LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article ; Online: Impact of pharmacist intervention in reducing vancomycin-associated acute kidney injury: A systematic review and meta-analysis.

Kunming, Pan / Xiaotian, Jiang / Qing, Xu / Chenqi, Xu / Xiaoqiang, Ding / Qian Zhou, Lv

British journal of clinical pharmacology

2022 Volume 89, Issue 2, Page(s) 526–535

Abstract: Aims: The aim was to quantify the relationship between pharmacist intervention and vancomycin-associated acute kidney injury (AKI).: Methods: Electronic databases were searched up to August 2020 for meta-analyses of cohort studies and/or randomized ... ...

Abstract	Aims: The aim was to quantify the relationship between pharmacist intervention and vancomycin-associated acute kidney injury (AKI). Methods: Electronic databases were searched up to August 2020 for meta-analyses of cohort studies and/or randomized controlled trials. Studies that compared the incidence of AKI in patients between post- and prepharmacist intervention were investigated. The primary outcome was incidence of AKI. We also evaluated the influence of pharmacist intervention in risk factors of vancomycin-associated AKI. Results: The search strategy retrieved 1744 studies and 34 studies with 19 298 participants were included (22 published articles and 12 abstracts from conference proceedings). Compared with the preintervention group, the postintervention group patients had a significantly lower incidence of vancomycin-associated AKI: 7.3% for post- and 9.6% for preintervention (odds ratio [OR] 0.52, 95% confidence interval [CI]; 0.41, 0.67], P < .00001). The rate of attaining target concentration was significantly higher in the post- than preintervention group (OR 2.86, 95% CI [2.23, 3.67], P < .00001). The postintervention group significantly improved the percentage of serum creatinine laboratory tests than preintervention group (OR = 3.24, 95% CI 2.02, 5.19], P < .00001). Patients postintervention had markedly lower risk of mortality than preintervention patients (OR 0.47, 95% CI [0.31, 0.72], P = .0004). Conclusion: Pharmacist intervention in vancomycin treatment significantly decreased the rate of vancomycin-associated AKI, while improving efficacy and reducing mortality. We speculate that this is because the pharmacist interventions optimized the rationality of vancomycin therapy, monitoring of vancomycin trough concentration and the monitoring of patients' renal function.
MeSH term(s)	Humans ; Vancomycin/adverse effects ; Anti-Bacterial Agents/adverse effects ; Pharmacists ; Retrospective Studies ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/prevention & control ; Creatinine
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2022-04-02
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1118: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Vancomycin associated acute kidney injury in patients with infectious endocarditis: a large retrospective cohort study.

Kunming, Pan / Ying, Huang / Chenqi, Xu / Zhangzhang, Chen / Xiaoqiang, Ding / Xiaoyu, Li / Xialian, Xu / Qianzhou, Lv

Frontiers in pharmacology

2023 Volume 14, Page(s) 1260802

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1260802
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Direct Regulation of the T Cell Antigen Receptor's Activity by Cholesterol

Salma Pathan-Chhatbar / Carina Drechsler / Kirsten Richter / Anna Morath / Wei Wu / Bo OuYang / Chenqi Xu / Wolfgang W. Schamel

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 8

Abstract: Biological membranes consist of hundreds of different lipids that together with the embedded transmembrane (TM) proteins organize themselves into small nanodomains. In addition to this function of lipids, TM regions of proteins bind to lipids in a very ... ...

