poorer prognosis. The chemo-preventive effects of CysLT 1 R antagonists were demonstrated in two large retrospective cohort studies. In summary, the roles of the CysLT pathway in cancer have been delineated, whereas further studies are still warranted.
    Keywords leukotriene ; montelukast ; zafirlukast ; chemoprevention ; cell death ; apoptosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 616
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: First-Line Anaplastic Lymphoma Kinase (ALK) Inhibitors for ALK-Positive Lung Cancer in Asian Populations

    Kuan-Li Wu / Hsiao-Ling Chen / Ying-Ming Tsai / Tai-Huang Lee / Hsiu-Mei Chang / Yu-Chen Tsai / Cheng-Hao Chuang / Yong-Chieh Chang / Yu-Kang Tu / Chih-Jen Yang / Jen-Yu Hung / Inn-Wen Chong

    Journal of Clinical Medicine, Vol 10, Iss 4376, p

    Systematic Review and Network Meta-Analysis

    2021  Volume 4376

    Abstract: Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs ... ...

    Abstract Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs has been made, and different efficacies of ALKIs may present across ethnicity. This study aims to compare newer generation ALKIs for treatment efficacy in Asian groups using network meta-analysis. Phase II/III trials that enrolled treatment-naïve Asian ALK-rearranged NSCLC patients treated by ALKIs were included. Progression-free survival (PFS) and overall response rate (ORR) of each trial were extracted as indicators of drug efficacy. Surfaces under cumulative ranking curves (SUCRAs) were calculated as a numeric presentation of the overall ranking associated with each agent. After a systematic literature review, six phase III clinical trials were included. Our results showed that newer generation ALKIs, such as alectinib, brigatinib, ensartinib, and lorlatinib, all demonstrated superior efficacy to crizotinib. Among those, ensartinib exhibited the best overall SUCRA value and ranked first among all agents. According to our network meta-analysis, ensartinib may currently be the most effective first-line treatment for Asian patients with ALK-positive NSCLC. However, this conclusion needs further validation by a larger scale of clinical trials or posthoc analysis of Asian populations. Moreover, in our comparison, low-dose alectinib (300 mg twice daily) exhibited an efficacy profile similar to a higher dose regimen in Asian populations.
    Keywords Asian ; anaplastic lymphoma kinase inhibitor ; non-small cell lung cancer ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The Electro-Deposition/Dissolution of CuSO4 Aqueous Electrolyte Investigated by In Situ Soft X-ray Absorption Spectroscopy

    Velasco-Vélez, Juan-Jesús / Axel Knop-Gericke / Bing-Jian Su / Cheng-Hao Chuang / Cheng-Jhih Hsu / Chung-Li Dong / Elias Frei / Hung-Yu Chou / Jin-Ming Chen / Katarzyna Skorupska / Peter Strasser / Robert Schlögl / Yu-Cheng Huang

    Journal of physical chemistry. 2018 Jan. 18, v. 122, no. 2

    2018  

    Abstract: The electrodeposition nature of copper on a gold electrode in a 4.8 pH CuSO4 solution was inquired using X-ray absorption spectroscopy, electrochemical quartz crystal microbalance, and thermal desorption spectroscopy techniques. Our results point out ... ...

    Abstract The electrodeposition nature of copper on a gold electrode in a 4.8 pH CuSO4 solution was inquired using X-ray absorption spectroscopy, electrochemical quartz crystal microbalance, and thermal desorption spectroscopy techniques. Our results point out that the electrodeposition of copper prompts the formation of stable oxi-hydroxide species with a formal oxidation state Cu+ without the evidence of metallic copper formation (Cu0). Moreover, the subsequent anodic polarization of Cu2Oaq yields the formation of CuO, in the formal oxidation state Cu2+, which is dissolved at higher anodic potential. It was found that the dissolution process needs less charge than that required for the electrodeposition indicating a nonreversible process most likely due to concomitant water splitting and formation of protons during the electrodeposition.
    Keywords copper sulfate ; cupric oxide ; desorption ; electrochemistry ; electrodes ; electrolytes ; gold ; oxidation ; pH ; protons ; quartz crystal microbalance ; X-ray absorption spectroscopy
    Language English
    Dates of publication 2018-0118
    Size p. 780-787.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1520-5207
    DOI 10.1021/acs.jpcb.7b06728
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Insights into dynamic molecular intercalation mechanism for AlC battery by operando synchrotron X-ray techniques

    Wang, Di-Yan / Shao-Ku Huang / Hsiang-Ju Liao / Yu-Mei Chen / Sheng-Wen Wang / Yu-Ting Kao / Ji-Yao An / Yi-Cheng Lee / Cheng-Hao Chuang / Yu-Cheng Huang / Ying-Rui Lu / Hong-Ji Lin / Hung-Lung Chou / Chun-Wei Chen / Ying-Huang Lai / Chung-Li Dong

    Carbon. 2019 May, v. 146

    2019  

    Abstract: Recently, a novel rechargeable Al ion battery (AIB) with high performance has been developed. Owing to its low cost, high-rate capability, excellent cyclability, and non-flammability, AIB provides a safe alternative to many commercial batteries used in ... ...

    Abstract Recently, a novel rechargeable Al ion battery (AIB) with high performance has been developed. Owing to its low cost, high-rate capability, excellent cyclability, and non-flammability, AIB provides a safe alternative to many commercial batteries used in the energy storage system. To improve its performance, identifying molecular structure and arrangement of chloroaluminate anion (AlCl4−) intercalated in the graphite layer remains a great challenge. In this work, operando analysis of X-ray diffraction (XRD) measurement and X-ray absorption (XAS) spectroscopy were performed to investigate the intercalation of AlCl4− anion and related molecular arrangement in the graphite layers. The intercalated stage and intercalant gallery height of graphite cathode electrode during AIB battery operation were observed to be stage 3 and 9.22 Å, respectively. Furthermore, the spectral evolution from ex-situ XAS at the Al and Cl K-edge was associated with closely packed intercalation of AlCl4− molecules. With density functional theory (DFT) calculation, three simulated models of intercalated AlCl4− molecules in the graphite layer were revealed successfully, which explained possible molecular structures at different charging states. This analytical methodology paves the way for better understanding the structural transformation of molecular ions de-/intercalation in graphite layers.
    Keywords X-radiation ; X-ray absorption spectroscopy ; X-ray diffraction ; aluminum ; batteries ; cathodes ; chemical structure ; density functional theory ; energy ; graphene ; ions ; models
    Language English
    Dates of publication 2019-05
    Size p. 528-534.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0008-6223
    DOI 10.1016/j.carbon.2019.01.038
    Database NAL-Catalogue (AGRICOLA)

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