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  1. Article: Correlation analysis between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil in 100 Han Chinese patients.

    Jiecheng Xiao, - / Xianwei Wu, - / Chengfei Zhao, -

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 3, Page(s) 789–792

    Abstract: This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA. All the ... ...

    Abstract This study explored correlation between CYP2C9 polymorphisms and liver injury induced by flurbiprofen axetil (FBA). A total of 100 patients undergoing primary total knee arthroplasty (TKA) were mainly administered with basic analgesic, FBA. All the patients participating in this study were required to take blood samples for detecting CYP2C9 polymorphisms before surgery after admission. After TKA surgery, the level of glutamic-pyruvic transaminase in blood was detected to determine whether liver injury occurred in patients. The overall incidence of liver injury after TKA was 12.00% and the incidence of liver injury was 12.22% for CYP2C9*1/*1 and 16.67% for CYP2C9*1/*3. The incidence of liver injury in patients with CYP2C9*1/*3 was higher than the incidence of overall patients and patients with CYP2C9*1/*1, but the difference was not statistically significant. However, given the occurrence of liver injury, clinicians should still pay attention to patients with CYP2C9*1/*3 to avoid serious liver injury that may be induced by FBA.
    Language English
    Publishing date 2023-08-14
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Promotional Effect of Na on Ru for pH-Universal Hydrogen Evolution Reactions

    Bingxin Guo / Chengfei Zhao / Yingshuang Zhou / Junjie Guo / Zhongzhe Wei / Jing Wang

    Catalysts, Vol 13, Iss 552, p

    2023  Volume 552

    Abstract: Alkali metals, as ideal electron donors, can effectively regulate the valence state distribution of the host metals. Nevertheless, no studies have reported the application of alkali metal promoters in the hydrogen evolution reaction (HER). Here, we ... ...

    Abstract Alkali metals, as ideal electron donors, can effectively regulate the valence state distribution of the host metals. Nevertheless, no studies have reported the application of alkali metal promoters in the hydrogen evolution reaction (HER). Here, we designed an efficient and wide pH-universal hydrogen evolution catalyst that utilizes alkali metal to control the valence, size, and dispersion of Ru NPs. The experimental results reveal that the alkali metal additives contribute to the dispersion and stabilization of metallic Ru. More importantly, the interaction between Na and Ru regulates the distribution of Ru valence states and helps to form more active components of Ru 0 . Additionally, NaCl functioned as an in situ template to assist the construction of a porous carbon skeleton promotes mass transfer and exposes more active sites, further promoting the synergistic effect of Ru and Na. As a result, the optimal Ru 0.3 /C−800 delivers high efficiency for HER with an overpotential as low as 29 mV in 1.0 M KOH and 83 mV in 0.5 M H 2 SO 4 under 10 mA cm −2 . Particularly, the catalytic performance of Ru 0.3 /C−800 even outbalanced that of commercial Pt/C in an alkaline medium. This rational construction strategy opens up new avenues for obtaining superior pH-universal electrocatalysts.
    Keywords alkali metal ; Ru based ; hydrogen evolution reaction ; wide-range pH ; promotional effect ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Insight into the DNA adsorption on nitrogen-doped positive carbon dots

    Li, Fenglan / Qianqian Cai / Xiaoli Hao / Chengfei Zhao / Zhengjun Huang / Yanjie Zheng / Xinhua Lin / Shaohuang Weng

    RSC advances. 2019 Apr. 23, v. 9, no. 22

    2019  

    Abstract: Considerable biosensors have been fabricated on the basis of DNA interaction with carbon nanomaterials, such as graphene oxide (GO) nanosheets. Few studies have focused on the rational design of sensors between carbon dots (CDs) and DNA due to the ... ...

    Abstract Considerable biosensors have been fabricated on the basis of DNA interaction with carbon nanomaterials, such as graphene oxide (GO) nanosheets. Few studies have focused on the rational design of sensors between carbon dots (CDs) and DNA due to the limited understanding of the real forces behind the adsorption of DNA on CDs. In this work, nitrogen doping-positive CDs (N-CDs), which can quench fluorophore-labeled DNA, were investigated to ascertain the interaction between the CDs and DNA. With reference to DNA adsorption on GO, the adsorption capacity and kinetics of N-CDs for DNA were studied. Desorption of DNA from these surfaces was also measured. Moreover, DNA desorption and anchoring force of N-CDs to DNA were different from those of GO, given that the prepared N-CDs and GO were positively and negatively charged, respectively. Accordingly, DNA was adsorbed on N-CDs mainly via electrostatic adsorption and other forces, such as nucleobase effect, hydrophobic interaction, and van der Waals (vdW) forces. This study enhanced the basic knowledge of DNA adsorption on some CDs for further study in the application of CDs in bioanalysis or biomedicine.
    Keywords DNA ; adsorption ; biosensors ; carbon quantum dots ; desorption ; graphene oxide ; hydrophobic bonding ; nanosheets ; nitrogen ; nucleobases ; van der Waals forces
    Language English
    Dates of publication 2019-0423
    Size p. 12462-12469.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/c9ra00881k
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: DNA electrochemical sensor for detection of PRSS1 point mutation based on restriction endonuclease technique.

    Qicai, Liu / Qiang, Yi / Wennan, Wu / Yu, Wang / Liqing, Lin / Chengfei, Zhao / Xinhua, Lin

    Preparative biochemistry & biotechnology

    2015  Volume 45, Issue 5, Page(s) 430–437

    Abstract: To construct a restriction endonuclease based biosensor technology for PRSS1 genotyping. We designed a thiol-modified hairpin probe where the neck has EcoRI endonuclease recognition sites according to the PRSS1 gene c.410 C>T (p.T137 M) mutation and it ... ...

    Abstract To construct a restriction endonuclease based biosensor technology for PRSS1 genotyping. We designed a thiol-modified hairpin probe where the neck has EcoRI endonuclease recognition sites according to the PRSS1 gene c.410 C>T (p.T137 M) mutation and it was fixed on the gold electrode. Different charge generated by the binding of MB to phosphate groups of DNA before and after hybridization was used for distinguishing the different genotypes and quantity. This showed that the novel sensor can better distinguish the complementary sequence, single-base mismatches, and completely noncomplementary sequences, and the linear range for the logarithm was Y=-0.0242 X+0.1574, R=0.9912(Y=current, X=log target DNA concentration); the detection limit for DNA detection is estimated to be 50 fM.
    MeSH term(s) Biosensing Techniques/methods ; Deoxyribonuclease EcoRI/chemistry ; Electrochemical Techniques ; Humans ; Limit of Detection ; Point Mutation ; Trypsin/genetics
    Chemical Substances Deoxyribonuclease EcoRI (EC 3.1.21.-) ; PRSS1 protein, human (EC 3.4.21.4) ; Trypsin (EC 3.4.21.4)
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ZDB-ID 1322522-4
    ISSN 1532-2297 ; 1082-6068
    ISSN (online) 1532-2297
    ISSN 1082-6068
    DOI 10.1080/10826068.2014.940971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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