Abstract	Biological membranes consist of hundreds of different lipids that together with the embedded transmembrane (TM) proteins organize themselves into small nanodomains. In addition to this function of lipids, TM regions of proteins bind to lipids in a very specific manner, but the function of these TM region-lipid interactions is mostly unknown. In this review, we focus on the role of plasma membrane cholesterol, which directly binds to the αβ T cell antigen receptor (TCR), and has at least two opposing functions in αβ TCR activation. On the one hand, cholesterol binding to the TM domain of the TCRβ subunit keeps the TCR in an inactive, non-signaling conformation by stabilizing this conformation. This assures that the αβ T cell remains quiescent in the absence of antigenic peptide-MHC (the TCR's ligand) and decreases the sensitivity of the T cell toward stimulation. On the other hand, cholesterol binding to TCRβ leads to an increased formation of TCR nanoclusters, increasing the avidity of the TCRs toward the antigen, thus increasing the sensitivity of the αβ T cell. In mouse models, pharmacological increase of the cholesterol concentration in T cells caused an increase in TCR clustering, and thereby enhanced anti-tumor responses. In contrast, the γδ TCR does not bind to cholesterol and might be regulated in a different manner. The goal of this review is to put these seemingly controversial findings on the impact of cholesterol on the αβ TCR into perspective.
Keywords	cholesterol ; lipid ; TCR ; signaling ; T cell ; nanocluster ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Extraction of Hidden Information under Sootiness on Murals Based on Hyperspectral Image Enhancement

Miaole Hou / Ning Cao / Li Tan / Shuqiang Lyu / Pingping Zhou / Chenqi Xu

Applied Sciences, Vol 9, Iss 17, p

2019 Volume 3591

Abstract: Changes in the environment and human activities can cause serious deterioration of murals. Hyperspectral imaging technology can observe murals in the range of visible to near infrared light, providing a scientific and non-destructive way for mural ... ...

Abstract	Changes in the environment and human activities can cause serious deterioration of murals. Hyperspectral imaging technology can observe murals in the range of visible to near infrared light, providing a scientific and non-destructive way for mural digital preservation. An effective method to extract hidden information from the sootiness of murals in order to enhance the visual value of patterns in ancient murals using hyperspectral imaging is proposed in this paper. Firstly, Minimum Noise Fraction transform was applied to reduce sootiness features in the background of the mural. Secondly, analysis of spectral characteristics and image subtraction were used to achieve feature enhancement of the murals. Finally, density slicing was performed to extract the patterns under the sootiness. The results showed that the extraction of hidden information was achieved with an overall accuracy of 88.97%.
Keywords	hidden information ; mural ; sootiness ; hyperspectral imaging ; visual enhancement ; Minimum Noise Fraction transform ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	006
Language	English
Publishing date	2019-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

Maorong Wen / Yunlei Cao / Bin Wu / Taoran Xiao / Ruiyu Cao / Qian Wang / Xiwei Liu / Hongjuan Xue / Yang Yu / Jialing Lin / Chenqi Xu / Jie Xu / Bo OuYang

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 13

Abstract: The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1- ...

Abstract	The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.
Keywords	Science ; Q
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Preparation, characterization and stability of curcumin-loaded zein-shellac composite colloidal particles

Sun, Cuixia / Chenqi Xu / Di Wang / Jie Yang / Like Mao / Yanxiang Gao

Food chemistry. 2017 Aug. 01, v. 228

2017

Abstract: Curcumin-loaded zein-shellac composite particles were prepared by the antisolvent co-precipitation method. The encapsulation efficiency of curcumin was significantly improved from 82.7% in zein particles to 93.2% in zein-shellac complex particles. The ... ...

Abstract	Curcumin-loaded zein-shellac composite particles were prepared by the antisolvent co-precipitation method. The encapsulation efficiency of curcumin was significantly improved from 82.7% in zein particles to 93.2% in zein-shellac complex particles. The result of differential scanning calorimetry suggested that curcumin in the polymeric matrix was in an amorphous state. Fourier transform infrared spectroscopy analysis revealed that curcumin had non-covalently interacted with zein and shellac, mainly through hydrogen bonding and hydrophobic interaction. Aggregates in irregular shapes, with large sizes, were found by atomic force microscopy, and conglutination, integration or fusion of different entities into network structures occurred at a high level of shellac. At the mass ratio of zein to shellac of 1:1, curcumin in the complex particles exhibited improved photochemical and thermal stability. Curcumin-loaded zein-shellac complex particles allowed the controlled release of curcumin in both PBS medium and simulated gastrointestinal fluids.
Keywords	atomic force microscopy ; colloids ; coprecipitation ; curcumin ; differential scanning calorimetry ; encapsulation ; Fourier transform infrared spectroscopy ; gastrointestinal system ; hydrogen bonding ; hydrophobic bonding ; thermal stability ; zein
Language	English
Dates of publication	2017-0801
Size	p. 656-667.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2017.02.001
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3634: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Fabrication and characterization of binary composite nanoparticles between zein and shellac by anti-solvent co-precipitation

