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  1. Article ; Online: Protective effects of Scoparia dulcis L. extract on high glucose-induced injury in human retinal pigment epithelial cells

    Heng-Dao Lin / Yuan-Chieh Lee / Chien-Yi Chiang / Yu-Jung Lin / Cheng Yen Shih / Rong-Kung Tsai / Pi-Yu Lin / Shinn-Zong Lin / Tsung-Jung Ho / Chih-Yang Huang

    Frontiers in Nutrition, Vol

    2023  Volume 10

    Abstract: Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. Scoparia dulcis L. ...

    Abstract Diabetic retinopathy (DR) is a major cause of vision loss in diabetic patients. Hyperglycemia-induced oxidative stress and the accumulation of inflammatory factors result in blood-retinal barrier dysfunction and the pathogenesis of DR. Scoparia dulcis L. extract (SDE), a traditional Chinese medicine, has been recently recognized for its various pharmacological effects, including anti-diabetic, anti-hyperlipidemia, anti-inflammatory, and anti-oxidative activities. However, there is no relevant research on the protective effect of SDE in DR. In this study, we treated high glucose (50 mM) in human retinal epithelial cells (ARPE-19) with different concentrations of SDE and analyzed cell viability, apoptosis, and ROS production. Moreover, we analyzed the expression of Akt, Nrf2, catalase, and HO-1, which showed that SDE dose-dependently reduced ROS production and attenuated ARPE-19 cell apoptosis in a high-glucose environment. Briefly, we demonstrated that SDE exhibited an anti-oxidative and anti-inflammatory ability in protecting retinal cells from high-glucose (HG) treatment. Moreover, we also investigated the involvement of the Akt/Nrf2/HO-1 pathway in SDE-mediated protective effects. The results suggest SDE as a nutritional supplement that could benefit patients with DR.
    Keywords retinal pigment epithelium ; diabetic retinopathy ; high glucose ; traditional Chinese medicine ; ROS ; inflammation ; Nutrition. Foods and food supply ; TX341-641
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Efficacy and Safety of Complementary Therapy With Jing Si Herbal Tea in Patients With Mild-To-Moderate COVID-19

    Po-Chun Hsieh / You-Chen Chao / Kuo-Wang Tsai / Chung-Hsien Li / I-Shiang Tzeng / Yao-Kuang Wu / Cheng Yen Shih

    Frontiers in Nutrition, Vol

    A Prospective Cohort Study

    2022  Volume 9

    Abstract: BackgroundSince late 2019, there has been a global COVID-19 pandemic. To preserve medical capacity and decrease adverse health effects, preventing the progression of COVID-19 to severe status is essential. Jing-Si Herbal Tea (JSHT), a novel traditional ... ...

    Abstract BackgroundSince late 2019, there has been a global COVID-19 pandemic. To preserve medical capacity and decrease adverse health effects, preventing the progression of COVID-19 to severe status is essential. Jing-Si Herbal Tea (JSHT), a novel traditional Chinese medicine formula was developed to treat COVID-19. This study examined the clinical efficacy and safety of JSHT in patients with mild-to-moderate COVID-19.MethodsIn this prospective cohort study, we enrolled 260 patients with mild-to-moderate COVID-19. The enrolled patients were divided into the JSHT (n = 117) and control (n = 143) groups. Both groups received standard management. The JSHT group was treated with JSHT as a complementary therapy.ResultsCompared with standard management alone, JSHT combined with standard management more effectively improved the reverse transcription–polymerase chain reaction cycle threshold value, C-reactive protein level, and Brixia score in the adult patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). The results revealed that the patients treated with JSHT combined with standard management had 51, 70, and 100% lower risks of intubation, Medisave Care Unit admission, and mortality compared with those receiving standard management only.ConclusionsJSHT combined with standard management more effectively reduced the SARS-CoV-2 viral load and systemic inflammation and alleviated lung infiltrates in the patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). JSHT combined with standard management may prevent critical status and mortality in patients with mild-to-moderate COVID-19. JSHT is a promising complementary therapy for patients with mild-to-moderate COVID-19.
    Keywords mild-to-moderate COVID-19 ; Jing Si Herbal Tea ; complementary and alternative medicine ; traditional Chinese medicine ; phytomedicine ; herbal medicine ; Nutrition. Foods and food supply ; TX341-641
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Article: Hepatoprotection by palm tocotrienol-rich fraction

    Lee, Shu-Ping / Yang, Shyh-Chyun / Cheng, Yen-Shih / Lien, Wan-Jung / Ng, Lean-Teik

    European journal of lipid science and technology. 2010 July, v. 112, no. 7

    2010  

    Abstract: Tocotrienols, a group of important phytonutrients of palm oil, have been shown to possess antioxidant, anticancer, neuroprotectory, and anti-inflammatory activities. In this study, our objective was to examine the protective effects of tocotrienol-rich ... ...

    Abstract Tocotrienols, a group of important phytonutrients of palm oil, have been shown to possess antioxidant, anticancer, neuroprotectory, and anti-inflammatory activities. In this study, our objective was to examine the protective effects of tocotrienol-rich fraction (TRF) from palm oil on chronic carbon tetrachloride (CCl₄)-induced hepatotoxicity in rats. Animals were subjected to vehicle only (control), CCl₄ only, CCl₄ + 100 mg/kg silymarin (silymarin), CCl₄ + 25 mg/kg TRF (TRF-25) and CCl₄ + 50 mg/kg TRF (TRF-50) treatments for a period of 8 wks. Results showed that daily oral administration of TRF-25, TRF-50, and silymarin prevented the elevation of serum glutamate oxalate transaminase (sGOT) and glutamate pyruvate transaminase (sGPT), liver thiobarbituric acid reactive substances (TBARS), triglycerides and total cholesterol levels, as well as enhancing the liver catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels in rats with hepatotoxicity. At 50 mg/kg, the hepatoprotection of TRF was as good as or better than silymarin (100 mg/kg) in normalization of oxidative stress parameters in liver injury rats. These results suggest that TRF exerts effective protection against chronic CCl₄-induced hepatic injury in rats, and its mechanism of action could be related to reducing oxidative stress in the liver tissue.
    Keywords anti-inflammatory activity ; carbon tetrachloride ; catalase ; cholesterol ; glutamates ; glutathione peroxidase ; hepatotoxicity ; liver ; mechanism of action ; oral administration ; oxidative stress ; palm oils ; protective effect ; rats ; silymarin ; superoxide dismutase ; thiobarbituric acid-reactive substances ; tocotrienols ; triacylglycerols
    Language English
    Dates of publication 2010-07
    Size p. 712-719.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 2003265-1
    ISSN 1438-7697
    ISSN 1438-7697
    DOI 10.1002/ejlt.200900175
    Database NAL-Catalogue (AGRICOLA)

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  4. Book: Lenin's fight against revisionism and opportunism

    Cheng, Yen-shih

    1965  

    Author's details comp. by Cheng Yen-shih
    Language English
    Size 275 S
    Publisher Foreign Languages Pr
    Publishing place Peking
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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