Chen, Shuai / Chenqi Xu / Cuixia Sun / Fuguo Liu / Lei Dai / Like Mao / Yanxiang Gao

Institution of Chemical Engineers Food and bioproducts processing. 2017,

2017

Abstract: The anti-solvent co-precipitation method was applied to fabricate zein (Z) and shellac (S) composite nanoparticles with different mass ratios (Z:S, 50:1, 10:1, 5:1, 2.5:1, 1:1, 1:1.5 and 1:2.5) at pH 8.0. Measurement of particle size and turbidity, in ... ...

Abstract	The anti-solvent co-precipitation method was applied to fabricate zein (Z) and shellac (S) composite nanoparticles with different mass ratios (Z:S, 50:1, 10:1, 5:1, 2.5:1, 1:1, 1:1.5 and 1:2.5) at pH 8.0. Measurement of particle size and turbidity, in combination with analyses of Fourier transform infrared spectroscopy (FTIR), circular dichroism (CD), differential scanning calorimetry (DSC), fluorescence spectroscopy, and atomic force microscope (AFM) were performed to characterize ZâS composite nanoparticles. Results showed that hydrogen bonding and hydrophobic attraction were involved in the interactions between zein and shellac, leading to the changes in secondary structure and thermal stability of zein. At low levels of shellac (Z:S, from 50:1 to 2.5:1), a compact structure of ZâS composite nanoparticles was formed, which had smaller particle sizes, higher turbidity value and better thermal stability. At high levels of shellac (Z:S, from 2.5:1 to 1:2.5), a cross-linked structure of ZâS composite nanoparticles was generated, which exhibited larger particle sizes, lower turbidity value, and poorer thermal stability. The potential mechanism of a two-step process was proposed to explain the formation of ZâS composite nanoparticles. Findings in the present work will help further understand the interaction between alcohol-soluble biopolymers (e.g. zein and shellac) and provide a new insight into the development of potential carriers for bioactive compounds.
Keywords	atomic force microscopy ; bioactive compounds ; biopolymers ; circular dichroism spectroscopy ; coprecipitation ; crosslinking ; differential scanning calorimetry ; fluorescence emission spectroscopy ; Fourier transform infrared spectroscopy ; hydrogen bonding ; hydrophobicity ; nanoparticles ; particle size ; pH ; thermal stability ; turbidity ; zein
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2008001-3
ISSN	0960-3085
ISSN	0960-3085
DOI	10.1016/j.fbp.2017.11.003
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates

Ao Sun / Ke Xu / Haifeng Liu / Hua Li / Yaohuang Shi / Xiaoyan Zhu / Tao Liang / Xinyue Li / Xianxia Cao / Yanhong Ji / Taijiao Jiang / Chenqi Xu / Xiaolong Liu

Scientific Reports, Vol 10, Iss 1, Pp 1-

2020 Volume 13

Abstract: Abstract The recombination activating gene (RAG or RAG1/RAG2 complex)-mediated adaptive immune system is a hallmark of jawed vertebrates. It has been reported that RAG originated in invertebrates. However, whether RAG further evolved once it arose in ... ...

Abstract	Abstract The recombination activating gene (RAG or RAG1/RAG2 complex)-mediated adaptive immune system is a hallmark of jawed vertebrates. It has been reported that RAG originated in invertebrates. However, whether RAG further evolved once it arose in jawed vertebrates remains largely unknown. Here, we found that zebrafish RAG (zRAG) had a lower activity than mouse RAG (mRAG). Intriguingly, the attenuated stability of zebrafish RAG2 (zRAG2), but not zebrafish RAG1, caused the reduced V(D)J recombination efficiency compared to mRAG at 37 °C which are the body temperature of most endotherms except birds. Importantly, the lower temperature 28 °C, which is the best temperature for zebrafish growth, made the recombination efficiency of zRAG similar to that of mRAG by improving the stability of zRAG2. Consistent with the prementioned observation, the V(D)J recombination of Rag2 KI/KI mice, which zRAG2 was substituted for mRAG2, was also severely impaired. Unexpectedly, Rag2 KI/KI mice developed cachexia syndromes accompanied by premature death. Taken together, our findings illustrate that the evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors

Zhenzhen Fan / Yahui Tian / Zhipeng Chen / Lu Liu / Qian Zhou / Jingjing He / James Coleman / Changjiang Dong / Nan Li / Junqi Huang / Chenqi Xu / Zhimin Zhang / Song Gao / Penghui Zhou / Ke Ding / Liang Chen

EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)

2020

Abstract: Abstract Small molecular PD‐1 inhibitors are lacking in current immuno‐oncology clinic. PD‐1/PD‐L1 antibody inhibitors currently approved for clinical usage block interaction between PD‐L1 and PD‐1 to enhance cytotoxicity of CD8+ cytotoxic T lymphocyte ( ... ...

Abstract	Abstract Small molecular PD‐1 inhibitors are lacking in current immuno‐oncology clinic. PD‐1/PD‐L1 antibody inhibitors currently approved for clinical usage block interaction between PD‐L1 and PD‐1 to enhance cytotoxicity of CD8+ cytotoxic T lymphocyte (CTL). Whether other steps along the PD‐1 signaling pathway can be targeted remains to be determined. Here, we report that methylene blue (MB), an FDA‐approved chemical for treating methemoglobinemia, potently inhibits PD‐1 signaling. MB enhances the cytotoxicity, activation, cell proliferation, and cytokine‐secreting activity of CTL inhibited by PD‐1. Mechanistically, MB blocks interaction between Y248‐phosphorylated immunoreceptor tyrosine‐based switch motif (ITSM) of human PD‐1 and SHP2. MB enables activated CTL to shrink PD‐L1 expressing tumor allografts and autochthonous lung cancers in a transgenic mouse model. MB also effectively counteracts the PD‐1 signaling on human T cells isolated from peripheral blood of healthy donors. Thus, we identify an FDA‐approved chemical capable of potently inhibiting the function of PD‐1. Equally important, our work sheds light on a novel strategy to develop inhibitors targeting PD‐1 signaling axis.
Keywords	immunotherapy ; methylene blue ; PD‐1 ; small molecular inhibitor ; transgenic mouse model ; Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis

Yu Cui / Xufeng Chen / Jiali Zhang / Xiang Sun / Haifeng Liu / Li Bai / Chenqi Xu / Xiaolong Liu

Cell Reports, Vol 15, Iss 2, Pp 256-

2016 Volume 263

Abstract: Uhrf1 (also known as Np95) is a regulator of DNA methylation and histone ubiquitination and plays an important role in embryogenesis and tumorigenesis. Here, we report that Uhrf1 is essential for invariant natural killer T (iNKT) cell development. We ... ...

Abstract	Uhrf1 (also known as Np95) is a regulator of DNA methylation and histone ubiquitination and plays an important role in embryogenesis and tumorigenesis. Here, we report that Uhrf1 is essential for invariant natural killer T (iNKT) cell development. We found that Uhrf1 was significantly upregulated in stage 1 iNKT cells. Targeted disruption of Uhrf1 resulted in stage 1-specific transition defects as observed by not only increased apoptosis, but also aberrant effector differentiation, which eventually led to the impaired generation of iNKT cells in Uhrf1-deficient mice. Notably, Uhrf1 deficiency resulted in attenuated activation of Akt-mTOR signaling in stage 1 iNKT cells and overexpression of active Akt rescued iNKT cell developmental defects. Collectively, our results suggest that Uhrf1 regulation of the Akt-mTOR signaling pathway is required for iNKT cell development.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2016-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED